• 300 mg/dL or those who have type 3 hyperlipoproteinemia owing to an increased secretion of triglyceride-rich particles, which can produce marked hypertriglyceridemia in some cases. (medscape.com)
  • These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. (wjgnet.com)
  • Although the mechanisms linking excess triglyceride accumulation to diabetes are still unclear adipose tissue plays an important role since its primary function is the safe storage and handling of lipid. (duke-nus.edu.sg)
  • Incubation of conditioned medium with antimonocyte chemoattractant protein-1 antibodies prevented triglyceride accumulation. (unige.ch)
  • Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved. (unige.ch)
  • Low blood sugar stimulates increased cortisol production by the adrenal glands which causes the formation and accumulation of triglycerides (extra fat) in the body. (youandyourchildshealth.org)
  • Therefore it is the over-secretion of insulin that leads to the accumulation of fat in the body. (youandyourchildshealth.org)
  • Hepatic lipidosis, or fatty liver, is the condition of triglyceride accumulation in the liver which can be either physiologic or pathologic. (purdue.edu)
  • The science is quite clear regarding the over consumption of simple sugars and their collective effects upon blood sugar, insulin secretion, body fat accumulation, triglyceride production, and blood pressure. (wakeup-world.com)
  • Lomitapide inhibits microsomal triglyceride transfer protein, which plays a key role in apolipoprotein B-containing lipoprotein assembly and secretion in the liver and intestines. (medscape.com)
  • PGC-1α overexpression in hepatocytes lowered expression of genes critical to VLDL assembly and secretion (apolipoprotein B and microsomal triglyceride transfer protein). (eurekamag.com)
  • BS fetal livers had enhanced mRNA expression of microsomal triglyceride transfer protein (Mttp) (P (cuny.edu)
  • Long-chain triglycerides are subsequently coated with lipoprotein, cholesterol, and phospholipid to form chylomicrons. (medscape.com)
  • Taking CLA by mouth or drinking milk containing CLA doesn't seem to improve levels of cholesterol or blood fats called triglycerides in people with mildly high cholesterol levels . (webmd.com)
  • Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
  • Fasting reduces LDL cholesterol and triglyceride levels. (amalunawellness.com)
  • Cholesterol and fatty acids (as triglycerides) are exported from the liver as VLDL, to distribute triglycerides and cholesterol-fatty acid esters to all peripheral tissues that require these lipids for membrane synthesis, or for storage in the adipose tissue, with the resulting LDL particles being taken up again mainly by the liver. (fatsoflife.com)
  • However, its role in regulation of biliary cholesterol secretion and gallstone formation remains unknown. (ijbs.com)
  • Dysregulation in genes controlling hepatobiliarycholesterol secretion has been shown to have a remarkable influence on cholesterol gallstone development. (ijbs.com)
  • ABCG5 and ABCG8 are two heterodimeric ATP-binding cassette (ABC) transporters on hepatic canalicular membrane and are major contributors of hepatocytes cholesterol secretion into bile [ 4 ], as evidenced by approximately 75% reduced biliary cholesterol secretion rate in Abcg5 and/or Abcg8 KO mice [ 5 ]. (ijbs.com)
  • Other than ABCG5/8, scavenger receptor class B type I (SR-BI), coding by Scarb1 in mice, has also been identified for efficient conduction of biliary cholesterol secretion in physical condition [ 7 ]. (ijbs.com)
  • Adenovirus-mediated hepatic overexpression of SR-BI has preferentially increased its canalicular membranes distribution and resulted in accelerated biliary cholesterol secretion rate in wild type (WT) or Abcg5 KO mice [ 8 ]. (ijbs.com)
  • In contrary, Scarb1 KO or Scarb1/Abcg 5 double KO mice exhibited reduced biliary cholesterol secretion [ 5 ]. (ijbs.com)
  • Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)
  • There are 2 major types of lipids in the study comprising 1155 diabetic type 2 pa- blood: cholesterol and triglycerides. (who.int)
