Secretion of pro inflammatory. Medical search. Frequent questions

Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. (cdc.gov)
MZ B cells were found to produce large quantities of the inflammatory cytokine interleukin (IL)-6, as well as some chemokines, in response to LPS stimulation. (infectioncontroltoday.com)
Thorax trauma (TxT) drives the release of pro-inflammatory small extracellular vesicles (sEVs) from endothelial cells, which systemically propagate endothelial inflammation, cytokine release, neutrophil activation, endothelial barrier disruption and secondary organ damage in kidneys (trauma-related acute kidney injury, TRAKI). (uni-ulm.de)
These data suggest that truncated glycans of lubricin, as found in OA, promote synovial proinflammatory cytokine production and exacerbate local synovial inflammation. (lu.se)
In both sepsis and acute pneumonia models of infection, treatment with WVDC-0357 and WVDC-0496 significantly reduced bacterial burden and inflammatory cytokine production post-challenge. (bvsalud.org)
Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes. (cdc.gov)
Principal component analysis of the cytokine secretion showed close clustering for the s.a. and p.n. equivalent treatments. (cdc.gov)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

The effect of n-butanol fraction on the induction of pro-inflammatory cytokines secretion in Vk2/E6E7 cells and transepithelial resistance in Caco-2 and HEC-1A cells was investigated. (nih.gov)
Cytotoxicity, cytokines secretion and transcriptional changes were evaluated. (cdc.gov)

Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
The anti-inflammatory activity of CPE was assessed by measuring its ability to inhibit the pro-inflammatory enzyme 5-lipoxygenase (5-LOX) and the pro-inflammatory mediators prostaglandin E2 (PGE2), reactive oxygen species (ROS), nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). (upm.edu.my)
CONCLUSION: Crenotherapy induced a down-regulation of nasal mucosal inflammatory mediators in children with CRS. (medicinatermale.it)
Immune cells as Microglia, Astrocytes and neurons are liable for inflammatory reaction that activate and produce inflammatory mediators to clear cellular debris from the damage area. (omicsonline.org)
Macrophage, also secrete numerous soluble mediators to stimulate inflammatory and fibrotic responses 10 facilitate clearance and tissue repair, Under pathologic conditions, the responses become exacerbated and pulmonary fibrosis takes place, causing excessive deposition of collagen fibers and destruction of lung structures. (cdc.gov)

In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. (biolegend.com)

None of the tested forms induced a pro-inflammatory response in Caco-2 cells or in macrophages either. (springer.com)
However, the various lactoferrin forms did effectively inhibit the pro-inflammatory response in macrophages that were activated with lipopolysaccharide with the most potent effect observed for apolactoferrin. (springer.com)
Classical "inflammatory" monocytes can give rise to non-classical "patrolling" monocytes or further differentiate into macrophages or monocyte-derived dendritic cells (MoDCs). (frontiersin.org)
Multi-walled carbon nanotube s activate macrophages and NF-KB signaling to elicit inflammatory and fibrotic responses in mouse lungs. (cdc.gov)
elevated levels of proinflammatory cytokines in the BAL fluid and lung parenchyma, and increased deposition of collagen fibers in the interstitial space, Macrophages were a dominant cell type during inflammatory infiltration in the early phase response and for the formation of granulomas and chronic fibrosis. (cdc.gov)
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. (frontiersin.org)
A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. (frontiersin.org)
In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. (frontiersin.org)
In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)

Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)

Using Inflammatory Multi- Analyte Cytokines ELISArray Kit we investigated the release of cytokines under basal conditions, after PGF 2α treatment for 24 hours to induce pro-inflammatory phenotype, and after PGF 2α treatment and incubation in the presence of L-C-Propargylglycine (PGG, 1 mmol/l), a selective inhibitor of cystathionine-gamma-lyase (CSE). (pensoft.net)
For example, HSC activation and the subsequent matrix secretion by activated HSCs induce liver fibrosis, leading to cirrhosis in chronic liver injury ( 10 ). (spandidos-publications.com)
We know that short-chain fatty acids increase secretion of immunoglobulins, induce regulatory T-cell tissue repair, promote antimicrobial peptides and mucus production, and basically optimize intestinal function and the intestinal barrier integrity. (medscape.com)

