Seen metaplasia. Medical search. Frequent questions

Today, I want to talk about the management of gastric intestinal metaplasia (GIM). (medscape.com)
There are two instruments used for histopathologic assessment that can portend greater risk for progression: the operative link on gastritis assessment (OLGA) and the operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems. (medscape.com)
In some cases, intestinal metaplasia may be associated with gastric neoplasia. (nih.gov)
Whenever present, intestinal metaplasia should be diagnosed and graded based on the number of metaplastic glands present. (nih.gov)
The effect of sex differences on induction of intestinal metaplasia in rats. (nih.gov)
Stomach, Glandular stomach - Metaplasia, Intestinal in a male F344/N rat from a chronic study. (nih.gov)
Metaplasia of fundic glands to intestinal glands (arrow). (nih.gov)
The following is a summary of "Gastric Intestinal Metaplasia in Children: Natural History and Clinicopathological Correlation," published in the September 2023 issue of Pediatrics by Mansuri, et al. (physiciansweekly.com)
Gastric intestinal metaplasia (GIM) is where intestinal-type epithelium replaces normal gastric epithelium. (physiciansweekly.com)
New evidence-based clinical guidelines from the American Gastroenterological Association (AGA) provide recommendations for managing patients with gastric intestinal metaplasia detected as part of routine upper endoscopy . (acpinternist.org)
In patients with gastric intestinal metaplasia, the guidelines recommend testing for H. pylori followed by eradication over no testing and eradication (strong recommendation, moderate-quality evidence). (acpinternist.org)
however, they noted that surveillance could be reasonably chosen by patients with gastric intestinal metaplasia at higher risk for gastric cancer who place a high value on a potential but uncertain reduction in gastric cancer mortality and a low value on potential risks of surveillance endoscopies. (acpinternist.org)
Based on shared decision making, patients may reasonably elect repeated endoscopy within one year for risk stratification if they have gastric intestinal metaplasia and high-risk stigmata, are concerned about completeness of baseline endoscopy, and/or are at overall increased risk for gastric cancer, the guidelines said. (acpinternist.org)
They called for future studies on the impact of surveillance versus no surveillance on outcomes, as well as the importance of extensive versus limited gastric intestinal metaplasia on risk for gastric cancer, among other topics. (acpinternist.org)
Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC. (bmj.com)
Relationship between gastric intestinal metaplasia and colorectal neoplasms. (authorea.com)
Gastric intestinal metaplasia is considered a precancerous lesion that can progress into gastric cancer. (authorea.com)
Even though there are previous publications stating that Helicobacter pylori and intestinal metaplasia are related to colorectal adenomas, there are also studies stating the opposite. (authorea.com)
This study aims to determine the relationship between gastric intestinal metaplasia and colorectal neoplasia. (authorea.com)
The association of intestinal metaplasia and Helicobacter pylori infection with colorectal neoplasia was evaluated in these patients. (authorea.com)
A statistically significant correlation was found between intestinal metaplasia and colon neoplasm prevalence (p= 0.03). (authorea.com)
Conclusion: A positive correlation was found between gastric intestinal metaplasia, which is a precancerous lesion, and colon neoplasia. (authorea.com)
Even though this correlation indicates higher prevalence rates of colon neoplasia in patients with gastric intestinal metaplasia, how to evaluate these patients in terms of colon neoplasia remains a controversial issue. (authorea.com)
Gastric intestinal metaplasia (GIM) is a precancerous gastric carcinoma (GC) lesion with pivotal roles in carcinogenesis. (oncotarget.com)
So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)
During this multistep procession, gastric intestinal metaplasia (GIM) is considered to be a precancerous lesion of GC and to play a pivotal role in GC tumorigenesis [ 4 , 5 ]. (oncotarget.com)
Is there a cure for intestinal metaplasia? (ghsagenda.org)
Intestinal metaplasia is a condition in which cells in the lining of the stomach or esophagus transform to resemble intestinal cells. (ghsagenda.org)
The crucial question that many people have in mind is whether intestinal metaplasia is curable. (ghsagenda.org)
The answer is that while intestinal metaplasia can be reversed in some cases, in others, complete regression can be more challenging. (ghsagenda.org)
Treatment of intestinal metaplasia is primarily aimed at controlling chronic irritation in the cells lining the stomach or esophagus, as well as eliminating or reducing risk factors that may contribute to its development. (ghsagenda.org)
Treatment of the Root Cause: If intestinal metaplasia is related to H. pylori infection, eradication of this bacteria is a priority. (ghsagenda.org)
Regular Medical Monitoring: Intestinal metaplasia requires regular medical monitoring to monitor its progress. (ghsagenda.org)
Although intestinal metaplasia is not a definitive sentence, it is essential to take a proactive approach to its treatment and management. (ghsagenda.org)
Narita T, Ohnuma H, Yokoyama S. Peutz-Jeghers syndrome with osseous metaplasia of the intestinal polyps. (ac.ir)
intestinal metaplasia with goblet cells and neuroendocrine cells are present in some cases. (nih.gov)
Together, these data indicate that Hh signaling induces expression of genes that determine an intestinal phenotype in esophageal squamous epithelial cells and may contribute to the development of Barrett's metaplasia. (elsevierpure.com)
A Treatment For Intestinal Metaplasia? (drweil.com)
HE4, which was absent in the normal stomach, was expressed in SPEM of human and mouse and in intestinal metaplasia and gastric cancer in human beings. (arizona.edu)
Mongolian gerbils infected with Helicobacter pylori (Hp) develop goblet cell intestinal metaplasia and adenocarcinoma, but the presence of SPEM has not been studied in gerbils. (fujita-hu.ac.jp)
In uninfected animals, no SPEM or intestinal metaplasia was observed. (fujita-hu.ac.jp)
Goblet cell intestinal metaplasia developed only late in the infection. (fujita-hu.ac.jp)
Dual staining for TFF2 and MUC2 showed glands containing both SPEM- and MUC2-positive goblet cell intestinal metaplasia. (fujita-hu.ac.jp)
SPEM develops early in Hp infection in Mongolian gerbils, and alterations in gland morphology arise from SPEM glands during the course of gastric infection with goblet cell intestinal metaplasia developing subsequent to SPEM. (fujita-hu.ac.jp)
Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)
Intestinal metaplasia typically begins in the antrum in response to chronic mucosal injury and may extend to the body. (msdmanuals.com)
Intestinal metaplasia is classified histologically as complete (most common) or incomplete. (msdmanuals.com)