  • Activation of phosphatidic acid phosphatase promotes hepatic triglyceride synthesis, induces secretion of triglyceride-rich, very low-density lipoprotein particles, and consequently, increases plasma triglyceride levels. (medscape.com)
  • Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of candesartan on blood pressure. (nih.gov)
  • These effects may be mediated by AMP kinase-induced fat oxidation, leading to reduced intramyocellular and liver triglyceride content. (diabetesjournals.org)
  • At E17.5, BS reduced fetal adiposity and prevented liver triglyceride overaccumulation in HF versus NF fetuses (P (cuny.edu)
  • These mice also had more triglycerides in their livers than control littermates due, in part, to impaired secretion of triglyceride-rich lipoproteins and reduced capacity for fatty acid oxidation. (sdsc.edu)
  • It should be replaced by 'The concentration of triglyceride-rich lipoproteins may also fall. (bmj.com)
  • MTTP which is involved in the VLDL pathway also plays important roles in viral particle maturation and secretion. (wjgnet.com)
  • Similar to chronic pharmacological inhibition of DP4, DP4 deficient rats exhibited a phenotype involving reduced diet-induced body weight gain and improved glucose tolerance associated with increased levels of glucagon-like peptide-1 (GLP-1) and bound leptin as well as decreased aminotransferases and triglycerides. (mcw.edu)
  • Dietary fat and fructose, which do not increase insulin secretion, lead to reduced leptin production, suggesting a mechanism for high-fat/high-sugar diets to increase energy intake and weight gain. (diabetesjournals.org)
  • The results showed that when PPARγ was silenced, cell viability, proliferation, and triacylglycerol secretion were obviously reduced. (bvsalud.org)
  • PPARγ overexpression improved cell viability, proliferation, and triacylglycerol secretion. (bvsalud.org)
  • The pharmacokinetic profiles of CBD in rats were evaluated after oral administrations of CBD oil and CBD-NE, and the effect of bile secretion on CBD absorption was also evaluated. (karger.com)
  • The novel NE formulation developed in this study successfully improved the absorption of CBD regardless of bile secretion. (karger.com)
  • Do bile acid resins increase triglycerides? (moviecultists.com)
  • It is characterized by the low endogenous GnRH-induced gonadotropin secretion, thus triggering the ovarian blockade and a hypoestrogenic condition. (researchgate.net)
  • The goal is to create hyperglycemia which stimulates the endogenous insulin secretion, thus leading to increased uptake of lipids to the cells and reduced degredation of fattty tissue. (slu.se)
  • The degree of hyperglycemia that is required for sufficient effect on the endogenous insulin secretion and a reduction of triglycerides is, however, unknown. (slu.se)
  • Insufficient secretion of insulin is required for the development of Type 2 Diabetes, a disease with a soaring incidence. (lu.se)
  • It also blocks the inhibitory effects of serotonin on glucose-mediated insulin secretion [ 15 ]. (hindawi.com)
  • In response, beta cells in the pancreas step up the secretion of insulin to deal with the blood sugar spike, facilitating glucose transport through cell membranes and lowering blood sugar. (vitalitymagazine.com)
  • Finally, TCF7L2 polymorphisms have been associated with impaired insulin secretion, glucose production, and glucose tolerance via direct effects on pancreatic islet beta cells. (medscape.com)
  • Association of triglyceride-glucose index with atherosclerotic cardiovascular disease and mortality among familial hypercholesterolemia patients. (cdc.gov)
  • Glucagon-like peptide 1 (GLP-1), a hormone produced by intestinal L cells in response to nutrient ingestion, lowers postprandial plasma glucose via glucose-dependent stimulation of insulin secretion, suppression of glucagon secretion, and delayed gastric emptying. (medscape.com)
  • In diabetics, low zinc levels have been linked with higher rates of associated conditions, including high blood pressure (hypertension), coronary artery disease and high triglyceride levels. (naturalnews.com)