Sjögren syndrome is a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs. (medscape.com)
This can eventually lead to systemic inflammatory response syndrome (SIRS), and even death. (infectioncontroltoday.com)
In a fashion, chronic local inflammation in periodontal tissue promotes the secretion of pro-inflammatory cytokines into systemic circulation. (degruyter.com)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. (lu.se)

A research team centered at the University of Tsukuba has now revealed that MZ B cells also produce the signaling proteins cytokines and chemokines involved in inflammatory responses. (infectioncontroltoday.com)
MZ B cells therefore emerge as a regulator of immune responses with a strong pro-inflammatory role in IL-6 production in endotoxic shock. (infectioncontroltoday.com)
Altogether, the altered immune and inflammatory responses, and endotoxemia contribute to the dysfunction and stress in cardiovascular cells (e.g . endothelial cells, vascular smooth muscle cells and cardiomyocytes), increasing cardiovascular risks. (degruyter.com)
These data suggest that GSP inhibits inflammatory responses in HSCs by inactivating the NF-κB signaling pathway via MAP kinases. (spandidos-publications.com)

A variety of proanthocyanidins have multiple functions such as antibacterial, antiviral ( 5 ), anticarcinogenic ( 5 , 6 ) and anti-inflammatory activity ( 7 ). (spandidos-publications.com)

After liver injury, recruited inflammatory cells accumulate in the damaged site. (spandidos-publications.com)

We found that MWCNT administered to mice by pharyngeal aspiration elicited signif,cant inflammatory and fibrotic pathology in lhe lungs, The early phase response was characterized by prominent infammatory infiltration. (cdc.gov)
To understand the molecular mechanisms driving this pathological process, studies within the Program were the first to discover that the intestinal epithelium balances the secretion of pro- and anti-inflammatory lipids through surface efflux pumps (multidrug resistance transporters) to control neutrophil infiltration and maintain homeostasis in the healthy intestine. (umassmed.edu)
Furthermore, histopathological examination of the lungs revealed that WVDC-0357 and WVDC-0496 reduced inflammatory cell infiltration. (bvsalud.org)

Crohn's is a type of inflammatory bowel disease (IBD) that causes inflammation in the digestive tract. (medicalnewstoday.com)
Oral dysbiosis promotes periodontitis pathogenesis, enhancing chronic local inflammation in periodontal tissue, local production of pro-inflammatory cytokines and permeability of surrounding capillaries. (degruyter.com)
Thus, we want to test the hypothesis that inhibiting sEV-secretion or -uptake by endothelial cells/neutrophils might be a promising strategy to attenuate aberrant inflammation after severe trauma. (uni-ulm.de)
We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)

The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
Rheumatoid arthritis is a destructive autoimmune disease driven by the effects of pathogenic autoantibodies and pro-inflammatory cytokines. (bms.com)
The role of pro-inflammatory cytokines in rheumatoid arthritis is well known, and recent research has deepened our understanding of the role of pathogenic autoantibodies in disease. (bms.com)

Glycan-inhibitable surface binding of galectin-8 to these cells increased gene transcription and the secretion of functional disease markers. (nih.gov)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
From this, we looked for inflammatory markers that coincided with the increased amount of O-linked Tn antigen (GalNAcα1-Ser/Thr) glycan on SF lubricin. (lu.se)
Inflammatory markers in plasma and SF in OA patients and controls were measured using a 44-multiplex immunoassay. (lu.se)
Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. (who.int)
No association was observed between physical activity level and inflammatory markers. (who.int)

In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)

Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)

The gut needs to produce a strong protective immune response to resist the invasion of pathogenic antigens, while similar reactions to harmless antigens such as dietary proteins or symbiotic microorganisms, may lead to chronic inflammatory diseases. (frontiersin.org)

Monocytes derived from either of these lineages consist of two main types: (1) classical "inflammatory" monocytes that are CCR2 + Ly6C hi in mice and CD14 + CD16 − in humans, and (2) non-classical "patrolling" monocytes that are CCR2 lo Ly6C lo in mice and CD14 lo CD16 + in humans. (frontiersin.org)

Therefore, in this study, the effect of cocoa polyphenolic extract (CPE) on RAW 264.7 macrophage cells sensitized by lipopolysaccharide as in vitro inflammatory model was investigated. (upm.edu.my)