Osseous metaplasia is defined as the formation of lamellar bone inside soft tissue structures where bone normally does not exist. (jkaoms.org)
We report a case of osseous metaplasia of the maxilla, a rare benign tumor in an uncommon region. (jkaoms.org)
The mass was biopsied and diagnosed as an osseous metaplasia. (jkaoms.org)
We review the clinical, radiographic, and histologic features and common causes of osseous metaplasia and report a rare case of osseous metaplasia of the palate. (jkaoms.org)
Osseous metaplasia is usually caused by osteoblasts differentiating from fibroblasts secondary to inflammation, tissue damage, exposure to substances such as bone morphogenetic proteins released from neoplastic cells, or dystrophic calcification in necrotic tissue. (jkaoms.org)
Several cases of osseous metaplasia has been reported to occur in thyroid gland, endometrium, breast, etc. (jkaoms.org)
Here we present a case of osseous metaplasia of the palate that did not result from an ill-fitting dental prosthesis, trauma, or intra-oral carcinoma. (jkaoms.org)
Based on clinical and radiographic examination, the clinical diagnosis was osseous metaplasia of the right palate, and we planned to excise the mass under general anesthesia. (jkaoms.org)
Histological examination revealed osseous metaplasia. (jkaoms.org)
Osseous metaplasia has been reported to occur systemically other than intra-oral portion. (jkaoms.org)
2 reported three cases of osseous metaplasia of the thyroid gland in female patients with thyroid nodules who were diagnosed with nodular hyperplasia with osseous metaplasia and mature bone formation. (jkaoms.org)
The pathogenesis of osseous metaplasia in colorectal tumors remains unclear, but the process seems to have no clinical significance. (mssm.edu)
Osseous metaplasia is exceedingly rare in colonic polyps. (ac.ir)
We present a case of rectal juvenile polyp with stromal osseous metaplasia in a 10-year-old male child. (ac.ir)
Bhat V, Roopa A, Shariff S. Juvenile rectal polyp with osseous metaplasia - A rare case with review of literature. (ac.ir)
Bhattacharya N, Sarkar T. Osseous metaplasia in a juvenile polyp: A rare case report in India. (ac.ir)
Hjelkrem M, Fair K, Pabby A. Osseous metaplasia in a colon polyp. (ac.ir)
Osseous Metaplasia in Rectal Polyp: A Case Report with Review of Probable Pathogenesis', Advanced Biomedical Research , 2018(May), pp. 1-3. (ac.ir)
Osteolipomas are subtypes of lipoma with osseous metaplasia, mostly with bone inside and extremely rare occurrence in the oral cavity, so that in the literature, at time, there are only 12 papers. (bvsalud.org)

