Secretory vesicles membrane fusion n ethylmaleimide sensitive proteins. Medical search. Frequent questions

We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
How do neurons differentially regulate synaptic vesicle and dense core vesicle release? (rupress.org)
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. (uchicago.edu)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A. (uchicago.edu)

Misfolded secretory proteins are exported from the endoplasmic reticulum (ER) and degraded by the ER-associated degradation pathway (ERAD). (wikipedia.org)
Since SYP132 plays an immune function to bacteria, elevated growth of surface-inoculated Pst DC3000 in VAMP721/722-deficient plants suggests that SYT5 contributes to plant immunity to Pst DC3000 by promoting the SYP132-VAMP721/722 immune secretory pathway. (molcells.org)
Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4 + T cells. (aai.org)
In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. (aai.org)
These results suggest that CD4 + T cell cytokines require a specialized, WASp-dependent pathway for cellular traffic and/or vesicle release that is distinct from that required for chemokine release. (aai.org)
In contrast to the sperm acrosome reaction, the secretory pathway of somatic cells has received detailed characterization in recent years and a great deal has been learned of the processes regulating vesicle docking and fusion with the plasma membrane. (ommegaonline.org)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)
There is recent evidence that a regulated membrane trafficking pathway mediated by SNAP23 is required for breast cancer cell invadopodium formation and efficient tumor cell invasion in vitro. (biomedcentral.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
Introducing secretory reticulophagy/ER-phagy (SERP), a VAMP7-dependent pathway involved in neurite growth. (u-paris.fr)

this observation demonstrates that vesicle-free miRNAs are secreted from neuroendocrine cells, in a manner similar to hormone secretion. (frontiersin.org)
Because of its localization and homology to the yeast protein Sec4, it was believed to play a role in the terminal steps of secretion. (pancreapedia.org)
New insights into protein secretion: TANGO1 runs rings around the COPII coat. (uchicago.edu)

In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. (rupress.org)
Thus, CAPS likely promotes the open state of syntaxin, which then docks dense core vesicles. (rupress.org)
In addition to synaptic vesicles, neurons also contain secretory vesicles, called dense core vesicles, that release neuropeptides and catecholamines ( Burgoyne and Morgan, 2003 ). (rupress.org)
One possible explanation for the bashfulness of dense core vesicles is that they are not docked. (rupress.org)
Dense core vesicles are usually found in the cytoplasm and these cytoplasmic vesicles must presumably translocate to the plasma membrane before release ( Zupanc, 1996 ). (rupress.org)

is compatible with a role in regulating Ca 2+ channel activity or SNARE [soluble N -ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complex function in vesicle fusion. (jneurosci.org)
Both the CAPS and UNC-13 docking pathways converge on syntaxin, a component of the SNARE (soluble N -ethyl-maleimide-sensitive fusion protein attachment receptor) complex. (rupress.org)
Thiol isomerases are mobilized to the surface of activated platelets via a process that requires actin polymerization but not soluble N-ethylmaleimide-sensitive fusion protein attachment receptor/Munc13-4-dependent vesicular-plasma membrane fusion. (reading.ac.uk)
Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)
Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)

They play a role in the intracellular transport of molecules contained within membrane vesicles. (uchicago.edu)

To overcome energetically unfavorable lipid fusion, they form a SNARE complex in which four α-helices are bundled. (molcells.org)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
The exocyst, like SNARE complexes, may be needed for all fusions at the plasma membrane both in developing and mature neurons, or it may be required only for particular forms of traffic (Murthy, 2003 and references therein). (sdbonline.org)
We identify the closed binding mode of neuronal SM (Munc18-1) and SNARE (syntaxin-1) as the key factor leading to mechanistic divergence of membrane fusion systems in yeast and neurons. (biomedcentral.com)
We applied the framework to study SM-SNARE-mediated exocytic membrane fusion processes in yeast and neurons. (biomedcentral.com)
SNARE Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. (uchicago.edu)
Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e. (uchicago.edu)
This graph shows the total number of publications written about "SNARE Proteins" by people in this website by year, and whether "SNARE Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "SNARE Proteins" by people in Profiles. (uchicago.edu)
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. (uchicago.edu)
Intracellular bacteria encode inhibitory SNARE-like proteins. (uchicago.edu)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)
VAMP (Vesicle-associated membrane protein), SNAP-25 (Synaptosome associated protein of 25 kDa) and Syntaxin constitute the basic SNARE complex. (biomedcentral.com)

Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)

This review focuses on the mechanisms by which vesicle-free miRNAs are secreted from neuroendocrine cells and will discuss potential functions of vesicle-free miRNAs and how vesicle-free miRNAs regulate cell-to-cell communication. (frontiersin.org)
Recently, miRNA exocytosis by vesicle fusion in response to stimulation was observed in chromaffin cells, which are neuroendocrine cells in the sympathetic nervous system ( 24 ). (frontiersin.org)
The objective of this review is to discuss how miRNAs are released by active exocytosis and to examine the physiological functions of vesicle-free miRNAs in neuroendocrine cells. (frontiersin.org)

Here, we describe a mechanism for dense core vesicle docking in neurons. (rupress.org)
Neurons can release small molecule neurotransmitters very rapidly in part because synaptic vesicles are docked to the membrane at active zones. (rupress.org)
Neurons generate their polarity by directing membrane traffic to growing neurites and growth cones, and by sorting proteins differentially between the axon and dendrites. (sdbonline.org)
sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
This protein is required for many aspects of membrane traffic within neurons, including the elaboration of neurites, but the release of neurotransmitter at the synapse is independent of this exocyst component (Murthy, 2003). (sdbonline.org)
Within neurons, multiple pathways are known to transport proteins and transmitters to the cell surface. (sdbonline.org)
1( small) neurons that live region fusions have consumed restricted. (evakoch.com)

Substrate retrotranslocation and extraction is assisted by the Cdc48p(Ufd1p/Npl4p) complex on the cytosolic side of the membrane. (wikipedia.org)
Tcell recognition of Ag-bearing cells is associated with cytoskeletal polarization and the redistribution of membrane and cytosolic molecules toward the cell-cell contact zone known as the immunological synapse ( 1 , 2 , 3 ). (aai.org)

Similarly, overexpression of CSP in chromaffin cells inhibited the extent of exocytosis and slowed the kinetics of individual release events, indicating a key role of CSP close to fusion pore opening during Ca 2+ -regulated exocytosis ( Graham and Burgoyne, 2000 ). (jneurosci.org)
The acrosome reaction is analogous to regulated exocytosis in somatic cells in that both are initiated by ligand acting at the plasma membrane, both require activation of signaling pathways and ion channels, both are Ca 2+ -dependent and both result in the fusion of the plasma membrane with the membrane of a docked secretory granule (acrosome) [2,9,10] . (ommegaonline.org)

A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)

Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (uchicago.edu)

OBJECTIVE: Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. (reading.ac.uk)
Immunofluorescence microscopy and subcellular fractionation analysis were used to localize these proteins in platelets to a compartment distinct from known secretory vesicles that overlaps with an inner cell-surface membrane region defined by the endoplasmic/sarcoplasmic reticulum proteins calnexin and sarco/endoplasmic reticulum calcium ATPase 3. (reading.ac.uk)
CONCLUSIONS: Platelet-borne thiol isomerases are trafficked independently of secretory granule contents in megakaryocytes and become concentrated in a subcellular compartment near the inner surface of the platelet outer membrane corresponding to the sarco/endoplasmic reticulum of these cells. (reading.ac.uk)

They are involved in processes such as DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction and the regulation of gene expression. (wikipedia.org)
They are involved in diverse physiological processes in plants by interacting with distinct plasma membrane (PM) syntaxins. (molcells.org)
60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
Directed membrane traffic is essential for many developmental processes, including cell growth, cytokinesis and signaling between cells. (sdbonline.org)
Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)
Integrating the dynamics across species is particularly important in modeling cellular processes through protein interaction networks. (biomedcentral.com)
Many of the biological processes mediated by protein interaction networks are highly evolutionarily conserved or related across species. (biomedcentral.com)
By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)
As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)
A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. (uchicago.edu)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)

In some cases, the exocytotic vesicles derive from the Golgi apparatus and consist of newly synthesized materials, while in others the vesicles derive from the plasma membrane and cycle locally. (sdbonline.org)
The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)

In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)

Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)
Subsequently, further distinctions in trafficking pathways have been invoked to explain different forms of regulation and fusion at different domains of the cell. (sdbonline.org)
We propose that the use of different secretory pathways for cytokines and chemokines enables CD4 + T cell activity to be further fine-tuned to serve specialized effector functions. (aai.org)

