• Some symp- the Americas during the current COVID-19 pandemic, caus- toms of DENV infection, such as nonspecific fever, are similar ing concerns about persons with COVID-19 antibodies being to those caused by infection with SARS-CoV-2, the virus that misdiagnosed based on results from a flavivirus antibody test causes COVID-19. (cdc.gov)
  • A more extensive evaluation severe dengue disease resulting in life-threatening conditions, of 11 SARS-CoV-2 immunochromatographic antibody tests such as dengue hemorrhagic fever and dengue shock syndrome. (cdc.gov)
  • Dengue fever is a benign, acute febrile syndrome occurring in tropical regions. (medscape.com)
  • In a small proportion of cases, the virus causes increased vascular permeability that leads to a bleeding diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). (medscape.com)
  • The WHO estimates that 50-100 million cases of dengue infection occur annually, with approximately 500,000 of those cases resulting in dengue hemorrhagic fever (DHF), with an estimated 22,000 deaths per year, mostly in children. (medscape.com)
  • Dengue fever is not contagious through person-to-person contact. (medscape.com)
  • Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. (wikipedia.org)
  • In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • Paracetamol (acetaminophen) is recommended instead of nonsteroidal anti-inflammatory drugs (NSAIDs) for fever reduction and pain relief in dengue due to an increased risk of bleeding from NSAID use. (wikipedia.org)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • Therefore, travelers returning from endemic areas are unlikely to have dengue fever if symptoms start more than 14 days after arriving home. (wikipedia.org)
  • The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. (wikipedia.org)
  • An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. (wikipedia.org)
  • Dengue and dengue hemorrhagic fever (DHF) result from infection by any of four serotypes of dengue viruses. (cdc.gov)
  • 33 Antigen detection assays are not available for MVEV, but have been used for JEV and Dengue fever virus. (mja.com.au)
  • 11 It is also possible that prior immunisation with yellow fever virus or JEV vaccine may induce cross-reactive antibodies. (mja.com.au)
  • Increased blood vessel permeability, which occurs in dengue haemorrhagic fever and dengue shock syndrome patients, has been correlated with secondary heterotypic infections and has been postulated to arise from antibody-enhanced infection of monocytes. (microbiologyresearch.org)
  • Hemostatic defects in dengue hemorrhagic fever. (microbiologyresearch.org)
  • Assay (ELISA) and MRL Dengue Fever Virus Immunoglobulin M Capture ELISA for Diagnosis of Dengue Virus Infections in Southeast Asia. (proteincrystallography.org)
  • Scientists have discovered cell populations in blood which clearly indicate whether a person infected with dengue fever is likely to progress to life-threatening severe disease or not. (sflorg.com)
  • About half of the world's population is at risk of dengue fever, with almost 400 million annual cases. (sflorg.com)
  • Until now, there has been no accurate way to predict which patients will progress to severe dengue fever. (sflorg.com)
  • Health facilities in areas prone to dengue fever are often overwhelmed with patients who are admitted for observation. (sflorg.com)
  • Professor Hansen's team is confident that the results will enable it to develop a biomarker test, like a COVID Rapid Antigen Test, for dengue fever. (sflorg.com)
  • We are beginning a second clinical study in an endemic area of Indonesia, to obtain more specificity in profiling particular cells predicting progression to severe dengue, to get a step closer to the development of a test for patients at the onset of fever. (sflorg.com)
  • Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
  • Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
  • Dengue Hemorrhagic Fever 10 cases and 32 cases of Dengue Fever. (unair.ac.id)
  • Until now spectrum of clinical illness dengue virus infection from an asymptomatic or mild febrile illness to classical dengue fever (DF) and then to the most severe illness for example dengue hemorrhagic fever (DHF) are always found in Indonesia town. (unair.ac.id)
  • CONCLUSIONS: To prevent the outbreak of dengue hemorrhagic fever the Health Center doctor should give health education to community for decreasing Aedes aegeypti Mosquito around their houses. (unair.ac.id)
  • Dengue haemorrhagic fever and dengue shock syndrome are responsible for heavy morbidity and mortality every year, it's burden have been rising in the recent years and become a public health problem of global importance [3]. (who.int)
  • A cross-sectional study was conducted during summer season to determine the entomological, behavioral, social and economic risk factors associated with dengue fever prevalence in Kassala area. (who.int)
  • The Panbio dengue IgM Capture ELISA is for the qualitative detection of IgM antibodies to dengue antigen in serum, as an aid in the clinical laboratory diagnosis of patients with clinical symptoms consistent with dengue fever. (ncnsd.org)
  • Serum IgM antibodies can be detected from dengue patients as early as three to five days after the onset of fever and generally persist for 30 - 90 days, although detectable levels may be present eight months post-infection. (ncnsd.org)
  • Significantly higher TNF-alpha levels were found in Afro-Colombians than in Mestizos in both dengue fever (DF) and dengue hemorrhagic fever (DHF). (qxmd.com)
  • The study was conducted to assess the role of Nitric Oxide (NO) in the pathogenesis of Dengue fever (DF). (ijmm.ir)
  • The dengue virus is transmitted by the mosquito that also transmits yellow fever ( Aedes aegypti ) and by the tiger mosquito ( Aedes albopictus ). (sciensano.be)
  • 5% ) of those infected have a severe form of dengue (formerly known as dengue haemorrhagic fever). (sciensano.be)
  • If the doctor suspects dengue fever, the diagnosis can be made by way of a blood test . (sciensano.be)
  • A vaccine for use in individuals four years of age and older ( QDENGA ) has been approved in Europe end of 2022, which provides protection against fever and hospitalisation resulting from dengue disease caused by any of the four dengue virus serotypes. (sciensano.be)
  • Here we investigate the immunoglobulin responses of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF) to NS1. (ox.ac.uk)
  • 50-100 million cases of dengue fever brate hosts of dengue virus in nature cessed by multiplex polymerase chain and 500 000 of dengue haemorrhagic are humans and several species of Asian reaction (PCR) in which the presence fever (DHF) reported annually ( 4 ). (who.int)
  • Dengue fever (DF) has rapidly spread over the last few decades and is currently found in most tropical and subtropical areas throughout the world. (who.int)
  • In Japan, DF and dengue haemorrhagic fever (DHF) have been notifiable diseases regulated by the Infectious Disease Control Law since April 1999. (who.int)
  • Though uncommon, false-positive nonstructural protein 1 (NS1) results may occur in individuals with active infection due to other flaviviruses, including West Nile virus and yellow fever virus. (marshfieldlabs.org)
  • Following dengue infection, the incubation period varies from 3 to 7 days, and while some infections remain asymptomatic, the majority of individuals will develop classic dengue fever. (marshfieldlabs.org)