Metaplasia is not synonymous with dysplasia, and is not considered to be an actual cancer. (wikipedia.org)
The medical significance of metaplasia is that in some sites where pathological irritation is present, cells may progress from metaplasia, to develop dysplasia, and then malignant neoplasia (cancer). (wikipedia.org)
Cervical Metaplasia And Dysplasia is a basic item of interest because it is of concern when evaluating Cervical Dysplasia While Pregnant, Cervical Hyperplasia Vs Dysplasia, and Cervical Intraepithelial Neoplasia Grade III With Severe Dysplasia. (cervicaldysplasiacure.com)
Why is this a concern: Cervical Metaplasia And Dysplasia? (cervicaldysplasiacure.com)
Why is this a problem: Cervical Metaplasia And Dysplasia? (cervicaldysplasiacure.com)
Transitional cell metaplasia of the uterine cervix and vagina: an underrecognized lesion that may be confused with high-grade dysplasia. (nih.gov)
Evaluation of patient samples revealed FOXA2 expression in Barrett's metaplasia, dysplasia, and adenocarcinoma but not in esophageal squamous epithelium or squamous cell carcinoma. (elsevierpure.com)
In incomplete metaplasia, the epithelium assumes a histologic appearance closer to that of the large intestine and frequently exhibits dysplasia. (msdmanuals.com)

Gastric metaplasia and Helicobacter pylori infection. (bmj.com)
Spasmolytic polypeptide (TFF2)-expressing metaplasia (SPEM) is observed in mucosa adjacent to human gastric cancer and in fundic glands showing oxyntic atrophy in Helicobacter felis-infected mice. (fujita-hu.ac.jp)

With complete metaplasia, gastric mucosa is completely transformed into small-bowel mucosa, both histologically and functionally, with the ability to absorb nutrients and secrete peptides. (msdmanuals.com)

One example of pathological irritation is cigarette smoke, which causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial cells that line the airways to be replaced by stratified squamous epithelium, or a stone in the bile duct that causes the replacement of the secretory columnar epithelium with stratified squamous epithelium (squamous metaplasia). (wikipedia.org)
Metaplasia is an adaptation that replaces one type of epithelium with another that is more likely to be able to withstand the stresses it is faced with. (wikipedia.org)
Chronic inflammation can result in metaplasia of the gastric pitsto a mucus-type hyperplastic epithelium, similar to that of the intestine. (nih.gov)
Squamous metaplasia is a common form of metaplasia, presumably because squamous epithelium is more resistant to damage than other forms of epithelia. (nih.gov)
Squamous metaplasia is usually the result of chronic irritation, but it can have other causes (e.g., hypovitamnosis A). In the salivary ducts, metaplasia of the normally cuboidal ductal epithelium to stratified squamous epithelium has been seen in response to chemicals, ionizing radiation, viral infections, vitamin A deficiency, and blockage of ducts by salivary calculi. (nih.gov)
Squamous metaplasia of the ductular epithelium may be a preneoplastic lesion progressing to squamous cell carcinoma. (nih.gov)
Squamous metaplasia of the salivary duct should be diagnosed and graded based on the number of areas involved and the thickness of the squamous epithelium. (nih.gov)
We showed previously that Hh signaling is reactivated in Barrett's metaplasia and overexpression of Sonic hedgehog (SHH) in mouse esophageal squamous epithelium leads to a columnar phenotype. (elsevierpure.com)
The epithelium of the minor salivary ducts often shows squamous metaplasia. (medscape.com)

