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  • dynamics
  • In any case, our data show that p25 and presumably other p24 proteins are endowed with the intrinsic capacity to form highly specialized domains that control membrane composition and dynamics. (biologists.org)
  • Our paper on the role of dynamics in the evolution of the GK protein interaction domain family is published. (uoregon.edu)
  • High-speed AFM imaging can capture real-time dynamics of CNTP motion in the supported lipid bi-layer membrane. (phys.org)
  • As a result, it can be concluded that the symbiosome possesses organelle-like characteristics due to its metabolic behavior, the composite origin and differentiation of its membrane, the retargeting of host cell proteins, the control of microsymbiont proliferation and differentiation by the host legume, and the cytoskeletal dynamics and symbiosome segregation during the division of rhizobia-infected cells. (scoop.it)
  • Finally, we discuss cross-correlation microscopy methods, application of antigen-patterned surfaces, and fluorescence-based trafficking assays to study dynamics of stimulated proteins interactions and membrane trafficking. (schoolbag.info)
  • In eukaryotes, cell differentiation is often accompanied by modifications of MT dynamics. (rupress.org)
  • basolateral
  • these include the inhibition of adenylyl cyclase at the basolateral membrane and the stimulation of Na+ channel activity at the apical membrane. (pnas.org)
  • By using specific alpha i antibodies and immunofluorescence, the alpha i-2 subunit was found to be localized to the basolateral membrane, whereas the alpha i-3 subunit was concentrated in the Golgi and was also detectable at low levels on apical membranes in some cells. (pnas.org)
  • Induction of a chimeric mouse metallothionein 1-rat or canine alpha i-2 gene stably transfected into the LLC-PK1 cells produced an increase in the content of the alpha i-2 subunit, which was targeted only to the basolateral membrane. (pnas.org)
  • By contrast, stable microtubules, which are not functionally affected by 201-F treatment, are involved in the transport of membrane proteins to the basolateral surface. (rupress.org)
  • pathogens
  • Disease can result when proteins fail to cooperate, and many pathogens try to trick our proteins into working with them. (uoregon.edu)
  • Immune cells express a variety of receptors to detect foreign antigens and respond in a selective manner to clear pathogens and infected cells from the body. (schoolbag.info)
  • eukaryotic cell
  • Mitochondria exist in all eukaryotic cell types and are involved in apoptosis, respiratory ATP production, and iron-sulfur cluster assembly ( Schleiff and Becker, 2011 ). (frontiersin.org)
  • organelle
  • We study how cells transport materials to and from different organelle membranes within the cell. (sfu.ca)
  • This study indicates that Zera-protein fusion is still the major protein component of the new formed organelle in tobacco leaves. (biomedcentral.com)
  • Like their ancestors, chloroplasts, and mitochondria contain two envelope membranes that function as chemical and physical barriers to separate organelle-localized metabolic reactions and processes from the cytosol. (frontiersin.org)
  • transmembrane
  • The team created simple and versatile artificial membrane pore equivalents-CNTPs -that are made of short segments of single-wall carbon nanotubes that can self-insert into the lipid membrane and form a transmembrane pore. (phys.org)
  • Tetraspanins compose a family of proteins with four transmembrane domains delineating two extracellular domains of unequal size. (rupress.org)
  • DHA-induced apoptosis of breast cancer cells was also associated with up-regulation of the transmembrane heparan sulfate proteoglycan syndecan-1 [ 27 ]. (hindawi.com)
  • spindle
  • The mitotic spindle must also align along the polarity axis so that the cleavage furrow will bisect the the two membrane domains containing different fate determinants. (uoregon.edu)
  • One of the spindle orienting proteins we've identified is a protein interaction domain that resembles the guanylate kinase (GK) enzyme, which catalyzes the formation of GDP from GMP and ATP. (uoregon.edu)
  • fidelity
  • In prokaryotes, and especially in eukaryotes, replication and transcription regulation involve the interaction of many specialized protein factors at regulator locations on the sequence to insure correct sequence recognition, initiation, processivity, fidelity, and kinetic control. (berkeley.edu)
  • roles
  • RPE cells play critical roles in the maintenance of photoreceptors, including the recycling of visual chromophore for the opsin visual pigments. (readbyqxmd.com)
  • In present-day eukaryotic cells, these two organelles play pivotal roles in photosynthesis and ATP production. (frontiersin.org)
  • genes
  • With yeast cells we can remove genes, replace them with genes from humans or any other organism, and express those genes at any time. (sfu.ca)
  • Further, we deleted a bunch of other genes that encode proteins that stick membranes together inside the cell. (sfu.ca)