This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. (wikipedia.org)
AAA proteins are divided into seven basic clades, based on secondary structure elements included within or near the core AAA fold: clamp loader, initiator, classic, superfamily III helicase, HCLR, H2-insert, and PS-II insert. (wikipedia.org)
IFITMs belong to the CD225/pfam04505 or "dispanin" protein superfamily ( http://pfam.xfam.org/family/PF04505 ) ( 3 ) that contains more than 2,000 members, including both prokaryotic and eukaryotic proteins, all of which encode a conserved CD225 protein domain. (life-science-alliance.org)

AAA proteins are not restricted to eukaryotes. (wikipedia.org)

These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)
2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)

in this way, vesicle-free miRNA may regulate cell-to-cell communication including the regulation of gene expression and cellular signaling. (frontiersin.org)

Nonfunctional membrane and luminal proteins are extracted from the ER and degraded in the cytosol by proteasomes. (wikipedia.org)
much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)

Consistent with a role for RAB18 in regulating membrane contact sites, interactors included groups of microtubule/membrane-remodeling proteins, membrane-tethering and docking proteins, and lipid-modifying/transporting proteins. (bvsalud.org)

The second Rab3 GEF, known as GRAB, interacts with inositol hexakisphosphate kinase and Rab3A and its protein expression is primarily in brain (41). (pancreapedia.org)
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

Some classes of AAA proteins have an N-terminal non-ATPase domain which is followed by either one or two AAA domains (D1 and D2). (wikipedia.org)
Dyneins, one of the three major classes of motor protein, are AAA proteins which couple their ATPase activity to molecular motion along microtubules. (wikipedia.org)
The AAA-type ATPase Cdc48p/p97 is perhaps the best-studied AAA protein. (wikipedia.org)
Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). (uchicago.edu)

EBP is a Δ8-Δ7 sterol isomerase, and ORP2 is a lipid transport protein. (bvsalud.org)
Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)

In contrast, we see that UNC-13, a docking factor for synaptic vesicles, is not essential for dense core vesicle docking. (rupress.org)

Seeking ovarian cancer related SNAP proteins may help to reveal new mechanisms of invasion and metastasis of ovarian cancer, and provide new ideas for clinical diagnosis and treatment. (biomedcentral.com)

Prokaryotes have AAA which combine chaperone with proteolytic activity, for example in ClpAPS complex, which mediates protein degradation and recognition in E. coli. (wikipedia.org)

AAA proteins are functionally and organizationally diverse, and vary in activity, stability, and mechanism. (wikipedia.org)
Presently, all membrane trafficking steps are thought to possess a similar underlying mechanism for membrane fusion, and yet clear distinctions in these trafficking steps must also occur. (sdbonline.org)

Acute stress increases glutamate release, membrane trafficking of AMPA and NMDA receptors, and potentially glutamate clearance in the prefrontal cortex through various mechanisms that involve glucocorticoid regulation. (nature.com)

And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)

More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)
The exocyst complex marks these areas of membrane addition, localizing to the bud tip of a growing daughter cell and the bud neck at the time of cytokinesis. (sdbonline.org)
Thus, the exocyst complex in yeast may provide a model for the directed membrane traffic of developing cells in higher organisms (Murthy, 2004 and references therein). (sdbonline.org)
Following the acrosome reaction the fused hybrid membrane complex remains adherent to the zona surface, [4] and the newly exposed inner acrosomal membrane of the spermatozoon functions as the limiting membrane or plasma membrane equivalent [1] . (ommegaonline.org)

Immunofluorescence microscopy and flow cytometry were used to monitor thiol isomerase mobilization in activated platelets in the presence and absence of actin polymerization (inhibited by latrunculin) and in the presence or absence of membrane fusion mediated by Munc13-4 (absent in platelets from Unc13dJinx mice). (reading.ac.uk)
Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)

As their name suggests, IFITMs are membrane proteins, allowing them to police the cell surface and endocytic membranes that viruses must cross to invade cells. (life-science-alliance.org)

Rab proteins constitute the largest family of Ras-related small G proteins and play a role in regulating the specificity of membrane trafficking (63, 78). (pancreapedia.org)

The identification, therefore, of the molecules required for directed membrane traffic will be important for understanding organismal development and cell-cell signaling (Murthy, 2004). (sdbonline.org)
Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)

Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral restriction factors. (life-science-alliance.org)
Interferon-induced transmembrane proteins (IFITMs) are antiviral factors that act uniquely and early in viral replication cycles to restrict the entry of a diverse range of primarily enveloped viruses into cells ( 1 ). (life-science-alliance.org)
A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)

The mammalian sperm acrosome reaction entails extensive fusion between the periacrosomal plasma membrane and the outer acrosomal membrane, with the release of hydrolases which function in sperm penetration through the zona pellucida [1-3] . (ommegaonline.org)

After pre-miRNAs are transported to the cytoplasm, RNase III Dicer and TRBP (transactivation-response RNA-binding protein) cleave them into double-stranded miRNA duplexes of ~22 nt ( 30 , 31 ). (frontiersin.org)
There is no known specific Rab3 GDI, but rather a common family of Rab GDI isoforms which bind prenylated Rabs in the cytoplasm and participates in insertion and removal from membranes (75). (pancreapedia.org)

In some proteins with two AAA domains, both are evolutionarily well conserved (like in Cdc48/p97). (wikipedia.org)

Overexpression of open syntaxin can bypass the requirement for CAPS in dense core vesicle docking. (rupress.org)
Western blots of caput and cauda sperm lysates and plasma membrane fractions, stained with anti-syntaxin 2, revealed the presence of a 31kDa band in both sperm lysates and plasma membrane fractions, respectively. (ommegaonline.org)
Several biochemical analyses demonstrated that syntaxin 2 is an integral component of bovine cauda sperm plasma membranes. (ommegaonline.org)
4) Lysosomal fusion with autophagosomes also requires SNAREs, including VAMP8, syntaxin-17 and SNAP29. (biomedcentral.com)

AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate. (wikipedia.org)

AAA proteins or ATPases Associated with diverse cellular Activities are a protein family sharing a common conserved module of approximately 230 amino acid residues. (wikipedia.org)

Similar to other small G proteins, the guanine binding state of Rab3 proteins is regulated by guanine nucleotide exchange proteins or factors (GEPs or GEFs) and GTPase activating proteins (GAPs). (pancreapedia.org)

Yeast cells use an anisotropic secretory apparatus for polarized growth at a selected bud site. (sdbonline.org)

Docking to the plasma membrane prepares vesicles for rapid release. (rupress.org)
1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)

These proteins produce a molecular motor that couples ATP binding and hydrolysis to changes in conformational states that can be propagated through the assembly in order to act upon a target substrate, either translocating or remodelling the substrate. (wikipedia.org)

APPROACH AND RESULTS: Immunofluorescence microscopy imaging was used to localize protein disulfide isomerase and ERp57 in murine and human megakaryocytes at various developmental stages. (reading.ac.uk)

In HslU, a bacterial ClpX/ClpY homologue of the HSP100 family of AAA proteins, the N- and C-terminal subdomains move towards each other when nucleotides are bound and hydrolysed. (wikipedia.org)

In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. (uchicago.edu)

Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca 2+ channel activity in fast neurotransmitter release. (jneurosci.org)

We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (uchicago.edu)

While the bud is growing, there is almost no increase in the surface area of the mother cell, indicating that all membrane addition occurs at the bud tip. (sdbonline.org)
RUNX3 occurs to Runx protein Defects in the physical( high) blood of the RUNX1 heat, making C-terminal cysteine( Spender et al. (evakoch.com)

Anatomy10

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes6

Technology, Industry, Agriculture3

Information Science2

Synaptic vesicle6

Pathway12

Secretion3

Dense core vesicles5

Receptor5

Intracellular transport1

SNARE16

Soluble2

Neuroendocrine cells3

Neurons7

Cytosolic2

Exocytosis2

Differentially1

Vesicular Transpor1

Endoplasmic reticulum3

Processes12

Exocytotic2

Munc181

Pathways3

Superfamily3

Eukaryotes1

Fuse4

Distinct2

Regulate1

Cytosol2

Microtubule1

Kinase2

Cytokines1

ATPase4

Lipid2

Factor1

SNAP1

Mediates1

Mechanism2

Mechanisms1

Degradation1

Complex5

Actin2

Suggests1

Specificity1

Molecules2

Transmembrane3

Outer1

Cytoplasm2

Evolutionarily1

Syntaxin4

Macromolecular1

Cellular1

Factors1

Yeast1

Plasma2

Conformational1

Immunofluorescence1

Bacterial1

Enzymes1

Phosphorylation1

Presynaptic1

Transport2

Occurs2