There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)

We therefore propose a drug repurposing screen to identify viable sEV-secretion and -uptake inhibitor candidates. (uni-ulm.de)
Project A06 seeks to disrupt these adverse events by identifying clinically approved drugs that block sEV secretion or uptake for endothelial cells and neutrophils. (uni-ulm.de)

The CSE inhibitor enhanced IL-6 production and suppressed IL-10 secretion. (pensoft.net)

Ilieva B, Marinova E, Gagov H, Konakchieva R (2017) Basal and PGF 2α -stimulated secretion of pro-inflammatory cytokines from 3T3-L1 adipocyte-like cells. (pensoft.net)
It is concluded that pro-inflammatory phenotype of differentiated 3T3-L1 adipocyte-like cells, induced by PGF 2α is characterized by enhanced TNF α production which critically depends on the ability of CSE to produce H 2 S. (pensoft.net)
These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)
Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
Mixed cellularity Hodgkin lymphoma showing both mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells (hematoxylin and eosin, original magnification X200). (medscape.com)
The n-butanol fraction did not cause an enhanced secretion of pro-inflammatory cytokines in Vk2/E6E7 cells. (nih.gov)
The researchers showed that mice injected with LPS from E. coli were more resistant to endotoxic shock and lived longer if they lacked MZ B cells, suggesting these cells' crucial role in inflammatory response against LPS. (infectioncontroltoday.com)
The article, 'Marginal zone B cells exacerbate endotoxin shock via interleukin-6 secretion induced by Fc? (infectioncontroltoday.com)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
Besides, we will generate targeted, therapeutic sEVs with siRNAs against cytokines to impair sEV-loading of pro-inflammatory transcripts in ICAM-1-positive endothelial and lung alveolar cells. (uni-ulm.de)
However, there have been no studies on the anti-inflammatory effects of GSP in human hepatic stellate cells (HSCs). (spandidos-publications.com)

Macrophage activation in the rheumatoid joint leads to further secretion of pro-inflammatory cytokines, including IL-1, IL-6, IL-8, and TNF-α, which all coordinate to drive further T-cell activation. (bms.com)

A subset of diarrheal pathogens, including Salmonella Typhimurium and Shigella can cause inflammatory events that mimic several clinical hallmarks of IBD, including a massive neutrophil influx into the intestinal lumen. (umassmed.edu)

In the current study, induction of ischemia enhanced the levels of pro-inflammatory cytokines and increased phosphorylation of MAPK signaling factors in the hippocampus and basolateral amygdala. (iasp-pain.org)
Genome-wide array analysis revealed induction of a pro-degradative/inflammatory gene signature, largely under control of NF-κB signaling. (nih.gov)

The former maintains intestinal health, while the latter plays an important role in the occurrence of inflammatory reactions. (frontiersin.org)

The HMGA-NAMPT-NAD + signalling axis promotes the proinflammatory SASP by enhancing glycolysis and mitochondrial respiration. (nature.com)
When assembled, this inflammasome, a multiprotein complex, activates caspase-1, which promotes secretion of proinflammatory cell-signalling protein molecules (cytokines). (europa.eu)

Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels, and cerebral ischemia activates mitogen-activated protein kinase (MAPK) and induces secretion of pro-inflammatory cytokines. (iasp-pain.org)

DNA damage assessment and cell cycle analysis revealed differences in the modes of cell death between asbestos and respective CF. There was an increase in chemokines, but not pro-inflammatory cytokines after all EMP treatments. (cdc.gov)

Here, we show that nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD + salvage pathway, governs the proinflammatory SASP independent of senescence-associated growth arrest. (nature.com)
In these cases, caspase-1 was seen to reduce proteolytic activity, resulting in overactivity of the pro-inflammatory RIP-2 pathway. (europa.eu)
MWCNT directly stimulated secretion of proinflammatory and profibrotic cytokines and growth factors, and activation of the NF-kB pathway. (cdc.gov)

Inflammatory bowel diseases (IBD) impose a significant health and monetary burden in the developed world, with ~1 in 200 people affected in the US. (umassmed.edu)