The image shows squamous metaplasia in a prostate needle biopsy in a patient with remote history of external beam radiation therapy for prostate cancer. (webpathology.com)

Myelofibrosis with myeloid metaplasia (MMM) is a Philadelphia chromosome-negative myeloproliferative disorder that is characterised by constitutional symptoms, progressive anaemia and extramedullary haematopoiesis. (elsevierpure.com)
Peripheral smear of a patient with agnogenic myeloid metaplasia (myelofibrosis) shows leukoerythroblastosis. (medscape.com)

Superficial gastritis may be present, as may partial gland atrophy and metaplasia. (msdmanuals.com)

Gastric squamous metaplasia observed by image-enhanced endoscopy. (bvsalud.org)

Agnogenic myeloid metaplasia is considered a 'low grade' disease, in that, while it is not curable, progresses slowly and can be successfully managed for long periods of time. (science-bbs.com)
Thrombosis is the most common cause of death, followed by the complications of myeloid metaplasia and hemorrhage. (fundacionmapfre.org)
Myelofribrosis or myeloid metaplasia causes during its evolution asthenia, anemia, weight loss of weight, splenomegaly, and in half of the cases hepatomegaly. (fundacionmapfre.org)

Predisposition to urinary tract epithelial metaplasia in Schistosoma haematobium infection. (ajtmh.org)
Barrett's esophagus is a squamous-to-columnar epithelial metaplasia caused by reflux esophagitis. (elsevierpure.com)

Squamous metaplasia and ossification in colonic adenocarcinoma. (ac.ir)

Background & Aims: Loss of gastric parietal cells is a critical precursor to gastric metaplasia and neoplasia. (arizona.edu)

Among 705 evaluable cytology specimens, prevalence of inflammation (39%), hyperkeratosis (30%), metaplasia (33%), and frank atypia (0.4%) was notably higher than in previously studied, non-endemic populations. (ajtmh.org)
Age-group analysis confirmed parallel increases in metaplasia and S. haematobium infection prevalence early in life (from age I to 15 for both boys and girls). (ajtmh.org)
However, above age 20, metaplasia prevalence persisted at 33-45% prevalence despite a decline in infection prevalence and intensity. (ajtmh.org)

In this study, seven cases fulfilling the morphologic criteria of transitional metaplasia of the uterine cervix were investigated with these markers to determine whether there was evidence of true urothelial-type differentiation in these lesions. (york.ac.uk)
Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women. (nih.gov)

This condition is usually secondary to benign prostatic hyperplasia or squamous metaplasia. (furrycritter.com)
Established benign lesions, which are rare, include simple gastric metaplasia and lobular endocervical glandular hyperplasia (LEGH) (complex gastric metaplasia). (nih.gov)
Squamous metaplasia is usually an incidental finding in the setting of prostatitis and infarction in the nodules of benign prostatic hyperplasia. (webpathology.com)

It is a benign (i.e. non-cancerous) change that occurs as a response to change of milieu (physiological metaplasia) or chronic physical or chemical irritation. (wikipedia.org)
Salivary gland, Duct - Metaplasia, Squamous in a male F344/N rat from a chronic study. (nih.gov)

Transitional cell metaplasia of fallopian tube fimbriae: a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women With BRCA mutations. (nih.gov)

