MucosaMucosalUlcerPentagastrin-stimulated gastricBasalGastrinIncrease gastricStimulatesPancreaticGlandsChanges in gastricInhibitionHistamineIndomethacinInsulin secretionGastrointestinalStimulationPathwayJuiceApical plasma membraneInhibitory polypeptidePhysiologyLansoprazoleEsomeprazoleDevelopment of gastricLumenUlcersReceptorOutlet obstructionIncreasesMucusSomatostatinParietal cellHepaticAchlorhydriaUlcerationHormonePyloriGastritisEsophagealAcuteIndigestion
Mucosa7
- Helicobacter pylori infection induces chronic inflammation of the gastric mucosa and thus profoundly affects gastric physiology. (nih.gov)
- The morphological damage of the gastric mucosa, changes in gastric hormone release, and disruption of neural pathways all contribute to influence gastric acid secretion in a distinct manner. (nih.gov)
- Corpus-predominant gastritis and corpus atrophy are accompanied by hypochlorhydria and carry the highest risk for gastric cancer, whereas antrum-predominant gastritis with little involvement of the corpus-fundic mucosa is associated with hyperchlorhydria and predisposes to duodenal ulcer disease. (nih.gov)
- This study suggests that the intragastric administration of calcium results in independent release of gastric acid and gastrin from the gastric mucosa. (bmj.com)
- These results indicate that pancreatic polypeptide is capable of acting centrally in the brain to stimulate gastric acid and pepsin secretion through a vagal, muscarinic pathway and in so doing exerts an ulcerogenic action on the gastric mucosa. (duke.edu)
- The symptoms of Zollinger-Ellison syndrome (ZES) are secondary to hypergastrinemia, which causes hypertrophy of the gastric mucosa, leading to increased numbers of parietal cells and increased maximal acid output. (medscape.com)
- In immune-mediated diseases (eg, pernicious anemia), acid secretion cannot be restored after destruction of the gastric secretory mucosa. (medscape.com)
Mucosal5
- Scholars@Duke publication: Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats. (duke.edu)
- The cytoprotective action of the green tea- catechins against ethanol - or restraint plus water -immersion stress-induced acute gastric mucosal injury, and acetic acid-induced chronic gastric ulcers in rats has been reported. (rsc.org)
- The prophylactic action of the tea seed-derived triterpene saponins against ethanol -induced gastric mucosal lesions, 6,7 and of BT extract against various ulcerogens 8,9 have been reported in rat models. (rsc.org)
- It is concluded that high concentrations of lysolecithin in the secretion of gastric ulcer patients results in the weakening of the gastric mucosal barrier by depleting its glyceroglucolipid component. (researchwithrutgers.com)
- The etiopathogenetic cascade currently available treatments, surgery to multiple endoscopic gastric mucosal of the infection leads to various errors in and radio-chemotherapy, is less than tissue biopsies. (who.int)
Ulcer9
- Disease and disorder research has been conducted in relation to the Gastric Acid Secretion Pathway and Ulcer, Duodenal Ulcer, Gastric Ulcer, Peptic Ulcer, Gastroesophageal Reflux Disease. (novusbio.com)
- Przewozniak, Diane M., "Effects of Indomethacin on Gastric Secretion and Duodenal Ulcer Formation in Bile Duct-Ligated Rats" (1977). (wmich.edu)
- The present study was carried out to investigate the central effects of pancreatic polypeptide on gastric secretion and gastric ulcer formation in conscious rats. (duke.edu)
- In addition, the ability of KT4 to reduce gastric acid secretion might also contribute to its ulcer-healing activity. (rsc.org)
- Basal and pentagastrin-stimulated gastric secretions, collected (at 15-min intervals for 1 h) from six duodenal ulcer and six gastric ulcer patients, were analyzed for their content of lecithin, lysolecithin, and glyceroglucolipids. (researchwithrutgers.com)
- The basal secretions of patients with duodenal ulcer contained about 4.5-fold less (204 μmol/l) of lysolecithin than those from patients with gastric ulcer (932 μmol/l). (researchwithrutgers.com)
- After pentagastrin stimulation, the lysolecithin concentrations in the secretion from duodenal ulcer patients rose slightly (to 212 μmol/l), whereas a twofold decrease (to 440 μmol/l) in lysolecithin was observed in the secretion from patients with gastric ulcer. (researchwithrutgers.com)
- 0.01) secretions from patients with gastric ulcer. (researchwithrutgers.com)
- The leaves of Gongronema latifolium increase gastric acid output and prevent gastric ulcer in diabetic rats. (uwi.edu)
Pentagastrin-stimulated gastric1
- Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. (elsevierpure.com)
Basal2
- A key substrate in the production of gastric acid is CO2, and diffusion of CO2 through the basal surface of the parietal appears to be the rate limiting step in acid synthesis. (epomedicine.com)
