Secondary metabolites. Medical search. Frequent questions

In this review, we analyzed patents related to the production of secondary metabolites and biotransformation processes through endophytic fungi and their fields of application. (nih.gov)
Microbial secondary metabolites are compounds produced mainly by actinomycetes and fungi, usually late in the growth cycle idiophase. (web.app)
International Journal of Secondary Metabolite (IJSM) purposes the publication of articles related to secondary metabolites of plant and allied organisms (algae, fungi, and lichens). (dergipark.org.tr)
IJSM is published 4 issues per year (March, June, September, December), and accepting manuscripts related to secondary metabolites of plant and allied organisms (algae, fungi, and lichens). (dergipark.org.tr)
Isolation, purification and characterization of secondary metabolites form endophytic fungi of phyllanthus Sp. (ncl.res.in)
In this article we review an important area of biotechnology, since the recent evidence indicates that bacteria and fungi, growing under SSF conditions, are more than capable of supplying the growing global demand for secondary metabolites. (ulster.ac.uk)
Characterization of fungi in office dust: comparing results of microbial secondary metabolites, fungal ITS region sequencing, viable culture, and other microbial indices. (cdc.gov)
We compared three fungal analytical methods by analyzing floor dust samples collected from an office building for fungi using viable culture, internal transcribed spacer (ITS) sequencing, and secondary metabolites using liquid chromatography-tandem mass spectrometry. (cdc.gov)
Of the 32 metabolites identified, 29 had a potential link to fungi with levels ranging from 0.04 (minimum for alternariol monomethylether) to 5,700 ng/g (maximum for neoechinulin A). The number of fungal metabolites quantified per sample ranged from eight to sixteen (average=13/sample). (cdc.gov)

The aim of this chapter is to provide an overview of the current knowledge on these metabolites regarding their biosynthesis, main sources and methods for their obtaining and use. (eurekaselect.com)
Secondary metabolite biosynthesis in Camellia sinensis is differentially regulated in different tissues during growth and development. (biomedcentral.com)
In total, 1719 unigenes were identified as being involved in the secondary metabolic pathways in C. sinensis , and the expression patterns of the genes involved in flavonoid, caffeine, and theanine biosynthesis were characterized, revealing the dynamic nature of their regulation during plant growth and development. (biomedcentral.com)
Remarkably, not only did the data reveal the possible critical check points in the flavonoid, caffeine, and theanine biosynthesis pathways, but also implicated the key transcription factors and related mechanisms in the regulation of secondary metabolite biosynthesis. (biomedcentral.com)

Therefore, they could be an alternative source of secondary metabolites for applications in medicine, pharmacy and agriculture. (nih.gov)
Plants are an important source of secondary metabolites that have been used throughout history as drugs, pesticides, pigments, flavors and fragrances. (eurekaselect.com)

The abundance and diversity of secondary metabolites are coupled with wide pharmaceutical, therapeutic and medicinal values. (benthamscience.com)

The here presented comprehensive and multifactorial assessment of the productive and qualitative response of basil provides evidence of the positive effects (from biomass to specialized metabolites) that can be obtained from the management of the pre-harvest factors in soilless cultivation. (frontiersin.org)
Further, light properties play a critical role in plant vegetative growth and reproductive (flowering) developmental stages, as well as in biomass, secondary metabolite synthesis, and accumulation. (frontiersin.org)
Therefore, there is great economic and social value to find an effective strategy to enhance plant biomass and the content of medicinal secondary metabolites of cultivated Astragalus in regions with lower precipitation. (biomedcentral.com)

Microbial secondary metabolites production and strain. (web.app)
The study's main goals are to differentiate between distinct plant secondary metabolites, their origins, functions, and biotechnological uses, as well as microbial secondary metabolites. (digiwire.co.in)

We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. (nature.com)

Her research is also focused on the discovery and characterization of novel fungal metabolites through genetic manipulation and "-omics" approaches to study their role in fungal-host interactions and microbiome dynamics. (ornl.gov)

Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster. (jcvi.org)
The global regulatory veA gene governs development and secondary metabolism in numerous fungal species, including Aspergillus flavus. (jcvi.org)
Studies of the A. flavus genome revealed many gene clusters possibly connected to the synthesis of secondary metabolites. (jcvi.org)
Many of these metabolites are still unknown, or the association between a known metabolite and a particular gene cluster has not yet been established. (jcvi.org)
Twenty-eight out of the predicted 56 secondary metabolite gene clusters include at least one gene that is differentially expressed depending on presence or absence of veA. (jcvi.org)
Secondary metabolites from marine cyanobacteria have gained much attention the last decades, however few comprehensive studies on secondary metabolites and their biosynthetic gene clusters from terrestrial cyanobacteria have been conducted. (uit.no)
Gene expression analysis by RT-qPCR of predicted gene clusters and the production of secondary metabolites by UPLC-HR-MS were conducted. (uit.no)
The results from this thesis give valuable knowledge for further cultivation of terrestrial cyanobacteria, with the purpose of awaking cryptic gene clusters and identifying novel secondary metabolites. (uit.no)
This allowed her to characterize various secondary metabolite biosynthetic gene clusters and virulence factors in this organism. (ornl.gov)
This study aimed to generate expression profiles for C. sinensis tissues and to build a gene regulation model of the secondary metabolic pathways. (biomedcentral.com)
The gene network responsible for the regulation of the secondary metabolic pathways was analyzed. (biomedcentral.com)
Our work elucidated the possible cross talk in gene regulation between the secondary metabolite biosynthetic pathways in C. sinensis . (biomedcentral.com)

Abstract The aim of this study is to examine the bioactive compounds from secondary metabolites of the fungus Rhizoctonia solani against some selected strains of pathogenic bacteria. (qscience.com)

The use of plant tissue culture has been proposed as an alternative to conventional agriculture for the production of secondary metabolites due to the possibility of controlling the quality and quantity of the compound of interest by controlling the factors affecting its synthesis and/or accumulation. (eurekaselect.com)
The genes responsible for the synthesis of aflatoxins are clustered, a signature common for genes involved in fungal secondary metabolism. (jcvi.org)
The recent developments in biotechnological methods like plant tissue culture, enzyme and fermentation technology have facilitated in vitro synthesis and production of plant secondary. (web.app)
These physiological and biochemical changes disrupt the balance of primary and secondary metabolite synthesis, thus the secondary metabolite synthesis pathway of plants may be affected under drought and other abiotic stress [ 7 ]. (biomedcentral.com)

Production of useful secondary metabolites through regulation of biosynthetic pathway in cell and tissue suspension culture of medicinal plants 199 combinations, which made finding the. (web.app)

Qualitative and quantitative characterization of secondary metabolites" by W.-F. Zhong, W.-S. Tong et al. (jfda-online.com)

These techniques include production of secondary metabolites by biotechnological methods such as plant tissue culture and microbial biotransformation of natural substances. (benthambooks.com)

Plants are capable of producing and synthesizing diverse groups of organic compounds and are divided into two major groups: primary and secondary metabolites. (wikipedia.org)
These metabolites could be interesting COVID-19 therapeutic options because the majority of these compounds have demonstrated substantial pharmacological actions, such as neurotoxicity, cytotoxicity, and antiviral activity against HCMV, HSV-1, HHV-6, and HIV-1. (nih.gov)
Keeping in view of the huge world market for plant secondary metabolites, it is a challenge for biotechnologists to find techniques to produce these compounds in sufficient quantity and quality. (benthamscience.com)
However, one of the main constraints to the use of cultivated plants as a source of these metabolites is the ability to ensure the constant and efficient supply of the compounds, since the yields are usually affected by the genetic background, as well as by the geographic location, edaphic and climatic conditions at the site of cultivation, combined with the potential effect of harvest and transport methods. (eurekaselect.com)
Secondary metabolites such as terpenes and phenolic acid compounds have become very important due to their chemical and biological properties and play a major role in plant and human health. (eurekaselect.com)
On the other hand, phenolic acid compounds are plant metabolites widely distributed throughout the plant kingdom, which have a potential use as natural antioxidants in processed foods. (eurekaselect.com)
Genomic studies suggest that organisms that produce secondary metabolites with antimicrobial properties have the potential to make a wide range of such compounds. (gardp.org)
Secondary metabolites are known as organic compounds which are not specifically associated with the normal growth of an organism, improvement, or propagation of it. (springeropen.com)
In the previous two decades, there has been a decrease in the revelation of new critical compounds from basic soil derived actinomycetes where they have produced huge numbers of previously described secondary metabolites [ 6 , 7 ]. (springeropen.com)
There is concern for potential health impacts of secondary organic compounds formed via terpene oxidation reactions (Rohr, 2013). (cdc.gov)