  • However, children and young adults remain at increased risk for progression to dengue hemorrhagic fever and dengue shock syndrome, particularly during repeat infection with a new DV serotype. (marshfieldlabs.org)
  • There are four distinct virus serotypes, each capable of producing a wide spectrum of signs and symptoms that characterize dengue fever, ranging from subclinical infection, to a debilitating but self-limiting illness with symptoms resembling influenza, to severe disease known as dengue haemorrhagic fever. (who.int)
  • Before 1970, only nine countries had experienced dengue haemorrhagic fever. (who.int)
  • 1.2 million cases of dengue fever and dengue haemorrhagic fever were reported from 56 countries, was unprecedented. (who.int)
  • it is estimated that each year 50 million infections occur, with 500 000 cases of dengue haemorrhagic fever and at least 12 000 deaths, mainly among children, although fatalities could be twice as high. (who.int)
  • The resurgence of epidemic dengue fever and the emergence of dengue haemorrhagic fever as major public health problems are rooted in the demographic trends and socioeconomic policies of the twentieth century. (who.int)
  • The species thrives in intimate association with humans and is also the vector of the virus of urban yellow fever, a vaccine-preventable disease. (who.int)
  • potentially also of yellow fever and other arthropod-borne viruses in these new epidemiological settings remains to be determined. (who.int)
  • 1999) Comparison of PanBio Dengue Duo Enzyme-Linked Immunosorbent Assay (ELISA) and MRL Dengue Fever Virus Immunoglobulin M Capture ELISA for Diagnosis of Dengue Virus Infections in Southeast Asia. (fluidsforlife.com)
  • It was first proved experimentally in in-vitro studies done on West Nile fever virus and was subsequently demonstrated for an ever-growing number of human and animal disease-causing viruses. (tigs.res.in)
  • They currently help in removal of mosquito breeding places during episodes of dengue fever, participate in health education programs, ensure distribution of children's vaccination cards, and help train auxiliary staff in oral vaccination campaigns. (blackagendareport.com)
  • However, in a secondary infection with another serotype, the preexisting antibodies may cause antibody-dependent enhancement (ADE) of infection of macrophage cells, leading to the development of the more severe form of disease, dengue hemorrhagic fever. (rcsb.org)
  • With the exception of a vaccine for yellow fever and ribavirin, which is used as a drug treatment for some arenaviral infections, no cures or drug treatments for viral hemorrhagic fever exist. (medscape.com)
  • Not all viruses in these families cause viral hemorrhagic fever. (medscape.com)
  • However, different viruses can cause a range of various clinical problems in addition to viral hemorrhagic fever. (medscape.com)
  • The A aegypti mosquito is a known transmitter of dengue fever and yellow fever. (medscape.com)
  • The morphological alterations observed in lungs were similar to the observed in human cases of dengue fever and dengue hemorrhagic fever. (fiocruz.br)
  • As we all know, Guangdong suffered the worst dengue fever in 20 years in 2014. (hizy.net)
  • Notably, The symptoms of dengue fever vary from mild to severe, In the early days, Similar to colds and flu, It is easy to be misdiagnosed. (hizy.net)
  • At present, there is no vaccine to prevent dengue fever. (hizy.net)
  • There is no scientific basis for folklore such [tricks] [artifacts] as vitamin B1 crushed and dissolved water applied to the body, balm essence camphor balls smoked in the room, wearing mosquito repellent bracelets and mosquito repellent stickers, using mosquito repellent traditional Chinese medicine bags, ultrasonic mosquito repellent, Don't try during the dengue fever epidemic. (hizy.net)
  • Dengue fever is a febrile illness that affects infants, young children and adults. (dengue.lk)
  • Dengue Haemorrhagic Fever is a mosquito-borne viral infection endemic in the tropical and sub-tropical regions. (dengue.lk)
  • Abdominal pain may occur and if severe suggests DHF pattern.The signs of dengue fever/ Dengue haemorrhagic fever are- High fever, rash, hypotension and narrow pulse pressure, poor capillary refill. (dengue.lk)
  • The Zika virus is spread by the mosquito Aedes aegypti, which also transmits diseases such as chikungunya fever and dengue fever. (bvsalud.org)
  • Z ported human infections indicated that clinical characteris- ika virus (ZIKV) is a mosquito-transmitted virus in the tics of infection with ZIKV included fever, headache, mal- family Flaviviridae and genus Flavivirus . (folkhalsomyndigheten.se)
  • in all cases infection appeared relatively mild, self- sus monkey during a yellow fever study in the Zika forest limiting, and nonlethal ( 6 , 8 - 10 ). (folkhalsomyndigheten.se)
  • The Zika virus is a mosquito-borne flavivirus that is antigenically and structurally similar to the viruses that cause dengue, yellow fever, and West Nile virus. (msdmanuals.com)
  • however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. (mdpi.com)
  • Although the incidence of hemorrhagic dengue in United States travelers abroad is low,(13,15) clinicians in this country may encounter severe cases of dengue, particularly among immigrants from areas with a high incidence of DHF. (cdc.gov)
  • 17) Hemorrhagic manifestations, including gastrointestinal hemorrhage, were described during dengue epidemics in Texas and Louisiana in 1922. (cdc.gov)
  • 14,18,19) Nevertheless through the first half of the 20th century, dengue was generally described as a self-limited, nonfatal febrile illness, with occasional hemorrhagic manifestations such as petechiae, epistaxis, gingival bleeding and menorrhagia, that only rarely resulted in more severe or fatal outcomes. (cdc.gov)
  • Subsequent infections by other serotypes also increase the risk of developing severe, or hemorrhagic, dengue. (pasteur.fr)
  • Viral hemorrhagic fevers share certain clinical manifestations, regardless of the virus that causes the disease. (medscape.com)
  • Despite the diverse taxonomy of the four virus families involved in viral hemorrhagic fevers (VHFs), they share some common characteristics. (medscape.com)
  • Zika virus IgM, and SARS-CoV-2 antibodies indicated 98% have detectable levels of antibodies against the other. (cdc.gov)
  • A number of tests are available to confirm the diagnosis including detecting antibodies to the virus or its RNA. (wikipedia.org)
  • Also, it is known that secondary DENV infections may be more severe than primary infections due to the antibody-dependent immune response (i.e., heterotypic sub-neutralizing antibodies that increase virus entry into poorly susceptible cells) (2,3). (paho.org)
  • Infection enhancement of dengue type 2 virus in the human U-937 monocyte line by antibodies to Flavivirus cross-reactive determinants. (microbiologyresearch.org)
  • Monoclonal antibodies to Sindbis virus glycoprotein El can neutralize, enhance infectivity, and independently inhibit haemag-glutination or haemolysis. (microbiologyresearch.org)
  • Dengue Day 1 is a rapid solid phase immuno-chromatographic test for the qualitative detection of Dengue NS1 Antigen and differential detection of IgM and IgG antibodies to Dengue virus in Human serum/plasma. (microsidd.com)
