Secretion of bicarbonate. Medical search. Frequent questions

In control dogs, we detected net colonic absorption of sodium and chloride and secretion of potassium and bicarbonate. (avma.org)
In situ perfusion of rat intestine was used to evaluate the effect of bicarbonate on the efficacy of a low sodium (35 mmol/l) glucose-electrolyte oral rehydration solution in normal and cholera toxin-treated rat small intestine. (bmj.com)
Net sodium secretion occurred in normal and secreting intestine but was significantly less with the bicarbonate containing oral rehydration solution. (bmj.com)
By slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport, may inhibit carbonic anhydrase in the ciliary processes of the eye. (medscape.com)
Reversibly inhibits carbonic anhydrase, reducing hydrogen ion secretion at renal tubule and increasing renal excretion of sodium, potassium bicarbonate, and water to decrease production of aqueous humor. (medscape.com)
Sometimes these along with some baking chemicals such as sodium bicarbonates and preservatives such as sodium benzoate cause damage to the mucus membrane of the digestive system. (hubpages.com)
Acetazolamide, a major carbonic anhydrase inhibitor, blocks the re-absorption of sodium bicarbonate, resulting in an alkaline diuresis with loss of sodium and bicarbonate in the urine. (aspetjournals.org)
Analysis of serum electrolytes gave the following results: sodium 124 mmol/L, potassium 4 mmol/L, chloride 84 mmol/L, bicarbonate 29 mmol/L and creatinine 0.4 mg/dL. (who.int)
He underwent fluid resuscitation and investigations showed the following results: serum sodium 128 mmol/L, chloride 76 mmol/L, potassium 3.3 mmol/L, bicarbonate 28 mmol/L, anion gap 15.6 mmol/L, urea 35 mg/dL, creatinine 1.3 mg/dL, calcium 10.5 mg/dL, phosphorus 7.6mg/dL and magnesium 2.3 mg/dL. (who.int)

The specific aims were to study the regulation of acid-induced duodenal mucosal bicarbonate secretion (DMBS) and the antral feedback inhibition of meal-induced gastrin release. (gu.se)

The inhibition of pancreatic secretion by the undissociated glycodiazine is presumably caused by its effects on the mitochondrial energy production. (mpg.de)
Our results directly illustrate the importance of GDH in the regulation of insulin secretion from pancreatic β-cells. (diabetesjournals.org)
Gastric acid aids digestion by creating the optimal pH for pepsin and gastric lipase and by stimulating pancreatic bicarbonate secretion. (merckmanuals.com)
In this report, we discuss the significance of protein interactions to HCO 3 - secretion in pancreatic duct cells. (elsevierpure.com)
In pancreatic ducts HCO 3 - secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl - /HCO 3 - exchange activity and HCO 3 - absorption is achieved by Na + -dependent mechanisms including Na + /H + exchanger 3 (NHE3). (elsevierpure.com)
These findings reveal that protein complexes in the plasma membrane of pancreatic duct cells are highly organized for efficient HCO 3 - secretion. (elsevierpure.com)

By inhibiting prostaglandin production via blockage of the enzyme cyclooxygenase (COX), NSAIDs reduce gastric blood flow, reduce mucus and HCO3 secretion, and decrease cell repair and replication. (merckmanuals.com)
A low plasma bicarbonate (HCO3-) concentration represents, by definition, metabolic acidosis, which may be primary or secondary to a respiratory alkalosis. (medscape.com)

the OH − ions thereby promoting the buffer secretion. (mpg.de)
p less than 0.01) from the oral rehydration solution containing bicarbonate than from the solution in which bicarbonate was replaced by chloride ions (59.5 (7.2) microliters/min/g and -7.8 (0.8) mumol/min/g, respectively). (bmj.com)
Hydrogen ions approaching the epithelium will react with bicarbonate to form CO2 and water. (gu.se)
The metabolic acidosis that results from RTA may be caused either by failure to reabsorb sufficient bicarbonate ions (which are alkaline) from the filtrate in the early portion of the nephron (the proximal tubule) or by insufficient secretion of hydrogen ions (which are acidic) into the latter portions of the nephron (the distal tubule). (successcds.net)
An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. (drugbank.com)