- Gastrin by itself also stimulates acid secretion, resulting in increased basal acid secretion. (medscape.com)
Gastrin3
- Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man. (bmj.com)
- Gastrin stimulates the gastric secretion. (zigya.com)
- Surgical antrectomy results in normalization of serum gastrin levels and disappearance of multicentric gastric carcinoids. (medscape.com)
Increase gastric2
- In contrast, intraperitoneal injection of even higher doses of pancreatic polypeptide (250, 1000, and 2500 ng/rat) failed to increase gastric secretion. (duke.edu)
- Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial AMERICAN JOURNAL OF CLINICAL NUTRITION. (nottingham.ac.uk)
Stimulates1
- Ileal protein which stimulates gastric acid and pepsinogen secretion. (hmdb.ca)
Pancreatic3
- Intracisternal injection of rat pancreatic polypeptide (62.5, 250, and 1000 ng/rat) into pylorus-ligated rats resulted in a dose-dependent stimulation of gastric acid and pepsin secretion. (duke.edu)
- Absence of duodenal inhibition of gastric acid secretion by fat following pancreatic duct ligation. (umn.edu)
- Unger, Roger H. / Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats . (elsevierpure.com)
Glands2
Changes in gastric2
- Changes in gastric acid secretion, whether impaired or increased, are intimately related with the topographic phenotypes of gastritis and the presence of atrophy or absence of corpus atrophy. (nih.gov)
- Also, reports have been made of hypoglycemia, hypocholesteremia, low ascorbic-acid levels, gastrointestinal tract changes in gastric secretions and peristaltic motility, and changes in nerve conduction velocities. (cdc.gov)
Inhibition3
- Like antacids, these agents do not reduce the frequency of reflux, but they are very effective in decreasing the amount of acid in the refluxate through inhibition of acid production by blocking the histamine H2 receptors on gastric parietal cells. (medscape.com)
- Suppresses gastric acid secretion by specific inhibition of the (H+, K+)-ATPase enzyme system (ie, proton pump) at the secretory surface of the gastric parietal cell. (medscape.com)
- Inhibition of gastric acid secretion in the gastric brooding frog, Rheobatrachus silus. (bvsalud.org)
Histamine3
- Sodium pentobarbital depression of histamine- or insulin-stimulated gastric secretion. (utmb.edu)
- Inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which reduces gastric acid secretion, gastric volume, and hydrogen ion concentrations. (medscape.com)
- Competitively inhibits histamine at H2 receptor of gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and hydrogen ion concentrations. (medscape.com)
Indomethacin2
- Intracisternal injection of PP (500-2000 ng/rat) dose-dependently increased the severity of gastric lesions induced by 2-deoxy-D-glucose or indomethacin. (duke.edu)
- In contrast, intraperitoneal injection of PP failed to increase the severity of the gastric lesions induced by 2-deoxy-D-glucose or indomethacin. (duke.edu)
Insulin secretion1
- The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
Gastrointestinal2
- Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. (genome.jp)
- Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)
Stimulation1
- Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen. (genome.jp)
Pathway4
- The study of the Gastric Acid Secretion Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
- The Gastric Acid Secretion Pathway has been researched in relation to Acid Secretion, Secretion, Gastric Emptying, Regulation Of Gastric Acid Secretion, Pathogenesis. (novusbio.com)
- The Gastric Acid Secretion Pathway complements our catalog of research reagents including antibodies and ELISA kits against GAST, SST, CCK, INS, CCKBR. (novusbio.com)
- We have 1582 products for the study of the Gastric Acid Secretion Pathway that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)
Juice4
- Connect NG tube to the pump and collect four samples of gastric juice, each over 15 min into polystyrene cups. (endocrinesurgeon.co.uk)
- Alternatively, aspirate regularly and periodically with a 50ml syringe to collect gastric juice over each 15 min period. (endocrinesurgeon.co.uk)
- Accumulation of osmotically active hydrogen ion in the canaliculus generates an osmotic gradient across the membrane that results in outward diffusion of water - the resulting gastric juice is 155 mM HCl and 15 mM KCl with a small amount of NaCl. (epomedicine.com)
- It inhibits the secretion of gastric juice and slows gastric contraction. (zigya.com)
Apical plasma membrane1
- Analysis of Slp2-a mutant mice generated by homologous recombination showed a reduced number of mucus granules, a deficiency of granule docking with the apical plasma membrane in the gastric-surface mucous cells and reduction of mucus secretion by Slp2-a-deficient gastric primary cells. (elsevierpure.com)
Inhibitory polypeptide1