  • First line testing kit for detecting dengue infection from day 1 using NS1 Antigen & differential detection of IgM & IgG Antibodies. (microsidd.com)
  • The Panbio Dengue Duo IgM Capture & IgG Capture ELISA is for the qualitative detection of IgM and IgG antibodies to dengue virus in serum. (proteincrystallography.org)
  • Cuzzubbo, A., et al (1998) Detection of Specific Antibodies in Saliva during Dengue Infection. (proteincrystallography.org)
  • Sang, C., et al (1998) Evaluation of a Commercial Capture Enzyme-Linked Immunosorbent Assay for Detection of Immunoglobulin M and G Antibodies Produced during Dengue Infection. (proteincrystallography.org)
  • Following an infection with one DENV serotype, the antibodies induced are type-specific and also cross-reactive with other DENV sero-types (Wilder-Smith et al. (cdc.gov)
  • Based on our "know-how", a 3-in-1 dengue test (Dengue Day 1) has been developed by an Indian company for simultaneous point-of-care detection of Dengue NS1 Antigen & differential detection of IgM & IgG antibodies in Human Serum/ Plasma. (icgeb.org)
  • Determining which immunological mechanisms contribute to the development of broad neutralizing antibodies (bNAbs) during HIV-1 infection is a major goal to inform vaccine design. (bvsalud.org)
  • These data demonstrate that the initial B cell interaction with the founder HIV Env is important for the development of broadly neutralizing antibodies and provide evidence that events within HIV acute infection lead to downstream functional outcomes. (bvsalud.org)
  • Detection of IgM antibodies to dengue virus by ELISA is a valuable procedure, particularly in second and subsequent infections where the occurrence of complications is high. (ncnsd.org)
  • Groen, J., et al (2000) Evaluation of Six Immunoassays for Detection of Dengue Virus-Specific Immunoglobulin M and G Antibodies. (ncnsd.org)
  • Lam, K., et al (2000) Evaluation of a Capture Screening Enzyme-Linked Immunosorbent Assay for Combined Determination of Immunoglobulin M and G Antibodies Produced during Dengue Infection. (ncnsd.org)
  • The increased risk of developing severe symptoms with secondary infection has been associated with the presence of non-neutralizing antibodies, which are thought to exacerbate the infection rather than preventing it. (pasteur.fr)
  • One model of the mechanism underlying severe disease proposes that weakly cross-reactive antibodies induced during a primary infection facilitate virus entry into Fc receptor-bearing cells during a subsequent secondary infection, increasing viral replication and release of cytokines and vasoactive mediators, culminating in shock. (vumc.org)
  • There is a concern that potent neutralizing antibodies must be generated to all four dengue virus serotypes, as a vaccine that induce weakly cross-reactive non-neutralizing antibodies may increase the likelihood of developing severe disease. (vumc.org)
  • Ideally, the reactivity of epitopes bound by enhancing antibodies should be reduced or eliminated in candidate antigens during the rational development of a dengue vaccine, so as to discourage such dominant recognition of these antigenic features by the humoral immune response. (vumc.org)
  • The long-term goal is to use such molecular information in the rational design of dengue vaccines that enhance the induction of protective neutralizing antibodies and reduce the risk of development of severe disease. (vumc.org)
  • For example, we have studied that role of a type of antibody, known as IgM, and the particular B cells that generate these antibodies, during both acute and chronic infection by a rickettsiae of the genus ehrlichia. (upstate.edu)
  • AbstractThe role of NS1-specific antibodies in the pathogenesis of dengue virus infection is poorly understood. (ox.ac.uk)
  • We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
  • and monoclonal recombinant antibodies are also currently being pursued for prevention of HIV-1 infection in large Phase IIb clinical trials (NTC02716675 and NCT02568215). (frontiersin.org)
  • Erratum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus (Nat. (kku.ac.th)
  • Serologic testing for the presence of IgM and IgG antibodies to dengue virus is recommended in such cases. (marshfieldlabs.org)
  • Concurrent evaluation for the NS1 antigen alongside testing for IgM- and IgG-class antibodies to DV (DENGM / Dengue Virus Antibody, IgG and IgM, Serum) provides optimal diagnostic potential for both early and late dengue disease. (marshfieldlabs.org)
  • These results were obtained even though 91% of the children had circulating dengue or Japanese encephalitis antibodies before vaccination, neutralizing antibodies developed to all 4 DENVs, and neutralizing antibody titers increased 2-3 fold after 3 doses of vaccine in 80%-90% of vaccinated children. (blogspot.com)
  • Studies on human primary immune responses to dengue infection have identified critical attachment sites on the virion for neutralizing antibodies ( 4 ). (blogspot.com)
  • It has therefore been assumed that persons with DENV neutralizing antibodies are protected against infection. (blogspot.com)
  • Antibodies are of several kinds (IgG, IgM, IgA, IgE and IgD) depending on when and where they are produced in the body post infection. (tigs.res.in)
  • Although all of them have Fab capable of binding to various parts of the virion, only a subset of these antibodies are able to block the infection. (tigs.res.in)
  • Antibodies can neutralize viral infections in a number of ways. (tigs.res.in)
  • The beneficial roles of antibodies are well known, however, sometimes the invading viruses are able to exploit these antibodies to facilitate their own entry into cells and hence result in enhanced infection. (tigs.res.in)
  • Such a situation typically arises when antibodies are produced against a particular virus during a primary infection event followed by a secondary infection later, by similar viruses sharing partially similar epitopes (e.g different serotypes of a given virus) or other viruses having similar epitopes. (tigs.res.in)
  • Laboratory testing with a rapid conducted at that time showed that 6.1% of the residents assay suggested that a dengue virus (DENV) was the caus- in nearby regions of Uganda had specifi c antibodies to ative agent. (folkhalsomyndigheten.se)
  • Importantly, the study used concomitant testing of Zika virus in patient serum as well as cerebral spinal fluid (CSF) samples and was the first to simultaneously test for CSF, Zika virus, and dengue IgM antibodies in order to exclude the confounder of cross-reactivity from flavivirus, which is highly common in Central and South America. (medscape.com)
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • 10) Adding to the concern of indigenous dengue transmission is the recent establishment in the United States of another known dengue vector, Aedes albopictus, which was probably imported in shipments of tires from Asia. (cdc.gov)
  • Zika virus is a mosquito-borne flavivirus transmitted primarily by Aedes aegypti mosquitoes. (cdc.gov)
  • Zika virus is transmitted primarily by Aedes aegypti mosquitoes ( 1 , 7 ). (cdc.gov)
  • Aedes albopictus mosquitoes also might transmit the virus. (cdc.gov)
  • Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
  • In 2013, Camino Verde, a cluster-randomised controlled trial in Managua, Nicaragua, and Mexico's Guerrero State, demonstrated impact of evidence-based community mobilisation on recent dengue infection and entomological indexes of infestation by Aedes aegypti mosquitoes. (biomedcentral.com)
