• This oncosuppression is accomplished by initiating a form of cell death such as apoptosis or necrosis or by inducing cellular senescence. (wikipedia.org)
  • Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance. (wikipedia.org)
  • When the mitotic checkpoint complex is formed, it binds to the anaphase promoting complex and prevents its ability to promote cell cycle progression. (wikipedia.org)
  • It phosphorylates several key proteins to control progression through the different phases of the cell cycle. (bvsalud.org)
  • Conversely, we are investigating how complex mechanical cues influence important biological processes such as cell division, differentiation, or cancer progression. (stanford.edu)
  • We seek to understand how the mechanical properties of the extracellular matrix regulate processes such as breast cancer progression, stem cell differentiation, and cell division. (stanford.edu)
  • During cell-cycle progression, substrates of a single master regulatory enzyme can be modified in a specific order. (biomedcentral.com)
  • Progression through the cell cycle is accompanied by dramatic changes in cellular content and behavior, and involves a large number of proteins and processes. (biomedcentral.com)
  • This ordering of substrate modification allows a small number of master regulators to carry out their functions over a large time window with high temporal resolution, enabling precise and robust control of the numerous processes underlying cell cycle progression [ 1 , 2 ]. (biomedcentral.com)
  • The APC/C is an E3 ubiquitin ligase that drives mitotic progression by promoting timely degradation of key regulatory proteins [ 3 ]. (biomedcentral.com)
  • The activator Cdc20 is then replaced by a second activator, Cdh1, and APC/C Cdh1 promotes complete degradation of M cyclin, followed by polo-like kinase 1, Aurora A, and other substrates, to complete mitosis and cytokinesis and drive progression into G1 [ 1 , 2 ]. (biomedcentral.com)
  • Serine/threonine protein kinase Aurora B gene plays a regulatory role from G2 to cytokinesis, encompassing key cell cycle events such as centrosome duplication, chromosome bi-orientation, and segregation. (irdrjournal.com)
  • Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)
  • Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
  • In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
  • In G1 phase, cells have a single centrosome consisting of two centrioles joined by cohesion fibers. (biomedcentral.com)
  • Each cell inherits one centrosome after the completion of cytokinesis. (biomedcentral.com)
  • Centrosome duplication is tightly regulated and limited at once per cell cycle through a mechanism that prevents re-duplication. (biomedcentral.com)
  • Normally, activation of the anaphase promoting complex leads to the separation of sister chromatids and the cell exiting mitosis. (wikipedia.org)
  • Our exploration will range from a broad overview to an intricate, detailed examination of the series of events that transpire during anaphase, commencing with the separation of sister chromatids to their migration towards opposite cell poles. (biologyideas.com)
  • One usage of the term mitotic catastrophe is to describe an oncosuppressive mechanism (i.e. a mechanism to prevent the proliferation of cancerous cells and the develop of tumors) that occurs when cells undergo and detect a defective mitosis has occurred. (wikipedia.org)
  • Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
  • The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. (rupress.org)
  • At the onset of mitosis, centrosomes become the core structures of spindle poles and direct the formation of mitotic spindles. (biomedcentral.com)
  • During mitosis the two centrosomes are present and form the mitotic spindle poles. (biomedcentral.com)
  • Therapeutic inhibition of Aurora kinase showed great promise as a probable anticancer regime because of its important role during cell division. (irdrjournal.com)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • By analysing tum/RacGAP50C mutant Drosophila embryos we show that cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase, Diaphanous, Pav-KLP and Anillin. (biologists.com)
  • Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
  • for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
  • A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. (lookformedical.com)
  • Unattached kinetochores promote the formation of the mitotic checkpoint complex which is composed of four different proteins known as Mad2, Cdc20, BubR1, and Bub3 in humans. (wikipedia.org)
  • The production of different proteins determines the trait (inherited characteristic) of an organism. (newpathworksheets.com)
  • The term has been used to define a mechanism of cellular death that occurs while a cell is in mitosis or as a method of oncosuppression that prevents potentially tumorigenic cells from dividing. (wikipedia.org)
