Analysis of confiscated glutethimide seems to invariably show the drug or the results of attempted synthesis, whereas purported methaqualone is in a significant majority of cases found to be inert, or contain diphenhydramine or benzodiazepines. (wikipedia.org)
[ 5 ] Because they are prescribed so commonly, benzodiazepines have the highest morbidity and mortality of the sedative-hypnotics and represent nearly half of reported exposures. (medscape.com)
Barbiturates2
Glutethimide is a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. (wikipedia.org)
Glutethimide seems to be a GABA agonist which helps induce sedation. (drugbank.com)
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. (wikimili.com)
Alcohol2
Severe respiratory depression is more likely to occur when a sedative-hypnotic is ingested with other CNS depressants or alcohol. (medscape.com)
CNS Depression: Morphine should be used only with caution and in reduced dosage during concomitant administration of other opioid analgesics, general anesthetics, phenothiazines and other tranquilizers, sedative-hypnotics, tricyclic antidepressants and other CNS depressants (including alcohol). (rxmed.com)
Mechanism of Act1
The Effexor mechanism of action occurs without the various cardiovascular, sedative, and anticholinergic effects seen in other drugs in this class. (addictionresource.com)
Depressants2
All the sedative-hypnotics are general CNS depressants. (medscape.com)
Taking ZURZUVAE with other CNS depressants may increase the impairment of motor performance or sedative effects. (wikimd.com)
Depressant1
It is a central nervous system depressant and was soon found to be an effective anticonvulsant , hypnotic and sedative . (wikipedia.org)
Glutethimide is a CYP2D6 enzyme inducer. (wikipedia.org)
Stimulate1
Psychedelic drugs stimulate serotonin release, and sedative-hypnotic drugs potentiate the γ-aminobutyric acid receptor. (aafp.org)
Insomnia3
In this brief overview, medications used to treat insomnia such as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome are discussed. (springer.com)
Other pharmacological agents producing sedation (sedatives and agents used off-label for sedative side-effects) should be used cautiously for the treatment of insomnia due to the increased risk of next day sleepiness as well as for known toxicities and adverse side effects. (springer.com)
Medications for treating insomnia are classified as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome (RLS) (Curry et al. (springer.com)
Effects3
GHB is a sedative-hypnotic that is banned for sale to the public because of frequent abuse (eg, "date rape") and serious toxic adverse effects. (medscape.com)
Sedatives and other medications used off-label for sedative side-effects are a contributing factor to drug induced hypersomnolence, a factor in more than 30% of motor accident deaths. (springer.com)
ZURZUVAE can affect the ability to perform tasks that require alertness, such as driving or using machinery, due to its sedative effects. (wikimd.com)
Drugs1
Sedative-hypnotics are a group of drugs that cause central nervous system (CNS) depression. (medscape.com)
General1
The general sedative effect of the glutethimide also adds to the effect of the combination. (wikipedia.org)
Combination1
The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Glutethimide. (drugbank.com)
Agents1
Other agents include the nonbarbiturate nonbenzodiazepine sedative-hypnotics. (medscape.com)
Found1
glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces. (drugbank.com)
Hypnotic6
Glutethimide is a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. (wikipedia.org)
Most cases of severe sedative-hypnotic poisoning are deliberate (suicidal). (medscape.com)
Severe respiratory depression is more likely to occur when a sedative-hypnotic is ingested with other CNS depressants or alcohol. (medscape.com)
GHB is a sedative-hypnotic that is banned for sale to the public because of frequent abuse (eg, "date rape") and serious toxic adverse effects. (medscape.com)
Sedative-hypnotics are a group of drugs that cause central nervous system (CNS) depression. (medscape.com)
Other agents include the nonbarbiturate nonbenzodiazepine sedative-hypnotics. (medscape.com)
New psychoactive substances (NPS) have become available as substitutes for controlled sedative-hypnotics. (medscape.com)
Death from sedative-hypnotics is caused by respiratory arrest. (medscape.com)
All the sedative-hypnotics are general CNS depressants. (medscape.com)
According to the 2020 Annual Report of the American Association of Poison Control Centers' National Poison Data System (AAPCC-NPDS), sedative/hypnotics/antipsychotics exposures were the fifth most frequent exposure documented overall and the second most frequent exposure in adults aged 20 years or older. (medscape.com)
However, sedative/hypnotics/antipsychotics exposures were involved in 334 fatalities in where more than one substance was present, which was the highest number of fatalities of any category. (medscape.com)
[ 5 ] Because they are prescribed so commonly, benzodiazepines have the highest morbidity and mortality of the sedative-hypnotics and represent nearly half of reported exposures. (medscape.com)
Analysis of confiscated glutethimide seems to invariably show the drug or the results of attempted synthesis, whereas purported methaqualone is in a significant majority of cases found to be inert, or contain diphenhydramine or benzodiazepines. (wikipedia.org)
Descriptor1
Glutethimide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Group1
Alkaline hydrolysis of the nitrile group into an amide group, and subsequent acidic cyclization of the product affords the desired glutethimide (4). (wikipedia.org)