  • Several studies have explored the links between water supply, Aedes aegypti ecology and dengue transmission risk. (biomedcentral.com)
  • It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
  • Dengue is a vector-borne virus infection, which is transmitted to humans by infected Aedes mosquitoes. (who.int)
  • The causes of dengue increasing spread are attributed to geographic expansion of the vector, the Aedes aegypti mosquitoes, leading to the increased co-circulation of the virus mainly in urban areas [7]. (who.int)
  • Dengue is a viral disease transmitted to humans by mosquitoes of the Aedes genus. (pasteur.fr)
  • Sciensano is responsible for the epidemiological surveillance of dengue in humans in Belgium, as well as for the monitoring of exotic mosquitoes of the Aedes genus (through the MEMO + project). (sciensano.be)
  • However, one of the mosquito vectors for dengue, Aedes albopictous , inhabits Japan and a major outbreak in western Japan occurred between 1942 and 1945. (who.int)
  • Dengue virus (DV) is a globally distributed flavivirus with 4 distinct serotypes (DV-1, -2, -3, -4) and is primarily transmitted by the Aedes aegypti mosquito, found throughout the tropical and subtropical regions of over 100 countries. (marshfieldlabs.org)
  • The transmission of dengue virus is mainly through the bite of Aedes mosquitoes (Aedes aegypti and Aedes albopictus). (hizy.net)
  • Dengue is transmitted by the bite of an Aedes mosquito infected with any one of the four dengue viruses. (dengue.lk)
  • [ 3 ] Secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for the development of DHF. (medscape.com)
  • It is approved only in individuals previously infected by any dengue virus serotype or in whom this information is unknown. (medscape.com)
  • Surveillance of vulnerable people and mosquitoes transmit dengue viruses can help monitor the epidemiological picture of local human populations and mosquito populations harboring specific serotype and provides an early warning sign to predict an impending epidemic [3, 6]. (who.int)
  • In 1984 dengue outbreak caused by serotype 2 and 1 was confirmed in Port Sudan. (who.int)
  • Interestingly, mAbs that display serotype specific, virion-only binding, and exhibit potent serotype specific neutralizing activity with little enhancing properties also are produced naturally by humans in response to infection. (vumc.org)
  • Infection with one serotype results in immunity to that specific serotype, but not to other serotypes. (sciensano.be)
  • We speak of primary dengue when a person is infected with the virus for the first time and of secondary dengue when a person is reinfected with a different serotype. (sciensano.be)
  • The present study demonstrates that the BALB/c mice, during the secondary infection by a heterologous serotype of DENV, develop morphological alterations in lung tissue more severe than those observed in the primary infection. (fiocruz.br)
  • It is thought that infection with a secondary serotype is what leads to severe haemorrhagic disease. (dengue.lk)
  • Laboratory diagnosis of dengue disease focuses on the detec- with various serologic tests, indicating possible cross-reactivity tion of viral RNA by real-time reverse transcription-poly- in these tests for DENV and SARS-CoV-2 infections ( 1 , 2 ). (cdc.gov)
  • therefore, IgM antibody detec- based patients with confirmed COVID-19 were tested using tion by ELISA becomes the primary option for diagnosing the DENV Detect IgM Capture enzyme-linked immuno- recent DENV-1-4 infections ( 4 ). (cdc.gov)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • In order to discuss this hypothesis it must be taken into account that Zika, dengue (DENV) and chikungunya viruses are closely related flaviviruses, with identical urban transmission and some immune interactions (1). (paho.org)
  • 2019). Global estimates for 2013 suggest a total of 58 million symptomatic DENV infections (95% CI 24-122) and 13,586 fatal cases occurred (95% CI 4200-34,700), resulting in a total annual global cost of $8.9 billion (95% CI 3.7-19.7) (Shepard et al. (cdc.gov)
  • There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
  • Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
  • DENV is an enveloped, single-stranded, positive-strand RNA virus, member of the genus Flavivirus in the Flaviviridae family. (hindawi.com)
  • The outcomes of infection by any of the DENV types range from asymptomatic, subclinical to symptomatic infections [ 4 - 7 ]. (hindawi.com)
  • 90%) for identification of primary DENV infections. (hindawi.com)
  • Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
  • The virus isolation rate was only (4.5%: 1/22) from all patient sera, serotyping showed the presence of DENV-3 serotypes. (unair.ac.id)
  • Ab-dependent enhancement (ADE) of dengue virus (DENV) infection is mediated through the interaction of viral immune complexes with FcγRs, with notable efficiency of FcγRII. (bvsalud.org)
  • Dengue is caused by the dengue virus , of which there are four serotypes ( DENV -1, DENV -2, DENV -3 and DENV -4). (sciensano.be)
  • Although dengue virus (DENV) control strategies have targeted vector control and disease surveillance, the development of an effective vaccine is the holy grail of prevention. (blogspot.com)
  • Although protective immunity was raised in susceptible rhesus monkeys inoculated with all 4 DENVs at a single site, inoculation of 4 chimeric dengue viruses at 1 or 2 sites did not result in neutralizing antibody responses to all 4 DENV ( 3 ). (blogspot.com)
  • Recent work suggests that primary monocytes and macrophages may not respond in exactly the same fashion to infection by DENV immune complexes ( 8 ). (blogspot.com)
  • Dengue virus (DENV), a mosquito-borne virus, is responsible for millions of cases of infections worldwide. (rcsb.org)
  • Histological and ultrastructural alterations in lung of BALB/c mice reinfected with heterologous DENV by the intravenous route with non-neuroadapted dengue viruses serotypes 1 and 2 were analyzed. (fiocruz.br)
  • Severe high-risk groups include the following four groups: A, patients with secondary infection (dengue virus has four serotypes of DENV-1, DENV-2DENV-3 and DENV-4, All four serotypes can infect people. (hizy.net)
  • Patients were randomized 2:1 to receive either the vaccine or saline placebo and monitored for symptomatic virologically confirmed dengue (VCD) starting at day 0. (medscape.com)
  • The vaccine was approximately 76% effective in preventing symptomatic VCD disease among patients aged 9-16 years who were seropositive for dengue at baseline. (medscape.com)
  • Most infections are asymptomatic, and symptomatic disease generally is mild. (cdc.gov)
  • I. Epidemiology of Symptomatic Acute Dengue Infection in Children, 2006-2009. (ijmm.ir)
  • Symptomatic dengue virus infection ranges in disease severity from an influenza-like illness to life-threatening shock. (vumc.org)
  • 122 serum specimens from patients with confirmed dengue in the diagnosis of these diseases. (cdc.gov)
  • In 1917, a 12-year-old with features suggestive of MVEV infection recovered after receiving immune serum. (mja.com.au)