  • Here, we investigated the meiotic phenotype of Drosophila melanogaster spermatocytes expressing dsRNA of 52 genes encoding membrane-trafficking-related factors. (biologists.org)
  • About 5 % of the genes of a cell are related to lipid synthesis. (uvigo.es)
  • Using this screening system, we also identified three genes that promoted growth and migration of secondary cells in the accessory gland. (jove.com)
  • The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells. (jove.com)
  • chromatin
  • LBR-GFP-containing ER membranes then wrapped around chromatin over the course of 2-3 min, quickly and efficiently compartmentalizing nuclear material. (rupress.org)
  • Their functions include providing attachment sites for heterochromatin and the nuclear lamina, the latter of which is a meshwork of intermediate filaments that associates with interphase chromatin and lines the inner nuclear membrane (for review see Gerace and Burke, 1988 ). (rupress.org)
  • different
  • We then made use of these observations to study the intrinsic properties of these proteins, when present in a different membrane context. (biologists.org)
  • Different types of adult stem cells are capable of transdifferentiation more than others, and for many there is no evidence of its occurrence. (enacademic.com)
  • We have studied the Par complex, a set of three proteins that polarizes many different cell types, including neuroblasts. (uoregon.edu)
  • Here, we described the midgut cell ultrastructure of Callibaetis radiatus nymphs, which are bioindicators of water quality and the ultrastructural alterations in midgut under sublethal exposure to deltamethrin at three different periods (1, 12, 24 h). (readbyqxmd.com)
  • During polarisation, the cortex contracts, and this causes different PAR proteins to separate and accumulate at either the front or back of the cell, thereby breaking their previously symmetrical organisation and establishing polarity along the front/back axis. (eurekalert.org)
  • Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. (wikipedia.org)
  • mitotic
  • High resolution confocal time-lapse imaging in mitotic cells revealed LBR-GFP redistributing into the interconnected ER membrane system in prometaphase, exhibiting the same high mobility and diffusion constant as observed in interphase ER membranes. (rupress.org)
  • In most legumes, the rhizobia infect post-mitotic cells that have lost their ability to divide, although in some nodules cells do maintain their mitotic capacity after infection. (scoop.it)
  • During the initial mitotic divisions in Drosophila embryogenesis, Wolbachia exhibit a symmetric pattern of segregation. (biologists.org)
  • pathway
  • Proteins of the p24 family form a rather unique family of abundant, small (20-24 kDa) type I trans-membrane proteins in the early biosynthetic pathway. (biologists.org)
  • The Drosophila melanogaster secretory pathway involves several transport proteins. (biologists.org)
  • We provide a brief overview of MIRR signaling, which focuses on signaling through the IgE receptor in mast cells, and we highlight specific examples in which membrane compartmentalization plays a role in this signaling pathway. (schoolbag.info)
  • Activation of the p44/42 mitogen-activated protein kinase (MAPK) pathway plays a major role in regulating cell growth and survival in breast cancer cells [ 25 ] and is protective against apoptosis through phosphorylation of Bad [ 26 ]. (hindawi.com)
  • Moreover increase of syndecan-1 impairs signaling of the MAPK pathway by inhibiting phosphorylation of MEK, Erk, and Bad, that results in apoptosis induction in breast cancer cells [ 28 ]. (hindawi.com)
  • Biology
  • Trends in cell biology. (uvigo.es)
  • This overview should include a broad diversity of research areas ranging from biophysics, biochemistry, cell biology to pharmacology, but with a focus on drugs that function by selectively targeting membrane domains. (frontiersin.org)
  • Proliferation
  • Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion. (hindawi.com)
  • This paper aims to give a rapid overview of the effect of PUFAs on breast cancer cell proliferation, apoptosis, migration, and invasion. (hindawi.com)
  • In addition, DHA has been shown to affect cell proliferation whatever it comes from fish oil or microalgae [ 24 ]. (hindawi.com)
  • depends
  • Mechanosensory transduction by vertebrate hair cells depends on a protein complex at the tips of shorter stereocilia associated with mechanoelectrical transduction channels activated by tip links in the hair bundle. (readbyqxmd.com)
  • This self-renewal demands control of cell cycle as well as upkeep of multipotency or pluripotency, which all depends on the stem cell. (wikipedia.org)
  • characterize
  • By definition, this makes membrane domains appealing targets for drug treatment, which has sprouted in numerous research efforts to identify and characterize drugs that selectively target membrane domains. (frontiersin.org)
  • Drosophila
  • Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by paired, N-cadherin, and E-cadherin, which are Drosophila homologues of regulators of human prostate cancer progression. (jove.com)
  • These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. (jove.com)