• The impact of pharmacists-led medicines reconciliation on healthcare outcomes in secondary care: a systematic review and meta-analysis of randomized controlled trials. (ahrq.gov)
  • Prevalence, contributory factors and severity of medication errors associated with direct-acting oral anticoagulants in adult patients: a systematic review and meta-analysis. (ahrq.gov)
  • This systematic review and meta-analysis examined predictors of successful antipsychotic dose reduction in schizophrenia. (nih.gov)
  • Prospective clinical trials and randomized controlled trials (RCTs) investigating antipsychotic dose reduction in schizophrenia were selected for systematic review and meta-analysis, respectively. (nih.gov)
  • Systematic reviews are rarely used to inform study design - a systematic review and meta-analysis. (jameslindlibrary.org)
  • Systematic reviews are rarely used to contextualise new results-a systematic review and meta-analysis of meta-research studies. (jameslindlibrary.org)
  • N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. (jameslindlibrary.org)
  • To our knowledge, this study represents the most comprehensive systematic review and meta-analysis on this topic to date," they wrote. (medpagetoday.com)
  • The meta-analysis encompassed more than 18,000 participants, arguably enough to also examine whether adding aspirin to a mix of at least two hypertension meds and a statin made any difference to clinical outcomes across the trials, which were TIPS-3 , HOPE-3 , and PolyIran . (medscape.com)
  • The historical roots of meta-analysis can be traced back to 17th century studies of astronomy, while a paper published in 1904 by the statistician Karl Pearson in the British Medical Journal which collated data from several studies of typhoid inoculation is seen as the first time a meta-analytic approach was used to aggregate the outcomes of multiple clinical studies. (wikipedia.org)
  • 1 In addition to the outcomes measured in the meta-analysis table, WSIPP measures benefits and costs estimated from other outcomes associated with those reported in the evaluation literature. (wa.gov)
  • Secondary outcomes will include suicide mortality, suicidal ideation and depressive symptoms. (ox.ac.uk)
  • In a retrospective database analysis aimed at examining the associations between race, healthcare insurance, mortality, postoperative visits, and reoperation within a hospital setting in patients undergoing surgical treatment of CES, Corso et al found that whereas outcomes varied by race and insurance type, the latter was more strongly associated with outcomes than the former. (medscape.com)
  • A meta-analysis goes beyond critique and integration and conducts secondary statistical analysis on the outcomes of similar studies. (odu.edu)
  • This meta-analysis showed that cervical disc arthroplasty was superior over anterior discectomy and fusion for the treatment of symptomatic cervical disc disease in terms of overall success, NDI success, neurological success, implant/surgery-related serious adverse events, secondary procedure, functional outcomes, patient satisfaction and recommendation, and superior adjacent segment degeneration. (nih.gov)
  • To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences of the tools for outcome measurement. (ahrq.gov)
  • A recent meta-analysis assessed the efficacy and outcomes of botulinum toxin injections compared with placebo for both primary and secondary focal HH. (medscape.com)
  • This module included questions about regular (every (secondary prevention) for myocardial infarction, ischemic day or every other day) aspirin use. (cdc.gov)
  • Together, the trials suggest a highly significant 38% drop in risk for the meta-analysis primary endpoint, a composite of CV death, myocardial infarction (MI), stroke , or arterial revascularization, in participants on the fixed-dose regimens, for a number-needed-to-treat (NNT) of 52. (medscape.com)
  • False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review. (jameslindlibrary.org)
  • Here it is convenient to follow the terminology used by the Cochrane Collaboration, and use 'meta-analysis' to refer to statistical methods of combining evidence, leaving other aspects of 'research synthesis' or 'evidence synthesis', such as combining information from qualitative studies, for the more general context of systematic reviews. (wikipedia.org)
  • we looked for both primary and secondary studies in the extensive archive of Medline/PubMed and Cochrane library databases. (unimi.it)
  • A health sciences librarian will update and adapt the search strategy from the most recent Cochrane pairwise systematic review on this topic. (ox.ac.uk)
  • For example, by locating systematic reviews in the Cochrane Library Database, the authors of these articles have already gathered primary and secondary sources and data into one location based on a similar topic. (ukessays.com)
  • Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials. (epnet.com)
  • The percentage of aspirin mated only among those with preexisting ASCVD, stratified use for prevention of secondary of ASCVD varied by sociode- by sociodemographic characteristics and number of ASCVD mographic characteristics (Table 1). (cdc.gov)
