- The vacuolar ATPase (V-ATPase) is a highly conserved rotary motor proton pump that plays an essential role in cellular housekeeping functions. (upstate.edu)
- V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
- The Figure also describes relevant ion concentrations in mature ZG and emphasizes the decreasing lumen acidity during maturation along the compartments of the secretory pathway that participate in ZG maturation (for further details, see text). (pancreapedia.org)
- We conclude that the envelope protein acts as a proton channel in the ERGIC to mitigate the acidity of this intermediate compartment. (bvsalud.org)
- The exact function of CLN3 is unknown, but its expression is highest in secretory/glandular tissues and in gastrointestinal cells. (medscape.com)
- Secretory granules are located at the apex of pancreatic acinar cells. (pancreapedia.org)
- Secretagogues bind to their receptors at the basolateral membrane of acinar cells and trigger the activation of intracellular signaling pathways to elicit fusion of secretory granules with the apical plasma membrane that is followed by exocytosis of digestive pro-enzymes (the "zymogens") into the lumen. (pancreapedia.org)
- In type A acid-secretory intercalated cells of mouse OMCD, the indicate preliminary pHi was 7.31 0.01 (Desk 2). (acancerjourney.info)
- The coronavirus SARS-CoV-2, the agent of the deadly COVID-19 pandemic, is an enveloped virus propagating within the endocytic and secretory organelles of host mammalian cells. (bvsalud.org)
- Here, we show that infection of Vero E6 cells with the delta variant of the SARS-CoV-2 alkalinizes the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) as well as lysosomes, mimicking the effect of inhibitors of vacuolar proton ATPases. (bvsalud.org)