Circulating adiponectin levelsAdipocytesAdiposeAdipokine secretionAdipokines such as leptinSerum adiponectin levelsMetabolicResistinCytokinesAdipoR1 and AdipoR2Inversely correlatedReceptorsHormonesAnti-inflammatoryInsulin actionConcentrationsLipidProteinObesityLeptin levelsStimulatesInflammationGlucoseModulationELISACholesterolAdipocytePeroxisomeIncreasesAdipoQPathogenesisMetabolismInhibitsCellularResistanceRoleMRNAAntidiabeticEffectsActivityLowerMethodsLead
Circulating adiponectin levels1
- Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)
Adipocytes8
- Cyclodextrin-Mediated Cholesterol Depletion Induces Adiponectin Secretion in 3T3-L1 Adipocytes. (bvsalud.org)
- We modulated the cholesterol level in adipocytes to examine its effect on the secretion of adiponectin , an important hormone specifically secreted by adipocytes . (bvsalud.org)
- Our results show that MßCD-mediated cholesterol depletion elevates the secretion of adiponectin , highlighting the involvement of endosomes and lysosomes in adiponectin secretion in adipocytes . (bvsalud.org)
- Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. (qiagen.com)
- GDF12 stimulates adiponectin secretion from white adipose tissue by direct action on adipocytes. (fightaging.org)
- After its secretion by adipocytes, adiponectin oligomerizes in three forms: trimers of low molecular weight (LMW), hexamers of medium molecular weight (MMW), and multimers of high molecular weight (HMW) [ 8 ]. (hindawi.com)
- In addition to their main functions, adipocytes have endocrine functions and can secrete a variety of adipokines such as leptin, adiponectin, and resistin ( 2 - 4 ). (frontiersin.org)
- Since it is known that adipokines such as leptin and adiponectin can instigate their insulin signaling sensitizing effect via AMPK and Akt, we propose a mechanism that mechanical stretching of adipocytes may induce the secretion of insulin sensitizing adipokines like leptin and/or adiponectin, which in turn activates AMPK and Akt phosphorylation and, ultimately, improves insulin signaling in the adipose tissue. (unl.edu)
Adipose6
- Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
- Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)
- The adipose tissue participates in numerous endocrine functions via the secretion of bioactive molecules, such as adipokines [ 10 ]. (plos.org)
- Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. (hindawi.com)
- Hormones produced by adipose tissue, such as leptin and adiponectin, may have a role in the pathogenesis of obesity and diabetes. (vin.com)
- The results suggest that improvements in CEC, through improvement in adipose tissue health in terms of adipokine secretion and insulin sensitivity could be an important pathway in modulating obesity-related CVD risk. (biomedcentral.com)
Adipokine secretion1
Adipokines such as leptin1
- Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
Serum adiponectin levels2
- Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
- The rare G allele of +45T>G occurred more frequently than the common T allele in T2DM patients compared with controls, and was associated with lower serum adiponectin levels. (who.int)
Metabolic9
- Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. (frontiersin.org)
- Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). (frontiersin.org)
- Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
- In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. (frontiersin.org)
- In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. (frontiersin.org)
- Enhanced platelet aggregation and activation markers are found in the metabolic syndrome associated to low adiponectin concentrations. (cun.es)
- Diabetes mellitus (DM) is a metabolic disorder caused by defect in insulin secretion, insulin action, or both. (researchgate.net)
- ABSTRACT This study aimed to estimate the frequency of the SNPs (+45T>G and +276G>T) genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of T2DM in the Bahraini population. (who.int)
- We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver. (ku.dk)
Resistin4
- Making matters even worse is that there is also an increase in the secretion of a substance known as resistin that dampens the effect of insulin. (doctormurray.com)
- Adiponectin increases the activation of AMPk, while resistin impairs AMPk activity. (doctormurray.com)
- So, while adiponectin is associated with improved insulin sensitivity and metabolism, resistin is associated with poor blood sugar control, increased blood lipids, and the development of atherosclerosis . (doctormurray.com)
- Probiotics appear to help prevent and fight insulin resistance by increasing adiponectin levels and lowering resistin levels which in turn lead to AMPk activation. (doctormurray.com)