  • The Panbio Dengue Duo IgM Capture & IgG Capture ELISA offers an improvement over the HAI assay as an aid for the serological diagnosis of dengue infections between primary and secondary infection using a single dilution of serum, rather than a series of dilutions required for HAI assays. (proteincrystallography.org)
  • To identify the internal mechanisms used to control dengue virus infection in asymptomatic patients, scientists from the Institut Pasteur in Paris, the Institut Pasteur in Cambodia, the CNRS and Inria examined the composition of blood serum, immune cells and the gene expression profile in asymptomatic Cambodian children infected with the dengue virus and compared them to those of patients presenting with clinical signs. (pasteur.fr)
  • Serum levels of cytokines in two ethnic groups with dengue virus infection. (qxmd.com)
  • This study compared the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interferon gamma (IFN-gamma) in 78 Colombian patients, from two ethnic groups, with dengue virus infection. (qxmd.com)
  • Antibody responses to recombinant-NS1 are assessed in serum samples throughout illness of patients with acute secondary DENV1 and DENV2 infection by ELISA. (ox.ac.uk)
  • 2015 we analysed the serum samples of 140 patients with a suspicion of dengue, using ELISA and multiplex polymerase chain reaction. (who.int)
  • Serum samples from children given ≥1 doses of the dengue chimeric vaccine can now be tested for primary neutralizing antibody responses to each of the 4 DENVs. (blogspot.com)
  • Of these individuals, 35 (88%) showed molecular and/or serologic evidence of recent Zika virus infection in serum or cerebrospinal fluid . (medscape.com)
  • In addition, the recent introduction of Zika and chikungunya viruses in the Americas and the large-scale exposure of a uniformly unexposed population could affect subsequent transmission of dengue virus. (paho.org)
  • Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
  • Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
  • This and other observations suggest an immunopathological component in dengue pathogenesis, which is referred to as immune enhancement of disease. (medicofem.com)
  • Zika virus is a mosquito-borne flavivirus that was first identified in Uganda in 1947 ( 1 ). (cdc.gov)
  • Murray Valley encephalitis virus (MVEV) is a mosquito-borne virus that is found across Australia, Papua New Guinea and Irian Jaya. (mja.com.au)
  • Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
  • Dengue, a mosquito-borne viral disease, is becoming a major health problem in some parts of the world [1, 2]. (who.int)
  • The infections with dengue has increased by a 30-fold over the past 50 years, making dengue the most rapidly spreading mosquito-borne viral disease in the world [11]. (who.int)
  • World's first immunization against the mosquito-borne virus. (medicofem.com)
  • Zika virus (ZIKV) is a mosquito-borne fl avivirus fi rst studies in the absence of epidemics ( 6 - 8 ). (folkhalsomyndigheten.se)
  • We assessed predominantly pediatric patients in Vietnam with dengue and other febrile illness 3 months after acute illness. (researchgate.net)
  • Dengue is one of the causes of febrile illness in Sudan [16]. (who.int)
  • These tests identify a including Zika virus. (cdc.gov)
  • In May 2015, the first local transmission of Zika virus in the Region of the Americas was reported in Brazil. (cdc.gov)
  • it is not known how many of these cases are associated with Zika virus infection. (cdc.gov)
  • Although local transmission of Zika virus has not been documented in the continental United States, infections have been reported among travelers visiting or returning to the United States, and these likely will increase. (cdc.gov)
  • The best way to prevent Zika virus infection is to avoid mosquito bites by avoiding exposure and eliminating mosquito breeding areas. (cdc.gov)
  • Until more is known, pregnant women should consider postponing travel to any area with ongoing Zika virus transmission. (cdc.gov)
  • Health care providers should contact their state or local health department about testing patients with symptoms of Zika virus infection and a compatible travel history. (cdc.gov)
  • In May 2015, the World Health Organization reported the first local transmission of Zika virus in the Region of the Americas (Americas), with autochthonous cases identified in Brazil ( 4 ). (cdc.gov)
  • In December, the Ministry of Health estimated that 440,000-1,300,000 suspected cases of Zika virus disease had occurred in Brazil in 2015 ( 5 ). (cdc.gov)
  • Although local transmission of Zika virus has not been documented in the continental United States, Zika virus infections have been reported in returning travelers ( 7 ). (cdc.gov)
  • In light of the recent outbreaks in the Americas, the number of Zika virus disease cases among travelers visiting or returning to the United States is likely to increase. (cdc.gov)
  • In addition to mosquito-to-human transmission, Zika virus infections have been documented through intrauterine transmission resulting in congenital infection, intrapartum transmission from a viremic mother to her newborn, sexual transmission, blood transfusion, and laboratory exposure ( 5 ). (cdc.gov)
  • There is a theoretical concern that transmission could occur through organ or tissue transplantation, and although Zika virus RNA has been detected in breast milk, transmission through breastfeeding has not been documented ( 5 ). (cdc.gov)
  • During outbreaks, humans are the primary amplifying host for Zika virus. (cdc.gov)
  • An estimated 80% of persons who are infected with Zika virus are asymptomatic ( 2 ). (cdc.gov)
  • Dengue, zika, and chikungunya outbreaks in Central and South America countries have presented significant challenges related to their prevention and control. (paho.org)
  • However, in Salvador, Brazil, after the zika outbreak there was a significant decrease in the frequency of dengue cases (4). (paho.org)
  • A similar situation was observed in Colombia, where the decrease in dengue cases following the zika and chikungunya outbreaks went from 334.1 cases per 100 000 people in 2015 to 90.7 cases per 100 000 in 2017 and 173,1 cases per 100 000 in 2018 (5). (paho.org)
  • Although temporary associations do not prove causation, the strength and consistency of the observations suggest that infections with Zika virus and chikungunya virus could induce cross-protective immunity against dengue. (paho.org)
  • Prospective studies are needed to fully assess the risk of dengue infection after exposure to Zika and chikungunya viruses and to determine whether the supposed cross-protection is long-lasting. (paho.org)
  • 2016) Zika virus infection in pregnant women in Barcelona, Spain. (vircell.com)
  • 2020) Results of a Zika virus screening programme in asymptomatic pregnant women in Spain. (vircell.com)
  • The Zika virus was identified in 1947 in Rhesus monkeys in the Republic of Uganda and isolated in humans in 1952 in the same country. (bvsalud.org)
  • The first outbreak of the Zika virus occurred in Brazil in 2015, becoming a serious public health problem due to the increase in the number of cases of microcephaly in infected pregnant women. (bvsalud.org)
  • To describe the legal abortion at Zika virus infection during pregnancy regarding medical, emotional and social consequences. (bvsalud.org)
  • perspectives of abortion for the pregnant woman with Zika virus regarding the medical, emotional and social consequences. (bvsalud.org)
