SASPSenescentSenescencePathwayInhibitionGenesAnti-inflammatoryInflammatoryVesiclesCellsInflammationInsulinInfectionAbstractMaleHumanConfirmParacrineCatecholamineBiochemicalPathwayFibroblastsProteinsBehaviouralFactorsInvasionPredictOnsetClinicalProteinLungCellChronicRoleDataComplexResponseInfluenceDiseaseDevelopmentBackground
SASP12
- Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. (wikipedia.org)
- Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. (sens.org)
- The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. (rupress.org)
- this senescence-associated secretory phenotype (SASP) leads to cancer progression and chemoresistance. (kumamoto-u.ac.jp)
- Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
- Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
- Senescent cells continuously secrete a range of molecules that alter their local milieu, the Senescence Associated Secretory Phenotype (SASP). (uu.nl)
- She is widely known for her research on how senescent cells influence aging and cancer - in particular the senescence-associated secretory phenotype (SASP). (lifeboat.com)
- Cells that become senescent grow in size, cease to replicate, and generate a potent mix of molecules known as the senescence-associated secretory phenotype (SASP) . (fightaging.org)
- Senescence increases with age in the skeletal system , and selective depletion of senescent cells or inhibition of their senescence-associated secretory phenotype (SASP) has been reported to maintain or improve bone mass in aged mice. (fightaging.org)
- Inflammationv is one of the most recognizable signs of a senescent cell, and is triggered as part of the senescence-associated secretory phenotype (SASP) which occurs following damage to DNA. (dsm.com)
- The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders. (bvsalud.org)
Senescent2
- 2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)
- We also demonstrated that in an animal model of Sjögren's syndrome, which exhibit dry mouth symptoms, that hDPSCs-EVs could inhibit the acquisition of the senescent phenotype in salivary gland epithelial cells (SGECs) and alleviate the loss of glandular function. (lu.se)
Senescence8
- The aged immune system is characterized by the senescence -associated secretory phenotype, resulting in the release of proinflammatory cytokines contributing to inflamm-aging. (karger.com)
- 2019. Paracrine interaction of cancer stem cell populations is regulated by the senescence associated secretory phenotype. (uic.edu)
- This effect on longevity is apparently correlated with the midgut senescence phenotypes as a result of direct hormone action through both hormone receptors expressed in the enteroblasts or other midgut cell types. (bioone.org)
- Furthermore, these senescence phenotypes appear to be independent of insulin signaling and manifest in an organ-specific manner. (bioone.org)
- These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
- Various mechanisms, such as accelerated senescence due to premature telomere shortening and adaption of a "senescence associated secretory phenotype" with production of profibrotic mediators, surfactant abnormalities, and endoplasmic reticulum stress, lead to exhaustion of the alveolar epithelial precursor cells with consequent defective re-epithelialisation [ 14 - 19 ]. (ersjournals.com)
- Following irradiation, SFR decreased while senescence-associated β-galactosidase-positive cells (via immunofluorescences) and senescence-related genes and secretory-phenotypes (e.g., p21 and MMP3 in qRT-PCR) increased. (lu.se)
- SFR was unchanged following EVs treatment, but senescence-associated genes and secretory-phenotypes decreased. (lu.se)
Pathway4
- These data demonstrate that although chromogranins regulate the amine concentration in LDCVs, they are not completely essential, and other proteins unrelated to neurosecretion, such as fibrinogen, might compensate for their loss to ensure that vesicles are generated and the secretory pathway conserved. (nih.gov)
- We show here that the biogenesis of CLEL6 and CLEL9 peptides in Arabidopsis thaliana requires a series of processing events in consecutive compartments of the secretory pathway. (elifesciences.org)
- SBT6.1-mediated cleavage within the variable domain allows for continued passage of the partially processed precursors through the secretory pathway, and for subsequent post-translational modifications including tyrosine sulfation and proline hydroxylation within, and proteolytic maturation after exit from the Golgi. (elifesciences.org)
- Early to late endosome transport may be mediated by small vesicular intermediates, or may be a maturation process whereby early endosomes lose components through recycling pathways and gain components through fusion with vesicles derived from the secretory pathway. (wormbook.org)
Inhibition1
- 2017. Rapamycin and the inhibition of the secretory phenotype. . (oregonstate.edu)
Genes1
- These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
Anti-inflammatory2
Inflammatory1
- A paracrine pro-inflammatory phenotype developed in senescing cells. (bvsalud.org)
Vesicles1
- Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and chromaffin cells. (nih.gov)
Cells3
- Enteroendocrine cells (EEs) are evolutionarily conserved gastrointestinal secretory cells that show scattered distribution in the intestinal epithelium. (bioone.org)
- According to recent data, Ras-transformed cells require autophagy to survive and maintain malignant phenotype [ 5 - 10 ]. (aging-us.com)
- Macrophages are active secretory cells that display functionally distinct phenotypes that are regulated by inflammation. (rupress.org)
Inflammation1
- This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy, and inflammation. (medscape.com)
Insulin1
- [ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
Infection2
- Moreover, human astrocyte infection elicits a secretory phenotype that reduces neuronal viability. (hindustantimes.com)
- Whilst risk factors for HCC including Hepatitis C virus infection can influence T-cell phenotype, it is unknown whether HIV can influence functional characteristics of the T-cell infiltrate.MethodsFrom the Liver Cancer in HIV biorepository, we derived 129 samples of transplanted (76%) or resected (20%) HCC in 8 European and North American centres. (imperial.ac.uk)
Abstract1