Cytokines2
- Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor- and interleukin-1, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). (cdc.gov)
- Periodontal disease is considered a chronic infectious inflammatory disease characterized by intense leukocyte infiltration in the periodontal tissue resulting in secretion of various cytokines that lead to deleterious inflammatory processes and destruction of the periodontal tissue and alveolar bone 1 . (bvsalud.org)
AdipoR1 and AdipoR21
- The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin. (diabetesjournals.org)
Inversely correlated2
- Higher platelet aggregation was found in the MS. Adiponectin inversely correlated with P-selectin (R:-0.35, p:0.009), sCD40L (R:-0.24, p:0.05) and epinephrine and collageninduced aggregation (r=-0.80, p=0.005 and r=-0.70, p=0.011). (cun.es)
- Interestingly, only in the active group adiponectin levels were inversely correlated with forced expiratory volume (FEV) 1% decrease/year and FEV1% decrease. (hindawi.com)
Receptors2
- Adiponectin receptors were demonstrated by western blotting. (cun.es)
- Platelets express the receptors for adiponectin. (cun.es)
Hormones3
- These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (eg, adiponectin), and the gut hormone glucagonlike peptide-1 (GLP-1). (medscape.com)
- This review will address the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis on the most recent literature. (diabetesjournals.org)
- Work in our laboratory has primarily focused on the biology and regulation of three key adipocyte hormones: leptin, acylation-stimulating protein, and adiponectin. (diabetesjournals.org)
Anti-inflammatory2
- Under normal circumstances adiponectin presents anti-inflammatory, pro-apoptotic and anti-proliferative effects (Booth et al . (scielo.br)
- In addition, data from in vitro studies on lung cells were consistent with an anti-inflammatory function of adiponectin [ 11 , 12 ], and adiponectin-deficient mouse models develop lung function impairment and systemic inflammation [ 13 , 14 ]. (hindawi.com)
Insulin action2
- Adiponectin and leptin cotreatment normalizes insulin action in lipoatrophic insulin-resistant animals. (diabetesjournals.org)
- As the number and size of fat cells increase, they lead to a reduction in the secretion of compounds that promote insulin action, including a novel protein produced by fat cells known as adiponectin. (doctormurray.com)
Concentrations2
- AdipoR1 mRNA expression was positively correlated with in vivo insulin and C-peptide concentrations, first-phase insulin secretion, and plasma triglyceride and cholesterol concentrations before and after adjustment for sex, age, waist-to-hip ratio, and body fat. (diabetesjournals.org)
- The term "glucose toxicity" is used to describe the situation where beta cells are damaged by chronically high blood glucose concentrations, suppressing insulin secretion. (vin.com)
Lipid3
- Previous studies revealed that adiponectin played a causal role in maintaining energy homeostasis via regulation of glucose and lipid metabolism. (frontiersin.org)
- thus, insulin resistance results in increased insulin secretion to maintain normal glucose and lipid homeostasis. (medscape.com)
- Moreover, adiponectin levels negatively correlated with lipid profiles. (hindawi.com)
Protein2
- These improvements in patients' conditions are associated with immunometabolic processes involving adiponectin, leptin, and C-reactive protein. (hindawi.com)
- Adiponectin is an abundant serum adipokine composing up to 0.05% of total circulating protein [ 7 ]. (hindawi.com)
Obesity3
- BEVILACQUA, F. The potential role of leptin and adiponectin in obesity: a comparative review. (scielo.br)
- In non-obesity-related inflammatory disorders, adiponectin levels are increased [ 9 - 11 ]. (hindawi.com)
- The study included 56 individuals with obesity, of whom 30 individuals underwent Roux-en-Y gastric bypass surgery (RYGB) and twenty-six underwent sleeve gastrectomy (SG). (biomedcentral.com)
Leptin levels2
- Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls. (hindawi.com)
- Haque WA, Shimomura I, Matsuzawa Y, Garg A. Serum adiponectin and leptin levels in patients with lipodystrophies. (medscape.com)
Stimulates1
- GLP-1 is an incretin hormone that stimulates insulin secretion, causes B-cell mitosis while inhibiting apoptosis, inhibits glucagon secretion, and delays gastric emptying with overall antidiabetic effects. (medscape.com)
Inflammation1
- Prostaglandins are hormone-like compounds produced in body tissue that help control blood pressure, smooth muscle activity, inflammation, glandular secretion, calcium movement, hormone regulation, and cell growth control. (bodybuilding.com)
Glucose1
