• It also inhibited the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) both at gene and protein levels. (oncotarget.com)
  • Mechanistically, we found that wogonoside inhibited nuclear factor kappa B/ hypoxia-inducible factor two alpha (NF-κB/HIF-2α) activation via the phosphatidylinositol 3 kinase (PI3K) /AKT pathway. (oncotarget.com)
  • Both the expression and activity of inducible nitric oxide synthase, an intracellular marker of M1, were increased by MWCNTs up to 8.4-fold. (cdc.gov)
  • In line with this observation, inducible nitric oxide synthase and arginase 1 expression were also increased in allogeneic animals upon IL-33 administration. (uandes.cl)
  • Exendin-4 also significantly alleviated the increased malondialdehyde (MDA), nitrotyrosine content, and inducible nitric oxide synthase (iNOS) expression induced by high glucose in HUVECs. (hindawi.com)
  • iNOS (Inducible Nitric oxide, NO, NOS) is an inorganic, gaseous free radical that carries a variety of messages between cells. (thermofisher.com)
  • NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) and endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. (thermofisher.com)
  • This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. (biomedcentral.com)
  • M1 macrophages are associated with the expression of interleukin (IL)-1, -12, TNF-α and inducible nitric oxide synthase (iNOS) 7 . (ersjournals.com)
  • iNOS is found in a variety of cell types including macrophages, hepatocytes, synoviocytes, and smooth muscle cells. (thermofisher.com)
  • Three related iNOS pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. (thermofisher.com)
  • Endothelial nitric oxide (NO) is generated by constitutively active endothelial nitric oxide synthase (eNOS), an essential enzyme responsible for cardiovascular homeostasis. (nih.gov)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • The results of small-scale randomized controlled trials suggest that consumption of flavonoid-rich food and beverages containing anthocyanins or flavan-3-ols may improve vascular endothelial function. (oregonstate.edu)
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
  • endothelial ( eNOS or nitric oxide synthase type III) which is a calcium -dependent form found primarily in endothelial cells . (emf-portal.org)
  • Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. (uchicago.edu)
  • 3 However, T-cell activation leads to CD and simultaneously enhances the secretion of cytokines such as TNF-a, IL-1, IL-3, IL-6, inhibitory factors, and macrophage migration. (drugtargetreview.com)
  • 12 These all target the actions of various inflammatory mediators such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF-kβ, lipoxygenase (LOX) and arachidonic acid (AA). (drugtargetreview.com)
  • In vitro , wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE 2 ), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). (oncotarget.com)
  • Consistent with M1 polarization, MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor-a and interleukin-1beta, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). (cdc.gov)
  • Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
  • Recent studies have shown that administering L-arginine can restore blood circulation to body organs as well as provide substratums that are constitutive of nitric oxide synthase. (gvnc.org)
  • 5 grams of arginine supplements improved kidney function by three times. (gvnc.org)
  • Several types of tumors have aberrant arginine-metabolic enzymes and rely completely on extracellular arginine to support necessary biological processes, a requirement known as arginine auxotrophy. (biomedcentral.com)
  • Many tumors, including HCC, malignant melanoma, malignant pleural mesothelioma, and prostate and renal cancers, are arginine auxotrophic due to their variable loss of argininosuccinate synthase 1 (ASS1), which is severely reduced or absent in numerous types of aggressive and chemoresistant cancers. (biomedcentral.com)
  • Glucagon-like peptide-1 (GLP-1) is an important endogenous incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreatic islet cells and supports glucose homeostasis [ 7 ], as well as stimulating β -cell proliferation and inhibiting β -cell apoptosis, increasing insulin sensitivity, and inhibiting glucagon secretion and gastrointestinal motility [ 7 - 10 ]. (hindawi.com)
  • Enhanced M1-polarized macrophages in obese synovium decreased growth arrest-specific 6 (GAS6) secretion, resulting in impaired macrophage efferocytosis in synovial ACs. (elifesciences.org)
  • GAS6 secretion is decreased during M1 macrophage polarization during obese-OA, leading to impaired macrophage efferocytosis in synovial apoptotic cells. (elifesciences.org)