  • This definition of this mechanism has been described by the International Nomenclature Committee on Cell Death. (wikipedia.org)
  • The function of this mechanism is to prevent cells from accruing genomic instability which can lead to tumorigenesis. (wikipedia.org)
  • While more recent definitions of mitotic catastrophe do not use it to describe a bona fide cell death mechanism, some publications describe it as a mechanism of cell death. (wikipedia.org)
  • Cells have a mechanism to prevent improper segregation of chromosomes known as the spindle assembly checkpoint or mitotic checkpoint. (wikipedia.org)
  • This mechanism is important to ensure that the DNA within the cell is divided equally between the two daughter cells. (wikipedia.org)
  • This intricate phase, located within the larger mechanism of mitosis, is responsible for acting as a guarantor that each nascent cell obtains A precise set of chromosomes. (biologyideas.com)
  • Thus, the data described here use a novel genetic approach to birthdate centrosomes in human cells and identify asymmetric inheritance of centrosomes as a mechanism to maintain self-renewal properties and to ensure proper neurogenesis in human NPCs. (elifesciences.org)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • In this article, we will review the anti‐tumor mechanism of TTFields and discuss the emerging framework of TTFields‐based combination therapy for malignant brain tumors.ANTI‐TUMOR MECHANISMS OF TTFIELDSTissues and cells possess endogenous EF that influence biological activities and cellular events. (sagepub.com)
  • A systematic comparison of changes in cell number and clonogenic survival of 10 solid tumor‐derived cell lines after 72 h of TTFields exposure yielded that all cell lines exhibited a decrease in cell number and clonogenic survival.27 However, the mechanism of apoptosis induced by TTfields has not been elucidated completely. (sagepub.com)
  • Anaphase, a fundamental step in the process of cell division, plays a crucial role in ensuring accurate genetic information transfer. (biologyideas.com)
  • Residing in this sequential placement of the cell cycle, its role has a significant impact on the accuracy of cell division and genetic expression. (biologyideas.com)
  • It's during this step that each half of the cell has an exact copy of the genetic information, thereby ensuring that each new cell has a complete set of chromosomes. (biologyideas.com)
  • Anaphase holds vast importance in the division of cells and ensuring genetic continuity. (biologyideas.com)
  • Both in mitosis and meiosis, anaphase ensures each newly formed cell has a complete and accurate set of chromosomes, thus safeguarding the genetic integrity of an organism. (biologyideas.com)
  • Anaphase's influence extends to the organism's genetic makeup, emphasizing its far-reaching impact beyond mere cell division. (biologyideas.com)
  • A critical step for maintenance of genetic stability is chromosome segregation, which requires a high coordination of cellular processes. (irdrjournal.com)
  • Aberration of asymmetric segregation of centrosomes by genetic manipulation of the centrosomal, microtubule-associated protein Ninein alters fate decisions of NPCs and their maintenance in the VZ of human cortical organoids. (elifesciences.org)
  • Micronucleus - the smaller of the two nuclei present in some protozoa that contains the genetic material and controls cell reproduction. (newpathworksheets.com)
  • Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
  • Much of what we know about cell biology is based on studies of cells cultured on petri dishes, or rigid flat sheets of plastic. (stanford.edu)
  • Printable North Carolina Standard Course of Study High School Biology Worksheets and Answer Keys, Study Guides and Vocabulary Sets. (newpathworksheets.com)
  • Progress and challenges in stem cell biology. (caltech.edu)
  • The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, fosters AURKB activity, its overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. (novusbio.com)
  • Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
  • Centrosomes are the major microtubule organizing structures in vertebrate cells. (biomedcentral.com)
  • The PCM is an ordered lattice that anchors a large number of microtubule (MT)-associated proteins, many of which bear putative coiled-coil domains, a tertiary structure known to facilitate protein-protein interactions [ 4 ]. (biomedcentral.com)
  • In animal cells, centrosomes represent the major microtubule-organizing structures (MTOC). (biomedcentral.com)
  • Although the positioning signal is likely to be transmitted via the anaphase microtubule array to the cell cortex, exactly how the microtubule array determines the site of contractile ring formation remains unresolved. (biologists.com)