- Interestingly, many of the phytochemicals they contain have been demonstrated to possess antidiabetic activity such as lowering blood glucose levels, stimulating insulin secretion, and alleviating diabetic complications. (researchgate.net)
Modulation2
- Interestingly, MßCD treatment increased adiponectin in the medium without affecting its intracellular level, suggesting a modulation of secretion . (bvsalud.org)
- Moreover, orexins have been reported to greatly influence gonadotropin-releasing hormone neurons and their secretions to regulate reproductive functions via modulation of the hypothalamic-pituitary-gonadal axis. (researchgate.net)
ELISA1
- sCD40L and P-selectin secretion was measured in the supernatants by ELISA. (cun.es)
Cholesterol3
- By contrast, cholesterol addition did not affect adiponectin secretion , suggesting that cholesterol -depletion-induced intracellular cholesterol trafficking, but not reduced cholesterol level, accounted for MßCD-induced adiponectin secretion . (bvsalud.org)
- MßCD-induced adiponectin secretion was reduced after 10 µg/mL U18666A treatment that suppressed cholesterol transport out of late endosomes / lysosomes . (bvsalud.org)
- Depleting Niemann-Pick type C1 (NPC1) or NPC2 proteins , which mediate endosomal/lysosomal cholesterol export, consistently reduced MßCD-induced adiponectin secretion . (bvsalud.org)
Adipocyte1
- Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs. (nih.gov)
Peroxisome2
- Adiponectin production is stimulated by thiazolidinedione agonists of peroxisome proliferator-activated receptor-γ and may contribute to increased insulin sensitivity. (diabetesjournals.org)
- Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
Increases2
- Enhancing the breakdown ("burning") of fat - Raspberry ketone increases a process known as norepinephrine-induced lipolysis, and supplementation with raspberry ketone results in a higher secretion of the hormone adiponectin. (hammernutrition.com)
- It increases Adiponectin secretion, a hormone that regulates metabolism. (fitnessgraft.com)
AdipoQ2
- Adiponectin (ADPQ), which is encoded by the AdipoQ gene located on chromosome 3q27.3, is a 244-amino acid pleiotropic hormone with a molecular weight of approximately 30 kDa for its basic subunit. (frontiersin.org)
- Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)
Pathogenesis1
- Thus, the implication of adiponectin in the pathogenesis of cancer is well established in humans, but still undetermined in dogs. (scielo.br)
Metabolism2
- Both of these effects - increased norepinephrine-induced lypolysis and higher levels of adiponectin - enhance fat metabolism. (hammernutrition.com)
- Additionally, an increase in adiponectin (mention earlier) not only results in increased metabolism of fat, it also is associated with a decrease in fat storage. (hammernutrition.com)
Inhibits1
- Novel evidence is provided demonstrating that adiponectin has anti-thrombotic properties, since it inhibits platelet aggregation and platelet activation. (cun.es)
Cellular1
- Finally, MßCD treatment redistributed cellular adiponectin to lower-density fractions in sucrose gradient fractionation. (bvsalud.org)
Resistance1
- Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
Role3
- TAN, P.H. Evolving role of adiponectin in cancer controversies and update. (scielo.br)
- MANTZOROS, C.S. The role of adiponectin in cancer: a review of current evidence. (scielo.br)
- In the development and progression of lung cancer, a pathogenic role of adiponectin was defined by both in vivo and in vitro studies [ 15 , 16 ]. (hindawi.com)
MRNA1
- In multivariate linear regression models, mRNA expression of AdipoR1, but not AdipoR2, was a determinant of first-phase insulin secretion independent of insulin sensitivity and body fat. (diabetesjournals.org)
Antidiabetic1
- Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. (jci.org)
Effects1
- To evaluate the association of adiponectin and sCD40L levels with platelet aggregation in the MS and the effects of adiponectin on platelet aggregation and activation. (cun.es)
Activity1
- This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity. (hindawi.com)
Lower1
- Lower adiponectin levels may lead to an impaired ability to repair endothelial damage and inhibit the endothelial inflammatory response, but this is an area of ongoing research. (nature.com)
Methods1
- Subjects/Methods: Platelet aggregation and circulating adiponectin, sCD40L and P-selectin were determined in 30 controls and 30 patients with MS. (cun.es)
Lead1
- Dietary fat and fructose, which do not increase insulin secretion, lead to reduced leptin production, suggesting a mechanism for high-fat/high-sugar diets to increase energy intake and weight gain. (diabetesjournals.org)