Animals then underwent pylorus ligation to evaluate gastric secretion of acid, pepsinogen, and mucus. (nih.gov)
At preclinical level, Uliveto water increased acid and pepsinogen secretions as well as gastric emptying, without changes in bound mucus. (nih.gov)
The mucosa is therefore supplied with a number of defence mechanisms, including an unstirred layer of mucus into which bicarbonate is secreted by the mucosa. (gu.se)
In the lungs, people with CF have abnormal homeostasis of the airway surface liquid, with impaired hydration of secretions and mucus, reduced mucociliary clearance, inflammation and susceptibility to infection. (pulsetoday.co.uk)

The isolated cat pancreas was perfused with solutions containing different concentrations of bicarbonate- or glycodiazine buffer. (mpg.de)
This is, for example, to stimulate the secretion of water and bicarbonate from the pancreas as soon as the acidified stomach content passes into the small intestine. (tum.de)
The partly digested food leaves the stomach and enters the duodenum where it encounters secretions of the gall bladder and the pancreas. (curezone.org)
The heterocrine glands are glands that have two functions (hormone secretion and certain additional functions) (e.g., pancreas, testes, ovaries, etc). (vedantu.com)

Interestingly, insulin secretion is also exaggerated significantly at low glucose concentrations (2 and 5 mmol/l) but not at higher glucose concentrations (8-25 mmol/l). (diabetesjournals.org)
Although it primarily over a 2-year period with episodes of bicarbonate 22 mmol/L. The serum affects the respiratory and gastrointes- diarrhoea and vomiting associated levels of aldosterone (99 ng/dL) and tinal tracts, it can also involve other renin (84 ng/dL) were normal, so was organs. (who.int)
Of these, 397 (28%) had DKA (bicarbonate level<15 mmol/l and/or pH<7.25 (venous) or <7.30 (arterial or capillary) or mention of DKA in medical records) at diabetes onset. (cdc.gov)

The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. (aspetjournals.org)
Carbonic anhydrase plays an important role in bicarbonate reabsorption from the proximal tubule ( Ives, 2001 ). (aspetjournals.org)
The secretion of numerous organic anions, including endogenous metabolites, drugs, and xenobiotics, is an important physiological function of the renal proximal tubule. (aspetjournals.org)
A distinctive feature of type II pRTA is that it is nonprogressing, and when the serum bicarbonate is reduced to approximately 15 mEq/L, a new transport maximum for bicarbonate is established and the proximal tubule is able to reabsorb all of the filtered bicarbonate. (medscape.com)

In addition, because the binding of diuretics to plasma proteins is generally high (more than 90%), tubular secretion is the main route of urinary excretion of the diuretics. (aspetjournals.org)
The syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH) is defined by the hyponatremia and hypo-osmolality resulting from inappropriate, continued secretion or action of the hormone despite normal or increased plasma volume, which results in impaired water excretion. (medscape.com)
Primary metabolic acidoses that occur as a result of a marked increase in endogenous acid production (eg, lactic or keto acids) or progressive accumulation of endogenous acids when excretion is impaired by renal insufficiency are characterized by decreased plasma bicarbonate concentration and increased anion gap without hyperchloremia. (medscape.com)
The kidneys maintain acid-base balance by bicarbonate reclamation and acid excretion. (medscape.com)

The proximal convoluted tubule (PCT) is the major site for reabsorption of filtered bicarbonate. (medscape.com)
In proximal RTA (pRTA), bicarbonate reabsorption is defective. (medscape.com)