  • These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
  • UCD divides the mother cell into two daughter cells of different sizes. (elifesciences.org)
  • Multiple attempts to specifically define mitotic catastrophe have been made since the term was first used to describe a temperature dependent lethality in the yeast, Schizosaccharomyces pombe, that demonstrated abnormal segregation of chromosomes. (wikipedia.org)
  • Loss of mitotic regulation is a possible cause of aneuploidy in human epithelial malignancy and it is thought to create an abnormal nuclear morphology in cancer cells. (irdrjournal.com)
  • However, studies conducted several decades ago with mammalian cells revealed that Cdk1 also directly regulates the basal transcription machinery, most notably RNA polymerase II. (bvsalud.org)
  • However, mammalian cells in soft tissues function in 3D microenvironments, which are soft and viscoelastic, and in which cells are surrounded by neighboring cells and an extracellular matrix. (stanford.edu)
  • The role of polarization and early heterogeneities in the mammalian first cell fate decision. (caltech.edu)
  • Three isoforms have been described in mammalian cells. (lookformedical.com)
  • The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
  • If asymmetric segregation of centrosomes occurs in NPCs of the developing human brain, which depends on unique molecular regulators and species-specific cellular composition, remains unknown. (elifesciences.org)
  • The fundamental work that shows the preferential inheritance of the older centrosomes by the self-renewing daughter cells in human is supported by strong evidence. (elifesciences.org)
  • Centrosomes were first described at the end of the 19th century by Theodor Boveri who had also the intuition of their central role in cell life [ 1 ]. (biomedcentral.com)
  • Centrosomes are animal-specific non-membranous organelles that localize in close proximity to the cell nucleus for the duration of interphase. (biomedcentral.com)
  • The number of centrosomes within a cell is strictly controlled [ 5 ] (Figure 1 ). (biomedcentral.com)
  • However, the timing of cell death can vary from hours after mitosis completes to years later which has been witnessed in human tissues treated with radiotherapy. (wikipedia.org)
  • We are interested in elucidating the mechanics of cell-matrix interactions in soft tissues. (stanford.edu)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
  • Low-attenuation tissues , such as lungs and fat Cells , appear dark on a CT scan due to their low density. (studysmarter.co.uk)
  • Microscopes are used in laboratories to magnify samples, such as cells and tissues, so we can see structures that would not be possible to observe with the naked eye. (hellovaia.com)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)
  • I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Catastrophic mitotic errors that occur in late mitosis are impossibly rectified, and the cell membrane will rupture and blister.29 Then cancer cells will undergo cell death or apoptosis. (sagepub.com)
  • Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
  • Our studies provide a conceptual framework for understanding how ordered modification can be established among substrates of the same regulatory enzyme, and facilitate our understanding of how precise temporal control is achieved by a small number of master regulators to ensure a successful cell division cycle. (biomedcentral.com)
  • Recent work also indicates that direct regulation of the RNA polymerase II machinery promotes cell cycle entry. (bvsalud.org)
  • Here, we provide an overview of the regulation of basal transcription by Cdk1, and we hypothesize that the original function of the primordial cell-cycle CDK was to regulate RNAPII and that it later evolved into specialized kinases that govern various aspects of the transcription machinery and the cell cycle. (bvsalud.org)
  • The 2019 edition of the meeting, held from 18-20 October at the National Brain Research Centre (NBRC), Manesar, India and organised by Mahak Sharma (Indian Institute of Science Education and Research, Mohali) and Anindya Ghosh Roy (NBRC), was witness to stimulating research on a range of topics related to the cytoskeleton, including cytoskeletal organization, motor protein function and regulation, mechanical forces and vesicular transport, and trafficking in health and disease. (silverchair.com)
  • Although cell shape often predicts spindle orientation, there are numerous examples where this is not the case in somatic cells ( Finegan and Bergstralh, 2019 ). (elifesciences.org)
  • J Cell Biol (2019) 218 (12): 3977-3985. (silverchair.com)