  • The author concludes that biologic markers are useful in etiologic and mechanistic research, in secondary prevention of disease, in risk assessment, and in assessing the effectiveness of environmental controls. (cdc.gov)
  • Psychosocial interventions for the prevention of self-harm repetition: protocol for a systematic review and network meta-analysis. (ox.ac.uk)
  • METHODS AND ANALYSIS: We will perform a systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs) testing psychosocial interventions for the prevention of self-harm repetition. (ox.ac.uk)
  • Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. (ox.ac.uk)
  • In both primary and secondary prevention trials, the proportional reductions in the aggregate of all serious vascular events seemed similar for men and women. (ox.ac.uk)
  • The secondary endpoint is the assessment of endothelial (dys) function by looking at ex vivo vascular reactivity and mRNA expression of endothelial cells from the wall of discarded segments of internal mammary artery. (frontiersin.org)
  • All dollars are expressed in the base year chosen for this analysis (2018). (wa.gov)
  • Phase 1 was a review of reviews (ie, systematic reviews or meta-analyses) that were published 2010-2018. (cdc.gov)
  • We selected 14 systematic reviews and meta-analyses, 13 randomized controlled trials, 8 observational studies, and 1 narrative review. (unimi.it)
  • Meta-analysis of observational studies. (fortunejournals.com)
  • Design Retrospective observational analysis of administrative databases, using nine population based cohort studies and meta-analysis. (bmj.com)
  • We therefore undertook a meta-analysis to ascertain the role of CS in the management of critically ill patients with COVID-19. (fortunejournals.com)
  • This meta-analysis examined the efficacy of pharmacist-led medication reconciliation across 18 trials that included more than 6000 patients. (ahrq.gov)
  • If individual studies are systematically biased due to questionable research practices (e.g., data dredging, data peeking, or dropping studies) or publication bias, the meta-analytic estimate of the overall treatment effect may not reflect a treatment's actual efficacy. (wikipedia.org)
  • federated data analysis, where partners undertake synchronous, harmonised analyses on their independent datasets and then combine their results in a coauthored report, and trusted research environments where data are analysed in a controlled environment and only aggregate results are exported. (bmj.com)
  • A tertiary resource is of value to a researcher in that it can group information into one database or one article, can lead the researcher to significant primary and secondary resources and datasets, can analyze larger quantities of research studies or research data that are related to one another, and can assist in referencing a comprehensive article or dataset gathered by another researcher (Garrard, 2007). (ukessays.com)
  • Systematic review of a combination of RCTs and quasi-experimental, or quasi-experimental studies only, with or without meta-analysis. (libguides.com)
  • Systematic review of a combination of RCTs, quasi-experimental and non-experimental, or non-experimental studies only, with or without meta-analysis. (libguides.com)
  • Eight prospective randomized controlled trials (RCTs) were retrieved in this meta-analysis, including 1317 and 1051 patients in CDA and ACDF groups, respectively. (nih.gov)
  • Individual participant data meta-analyses compared with meta-analyses based on aggregate data. (jameslindlibrary.org)
  • We review how deidentification and anonymisation methods, including data perturbation, can reduce risks specifically associated with health data secondary use. (bmj.com)
  • A meta-analysis is the use of statistical methods to summarize the results of these studies. (odu.edu)
  • Meta-analysis is the use of statistical methods to summarize the results of independent studies. (odu.edu)
  • Meta-analytic methods estimated overall effects across participating sites. (bmj.com)
  • Secondary endpoints included CV mortality, worsening HF, CV hospitalization, and major adverse CV events (MACE). (mims.com)
  • The RR for mortality on analysis of the three studies that particularly reported on patients with significant pulmonary compromise secondary to SARS-CoV-2 infection was neutral (RR: 0.91, 95% CI: 0.63- 1.33, I2: 63.38). (fortunejournals.com)
  • Aspirin wasn't associated with significantly more important bleeding in the analysis, and dizziness was the only adverse effect to be more common on the fixed-dose strategy, he reported. (medscape.com)
  • The "usual approach" would be "a meta-analysis of studies randomized to polypill plus or minus aspirin," he said. (medscape.com)
  • To provide advice on such a controversial topic requires a strong research design involving a randomized comparison of polypill plus aspirin vs polypill minus aspirin. (medscape.com)
  • The first meta-analysis of all conceptually identical experiments concerning a particular research issue, and conducted by independent researchers, has been identified as the 1940 book-length publication Extrasensory Perception After Sixty Years, authored by Duke University psychologists J. G. Pratt, J. B. Rhine, and associates. (wikipedia.org)
  • the meta-analysis of research. (wikipedia.org)