We thus report a case of gastric squamous metaplasia without gastric neoplastic lesion in the gastric cardia whose lesions were endoscopically observed to change the size for more than 10 years and whose lesions were endoscopically evaluated with a texture and color enhancement imaging mode 1 and mode 2 and narrow band imaging . (bvsalud.org)

EpCAM and gpA33 are markers of Barrett's metaplasia. (ox.ac.uk)
AIMS: To characterise a specific and sensitive marker of Barrett's metaplasia (BM). (ox.ac.uk)

Acute parietal cell loss in gastrin-deficient mice treated with DMP-777 leads to the rapid emergence of spasmolytic polypeptide/trefoil factor family 2 (TFF2)-expressing metaplasia (SPEM) from the bases of fundic glands. (arizona.edu)

Ozone -induced mucous cell metaplasia. (cdc.gov)
Mucous gland metaplasia (pseudopyloric metaplasia) occurs in the setting of severe atrophy of the gastric glands, which are progressively replaced by mucous glands (antral mucosa), especially along the lesser curve. (msdmanuals.com)

The treatment approach and outcome depend on several factors, including the underlying cause of the metaplasia, the severity of the cellular change, and the presence of additional risk factors such as H. pylori infection or a family history of gastric cancer. (ghsagenda.org)

Metaplasia is often, but not always, an adaptive change that occurs in response to repeated epithelial damage and is therefore often accompanied by other lesions such as inflammation or necrosis. (nih.gov)

However, full urothelial differentiation was not observed, as CK20 and asymmetric unit membrane were never expressed in the transitional metaplasia. (york.ac.uk)
Based on these findings, the term of immature transitional metaplasia would be a more accurate description of this entity. (york.ac.uk)
Cytological features of transitional cell metaplasia of the lower female genital tract. (nih.gov)

Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype . (wikipedia.org)
Metaplasia can result when injury reactivates latent developmental signaling pathways that determine cell phenotype. (elsevierpure.com)

Metaplasia happens when there is an irritation to the breast (breast cyst). (wikipedia.org)

Squamous metaplasia may be reversible if the cause is removed. (nih.gov)

Conclusions: Although traditionally metaplasia was thought to originate from normal mucosal progenitor cells, these studies indicate that SPEM evolves through either transdifferentiation of chief cells or activation of a basal cryptic progenitor. (arizona.edu)

L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)

If the stimulus causing metaplasia is removed or ceases, tissues return to their normal pattern of differentiation. (wikipedia.org)
The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the change: Epigenetics Induced stem cells List of biological development disorders Pleomorphism Reprogramming Transdifferentiation The AMA Home Medical Encyclopedia, Random House, p. 683 Robbins and Cotran - Pathologic Basis of Disease, 7th Edition, Saunders, p. 10 Prof. Dr. Clark S., Australian Cancer institute, premalignant conditions. (wikipedia.org)
Metaplasia" is a concept of differentiated cells and tissues transformation that has been discussed since the second half of the19th century. (genescells.ru)

[4] This type of metaplasia represents an exception to the common rule of metaplasia increasing the risk for developing cancer in that apocrine metaplasia doesn't increase the possibility of developing breast cancer. (wikipedia.org)

In addition, induction of metaplasia elicits the expression of secreted factors, such as HE4, relevant to gastric preneoplasia. (arizona.edu)

Anatomy17

Organisms2

Diseases18

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Disciplines and Occupations1

Information Science1

Intestinal47

Osseous metaplasia19

Dysplasia8

Helicobacter2

Gastric mucosa1

Epithelium9

Shows squamous metaplasia1

Myelofibrosis2

Atrophy and metaplasia1

Endoscopy1

Myeloid3

Epithelial metaplasia2

Adenocarcinoma1

Neoplasia1

Prevalence3

Uterine cervix2

Hyperplasia3

Chronic2

Carcinoma1

Lesion1

Barrett's2

Fundic glands1

Mucous2

Infection1

Lesions1

Transitional3

Phenotype2

Irritation1

Reversible1

SPEM1

Pylori1

Tissues3

Common1

Induction1