Secondary metabolites often play an important role in plant defense against herbivory and other interspecies defenses. (wikipedia.org)
The biological effects of plant secondary metabolites on humans have been known since ancient times. (wikipedia.org)
citation needed] Plant secondary metabolites are classified by their chemical structure and can be divided into four major classes: terpenes, phenylpropanoids (i.e. phenolics), polyketides, and alkaloids. (wikipedia.org)
Some terpenoids that may have originated as secondary metabolites have subsequently been recruited as plant hormones, such as gibberellins, brassinosteroids, and strigolactones. (wikipedia.org)
Plant Secondary Metabolites: From Diseases to Health, Frontiers on Recent Developments in Plant Science (2012) 1: 3. (benthamscience.com)
Ilkay Erdogan Orhan , " Biotechnological Production of Plant Secondary Metabolites ", Bentham Science Publishers (2012). (eurekaselect.com)
Recent advances in the field of plant biotechnology show the potential of using plant cell and tissue cultures as a source for the large-scale production of valuable secondary metabolites instead of using whole plants and subsequent extensive land exploitation. (eurekaselect.com)
A great number of plant species produce secondary metabolites that possess valuable properties, many of which have been studied and applied mainly to the pharmaceutical and food industries. (eurekaselect.com)
Microbial biotransformation is beneficial in plant secondary metabolite production and derivatization (chemical modification of any compound made by a microorganism) and is chiefly applicable to several varieties of terpenes and steroids. (benthambooks.com)
Pdf production of secondary metabolites using plant cell. (web.app)
Analysis of secondary metabolites in plant and cell. (web.app)
Plant cell culture technologies were introduced at the end of the 1960s as a possible tool for both studying and producing plant secondary. (web.app)
Secondary metabolites are divided into three major groups plant secondary metabolites can be divided into three chemically distinct groups. (web.app)
Read this article to learn about the applications of secondary metabolites and the production process of secondary metabolites in plant cultures. (web.app)
It is a type of plant tissue culture that is used to study plant metabolic processes or to produce secondary. (web.app)
Biotechnology offers an opportunity to exploit the products of secondary metabolism in plant cells, tissues, organs and plants using tissue culture and genetic manipulation for increased. (web.app)
Vi secondary products from plant tissue culture james c. (web.app)
Enhancement of secondary metabolites in cultured plant. (web.app)
Production of secondary metabolites from plant cell. (web.app)
The main research programs for the production of secondary metabolites from plant cell cultures are represented in fig. Hairy root cultures also called transformed root culture. (web.app)
The basics of plant photobiology (photosynthesis and photomorphogenesis) and electrical lighting systems are discussed, with an emphasis on how the light spectrum and lighting strategies could influence cannabis production and secondary compound accumulation. (frontiersin.org)
Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis. (ornl.gov)
Secondary plant metabolites from the leaves of trees and shrubs, such as tannins and saponins, can potentially alter the microbial environment in the rumen of the dairy cattle and thereby reduce enteric methane formation. (europeanagroforestry.eu)
Plants grown in nutrient media often do not express important secondary plant metabolites because they are not threatened by damaging atmosphere elements, adverse soil conditions or pathogens or insects. (cosmeticsandtoiletries.com)
However, it was found that certain media components, such as ozone and plant growth regulators, can cause plants grown in culture to express secondary metabolites. (cosmeticsandtoiletries.com)
The results increase our understanding of how secondary metabolic pathways are regulated during plant development and growth cycles, and help pave the way for genetic selection and engineering for germplasm improvement. (biomedcentral.com)

They enhance their host's resistance against abiotic stress, disease, insects, pathogens and mammalian herbivores by producing secondary metabolites with a wide spectrum of biological activity. (nih.gov)
The inquiry and discovery of novel microorganisms that produce new secondary metabolites can be required to stay critical in the race against new and rising diseases and antibiotic-resistant pathogens [ 1 , 2 ]. (springeropen.com)

At present, cultivated Astragalus are the main source of the market supply, however, the content of medicinal second metabolites in cultivated Astragalus is obviously lower than that of the wild plants. (biomedcentral.com)

Secondary metabolites are metabolic intermediates or products which are not essential to growth and life of the producing plants but rather required for interaction of plants with their environment and produced in response to stress. (wikipedia.org)
Metabolic engineering has recently emerged as a promising approach for improving secondary metabolite production. (digiwire.co.in)
The chapter focuses on various approaches and metabolic engineering to boost secondary metabolite yield and scale-up production of the secondary metabolite of choice. (digiwire.co.in)
Until now, little was known about the expression patterns of genes involved in secondary metabolic pathways or their regulatory mechanisms. (biomedcentral.com)