  • Also called secondary or pre-appraised research. (tas.gov.au)
  • Examples of filtered research are evidence summaries , guidelines , systematic/scoping reviews and meta-analyses . (tas.gov.au)
  • Guide your decision-making or research by starting at the highest possible level of the 6S Pyramid to check if the body of evidence on your topic is synthesised and appraised in an EPOCH resource. (tas.gov.au)
  • Concerns are heightened for data without explicit informed consent for secondary research use. (bmj.com)
  • For your NUR 6020 assignment you must use primary resources but you can use secondary sources such as systematic reviews to identify the important research studies that have been published on your topic. (libguides.com)
  • Secondary data collection can be more financial and labor efficient than going through the planning and execution of your own research intervention and data analysis (Tantawi, 2017). (ukessays.com)
  • Disadvantages of secondary research is that there is no control over the quantitative component (experiment) or a qualitative component (survey questions). (ukessays.com)
  • Relying on tertiary data may result in loosing insight into the research topic (Garrard, 2007). (ukessays.com)
  • While much of what you will write in an English essay is based on your own analysis of a text, there is certainly a place for research and the use of secondary sources in an English essay. (essaywriter.guru)
  • As soon as you use your first secondary source, you are venturing into research. (essaywriter.guru)
  • He has research interests in the use and communication of meta-analysis. (kcl.ac.uk)
  • An advantage of a meta-analysis is the ability to be completely objective in evaluating research findings. (odu.edu)
  • Not all topics, however, have sufficient research evidence to allow a meta-analysis to be conducted. (odu.edu)
  • Dive into the research topics where Kristina Åkesson is active. (lu.se)
  • Statistical analyses and quality of individual participant data network meta-analyses were suboptimal: a cross-sectional study. (jameslindlibrary.org)
  • Given the resurgence of the newer variants of COVID-19 added with its multi-system manifestations, this project was conducted to study the clinical picture of NORSE secondary to COVID-19 infection. (dovepress.com)
  • Meta-analysis has also been criticized for averaging differences among heterogeneous studies because these differences could potentially inform clinical decisions. (wikipedia.org)
  • For instance, a meta-analysis may be conducted on several clinical trials of a medical treatment, in an effort to obtain a better understanding of how well the treatment works. (wikipedia.org)
  • After a randomized trial showed no clinical benefit of mitral valve repair among patients with chronic, moderate ischemic MR undergoing coronary artery bypass grafting, the LOE was changed from C (consensus) to B-R (moderate quality evidence from ≥1 randomized controlled trial [RCT] or meta-analyses of moderate-quality RCT) for the Class IIb recommendation for mitral valve repair in this population. (clinicaladvisor.com)
  • Regularly updated guidelines and summaries that integrate evidence-based information for whole clinical/health topics. (tas.gov.au)
  • Comprehensive clinical topic summaries. (tas.gov.au)
  • Note:systematic reviews, clinical guidelines and meta-analysis are secondary sources. (libguides.com)
  • You recently published a meta-analysis of decompressive craniectomy treatment for MCI in the journal Neurology Clinical Practice . (medscape.com)
  • Rather than restate known data, our meta-analysis attempted to ask and answer questions in a way that could provide clinical clarity. (medscape.com)
  • Available at: https://www.nhlbi.nih.gov/health-topics/coronary-heart-disease. (epnet.com)
  • For example, Wanous and colleagues examined four pairs of meta-analyses on the four topics of (a) job performance and satisfaction relationship, (b) realistic job previews, (c) correlates of role conflict and ambiguity, and (d) the job satisfaction and absenteeism relationship, and illustrated how various judgement calls made by the researchers produced different results. (wikipedia.org)
  • Fifteen studies, including a total of 17,507 HFpEF patients, met the eligibility criteria of this meta-analysis. (mims.com)
  • Defining Rapid Reviews: a systematic scoping review and thematic analysis of definitions and defining characteristics of rapid reviews. (jameslindlibrary.org)
  • Not all systematic reviews contain meta-analysis. (odu.edu)
  • Systematic literature reviews were performed, and data pooled by meta-analysis where possible. (bvsalud.org)
  • Barriers and facilitators to improving patient safety learning systems: a systematic review of qualitative studies and meta-synthesis. (ahrq.gov)
  • Combining data from similar studies (meta-analysis) can help to provide more reliable estimates of treatment effects. (jameslindlibrary.org)
  • Subgroup analysis demonstrated this to be primarily driven by studies with mixed HFpEF patients with or without hypertension, not HFpEF patients with hypertension," Alqadi and colleagues said. (mims.com)
  • A meta-analysis is a statistical analysis that combines the results of multiple scientific studies (especially randomised control trials). (wikipedia.org)
  • Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error. (wikipedia.org)
  • In addition to being able to provide an estimate of an unknown effect size, meta-analyses has the capacity to contrast results from different studies and identify both patterns and sources of disagreement among study results, or other relationships highlighted by multiple studies. (wikipedia.org)
  • For example, if there are two groups of patients experiencing different treatment effects studies in two randomised control trials reporting conflicting results, the meta-analytic average is representative of neither group, similarly to averaging the weight of apples and oranges, which is accurate for neither fruit. (wikipedia.org)
  • In performing a meta-analysis, an investigator must make choices which can affect the results, including deciding how to search for studies, selecting studies based on a set of objective criteria, dealing with incomplete data, analyzing the data, and accounting for or choosing not to account for publication bias. (wikipedia.org)
  • Meta-analysis is a statistical method to combine the results from separate studies on a program, policy, or topic in order to estimate its effect on an outcome. (wa.gov)
  • This is synthesised or summarised evidence drawing from evaluated primary, single studies on a topic. (tas.gov.au)
  • Design Meta-analysis of diagnostic accuracy studies. (bmj.com)
  • Five studies with SARS-CoV-2 infection were included in the meta-analysis. (fortunejournals.com)
  • Review questions can vary considerably in terms of both the number of included studies and the complexity of the question and analyses. (nice.org.uk)
  • Limitations of the meta-analysis included the small number of studies assessed and differences in lengths of treatment. (medpagetoday.com)
  • Many studies in the meta-analysis also were funded by the pharmaceutical industry, especially trials for nabiximols. (medpagetoday.com)
  • Single-arm designs with non-inferiority and superiority analyses are optimal for proof-of-concept and de-escalation studies in oncology. (bvsalud.org)
  • By combining information from all relevant studies, meta-analysis can provide more precise estimates of the effects of health care than those derived from the individual studies included within a review. (odu.edu)
  • Under these circumstances each cohort is treated as an individual study and meta-analysis is used to draw study-wide conclusions. (wikipedia.org)
  • Conclusions: From this up-to-date analysis, it has emerged that any type of anesthesia and neurological monitoring method is related to a better outcome after carotid endarterectomy. (unimi.it)
  • They can be considered safe drugs, as the analysis of serious adverse events did not show statistical significance, although the total number of adverse events is higher than in placebo for the treatment of symptoms in patients with MS. (medpagetoday.com)
  • Pooled analysis showed patients in CDA group achieved significantly higher rates of overall success, Neck Disability Index (NDI) success, neurological success and significantly lower rates of implant/surgery-related serious adverse events and secondary procedure compared with that in ACDF group. (nih.gov)
  • Different data-sharing approaches may be adopted according to data sensitivity and secondary use restrictions, moving beyond the traditional Open Access model of unidirectional data transfer from generator to secondary user. (bmj.com)
  • Data was extracted into an excel sheet and transferred to comprehensive meta-analysis software version 3, Biostat Inc., Englewood, NJ, USA, for analysis. (fortunejournals.com)
  • The purpose of this paper will be to effectively distinguish secondary and tertiary resources, identify the advantages and disadvantages, how and where to access this data, proper storage and filing once giving access rights, and data ownership. (ukessays.com)
  • Secondary data is data accessed by a researcher outside of the original study. (ukessays.com)
  • U.S. Census and Center for Disease Control National Database for Health Statistics as examples of larger public access secondary data sources. (ukessays.com)
  • Tertiary data is a collection of primary and secondary data that is filtered and analyzed together. (ukessays.com)
  • A meta-analysis is another example of tertiary data collection and is defined by pooling statistics systematically from journal articles (Garrard, 2007). (ukessays.com)
  • The use of secondary data sources has a variety of advantages. (ukessays.com)
  • A goal of this work is to link brain activity during creative performance to specific cognitive processes (such as memory, attention, and cognitive control), using network analysis and multivariate modeling of fMRI data. (psu.edu)
  • Meta promoted its model as a shortcut for researchers and students. (technologyreview.com)
  • Additionally, researchers-especially from under-resourced environments and the global South-may wish to participate in onward analysis of resources they collected or retain oversight of onward use to ensure ethical constraints are respected. (bmj.com)
  • WSIPP systematically evaluates all credible evaluations we can locate on each topic. (wa.gov)