  • Another usage of the term mitotic catastrophe is to describe a mode of cell death that occurs during mitosis. (wikipedia.org)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • When the cell undergoes cell death during mitosis this is known as mitotic death. (wikipedia.org)
  • Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. (caltech.edu)
  • Similarly, errors can also result in cells with missing or extra chromosomes, a condition known as 'aneuploidy', and can cause severe abnormalities. (biologyideas.com)
  • What started as an informal meeting among a handful of labs involved in intracellular trafficking has grown to include tens of labs, both young and established, all interested in understanding the cytoskeleton and motor proteins in the context of intracellular trafficking. (silverchair.com)
  • B) During cell division, the cell morphology under TTFields (hourglass‐like shape) produces an inhomogeneous intracellular EF, and all polar macromolecules and organelles will be pushed toward the CCF. (sagepub.com)
  • In early mitosis, the cohesion between the two pairs of centrioles is broken and each of them participates in the formation of the mitotic spindle pole. (biomedcentral.com)
  • Under this definition, cells that undergo mitotic catastrophe either senesce and stop dividing or undergo a regulated form of cell death during mitosis or another form of cell death in the next G1 phase of the cell cycle. (wikipedia.org)
  • Cells that undergo mitotic catastrophe death can lack activation of pathways of the traditional death pathways such as apoptosis. (wikipedia.org)
  • Some cells can have an erroneous mitosis yet survive and undergo another cell division which puts the cell at a higher likelihood to undergo mitotic catastrophe. (wikipedia.org)
  • For instance, cells can undergo a process called mitotic slippage where cells exit mitosis too early before the process of mitosis is finished. (wikipedia.org)
  • During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
  • During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
  • Western Blot: JTB Antibody [H00010899-B01P] - Analysis of JTB expression in transfected 293T cell line by JTB polyclonal antibody. (novusbio.com)
  • Renowned as the #1 antibody event in the industry, this year's agenda boasts 15 dedicated topic streams, 3 unmissable training course add-on options and will bring together more than 700 of the antibody and protein community. (cshlpress.com)
  • A model of the post-implantation human embryo derived from pluripotent stem cells. (caltech.edu)
  • Generation of Stem Cell-Based Mouse Embryo-Like Structures. (caltech.edu)
  • Stem-cell-based human and mouse embryo models. (caltech.edu)
  • Modeling human embryo development with embryonic and extra-embryonic stem cells. (caltech.edu)
  • The GAP activity of Tum is required for cytokinesis: in its absence cytokinesis fails early even though Tum is present on microtubules at the cell equator where the furrow should form. (biologists.com)
  • Here, we show that cell geometry and polarity domains cooperate, rather than compete, in positioning the cleavage plane during UCDs in early ascidian embryos. (elifesciences.org)
  • Using the early embryonic divisions of the ascidian Phallusia mammillata as a model to investigate mechanisms of unequal cell division, this study convincingly demonstrates that cell shape and cortical domains are cooperating, rather than competing, in order to establish cell size asymmetry, a significant conceptual advance for the field. (elifesciences.org)
  • In spite of the meticulous processes that normally ensure accurate chromosome separation, errors during anaphase can still occur, leading to chromosomal instability and disease. (biologyideas.com)
  • Importantly, cells sense and respond to the mechanical properties and dimensionality of the microenvironment, and a 3D microenvironment can be confining, serving as a physical barrier to processes such as cell migration or division that involve shape change or growth. (stanford.edu)
  • All of the processes involved in increasing CELL NUMBER including CELL DIVISION . (lookformedical.com)
  • Bioelectrical signaling regulates many essential processes to cellular homeostasis, and the biological circuitry of cancer cells is modified. (sagepub.com)
  • Such as the processes of tumor metastasis, which can be regulated by cellular ion channels.14 When potassium ion channels are overexpressed in tumor cells, more negative charges will be carried inside the cells, and the imbalance of voltage will lead to an increase in tumor growth and metastasis. (sagepub.com)
  • This allocation is pivotal to cell survival and further division, as it guarantees that both daughter cells receive a full set of chromosomes. (biologyideas.com)
  • Not limited to mitosis, anaphase also takes place in meiosis, another type of cell division that leads to the creation of sex cells. (biologyideas.com)