- From the abstract: 'Clear understanding of mental health phenotypes and associated socioeconomic, physical health and wellbeing impacts in adult women with an FMR1 premutation (PM) is needed for counselling and primary healthcare. (cdc.gov)
Male1
- They may result in a male or undervirilized male phenotype, ambiguous genitals at birth, and some degree of testicular and spermatogenic failure. (msdmanuals.com)
Human1
- Occasionally, economically detectable phenotypes distinguish such organisms when they are abundant in human stools. (cdc.gov)
Confirm1
- Conclusion: This study, the largest study to investigate associations between CC16 tagging SNPs and asthma phenotypes in adults, did not confirm an association of rs3741240 with adult asthma. (cdc.gov)
Paracrine2
- Pre-clinical data suggest that in response to DNA damage the tumor microenvironment (TME) adopts a paracrine secretory phenotype dependent on mTOR signaling which may provide an escape mechanism for tumor resistance, thus offering an opportunity to increase NAC effectiveness with mTOR blockade. (urotoday.com)
- A paracrine pro-inflammatory phenotype developed in senescing cells. (bvsalud.org)
Catecholamine3
- Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma. (medscape.com)
- 3. Age at diagnosis of pheochromocytoma differs according to catecholamine phenotype and tumor location. (nih.gov)
- 9. Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma. (nih.gov)
Biochemical2
- These tumors account for about 25% to 35% of paragangliomas and pheochromocytomas, are usually extra-adrenal, and tend to have a noradrenergic biochemical phenotype because these tumors lack the enzyme phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine. (cigna.com)
- 10. Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes. (nih.gov)
Pathway2
- Endoplasmic reticulum-based Nɛ-lysine acetylation serves as an important protein quality control system for the secretory pathway. (wisc.edu)
- Dysfunctional endoplasmic reticulum-based acetylation, as caused by overexpression of the acetyl coenzyme A transporter AT-1 in the mouse, results in altered glycoprotein flux through the secretory pathway and an autistic-like phenotype. (wisc.edu)
Fibroblasts2
- However, the co-culture with normal fibroblasts or treatment with the recombinant RSPO1 protein did not revert or reduce the EMT-like phenotype and invasion capability of PPK keratinocytes. (biomedcentral.com)
- Notably, RSPO1 -mutated PPK fibroblasts induced a hyperproliferative and dedifferentiated phenotype of age-matched normal control plantar keratinocytes. (biomedcentral.com)
Proteins2
- Integrating with the corresponding transcriptome, we derived an EMT-associated secretory phenotype (EASP) comprising of proteins that were differentially upregulated both at protein and mRNA levels. (nih.gov)
- Rspondins (RSPO) constitute a family of four secretory proteins (RSPO 1-4). (biomedcentral.com)
Behavioural2
- Intense artificial selection during the formation of dog breeds has led to diverse morphological and behavioural phenotypes, and, in some cases, considerable differences in disease risk across breeds. (nature.com)
- Behavioural analysis of SLPI null mice revealed no major phenotype when compared to wild-type, over a range of behavioural tests. (manchester.ac.uk)
Factors1
- These diseases can also occur earlier in life in subjects with higher genetic and environmental risk factors, which suggests an accelerated aging phenotype may play a role. (frontiersin.org)
Invasion1
- In vitro assays that detect toxins, adherence, or invasion phenotypes can also identify candidate diarrheagenic E. coli . (cdc.gov)
Predict1
- Club Cell Secretory Protein-Derived Acute Respiratory Distress Syndrome Phenotypes Predict 90-Day Mortality: A Reanalysis of the Fluids and Catheter Treatment Trial. (nih.gov)
Onset1
- These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
Clinical1
Protein1
- UNLABELLED: Club cell secretory protein (CC16) is a protein with potential utility as a lung-specific biomarker for acute respiratory distress syndrome. (nih.gov)
Lung1
Cell2
- Appendiceal GCAs (previously Goblet Cell Carcinoids) are composed of cells with secretory phenotypes. (enets.org)
- Here we show that tumor cells are able to elicit a strong induction of the COX-2/microsomal prostaglandin-E synthase-1 (mPGES-1)/PGE 2 axis in MSCs recruited to the tumor-associated stroma by releasing IL-1, which in turn elicits a mesenchymal/stem cell-like phenotype in the carcinoma cells. (aacrjournals.org)
Chronic1
- Chronological age is by far the largest predictor of most chronic diseases that bulk for morbidity, mortality and health expenditures and is also connected to geriatric syndromes like frailty, age-related muscle impairment, malcognitive impairment as well as phenotypes that we see in older individuals, that is how they look and their characteristics and decreased physical resilience or ability to recover after surgery or infection. (foresight.org)
Role1
Data1
- Our data show that NAD+ levels influence the secretory activity of senescent cells in a way that may promote tumor progression," said Zhang. (eurekalert.org)
Complex1
- It is an unanswered question as to what sample sizes and study designs should be employed to improve the power of mapping efforts for complex canine phenotypes 6 , 24 . (nature.com)
Response1
- Results The cumulative chloride secretory response of ΔI sc,carbachol , ΔI sc,cAMP/forskolin and ΔI sc,histamine was the best diagnostic ICM parameter (cut-off 34 μA/cm 2 between patients with known PS-CF and controls), differentiating patients with questionable CF into PS-CF (n=6) and 'CF unlikely' (n=55) groups. (bmj.com)
Influence1
- We focus here on interactions of carcinoma cells with mesenchymal stem cells (MSC), which are recruited to the tumor stroma and, once present, are able to influence the phenotype of the carcinoma cells. (aacrjournals.org)
Disease1
- 4-8 In contrast, single-organ disease phenotypes with associated demonstration of CFTR gene abnormality but not fitting the current CF diagnostic criteria have been described as CFTR-related diseases. (bmj.com)
Development1
Background1
- Background In questionable cystic fibrosis (CF), mild or monosymptomatic phenotypes frequently cause diagnostic difficulties despite detailed algorithms. (bmj.com)