- Orthologous to human GIPR (gastric inhibitory polypeptide receptor). (nih.gov)
Physiology1
- Five dogs undergoing experiments on gastric secretion in the Physiology Department, Imperial Institute of Experimental Medicine, St Petersburg. (wellcomecollection.org)
Lansoprazole1
- Comparative assessment of environmental risk when using the gastric acid secretion inhibitors esomeprazole, lansoprazole, omeprazole, pantoprazole and ranitidine from a Swedish perspective (Report Goodpoint 2019). (janusinfo.se)
Esomeprazole1
- Effects of ghrelin and esomeprazole, with or without pentagastrin, on gastric pH were studied. (diva-portal.org)
Development of gastric1
- This treatment does not affect the underlying gastric atrophy, inflammation, or the possible development of gastric carcinoma and should be followed with these risks in mind. (medscape.com)
Lumen3
- Pass the special double lumen naso-gastric tube (obtained from sister in endoscopy) with plenty of Xylocaine spray to the nose and throat, and lignocaine jelly to the nose. (endocrinesurgeon.co.uk)
- Chloride and potassium ions are transported into the lumen of the canaliculus by conductance channels, and such is necessary for secretion of acid. (epomedicine.com)
- 10 8 organisms) through contaminated food/water sources, the organism reaches the small intestine where V. cholerae (O-group 1) produces an enterotoxin (CTX) that promotes fluid secretion into the intestinal lumen. (unboundmedicine.com)
Ulcers1
- Misoprostol Tablets should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of complications from gastric ulcers associated with use of the NSAID, or is at high risk of developing gastric ulceration. (nih.gov)
Receptor1
- They are more effective at increasing gastric pH, and for a longer duration, compared with H2 receptor antagonists (H2RA). (medscape.com)
Outlet obstruction1
- Fewer than 5% of patients develop a complication, such as abdominal perforation, gastric outlet obstruction, or esophageal stricture. (medscape.com)
Increases3
- Increases secretion of mucous membranes, tenacious mucus. (abchomeopathy.com)
- Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
- Increases gastric pH above 4 and inhibits proteolytic activity of pepsin, reducing acid indigestion. (medscape.com)
Mucus2
- We also discovered that Slp2-a and Rab27A/B are predominantly localized at the apical region of gastric-surface mucous cells, where mucus granules are accumulated. (elsevierpure.com)
- if the mucus secretion of your airways is impaired. (who.int)
Somatostatin1
- The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. (elsevierpure.com)
Parietal cell2
- Proton pump inhibitors (PPIs) decrease acid secretion by irreversibly binding to and inhibiting the H+-K+-ATPase pump on the gastric parietal cell surface. (medscape.com)
- Decreases gastric acid secretion by inhibiting the parietal cell H + -K + -ATP pump. (medscape.com)
Hepatic1
- Gastric, hepatic and abdominal complaints That are aggravated by drinking Coffea Cruda Coffee . (abchomeopathy.com)
Achlorhydria3
- Measuring gastric output distinguishes secondary hyper-gastrinaemia (due to achlorhydria) from primary hyper-gastrinaemia. (endocrinesurgeon.co.uk)
- Achlorhydria associated with H pylori infection may respond to H pylori eradication therapy, although resumption of gastric acid secretion may only be partial. (medscape.com)
- Hypergastrinemia due to achlorhydria secondary to PPI therapy or resection of the gastric fundus is known to cause ECL cell hyperplasia and gastric carcinoids. (medscape.com)
Ulceration1
- The gastro-toxicity of non-steroidal anti-inflammatory drugs (NSAIDs), often leading to gastric ulceration and delayed healing, remains a crucial problem, despite recent pharmaceutical advances. (rsc.org)
Hormone1
- Bravo capsule system optimizes intragastric pH monitoring over prolonged time : effects of ghrelin on gastric acid and hormone secretion in the rat. (diva-portal.org)
Pylori4
- 5 It is believed that polyphenols or polyphenol derivatives from green tea may be useful either in prevention or treatment of H . pylori -associated gastric diseases. (rsc.org)
- The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori - associated gastritis and 20 individuals as the control group. (who.int)
- L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
- The standard, first-line therapy for gastric H pylori is as follows: PPI (20 mg bid) plus clarithromycin (500 mg bid) plus amoxicillin (1 g bid). (medscape.com)
Gastritis1
- The interplay of gastritis phenotype and acid secretion are key determinants in disease outcomes. (nih.gov)
Esophageal1
- As such, they can improve contractility of the lower esophagus, increase lower esophageal sphincter pressure, and augment the rate of gastric emptying. (medscape.com)
Acute1
- In the acute phase of infection, gastric acid secretion is transiently impaired. (nih.gov)