  • Anaphase is a key biological process that takes place during cell division, specifically in the broader context of mitosis. (biologyideas.com)
  • Further, we aim to determine the biophysics of cell migration and division in confining 3D microenvironments. (stanford.edu)
  • Golgi fragmentation is a highly regulated process that allows division of the Golgi complex between the two daughter cells. (biologists.com)
  • Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis. (elifesciences.org)
  • Whether and how such competition is also at work to determine unequal cell division (UCD), producing daughter cells of different size, remains unclear. (elifesciences.org)
  • Depending on the level of cell shape anisotropy or the strength of the polarity domain, one dominates the other and determines the orientation of the spindle. (elifesciences.org)
  • We found that the UCDs and their orientation at the ascidian third cleavage rely on the spindle tilting in an anisotropic cell shape, and cortical polarity domains exerting different effects on spindle astral microtubules. (elifesciences.org)
  • Yet, whether and how cell geometry and polarity domains compete with each other not only to determine the orientation but also the centering of the mitotic spindle leading to equal or unequal cell divisions (UCDs) remains unclear. (elifesciences.org)
  • or embryos ( Minc and Piel, 2012 ) and is the result of spindle alignment with the longest axis of the cell. (elifesciences.org)
  • Our approaches involve using force measurement instrumentation, such as atomic force microscopy, to exert and measure forces on materials and cells at the nanoscale, and the development of material systems for 3D cell culture that allow precise and independent manipulation of mechanical properties. (stanford.edu)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • For instance, cell cycle-stage-dependent activity of these complexes may be important for meeting the increased demand for various proteins involved in housekeeping, metabolism, and protein synthesis. (bvsalud.org)
  • A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre. (caltech.edu)
  • Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)
  • The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
  • It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
  • One such error is 'non-disjunction', where chromosomes fail to separate and are pulled to the same side of the cell, leading to one cell having too many chromosomes and the other having too few. (biologyideas.com)
  • This step is vital not only in maintaining cell functionality, but also in preserving the overall health of the organism. (biologyideas.com)
  • Genetics and heredity II By whom were first described the principles of dominance, segregation, and independent assortment? (newpathworksheets.com)
  • Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension. (caltech.edu)
  • Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro. (caltech.edu)
  • By systematically varying mitotic cell shape, we could modulate the effect of attractive and repulsive polarity domains and consequently generate predicted daughter cell size asymmetries and position. (elifesciences.org)
  • We therefore propose that the spindle position during UCD is set by the combined activities of cell geometry and polarity domains, where cell geometry modulates the effect of cortical polarity domain(s). (elifesciences.org)
  • Their findings provide a new perspective on the roles of cell polarity and shape in the control of spindle positioning, and are of broad interest to cell and developmental biologists. (elifesciences.org)
  • The least common outcome of mitotic catastrophe is senescence in which the cell stops dividing and enters a permanent cell cycle arrest that prevents the cell from proliferating any further. (wikipedia.org)
  • Reconstructing aspects of human embryogenesis with pluripotent stem cells. (caltech.edu)
  • An in vitro stem cell model of human epiblast and yolk sac interaction. (caltech.edu)
  • Disruption of the Pebble-interacting domain leaves Tum localised to the cell equator on cortically associated microtubules, again with no evidence of furrowing. (biologists.com)
  • Lastly, to enrich comprehension, there will be a comparison of anaphase in both mitosis and meiosis, finding the delicate differences and distinctive features of each process. (biologyideas.com)
  • They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. (biomedcentral.com)
  • Furthermore, we delve into the significant role of the mitotic spindle, the complex that serves as the catalyst for moving chromosomes during anaphase, and observe the consequential fallout in case of anaphase errors, putting emphasis on common mishaps like non-disjunction which could potentially trigger chromosomal disorders including cancer and Down syndrome. (biologyideas.com)