The Ecoli Metabolome Database (ECMDB) is a manually curated database of small molecule metabolites found in or produced by Escherichia coli (strain K12, MG1655). (chemspider.com)
It has been shown that closely related cystic fibrosis-associated Burkholderia species respond to trimethoprim with differing levels of expression of various secondary metabolites, highlighting the personalized nature of metabolomics in related bacterial strains. (wikipedia.org)
Of late there is a strong trend in the opposite direction ("from gene to secondary metabolites"), especially strengthened by the recent technological breakthroughs in genome sequencing and bioinformatics. (drexel.edu)
the complete set of small-molecule metabolites (such as metabolic intermediates, hormones and other signalling molecules, and secondary metabolites) to be found within a biological sample, such as a single organism. (umich.edu)
Ergo, metabolomics is the study of the complete collection of metabolites present in a cell or tissue under a particular set of conditions (= the metabolome) generating a biochemical profile. (umich.edu)
Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins, antibiotics, and pharmaceuticals. (jcvi.org)
Little is known of the dynamics of secondary metabolites of white asparagus during the production season. (wur.nl)
This Ph.D. project aimed to isolate biologically active secondary metabolites from actinomycetes associated with different Mediterranean sponges with the assistance of metabolomics tools to implement a rapid dereplication and chemically distinct candidate targeting for further up-scaling compounds isolation. (uni-wuerzburg.de)
FUA3430 T and Fructilactobacillus sanfranciscensis DSM20451 T to hydrolyse glycosides of secondary plant metabolites. (polyphenols-site.com)
Prof. Gänzle's data support the previous observation that many of the glycosyl hydrolases in lactobacilli are specific for glycosylated secondary plant metabolites rather than di- and oligosaccharides. (polyphenols-site.com)
Increased knowledge on their substrate specificity will facilitate the selection of fermentation organisms to secondary plant metabolites with desirable or undesirable biological activities in food fermentations. (polyphenols-site.com)
In terms of metabolite categories that distinguished between the culture conditions, conventional tea was observed to express higher primary metabolites such as amino acid, while naturally grown tea contained a superior dose of secondary metabolites, especially flavonoid. (heraldopenaccess.us)
Regulatory loci affecting metabolites were identified in a metabolome genome-wide association study (mGWAS). (biomedcentral.com)
We constructed a chicken serum metabolite dataset containing 7,191 metabolites to provide a reference for future chicken metabolome characterization work. (biomedcentral.com)
The principal interests of our group encompass basic and applied research on the discovery and production of novel secondary metabolites by bacteria and medicinal plants. (univie.ac.at)
We focus on isolation, genome-based bioprospecting and genetic manipulation of bacteria known as prolific producers of secondary metabolites, as well as development of approaches to sustainable plant micropropagation and production of bioactive compounds by plant organ and cell cultures. (univie.ac.at)
field populations are characterized by variability with regard to morphology, the mode of reproduction (conidiation or sclerotia formation), the spectrum of secondary metabolites (sm), and virulence. (liverpool.ac.uk)
Solid phase extraction used to extract the secondary metabolites from bacterial cultures. (benthamopen.com)
The metabolites profiles were compared to identify variations in strain's metabolomes. (benthamopen.com)
Although, the number of omic techniques is ever expanding, the most developed omics technologies are high throughput DNA sequencing, transcriptomics (focused on gene expression), epigenomics (focused on epigenetic regulation of gene expression), proteomics (focused on large sets of proteins, the proteome) and metabolomics (focused on large sets of metabolites, the metabolome). (who.int)
Human Metabolome Database1
Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)
Metabolomics1
In this study, we aim to examine serum metabolome of chickens using a non-targeted metabolomics approach and construct a metabolite dataset for chickens. (biomedcentral.com)
Metabolic2
dose effect of environmentally responsive phytochemicals, respectively, ranging widely over basic metabolic pathways and secondary metabolite biosynthesis. (heraldopenaccess.us)
The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions. (medicalxpress.com)
Pathogenic2
These global activators can be used as a source of investigation into how the metabolomes of pathogenic bacterial species respond to antibiotic stress and how bacterial species can vary in response to them. (wikipedia.org)
Objective: Characterization of the metabolome of white asparagus spears covering volatile and non-volatile composition in relation to quality aspects. (wur.nl)
Although any significant result has been appreciated, in terms of dry biomass and chlorophyll content, it is noteworthy the detection of small variations in the primary metabolome, as revealed by liquid-state 1H-NMR spectroscopy. (unina.it)
Component-wise approach from nutrition has led to determine antioxidants that work against oxidative damage to cells and tissues, which presumably contribute to primary and secondary prevention of chronic diseases. (heraldopenaccess.us)
Metabolism4