  • Nuclear magnetic resonance imaging, principle components analyses, and hierarchical clustering will be used to prioritize metabolite qualification and quantification via discriminant analyses of selected metabolites versus representative bioassay extracts for mechanism activities. (dal.ca)
  • We performed meta-analyses of standardized mean differences using random effects models to synthesize the evidence. (ahrq.gov)
  • 1 This pandemic has been known for its respiratory manifestations, but scientific literature has also reported neurological symptoms secondary to the COVID-19 infection. (dovepress.com)
  • Meta-analytic results are considered the most trustworthy source of evidence by the evidence-based medicine literature. (wikipedia.org)
  • Based on this analysis, syntheses of the available evidence were shared and recommendations were indicated complying with the GRADE-SIGN version methodology. (unimi.it)
  • EPOCH's meta-search engine TRIP allows searching for evidence across multiple resources at all levels of the 6S Pyramid. (tas.gov.au)
  • You might not always find the highest level of evidence (i.e., systematic review or meta-analysis) to answer your question. (academicwriting.sbs)
  • Level II: Evidence from a meta-analysis of all relevant randomized controlled trials. (academicwriting.sbs)
  • The number of review questions for each guideline, and how much time and resources are needed for them, will therefore vary depending on the topic and its complexity, and the nature of the evidence. (nice.org.uk)
  • These are articles in which the authors have already searched medical databases for the available literature on a medical topic and analyzed it to determine if the evidence supports a specific treatment. (libguides.com)
  • autonomy to dependence, and as the Swedish curriculum puts it, `The task of the school is to en- courage all students to discover their own uniqueness as individuals and thereby actively partici- pate in the life of society by giving of their best in responsible freedom' (Skolverket, 2019, p. 5). (lu.se)
  • Some literary secondary sources provide background information on literary texts, such as a text's reception by critics on its publication, or events in the author's life that may have influenced the text, and so on. (essaywriter.guru)
  • Feeling safe during an inpatient hospitalization: a concept analysis. (ahrq.gov)
  • Many undergraduate English essays do not require extensive use of secondary sources. (essaywriter.guru)
  • However, a recent large trial of pharmacist-led medication reconciliation with positive results was excluded from this meta-analysis. (ahrq.gov)
  • This makes meta-analysis malleable in the sense that these methodological choices made in completing a meta-analysis are not determined but may affect the results. (wikipedia.org)
  • Collectively, interventions had a favorable impact on students' PA and nutrition KAP, but behavioral and secondary outcome results (eg, body mass index) were mixed. (cdc.gov)
  • The results for the principal component analysis of standardized residues supports a unidimensional structure. (bvsalud.org)
  • There are some methodological problems with meta-analysis. (wikipedia.org)
  • It is reasonable to choose chordal-sparing mitral valve replacement over reduction annuloplasty mitral valve repair in patients operated on for severe, symptomatic (New York Heart Association class III or IV) secondary MR (stage D) (Class IIa, LOE B-R). (clinicaladvisor.com)
  • Meta-analyses are often, but not always, important components of a systematic review procedure. (wikipedia.org)
  • When the context is vague, secondary and tertiary resources often get grouped together (Garrard, 2007). (ukessays.com)
  • Patients reporting NORSE secondary to COVID-19 were included in this review. (dovepress.com)
  • New and modified recommendations have been made regarding indications for antibiotic prophylaxis for infective endocarditis (IE), the use of direct oral anticoagulants (DOACs) in patients with atrial fibrillation and heart valve disease, indications for transcatheter aortic valve replacement (TAVR), surgical management of patients with primary and secondary mitral regurgitation (MR), and management of patients with a heart valve prosthesis. (clinicaladvisor.com)
  • Cannabinoids were safe and demonstrated limited effectiveness in treating certain symptoms in multiple sclerosis (MS) patients, a meta-analysis and systematic review found. (medpagetoday.com)
  • La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
  • In the said study, multivariable analysis adjusted for systolic blood pressure (SBP) showed no significant association between PP and HF risk (OR, 0.89, 95 percent CI, 0.77‒1.04). (mims.com)
  • In addition, meta-analysis may also be applied to a single study in cases where there are many cohorts which have not gone through identical selection criteria or to which the same investigational methodologies have not been applied to all in the same manner or under the same exacting conditions. (wikipedia.org)
  • But a new patient-level analysis of three large, randomized trials seems to strengthen the case for the idea at the population level, at least for older adults with CV risk factors . (medscape.com)
  • The chance the benefits exceed the costs are derived from a Monte Carlo risk analysis. (wa.gov)