Chemical investigations of freshwater fungal isolates presented in this dissertation led to the isolation and identification of new secondary metabolites. (uncg.edu)

Specific secondary metabolites are often restricted to a narrow set of species within a phylogenetic group. (wikipedia.org)
Usually, secondary metabolites are confined to a specific lineage or even species, though there is considerable evidence that horizontal transfer across species or genera of entire pathways plays an important role in bacterial (and, likely, fungal) evolution. (wikipedia.org)
Research also shows that secondary metabolism can affect different species in varying ways. (wikipedia.org)
In the same forest, four separate species of arboreal marsupial folivores reacted differently to a secondary metabolite in eucalypts. (wikipedia.org)
Additionally, certain species evolve to resist secondary metabolites and even use them for their own benefit. (wikipedia.org)
Alkaloid, Glycoside and phenolics are the common secondary metabolites present in all these five Curcuma species. (phytojournal.com)
The number of cultured fungal species poorly correlated with OTUs, which did not correlate with the number of metabolites. (cdc.gov)

The pharmaceutical, agrochemical, and food sectors are all interested in secondary metabolites since they have a wide spectrum of biological functions. (digiwire.co.in)

Subsequently, the material was subjected to simple distillation, and phytochemical test that consisted in the identification of secondary metabolites according to precipitation and coloration of extracts diluted in solution and specific reagents for each alkaloids test, cardiac glycosides, flavonoids, coumarins, tannins, triterpenes and saponins. (ufsm.br)

Phenolics are the most abundant secondary metabolites of plants ranging from simple molecules such as phenolic acid to highly polymerized substances such as tannins. (wikipedia.org)

Adaptability of cyanobacteria to wide spectrum of environment can be contributed to the production of various secondary metabolites which are also therapeutic in nature. (nih.gov)

Plants are capable of synthesizing a huge variety of small organic molecules, called secondary metabolites, usually composed of very complex and unique carbon skeleton structures. (benthamscience.com)
Metabolites, which are molecules produced as a result of the chemical reactions that occur in our cells, can serve as disease biomarkers. (nih.gov)

The secondary metabolites that are produced by plants have various biological properties and many are used as drugs. (mdpi.com)
It is concluded that the ethanol extract of the leaves and fruits of E. uniflora presents secondary metabolites that need to be tested in biological assays in vitro and in vivo. (ufsm.br)
The secondary metabolites of actinobacteria are known for their role in various physiological, cellular, and biological processes. (springeropen.com)
The chemical and biological properties of natural products, or specialized metabolites, have been optimized for millions of years through evolutionary pressures to effect biology and life. (nih.gov)

30 years later a Polish botanist Friedrich Czapek described secondary metabolites as end products of nitrogen metabolism. (wikipedia.org)
Metabolites are the intermediate products of metabolism, and metabolism is a collection of life-sustaining chemical processes within organisms' cells. (digiwire.co.in)
The genome of antibiotic-producing colonies of the Pelagophyte alga Chrysophaeum taylorii reveals a diverse and non-canonical capacity for secondary metabolism. (nih.gov)

Microbes are a huge contributor to people's health around the world since they produce a lot of beneficial secondary metabolites. (nih.gov)
These secondary metabolites are also known to be beneficial to human health. (biomedcentral.com)