  • Recognizing the exceptional nature of this situation, it is sought to confer an interpretation according to the Constitution and Article 128 of the Criminal Code, based on an analogical application, which seeks to protect the physical and mental health of women infected by the Zika virus. (bvsalud.org)
  • Authorizing the termination of pregnancy after diagnosis of the virus Zika guarantees women the free exercise of their reproductive rights, which is not confused with state imposition of abortion or eugenic practice. (bvsalud.org)
  • In response, in February 2016 the World Health Organization (WHO) declared the situation of the Zika virus as a health emergency of international importance 5 . (bvsalud.org)
  • In addition to pregnant women being directly contaminated by the mosquito, it has also been established that the disease can be acquired through sexual intercourse with partners contaminated by the Zika virus, even if these partners do not show signs of the disease. (bvsalud.org)
  • Zika virus infection during pregnancy can cause microcephaly (a serious birth defect), eye abnormalities, and a number of developmental impairments termed congenital Zika syndrome. (msdmanuals.com)
  • Prevention involves avoiding mosquito bites, avoiding unprotected sex with a partner at risk of having Zika virus infection, and, for pregnant women and their partners, avoiding travel to areas with ongoing transmission. (msdmanuals.com)
  • A. albopictus is thought to be a secondary vector of epidemic Zika virus infection in the tropics, but whether it would do so in the more temperate climate of the United States is unclear. (msdmanuals.com)
  • In 1947, the Zika virus was first isolated from monkeys in the Zika Forest of Uganda but was not considered an important human pathogen until the first large-scale outbreaks in the South Pacific islands in 2007. (msdmanuals.com)
  • A rising tide of serious neurologic complications among adults in Brazil has been linked to the spread of the Zika virus, new research shows. (medscape.com)
  • Zika virus gained notoriety for causing congenital microcephaly in infants born to infected mothers. (medscape.com)
  • GBS was the first major neurologic syndrome linked to Zika infection that was not associated with pregnancy. (medscape.com)
  • Regions of French Polynesia and the Americas have reported up to a 40-fold increase in GBS associated with the spread of the Zika virus, compared with pre-Zika virus time frames. (medscape.com)
  • Outcomes at 3 months showed that 2 patients (6%) who were positive for Zika virus died: 1 with GBS and 1 with encephalitis. (medscape.com)
  • These findings are consistent with the previous reports of neurologic syndromes associated with Zika virus in other populations, the authors note. (medscape.com)
  • The rates of admissions to the intensive care unit, disability at 3 months, and mortality did not differ substantially in our cohort compared with other published cohorts of [Zika virus]-associated GBS from Colombia and French Polynesia. (medscape.com)
  • Compared with a seasonally similar time frame before the first documented Zika virus case, hospital admissions for GBS in the current study time frame of 2015 to 2016 showed increases from a mean of 1.0 per month to 5.6 per month. (medscape.com)
  • Dr Nascimento noted that the study did not identify factors associated with development of neurologic complications with Zika virus infection. (medscape.com)
  • Our study was not powered nor designed to compare patients with [Zika virus] who developed neurological complications in comparison those who did not," he said. (medscape.com)
  • infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. (wikipedia.org)
  • This paper, published in the scientific journal Science Translational Medicine on August 30, 2017, represents an important step in improving understanding of the role played by immunity in dengue viral infection. (pasteur.fr)
  • The findings of this original study open up new avenues of research for the development of a vaccine against the dengue virus that will offer more comprehensive protective immunity against the four serotypes of the dengue virus and also prevent the spread of this disease, which represents a considerable global threat. (pasteur.fr)
  • We believe that the unanticipated results of the dengue vaccine efficacy trial in Thailand call for new methods of assessing dengue immunity. (blogspot.com)
  • After being infected by dengue virus, the human body can produce lasting immunity to the same type of virus, but cannot form effective protection against heterotype virus infection. (hizy.net)
  • Dengue-like epidemics occurred in Egypt and on Java in 1779, but these may actually have been caused by chikungunya virus. (cdc.gov)
  • mosquitoes are found throughout much of the Americas, including parts of the United States, and also transmit dengue and chikungunya viruses. (cdc.gov)
  • Of primary concern is the risk of dengue transmission within the continental United States. (cdc.gov)
  • There is no specific pharmacologic treatment for dengue infection. (medscape.com)
  • There is currently no specific treatment for dengue, and vector control and vaccination are the only effective methods to prevent future outbreaks. (who.int)
  • 1) Outbreaks of the more severe form of dengue, DHF, occurred in Cuba in 1981 (2) and in Venezuela in 1989. (cdc.gov)
  • 9) Outbreaks of indigenous dengue transmission occurred in Texas in 1980 and again in 1986. (cdc.gov)
  • This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
  • Kassala locality, eastern Sudan has witnessed increasing incidence of dengue outbreaks during the last few years according to the clinical services records [5, 6]. (who.int)
  • in Kassala 2010, Portsudan 2014 and Alfashir2014 dengue outbreaks were reported (Ministry of Health personal communication) [19]. (who.int)
  • With the tiger mosquito now established in southern Europe, small outbreaks of dengue occur there with greater frequency (e.g. in France). (sciensano.be)
  • Despite 50 years of research, the pathophysiological mechanisms that lead some patients to develop a severe clinical form of dengue have not yet been clearly elucidated. (pasteur.fr)
  • Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
  • To our knowledge, only once has an in vitro test correctly predicted which children would be susceptible or have silent infections accompanying a second heterotypic dengue infection ( 9 ). (blogspot.com)
  • Infection by one of the four dengue virus serotypes has been shown to confer lasting protection against homotypic re-infection, but only transient protection against a secondary heterotypic infection. (medicofem.com)
  • Moreover, secondary heterotypic infection is associated with an increased risk of severe disease. (medicofem.com)
  • Patients with suspected dengue infection who are maintaining adequate hydration orally and have no warning signs/symptoms may be treated on an outpatient basis with appropriate anticipatory guidance and outpatient follow-up within 24 hours for reassessment. (medscape.com)
  • Symptoms typically begin three to fourteen days after infection. (wikipedia.org)
  • By looking at infected but asymptomatic patients, this study can help us understand the mechanisms that prevent the development of symptoms following infection. (pasteur.fr)
  • Around 1 in 4 people infected with dengue virus develop symptoms after an incubation period of 3 to 14 days. (sciensano.be)