The effect of the unregulated increase in GDH activity on insulin secretion was examined by overexpressing GDH266C in an insulinoma cell line, MIN6. (diabetesjournals.org)
Although glutamine alone did not stimulate insulin secretion from control MIN6-lacZ, it remarkably stimulated insulin secretion from MIN6-GDH266C. (diabetesjournals.org)
This finding suggests that constitutively activated GDH enhances oxidation of glutamate, which is intracellularly converted from glutamine to α-ketoglutarate, a tricarboxylic acid cycle substrate, which thereby stimulates insulin secretion. (diabetesjournals.org)

People with cystic fibrosis are missing a protein in the lining of the lung that releases bicarbonate, a key infection-fighting agent. (illinois.edu)

Reference ranges of serum bicarbonate vary by age in both males and females. (medscape.com)

These findings suggest that the demonstrable advantage of bicarbonate in promoting water absorption from this oral rehydration solution in normal rat intestine does not apply to cholera toxin treated secreting intestine. (bmj.com)

The enhancing actions of Uliveto on gastric secretions and emptying were prevented by L-365,260, an antagonist of gastrin/CCK-2 receptors. (nih.gov)
Acid secretion is initiated by food: the thought, smell, or taste of food effects vagal stimulation of the gastrin-secreting G cells located in the distal one third (antrum) of the stomach. (merckmanuals.com)

Saliva protects the teeth against acid by its bicarbonate as buffer and urea 5 . (bvsalud.org)

It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. (drugbank.com)

and renal tubular secretion of chlorothiazide and hydrochlorothiazide in the avian kidney ( Odlind and Lonnerholm, 1982 ). (aspetjournals.org)
Loss of bicarbonate stores through diarrhea or renal tubular wasting leads to a metabolic acidosis state characterized by increased plasma chloride concentration and decreased plasma bicarbonate concentration. (medscape.com)

Losing CFTR channel function makes airway surface liquid more acidic and disrupts salt secretion. (illinois.edu)

The channels released bicarbonate that had built up in cells and brought the pH and thickness of the airway surface liquid back within normal range. (illinois.edu)
Just as a simple prosthetic device can restore a lot of function to those missing a limb, we found that although amphotericin is not a perfect mimic of the CFTR protein, it can function as a bicarbonate channel and restore defense mechanisms in the airway surface liquid," Burke said. (illinois.edu)

1. The rates of bicarbonate and fluid secretion were proportional to the respective concentrations of the bicarbonate anion and total bicarbonate in the perfusate. (mpg.de)
2. In only 2 of 9 experiments could the secretory rate of fluid and bicarbonate be varied by altering the CO 2- pressure of the perfusate. (mpg.de)
4. The rate-limiting step for the enhancement of the glycodiazine and concomitant fluid secretion is the anion concentration in the perfusate, whereas by increasing concentrations of the undissociated acid of this buffer the secretory flow rate and total buffer secretion can be decreased. (mpg.de)
Linaclotide increases intracellular and extracellular cyclic guanosine monophosphate, which results in chloride and bicarbonate secretion into intestinal lumen, increasing intestinal fluid content and accelerated transit time. (kevinmd.com)
Analysis of the enzymes in salivary secretion and in the crevicular fluid may help to clarify the pathogenesis and improve the early diagnosis and prognosis of periodontal disease 8-10 . (bvsalud.org)

The reduction of salivary secretion or changes in the properties of the saliva are responsible for a lot of dental and oral problems, such as cavities or periodontal disease, as they remain major diseases, with a direct impact on the quality of life of patients affected by them 2-4 . (bvsalud.org)

The CFTR protein forms an ion channel that transports chloride and bicarbonate at the apical membrane of epithelial cells. (pulsetoday.co.uk)

no extrapulmonary lesions could be identified in these animals, although virus isolation and reverse transcription-polymerase chain reaction (RT-PCR) results for viral RNA from pharyngeal secretions, tracheobronchial secretions, urine, rectal swabs or stool, or kidney or lung tissues were positive. (cdc.gov)