Fig. 4: NMN enhances the inflammatory environment and cancer progression in vivo. (nature.com)
Our findings suggest that fine PM enhances allergic inflammatory response in pulmonary tissue through mechanisms involving increased oxidative stress. (cdc.gov)

HMGA proteins and NAMPT promote the proinflammatory SASP through NAD + -mediated suppression of AMPK kinase, which suppresses the p53-mediated inhibition of p38 MAPK to enhance NF-κB activity. (nature.com)
However, treatment with PDRN ameliorated short-term memory impairment by suppressing the production of pro-inflammatory cytokines and inactivation of MAPK signaling factors in cerebral ischemia. (iasp-pain.org)

Degradation of IκB frees NF-κB for translocation into the nucleus, where it binds to specific consensus sequences in promoter regions of NF-κB-dependent genes to initiate transcription of pro-inflammatory cytokines [ 6 ]. (biomedcentral.com)

The active n-butanol fraction was evaluated for its inhibition against HIV-1 reverse transcriptase, integrase, protease, pro-viral genome integration and viral Tat protein mediated transactivation. (nih.gov)
It leads to inhibition of apoptosis, proliferation, and secretion of proinflammatory cytokines. (medscape.com)

Probiotics , which are beneficial bacteria existing throughout the body, may help a person with Crohn's disease create more anti-inflammatory bacteria in the gut. (medicalnewstoday.com)

The expression of anti-inflammatory cell signaling molecules, including c-Jun N-terminal kinase (JNK), p38, extracellular signal regulated kinase (ERK), Akt, nuclear factor-κB (NF-κB), inhibitory-κBα (IκBα), iNOS and COX-2, was evaluated by western blot analysis. (spandidos-publications.com)

Currently, Cocoa-derived polyphenolics have shown anti-inflammatory effects in vivo, but the therapeutic benefits in vitro remain unclear. (upm.edu.my)

The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
Hence, we correlated the SF-inflammatory marker concentrations with the level of altered glycosylation of SF-lubricin. (lu.se)

More recently, we have shown that the gut microbiome is essential to the homeostatic control of this inflammatory response. (umassmed.edu)

Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)

We found that PGF 2α strongly increased TNF α secretion from differentiated adipocytes, the latter effect being antagonized by PGG. (pensoft.net)

Includes reduced secretion of proinflammatory cytokines in lung and skin and attenuation of neuroinflammation in brain via reduced activation of microglia. (varian.com)

Pretreatment with GSP before LPS treatment significantly suppressed the mRNA expression of pro-inflammatory cytokines such as IL-1β, IL-6 and IL-8. (spandidos-publications.com)

Lactoferrin was also able to neutralize microbial-derived antigens, thereby potentially reducing their pro-inflammatory effect. (springer.com)
Adenosine A2A receptor agonist, polydeoxyribonucleotide (PDRN), suppresses the secretion of pro-inflammatory cytokines and exhibits anti-inflammatory effect. (iasp-pain.org)
Furthermore, when exposing fibroblast-like synoviocytes from both controls and OA patients to glycovariants of recombinant lubricin, the secretion of IL-8 and MIP-1α and VEGFA were elevated using lubricin with Tn antigens, while lubricin with sialylated and nonsialylated T antigens had less or no measurable effect. (lu.se)

CD23 responds to high levels of IgE by downregulating IgE secretion. (biolegend.com)

Anatomy52

Organisms13

Diseases5

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology1

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Cytokine8

Cytokines secretion2

Mediators5

Release of pro-inflammatory1

Macrophages9

Reactive oxygen1

Induce3

Systemic4

Responses4

Anti-inflammatory activity1

Recruited inflammatory cells1

Infiltration3

Inflammation4

Autoantibodies3

Markers6

Insulin resistance2

Secrete1

Chronic inflammatory1

Monocytes1

Lipopolysaccharide1

Phenotypes1

Uptake2

Inhibitor1

Cells11

Macrophage1

Pathogens1

Induction2

Intestinal1

Promotes2

Activates1

Chemokines1

Pathway3

Diseases1

Enhances2

MAPK2

Translocation1

Inhibition2

Bacteria1

Molecules1

Vivo1

Concentrations2

Response1

Crucial1

Strongly1

Lung1

Significantly1

Effect3

Levels1