  • While Lovaza is indicated for lowering elevated triglycerides, its labeling specifically states that "the effect of Lovaza on cardiovascular mortality and morbidity in patients with elevated triglyceride levels has not been determined. (uspharmacist.com)
  • Unfortunately, the resins can increase triglyceride levels . (moviecultists.com)
  • Cholestyramine has been shown to increase triglyceride levels in studies . (moviecultists.com)
  • If you have high triglycerides, your healthcare provider will monitor your levels to ensure that they do not become too elevated. (moviecultists.com)
  • Compared to controls we detected a statistically significant in- crease in triglycerides level and a decrease in HDL-C levels. (who.int)
  • PGC-1α overexpression in primary hepatocytes produced an increase in markers of mitochondrial content and function (citrate synthase, mitochondrial DNA, and electron transport system complex proteins) and an increase in FAO, which was accompanied by reduced TAG storage and TAG secretion compared with control. (eurekamag.com)
  • [ 16 ] The syndrome appears to arise because of excessive water consumption during the physical exercise coupled with loss of sodium chloride in sweat and nonosmotic stimulation of AVP secretion (from stress, volume contraction, nausea, and NSAIDs). (medscape.com)
  • The milky secretions of this gland are expelled out of the gland duct at the head end of the larva. (wikipedia.org)
  • The larva sucks up the milky secretion and passes it directly to the midgut where it is slowly digested and assimilated. (wikipedia.org)
  • Chylous ascites is the extravasation of milky chyle rich in triglycerides into the peritoneal cavity, which can occur de novo as a result of trauma or obstruction of the lymphatic system. (medscape.com)
  • The greater the baseline level of triglycerides, the greater the percent triglyceride reduction will be with statin treatment. (medscape.com)
  • We have shown that risk individuals exhibit reduced insulin secretion due to an enhanced inhibitory effect of melatonin in islets. (lu.se)
  • Our focus is on identifying the metabolic signals that link fuel oxidation pathways with adipocyte processes such as lipolysis, adipokine secretion and insulin action. (duke-nus.edu.sg)
  • We were the first to describe that the hormone-sensitive lipase (HSL) is expressed in beta-cells, controlling break down of triglycerides. (lu.se)
  • Pharmacist-specific guidelines for these compounds undergo renal tubular secretion or reabsorption suggests possible interactions. (stonecottagegardens.com)
  • Using HSL knock out mice, we were able to demonstrate that the lipase controls insulin secretion. (lu.se)
  • In conclusion, overexpression of hepatic PGC-1α and subsequent increases in FAO through elevated mitochondrial content and/or function result in reduced TAG storage and secretion in the in vitro and in vivo milieu. (eurekamag.com)
  • Loci for insulin processing and secretion provide insight into type 2 diabetes risk. (cdc.gov)
  • True chylous ascites is defined as the presence of ascitic fluid with high fat (triglyceride) content, usually higher than 110 mg/dL. (medscape.com)
  • If you are overweight and are not active, you may have high triglycerides, especially if you eat a lot of carbohydrate or sugary foods or drink a lot of alcohol. (moviecultists.com)
  • Since carnitine, namely l-acetyl-carnitine (LAC), has been demonstrated to be effective in the modulation of the central hypothalamic control of GnRH secretion, we aimed to evaluate whether a combined integrative treatment for 12 weeks of LAC (250 mg/die) and l-carnitine (500 mg/die) was effective in improving the endocrine and metabolic pathways in a group of patients (n = 27) with FHA. (researchgate.net)
  • We examined regulation of lipid partioning in beta-cells and its control of insulin secretion. (lu.se)
  • We have taken a major interest in how mitochondria are genetically regulated, given their pivotal role in cellular energy metabolism and control of insulin secretion from beta-cells. (lu.se)
  • Most importantly, we described the critical role of pyruvate cycling in insulin secretion and how it underlies stimulus-secretion coupling in the beta-cell. (lu.se)