The ciliary epithelium, a bilayer of secretory neuroepithelial cells, is the site of synthesis of aqueous humor (inflow system), and it regulates its secretion by the coordinated action of a complex transport system that involves ion channels and active transporters. (yale.edu)
The ocular ciliary epithelium as a novel endocrine secretory epithelium: The secretion of aqueous humor and the regulation of intraocular pressure (IOP) are physiologically and pathophysiologically important processes for the integrity and normal function of the mammalian eye. (yale.edu)
The ciliary epithelium, a bilayer of secretory neuroepithelial cells, is the site of synthesis of aqueous humor (inflow system), and regulates its secretion by the coordinated action of a complex transport system involving ion channels and active ion secretion, from the stromal to the aqueous-humor surface, followed by osmotic water movement. (yale.edu)

This effect may decrease aqueous humor secretion, reducing IOP. (medscape.com)
The secretion of aqueous humor and the regulation of intraocular pressure are fundamental physiologic processes for the integrity and normal function of the mammalian eye. (yale.edu)
A balance between the rates of secretion and drainage of the aqueous humor determines the level of intraocular pressure. (yale.edu)
The most effective way to lower intraocular pressure is by targeting the inflow system with drugs that reduce the rate of secretion of aqueous humor. (yale.edu)
A balance between the rates of secretion and drainage of the aqueous humor determines the level of IOP. (yale.edu)

Effect of bicarbonate on efficacy of oral rehydration therapy: studies in an experimental model of secretory diarrhoea. (bmj.com)

3. Glycodiazine (Redul ® ) can partially replace the bicarbonate CO 2 buffer in its ability to promote water and solute secretion. (mpg.de)
In the healthy liver, cholangiocytes contribute to bile secretion via release of bicarbonate and water. (idsemergencymanagement.com)

However, in people with cystic fibrosis, the protein in the cell membrane that vents the bicarbonate to the surface, called CFTR, is defective or missing altogether. (illinois.edu)

It produces neurohormones which regulate the synthesis and secretion of pituitary hormones. (vedantu.com)

Secretion of H+ and organic substances. (uninsubria.eu)

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. (medscape.com)
A normal AG acidosis is characterized by a lowered bicarbonate concentration, which is counterbalanced by an equivalent increase in plasma chloride concentration. (medscape.com)

His height can appear at birth or later in the life ac- leading to a relatively high bicarbonate and weight were below the 3rd percen- cording to the type of mutation, which level in the contracted extracellular vol- tile, temperature was 38.7 °C, heart rate also predicts the severity of the disease ume (haemoconcentration) [ 3,8,9,15 ], 98/min, respiratory rate 30/min, blood [ 1 ]. (who.int)
Together with pH determination, bicarbonate measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with acid-base imbalance in the respiratory and metabolic systems. (cdc.gov)

Control of secretions. (uninsubria.eu)

These reactions cause the production of reflux secretions and this result in gastric disorders. (hubpages.com)

Ruiz-Jarabo I, Gregório SF, Gaetano P, Trischitta F, Fuentes J . High rates of intestinal bicarbonate secretion in seawater tilapia (Oreochromis mossambicus) . (ualg.pt)

The drug amphotericin can form channels to release bicarbonate in lung tissue, restoring the airway surface liquid's antibiotic properties. (illinois.edu)

Their secretions are absorbed into the immediate surrounding blood circulation, allowing them to reach certain organs and trigger a metabolic change. (vedantu.com)
Blood bicarbonate. (who.int)

Anatomy42

Organisms10

Diseases10

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes37

Information Science3

Health Care2

Sodium9

Duodenal mucosal bicarbonate secretion1

Pancreatic6

HCO32

Ions5

Mucus4

Pancreas4

Mmol3

Proximal tubule4

Excretion4

Reabsorption2

Insulin secretion3

Releases bicarbonate1

Serum1

Absorption1

Gastrin2

Urea1

Hydrochloric acid1

Renal tubular2

Acidic1

Airway surface liquid2

Fluid5

Salivary1

Epithelial cells1

Urine1

Epithelium3

Aqueous5

Secretory1

Water2

Protein1

Neurohormones1

Substances1

Plasma2

Respiratory2

Control1

Disorders1

Rates1

Release1

Blood2