  • Glucagon-like peptide 1 (GLP-1), a hormone produced by intestinal L cells in response to nutrient ingestion, lowers postprandial plasma glucose via glucose-dependent stimulation of insulin secretion, suppression of glucagon secretion, and delayed gastric emptying. (medscape.com)
  • Methods: We conducted a prospective case-control study in which we inclu ded 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. (scirp.org)
  • Results: The analysis of our results shows a statistically significant elevated TG values (p ﹣3 ), Lp (a) (p ﹣3 ), and CRP-us (p ﹣3 ) in type 2 diabetes compared with controls. (scirp.org)
  • We previously reported that NOS1AP SNP rs12742393 was associated with type 2 diabetes. (diabetesjournals.org)
  • Taking niacinamide by mouth might help slow the progression of type 1 diabetes. (medlineplus.gov)
  • A novel investigative study published in the Nov 2014 issue of The Journal of Endocrinology looked at the effects of turmeric (curcumin, specifically) on the insulin-producing cells of the pancreas called Beta cells (or B-cells) and Islet cells, in relation to type-2 diabetes conditions. (wakeup-world.com)
  • Promising findings in randomized controlled studies indicate that supplementation with flavan-3-ols or anthocyanidins may improve glycemic control in subjects at-risk or diagnosed with type 2 diabetes mellitus . (oregonstate.edu)
  • In patients with Type 2 diabetes mellitus (T2DM) parameters characterizing the degree of obesity significantly positively correlated with levels of CRP and CCL2. (medsci.org)
  • The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
  • In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
  • Both, obesity which is a major risk factor for the insulin resistance development and type 2 diabetes (T2DM), and the chronic hyperglycemia itself play an important role in its pathogenesis. (medsci.org)
  • Recently more stable GLP-1 analogues, such as exenatide, have been approved for clinical use against type 2 diabetes mellitus (T2DM). (hindawi.com)
  • Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
  • This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
  • The risk of cancers appears to be increased in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) ( 2 ). (frontiersin.org)
  • However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)
  • Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. (e-apem.org)
  • Type 2 diabetes (T2D) is a major health problem that has reached epidemic proportions around the world. (e-apem.org)
  • A large body of proof suggests that renal sodium retention in patients with the initial evaluation of a affected person with ascites should cirrhosis is secondary to arterial splanchnic vasodilation diabetes mellitus type 2 epidemiology in the philippines [url=http://brcp-1.gov.bd/pharmacy/Losartan/]buy discount losartan 25 mg line[/url]. (ehd.org)
  • A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)
  • 3) The C-terminal region (amino-acids 96-140) is associated with the major sites of metal binding and posttranslational modification, involved in modulating the protein structure, physiological functions, and toxicity. (encyclopedia.pub)
  • MCP-1 monocyte chemoattractant protein type 1 workplace. (cdc.gov)
  • Similarly, glucose stimulated insulin secretion from islets isolated from CKO was decreased compared with that from control mice. (diabetesjournals.org)
  • Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. (lu.se)
  • However, vast data from 30 years of further study indicate a tumor-suppressive role of p53 [ 1 , 3 ]. (nature.com)
  • The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)
  • Jain SK, Micinski D. Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. (springer.com)
  • The cytotoxic responses to different root canal sealers vary considerably, depending on the sealer's chemical composition4, namely zinc oxide eugenol, calcium hydroxide, mineral trioxide aggregate 9 , glass-ionomer or polymers (i.e., epoxy resins, polydimethylsiloxane and methacrylates). (bvsalud.org)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
  • They will take this work one step further and create new model systems to determine the 3-D relationships and functions of different epithelial cell types as the basal cells detect and respond to various drugs, hormones, chemicals and pathogens that appear in the cavity of the organ. (nih.gov)
  • Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells. (uchicago.edu)
  • Lundquist I, Mohammed Al-Amily I, Meidute Abaraviciene S, Salehi A. Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System. (lu.se)
  • There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
  • Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. (uchicago.edu)