  • A better understanding of the humoral immune response to natural dengue virus infection in humans is sorely needed. (vumc.org)
  • The inability of a mixture of 4 dengue chimeric viruses to elicit an initial primary neutralizing antibody response in nonhuman primates and susceptible humans was recognized during preclinical testing and explained by the phenomenon of interference ( 2 ). (blogspot.com)
  • Myeloid cells are major targets of dengue infection in humans. (blogspot.com)
  • Vertebrates, including humans, have a complex immune system, which constantly functions to protect them from harmful foreign agents including bacteria and viruses. (tigs.res.in)
  • the recent finding of a novel epstein-barr virus-related lymphocryptovirus (calhv-3) in a captive colony of common marmoset (callithrix jacchus) in the united states modifies the view that the host range of lymphocryptovirus is restricted to humans and old world primates. (liverpool.ac.uk)
  • Up to the year 2007 there were few cases of infection registered in humans in African and Asian countries 1 . (bvsalud.org)
  • Загальні відомості про арбовірусні, аренавірусні та філовірусні інфекції Arbovirus (arthropod-borne virus) applies to any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, chiefly insects (flies and mosquitoes). (msdmanuals.com)
  • Although A. aegypti feeds almost exclusively on humans, A. albopictus feeds on humans as well as variety of other animals that are not susceptible to the virus and are not involved in transmission chains. (msdmanuals.com)
  • The early history of dengue is clouded by the similarity of its clinical picture to that of other febrile illnesses. (cdc.gov)
  • Infectious virus titres increased in undifferentiated U937 cells following infection with clinical isolates but only when the cells were infected via their Fc receptors. (microbiologyresearch.org)
  • The case-fatality ratio for severe dengue is 10% or higher when untreated but can be reduced to less than 1% with good clinical management. (cdc.gov)
  • Based on this event, the clinical manifestation of dengue virus infection should be studied. (unair.ac.id)
  • Kassala witnessed increasing of dengue cases during the last three years according to the clinical services records [20]. (who.int)
  • Clinical Microbiology and Infection. (vircell.com)
  • Dengue virus infection has emerged as marker in clinical practice ( 11 ). (who.int)
  • This test is intended as an aid in the clinical laboratory diagnosis of secondary dengue virus infection, and can be used in conjunction with the Panbio Dengue IgM Capture ELISA for the presumptive differentiation between primary and secondary infection. (fluidsforlife.com)
  • These results suggest that ethnicity may contribute to differences in immune responses to dengue infections. (qxmd.com)
  • The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
  • Incidence of dengue has increased many fold in the past 50 years and has expanded to areas that were previously free from the disease. (who.int)
  • We evaluated the characteristics of dengue cases imported into Japan and the relationship between the incidence of infection and season of travel to popular destinations. (who.int)
  • The number of reported cases per number of Japanese travellers to a dengue-endemic country was calculated to estimate the country-specific incidence of imported dengue virus infection. (who.int)
  • The incidence of dengue infection among Japanese travellers was compared between dengue high season and low season in each country using relative risk (RR) and associated 95% confidence intervals (CI). (who.int)
  • Overall, higher incidence of imported cases appeared to be related to historic dengue high seasons. (who.int)
  • To estimate the incidence of dengue virus infection among Japanese travellers, we described the characteristics of dengue cases reported to the national case-based surveillance system and the relationship between the incidence of dengue infection and season of travel. (who.int)
  • To estimate the country-specific annual incidence of imported dengue virus infection among Japanese travellers, the number of reported cases returning from an endemic country for a given year was divided by the number of travellers that visited that country in that year. (who.int)
  • This test is for in vitro diagnostic use only and is intended as an aid in the earlier diagnosis of Dengue infection & presumptive diagnosis between primary and secondary Dengue infection. (microsidd.com)
  • 1997). Commercial Assays for the Serological Diagnosis of Dengue Infection. (proteincrystallography.org)
  • In 20-30% of DHF cases, the patient develops shock, known as the dengue shock syndrome (DSS). (medscape.com)
  • 2021) Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. (vircell.com)
  • When the tetravalent dengue chimeric vaccine was given to partially dengue-immune children and adults in the Philippines, a broad neutralizing antibody response was observed after administration of only 2 vaccine doses ( 7 ). (blogspot.com)
  • Antibody response plays a crucial role during viral infections. (tigs.res.in)
  • Scientists from the Institut Pasteur in Paris and the Institut Pasteur in Cambodia, in collaboration with teams from the CNRS and Inria, have demonstrated that asymptomatic dengue infection in children is associated with activation of the immune system via control mechanisms, resulting in the elimination of viral infection without excessive immune activation. (pasteur.fr)
  • We also provide and interpret evidence from studies that support a potential role for ADCP in either inhibiting or enhancing viral infection. (frontiersin.org)
  • Dengue is the most common and widespread arthropod-borne viral infection in the world. (who.int)
  • Recognition of viral infection by the innate immune system occurs through the cytoplasmic recognition of cellular receptors of viral nucleic acids. (medscape.com)
  • Dengue vaccine was approved by the FDA in 2019 for prevention of dengue disease caused by dengue virus serotypes 1, 2, 3, and 4 in individuals aged 9-16 years with laboratory-confirmed previous dengue infection who live in endemic areas. (medscape.com)
  • Dengue guidelines for diagnosis, treatment, prevention and control 2009. (ijmm.ir)
  • Dengue Guidelines for Diagnosis Treatment, Prevention and Control A joint publication of the World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR) 2009. (ijmm.ir)
  • Although research on dengue vaccines for public health use is in process, currently the only method for the prevention and control of the disease is vector control. (who.int)
  • Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
  • Protection against virologically confirmed dengue, severe dengue, and hospitalization for dengue. (cdc.gov)
  • Dengue Branch and the Division of Vector Borne Infectious Diseases, Centers for Disease Control, CID, Fort Collins, CO. Duane J. Gubler, Sc.D and Edward B. Hayes, MD. (cdc.gov)
  • the main vector of dengue, has proved highly difficult to control, and continues to expand its geographic range. (cdc.gov)
  • Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
  • The problem of dengue in Kassala area is compounded by the huge population, cross broader movement, poor medical and diagnostic facilities, inadequate mosquito control activities and all the ground conditions that favor expansion of the vector breeding sites [6, 7]. (who.int)