In addition to his research interests in chemical biology and microbiology of secondary metabolism in various organisms, Dr. Beld is deploying mass spectrometry in the Center for Advanced Microbial Processing. (drexel.edu)
Traditionally, natural products, a key resource from secondary metabolism, have been studied at a chemical level before the gene clusters or enzymes responsible for their biosynthesis were known. (drexel.edu)
the velvet complex in the gray mold fungus botrytis cinerea: impact of bclae1 on differentiation, secondary metabolism, and virulence. (liverpool.ac.uk)
In general, the elicitation of secondary metabolism (N-containing compounds, phenylpropanoids, and phytoalexins) and the down-accumulation of fatty acid biosynthesis compounds were common responses to different Zn forms. (unicatt.it)
Metabolite biosynthesis2
Multidisciplinary approach to unravelling secondary metabolite biosynthesis within bacterial microbiome of the bryozoan Cristatella mucedo. (univie.ac.at)
Microbial communities in marine sediments: preliminary analyses of diversity and secondary metabolite biosynthesis potential. (univie.ac.at)
Detection2
Here, comprehensive metabolome detection was performed using non-targeted LC-MS/MS on serum from a chicken advanced intercross line (AIL). (biomedcentral.com)
to inform secondary prevention by optimizing early detection strategies . (who.int)
Gene2
To further evaluate their biosynthetic potential, we sequenced the 5,183,331-bp S. tropica CNB-440 circular genome and analyzed all identifiable secondary natural product gene clusters. (nih.gov)
In Burkholderia species, certain antibiotics such as trimethoprim has been shown to induce and upregulate a large amount of the metabolome, inducing over 100 silent secondary metabolite gene clusters in Burkholderia thailandensis. (wikipedia.org)
Fungal1
To facilitate annotation of these clusters in sequenced fungal genomes, we developed the web-based software Secondary Metabolite Unique Regions Finder (SMURF) to systematically predict clustered SM genes based on their genomic context and domain content. (jcvi.org)
Genome1
Coupled with sensitive liquid chromatography we have a pipeline from genome to secondary metabolite. (drexel.edu)
Grown1
This study aimed to survey the growth performance and metabolome adjustment of beans grown in a growth medium containing ZnONPs at different concentrations and compared with bulk ZnSO4 as a positive control. (unicatt.it)
Molecules2
Of all the drugs used in a hospital to treat patients, about 75% are secondary metabolite or secondary metabolite derived molecules. (drexel.edu)
Collectively, these small molecules and their interactions within a biological system are known as the metabolome. (umich.edu)
Liquid chromatography1
The secondary metabolite profiling was done using ultra high performance liquid chromatography (UHPLC). (benthamopen.com)
Genetic2
Conclusion: The dynamics of the white asparagus metabolome is influenced by a complex relationship between the onset of spear development, the moment of harvest and the genetic background. (wur.nl)
However, the serum metabolite profile and genetic architecture of the metabolome in chickens have not been well studied. (biomedcentral.com)
Analysis2
The secondary metabolome analysis, conducted through mass spectrometry IT-TOF, has revealed that humic substances from artichoke determine a mild stress condition, inducing a modulation in the content of several flavonoids. (unina.it)
Multivariate statistical modelling by partial least squares-discriminant regression (PLSR) analysis was performed for revealing metabolome-scale differences. (biomedcentral.com)
Extract1
I'm trying to find a programmatic way to automatically extract the following information from a PDB file: RNA sequence Secondary structure restraints in bracket format, e.g. (stackexchange.com)
CNRS_PEPS ECOMOBS (2019) : Résistance écologique aux invasions biologique à travers l'étude des ports, habitats clés en écologie marine urbaine. (imbe.fr)
Description1
En milieu marin, les recherches se focaliseront, en amont de ces questionnements, sur une meilleure description de la biodiversité dans toutes ses composantes, sa structuration dans l'espace et son évolution. (imbe.fr)
Plants1
Among the ions taken up by the plant cells, Ca2+ plays an essential role as an intracellular secondary messenger in plants and thus the cytoplasmic free Ca2+ concentration ([Ca2+]c) is strictly regulated. (globalsciencebooks.info)
Development1
Cascading Effects of Root Microbial Symbiosis on the Development and Metabolome of the Insect Herbivore Manduca sexta L. (mdpi.com)
Conditions2
Les travaux s'appuieront sur des expérimentations in natura, en utilisant des systèmes intégrés régionaux d'observation (O3HP, CLIMED, Fontblanche), des sites-ateliers (OHM-BMP et OHM Littoral), mais aussi en mésocosmes (conditions semi-contrôlées, pépinière) et en microcosmes (conditions totalement contrôlées, phytotron, aquariums). (imbe.fr)
Three types of elicitors Fe 2 SO 2 , MgSO 4 , and Cu 2 SO 4 , were added to the growth medium to vary the growth conditions in the hope of producing different secondary metabolite. (benthamopen.com)
Department1
He has a secondary appointment in the Department of Biochemistry & Molecular Biology. (drexel.edu)
Early1
Heat-enhanced cultivation appeared to yield spears early in season with a similar metabolome to those harvested later. (wur.nl)
Impact1
Androgens such as dehydroepiandrosterone (DHEA) have been proposed to alter the POR follicular microenvironment, but the impact DHEA imposes on the FF metabolome and cytokine profiles is unknown. (biomedcentral.com)