  • Researchers treated B-cell lines and human Islet cells with preparations of turmeric and found impressive insulin secretion improvements, improved insulin sensitivity, and a reduction of PDEs, enzymes that are deleterious to health and function in the pancreas. (wakeup-world.com)
  • Nitric oxide synthase synthesizes (free radical) the free radical NO. Like cytochrome P450 enzymes, NO synthase uses Fe-heme, FAD, Fig 24. (ecoshelta.com)
  • 4 These inflammatory mediators elicit functions of synovial tissue, including expression of metalloproteinase, proliferation and secretion of other prostaglandins, chemokines, and adhesion molecules. (drugtargetreview.com)
  • There is a need for biomarkers to monitor the development and progression of type 1 DM. (indexindex.com)
  • This type of analysis can be conducted both in vitro and in vivo. (bvsalud.org)
  • Insulin resistance (IR) has been identified as a cardinal trigger of impaired glucose metabolism, T2D, and cardiovascular diseases [ 3 , 4 ]. (e-apem.org)
  • Methods: Pancreatic specific deletion (CKO) of NOS1AP mice were generated from floxed nos1ap (exon 3-5) mice and pdx1-cre mice. (diabetesjournals.org)
  • C57BL/6 wild-type mice were grafted with syngeneic or allogeneic skin transplants and treated with exogenous IL-33 daily. (uandes.cl)
  • 3) p53 null mice develop tumors with 100% penetrance. (nature.com)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • Furthermore, the results of studies using HGF‑overexpressing mice have indicated the therapeutic potential of HGF for various types of disease and injury. (spandidos-publications.com)
  • Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Adhesion molecule expression leads to T-cells excessively binding to synovial-type B-cells, which finally produces large amounts of MMP. (drugtargetreview.com)
  • Intra-articular injection of GAS6 restored the phagocytic capacity of macrophages, reduced the accumulation of local ACs, and decreased the levels of TUNEL and Caspase-3 positive cells, preserving cartilage thickness and preventing the progression of obesity-associated OA. (elifesciences.org)
  • Our comparative proteomic analysis of HCC cells grown in culture as monolayers (2D) and spheroids (3D) revealed that argininosuccinate synthase 1 (ASS1) expression was higher in 3D cells than in 2D cells due to upregulated endoplasmic reticulum (ER) stress responses. (biomedcentral.com)
  • Patients taking turmeric experienced significantly less pain and fatigue (per pain scale log assessments) at intervals of 3 weeks, as compared to placebo. (wakeup-world.com)
  • Leptin participates in the inflammatory responses in multiple cell types and animal models. (shengsci.com)
  • and 3) the interactions of corticosteroids and airway blood vessels by which inflammatory changes of the airway vasculature can be reversed in patients with asthma. (ersjournals.com)
  • Existing evidence suggests that the loss of NO in cultured human cerebrovascular endothelium causes increased expression of APP and β-site APP-cleaving enzyme 1 (BACE1) thereby resulting in increased secretion of amyloid β peptides (Aβ1-40 and Aβ1-42). (nih.gov)
  • Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. (oncotarget.com)
  • Treatment of J774A.1 murine macrophages with MWCNTs increased the expression of Alox5 mRNA in a concentration- and time-dependent manner, with the largest induction (5.3-fold over control) occurring at 10 mg/ml and 3 days post-exposure. (cdc.gov)
  • Alongside Alox5 induction, MWCNTs induced the expression of CD68, a cell surface marker of M1, by approximately 2.0-fold and that induction persisted for up to 3 days post-exposure. (cdc.gov)
  • the 2 procedures were equally effective in the treatment of low-risk patients with 3-vessel disease and in low- and intermediate-risk patients with left main CAD. (medscape.com)
  • Lastly, the cytokine pattern of ex vivo-stimulated draining lymph nodes indicates that IL-33 dampens interferon-γ and IL-17 production, stimulating IL-10 secretion. (uandes.cl)
  • Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. (thermofisher.com)
  • Accumulating evidence from randomized controlled trials suggests that consumption of flavan-3-ols and anthocyanidins can be beneficial for metabolic and cardiovascular health. (oregonstate.edu)
  • Transgenic animals have identified a role for specific manufacturing, auto body painting and repair and immunity, including the involvement of T-helper type 1/2 plastics manufacturing. (cdc.gov)
  • The IgA immune complex also generates excessive intra-articular tissue-growth-factor-β secretion, as well as bone erosion, which leads to RA symptoms. (drugtargetreview.com)
  • Knockdown of Alox5 using specific small hairpin-RNA suppressed MWCNT-induced M1 polarization, LTB4 secretion, and migration of neutrophils, implicating an important role of Alox5 in MWCNT-induced M1 polarization and function. (cdc.gov)