  • Several risk factors are associated with the presence of both dengue and its vector in Kassala area. (who.int)
  • A key strategy of the dengue control program relies on vector control to reduce viral transmission [21]. (who.int)
  • The second reason dengue should concern health care providers in this country is the potential for encountering cases of dengue among travelers arriving from dengue-endemic areas. (cdc.gov)
  • all the rest were travelers arriving from dengue-endemic areas. (cdc.gov)
  • In Japan, although dengue cases are currently seen only among travellers returning from endemic areas, the number of reported cases is rising according to the national case-based surveillance system. (who.int)
  • Subsequent infection with a different type increases the risk of severe complications. (wikipedia.org)
  • Infections with 2 different DENVs can protect against severe disease during subsequent infections ( 6 ). (blogspot.com)
  • Most infections create an immunological memory in our body so as to be prepared for subsequent infections from the same or similar pathogens. (tigs.res.in)
  • ABSTRACT Dengue is one of the most important arthropod-borne viral diseases. (who.int)
  • Dengue virus is transmitted to was approved by the Ethics Committee borne viral diseases worldwide ( 1 ). (who.int)
  • Though vaccines work well for many viral diseases where the pathogen does not evolve much, it is inefficient or requires seasonal doses for viruses that evolve rapidly (e.g. flu causing viruses). (tigs.res.in)
  • These febrile diseases result from infection by viruses from 4 viral families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. (medscape.com)
  • SCD patients should also receive counselling on hygiene, barrier protection against vectors, routine chemoprophylaxis for locally endemic diseases, and immunization for vaccine-preventable infections as a long-term preventive strategy against IAH. (bvsalud.org)
  • This data has been extracted from the Dengue IgM Capture and Dengue IgG Capture ELISA Instructions for Use. (proteincrystallography.org)
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
  • Les échantillons de sérum de 140 patients susceptibles d'avoir contracté le virus de la dengue ont été analysés entre mai et octobre 2015 à l'aide du test ELISA et de l'amplification en chaîne par polymérase multiplexe. (who.int)
  • The Panbio Dengue IgG Capture ELISA offers an alternative to the HAI assay as an aid in the serological diagnosis of secondary dengue infections. (fluidsforlife.com)
  • Use with the Dengue IgM Capture ELISA to detect and distinguish primary and secondary dengue with a high degree of confidence. (fluidsforlife.com)
  • The majority of those were excluded as describing different live attenuated dengue vaccines or not including primary trial data. (cdc.gov)
  • By elucidating how effective immune responses are generated, our work will contribute to the development of vaccines and therapies for infections caused by pathogens of public health importance. (upstate.edu)
  • Vaccines are substances that mimic an infection by activating our immune cells and thereby creating a defence memory. (tigs.res.in)
  • BACKGROUND: Since 1968 dengue virus infection has been found in several cities in Indonesia, especially Surabaya and Jakarta, this event occurs due to the changing of the hot weather to rainy season. (unair.ac.id)
  • Dengue usually occurs as epidemics in Sri Lanka following monsoon seasons. (dengue.lk)
  • In a study of dengue dis- threatening respiratory disease. (cdc.gov)
  • Dengue has been called the most important mosquito-transmitted viral disease in terms of morbidity and mortality. (medscape.com)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • 13-15) From 1980 through 1989, 1457 suspected and 276 confirmed cases of dengue in the continental United States and Hawaii were reported to the Centers for Disease Control. (cdc.gov)
  • This will enable doctors to triage patients at an early stage, instead of referring all those diagnosed with dengue virus disease on to hospital," she said. (sflorg.com)
  • Therefore, health education about dengue virus infection should always done to all community for understanding to prevent this disease. (unair.ac.id)
  • Sudden onset of dengue epidemics can be greatly mitigated using rapid and reliable diagnostic methods for the control and management of this disease [4]. (who.int)
  • Dengue, also known as "tropical flu", is continuing to spread rapidly across the world and is now considered as a re-emerging disease. (pasteur.fr)
  • The one commercially available vaccine is only partly effective against infection by the four serotypes of the virus, although it does reduce the risk of developing the severe form of the disease. (pasteur.fr)
  • The Flavivirus genus is composed of more than 70 arthropod-transmitted viruses, of which 30 are known to cause human disease. (medscape.com)
  • Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and suscepti- bility to infections, which may trigger infection-associated haemolysis (IAH). (bvsalud.org)
  • Travellers planning to visit dengue-endemic countries should be aware of historic dengue seasonality and the current dengue situation. (who.int)
  • In spite of these challenges, vaccine development has made remarkable progress in recent years, and the current dengue vaccine pipeline is advanced, diverse and overall promising. (medicofem.com)
  • Ribavirin (already established as therapy for hepatitis C virus, which is also in the Flaviviridae family) was used in a study of 153 Indian children with JEV encephalitis, but did not indicate any benefit compared with placebo. (mja.com.au)
  • Dengue infection is caused by the dengue virus that belongs to the family Flaviviridae . (mims.com)
  • There are 4 serotypes of the single-stranded RNA virus (flaviviridae). (dengue.lk)
  • This unique process, known as antibody-dependent enhancement of infection, has significantly hindered vaccine development. (vumc.org)
  • Dengue vaccine development has spanned many decades. (blogspot.com)
  • These evolving viruses are a major concern during vaccine development. (tigs.res.in)
  • Due to these dengue-specific complexities, vaccine development focuses on the generation of a tetravalent vaccine aimed at providing long-term protection against all virus serotypes. (medicofem.com)
  • One of the earliest, if not the first, dengue epidemics described in the medical literature occurred in Philadelphia in 1780. (cdc.gov)
  • 5-7) Dengue epidemics were reported in various parts of the south- eastern United States through the 19th and 20th centuries, (6) most recently in Louisiana in 1945. (cdc.gov)
  • 7) Dengue or dengue-like epidemics were reported through- out the 19th and early 20th centuries in the Americas, southern Europe, North Africa, the Middle East, Asia and Australia and on various islands in the Indian Ocean, South and Central Pacific and the Caribbean. (cdc.gov)
  • 7) Deaths occurred during dengue epidemics in Australia in 1897 and in Greece in 1928, when over 1000 deaths were reported. (cdc.gov)
  • Dengue epidemics are mainly occurring in eastern Africa and to a smaller extent in western Africa [15]. (who.int)
  • netic and serologic properties of the ZIKV associated with In 1977, ZIKV infection was confi rmed among 7 pa- this epidemic. (folkhalsomyndigheten.se)