We examined 245 patents (224 related to secondary metabolite production and 21 for biotransformation). (nih.gov)
CONCLUSION: Colour type has to be considered in maca production, as colour associates with variations in concentrations of distinct bioactive metabolites. (cipotato.org)
Studies on the production of some important secondary. (web.app)
Secondary metabolites of ginkgo biloba show great potential for future studies and production through biotechnology techniques such as cell culture and hairy root culture. (web.app)
Factors affecting the production of secondary metabolite production 3. (web.app)
Production of useful secondary metabolites through. (web.app)
Basic strategies for secondary metabolite production 2. (web.app)
In 1987, the production of secondary metabolites by. (web.app)
Cell culture for production of secondary metabolites. (web.app)
There have been several persistent endeavours to accomplish tissue culture strategies for the production of pharmaceutically important secondary metabolites. (web.app)
The identification of such biosynthetic genes responsible for the production of secondary metabolites is still a relatively unexplored area, and it remains many natural products for which a biosynthetic origin is unknown. (uit.no)
Solid state (substrate) fermentation (SSF) has been used successfully for the production of enzymes and secondary metabolites. (ulster.ac.uk)
These products are associated with the stationary phase of microbial growth and are produced on an industrial scale for use in agriculture and the treatment of disease, Many of these secondary metabolites are still produced by submerged liquid fermentations (SmF) even though production by this method has been shown to be less efficient than SSF As large-scale production increases further, so do the costs and energy demands. (ulster.ac.uk)
Robinson, T, Singh, D & Singh - Nee Nigam, P 2001, ' Solid-state fermentation: a promising microbial technology for secondary metabolite production ', Applied Microbiology and Biotechnology , vol. 55, no. 3, pp. 284-289. (ulster.ac.uk)
Although only one peak has been identified at this time as biotin, multiple peaks were observed in the extract, demonstrating that exposure to ozone causes the production of secondary metabolites by the rice meristem culture. (cosmeticsandtoiletries.com)
Research on the role of ontogeny in the production of, and immune responses to, reactive metabolites and research on the efficiency of detoxification mechanisms are particularly emphasized. (nih.gov)

In the current study, we isolated secondary metabolites from acetone leaf and bud extracts of Artemisia pallens Wall ex DC (Family: Asteraceae) and tested them for their porcine pancreatic α-amylase (PPA) inhibitory activity in vitro and in silico. (mdpi.com)

Such methods have led to an increased yield of secondary metabolite amount, the discovery of new biochemical derivatives and agricultural development. (benthambooks.com)
Selection of cell lines for high yield of secondary metabolites. (web.app)

Some secondary metabolites such as phenylpropanoids protect plants from UV damage. (wikipedia.org)

Secondary Metabolites from the Fungus Dictyosporium sp. (nih.gov)

KVJ20, KVJ2, and KVJ10 were recently sequenced which allowed us to conduct genome-wide predictions by AntiSMASH of their potential to produce secondary metabolites. (uit.no)

A goal of the Common Fund's Metabolomics program is to facilitate new ways to diagnose or treat diseases by improving the identification and analysis of metabolites. (nih.gov)

Hence, this article would concentrate on the recent scenario about diverse actinomycetes and their secondary metabolites. (springeropen.com)

Fungal secondary metabolites are known to possess privileged pharmacophores that can be ideal starting points for semi-synthetic (or synthetic) approaches to explore structure-activity relationship and produce new therapeutic candidates. (uncg.edu)

1-4 In order for the meristem cultures discussed here to produce secondary metabolites, ozone was chosen as the stressor, as it was the most effective at causing the culture to produce the most secondary metabolites as compared to other elicitors. (cosmeticsandtoiletries.com)

These cells are grown in a bioreactor and subjected to an ozone stress, which causes them to produce secondary metabolites. (cosmeticsandtoiletries.com)

Multiple antibiotics in common use have been developed from secondary metabolites, such as tetracycline and lipopeptide antibiotics. (gardp.org)

KRISHI Publication and Data Inventory Repository: Effect of post harvest ripening on bioactive secondary metabolites and antioxidant activity in mango cv. (icar.gov.in)

The chemical space of the isolated and synthesized fungal secondary metabolites were characterized by principal component analysis to correlate the observed bioactivities. (uncg.edu)

Anatomy10

Organisms68

Diseases1

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology1

Phenomena and Processes47

Disciplines and Occupations6

Technology, Industry, Agriculture7

Information Science4

Health Care5

Fungi9

Biosynthesis4

Source of secondary metabolites2

Diversity of secondary metabolites1

Biomass3

Microbial secondary metabolites2

Biosynthetic potential1

Fungal metabolites1

Gene12

Bioactive compounds1

Synthesis4

PATHWAY1

Characterization1

Biotechnological methods1

Compounds10

Plant26

Pathogens2

Medicinal1

Metabolic4

Isolation1

Species7

Wide spectrum of biological1

Identification of secondary1

Phenolic acid1

Cyanobacteria1

Molecules2

Biological4

Metabolism3

Beneficial2

Production16

Artemisia1

Yield2

Plants1

Fungus1

Genome1

Diseases1

Actinomycetes1

Approaches1

Elicitors1

Produce1

Antibiotics1

Antioxidant1

Correlate1