Loading...
  • onset
  • PLU protein is similar to a class of inhibitors identified in mammalian cells by their ability to block the onset of S phase. (searlescholars.net)
  • organism
  • We are using the fruit fly Drosophila melanogaster as a model organism because it permits the combined approaches of genetics, cell biology, and biochemistry. (searlescholars.net)
  • In this organism, replication origins are specified by the autonomous replication sequences (ARS), which are around 100 base pairs and contain a shared 11-base-pair autonomous consensus sequence (ACS). (biomedcentral.com)
  • Work on the topic generally requires an organism whose cell cycle is well-characterized. (wikipedia.org)
  • Schizosaccharomyces pombe has also become an important organism in studying the cellular responses to DNA damage and the process of DNA replication. (wikipedia.org)
  • Saccharomyces
  • The function of the essential MIF2 gene in the Saccharomyces cerevisiae cell cycle was examined by overepressing or creating a deficit of MIF2 gene product. (nih.gov)
  • Bell SP, Labib K (2016) Chromosome duplication in Saccharomyces cerevisiae . (springer.com)
  • chromatin
  • Alabert C, Bukowski-Wills J-C, Lee S-B et al (2014) Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. (springer.com)
  • Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA. (wikipedia.org)
  • The primary functions of chromatin are 1) to package DNA into a more compact, denser shape, 2) to reinforce the DNA macromolecule to allow mitosis, 3) to prevent DNA damage, and 4) to control gene expression and DNA replication. (wikipedia.org)
  • Chromatin is only found in eukaryotic cells (cells with defined nuclei). (wikipedia.org)
  • For example, Histone acetylation results in loosening and increased accessibility of chromatin for replication and transcription. (wikipedia.org)
  • forks
  • Alzu A, Bermejo R, Begnis M et al (2012) Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. (springer.com)
  • Bando M, Katou Y, Komata M et al (2009) Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks. (springer.com)
  • Unwinding of DNA at the origin and synthesis of new strands results in replication forks growing bi-directionally from the origin. (wikipedia.org)
  • gene
  • The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expression-the nucleus is, therefore, the control center of the cell. (wikipedia.org)
  • This represented the first case where the position of a gene in the chromosome had demonstrable biological significance, and prompted Nasmyth to abandon work on the cell cycle for a time and concentrate instead on studying gene silencing. (wikipedia.org)
  • At the IMP, Nasmyth changed his focus from gene silencing back to cell cycle control. (wikipedia.org)
  • There has been an assumption that centromeric heterochromatin is just as important as the kinetochore in segregating and stabilizing chromosomes, because heterochromatin is associated with protein recruitment and has the defining ability to silence gene expression. (wikipedia.org)
  • Deletion of certain fragments, including deletions that are a few hundred base pairs long, and hence gene segments is possible and consequently the production of double minute chromosomes. (wikipedia.org)
  • Thus
  • Thus, checkpoint controls ensure that cell cycle events occur in the proper order even if some perturbation delays performance of a particular event. (rupress.org)
  • In 1838, Matthias Schleiden proposed that the nucleus plays a role in generating cells, thus he introduced the name "cytoblast" (cell builder). (wikipedia.org)
  • Thus, each generation of cells should be twice as numerous as the previous generation. (wikipedia.org)
  • When cells have reached sufficient size during G2, the phosphatase Cdc25 removes the inhibitory phosphorylation, and thus activates Cdc2 to allow mitotic entry. (wikipedia.org)
  • gametes
  • As a result, four haploid gametes form from one diploid progenitor cell. (prolekare.cz)
  • When two gametes (an egg and a sperm) fuse, the resulting zygote is once again diploid, with the mother and father each contributing 23 chromosomes. (wikipedia.org)
  • phosphorylation
  • The cell cycle arrest is due to inhibitory phosphorylation of the master cell cycle regulatory cyclin-dependent kinase, Cdc28p, at tyrosine 19 ( Lew and Reed, 1995 a ). (rupress.org)
  • Ball HL, Myers JS, Cortez D (2005) ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. (springer.com)
  • The cell polarity protein kinase Pom1, a member of the dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) family of kinases, localizes to cell ends. (wikipedia.org)
  • molecular
  • In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. (wikipedia.org)
  • This covalent modification of the molecular structure of Cdc2 inhibits the enzymatic activity of Cdc2 and prevents cell division. (wikipedia.org)
  • multicellular organisms
  • Our laboratory is investigating how cell growth and division are coordinated with key differentiation processes during the development of multicellular organisms. (searlescholars.net)
  • The situation is much more complicated in multicellular organisms, as DNA replication can be initiated at any location during early development of Xenopus laevis and Drosophila melanogaster . (biomedcentral.com)