. equisimilis (81%) and S. anginosus (19%) were the causative organisms in the 2-year study period (2006-2007). (cdc.gov)
equisimilis (SDSE), frequently causes human infections. (cdc.gov)
equisimilis (SDSE) causes GAS-like infections, while Streptococcus agalactiae (GBS) is a common neonate pathogen that is rarely associated with pharyngitis. (nih.gov)
Pyogenic2
SDSE is a pyogenic β-hemolytic Streptococcus that is emerging as a human pathogen with a similar disease profile to S. pyogenes . (medscape.com)
Similar to infections with Streptococcus pyogenes, the prime example of a pyogenic streptococcal pathogen, infections with GCGS can develop into life-threatening necrotizing fasciitis, sepsis, and streptococcal toxic shock-like syndrome. (cdc.gov)
Pyogenes3
SDSE likely owes its virulence in humans to homologs of prominent S. pyogenes virulence genes ( 7 , 8 ). (cdc.gov)
This surface localized protein contributes substantially toward the virulence of both S. pyogenes and SDSE in human hosts because it acts as an adhesin, invasin, and antiphagocytic factor ( 11 ). (cdc.gov)
Among beta-haemolytic streptococci, Streptococcus pyogenes (GAS) is the prototype agent of bacterial pharyngitis and causes other human infections. (nih.gov)
Infections5
[ 4-6 ] While it primarily presents as skin and soft-tissue infections, including cellulitis and necrotizing fasciitis, [ 4 ] SDSE can also cause endocarditis, rheumatic fever, and streptococcal toxic shock-like syndrome. (medscape.com)
Vellore, a region in southern India, has a high incidence of severe human infections with β-hemolytic group C and G streptococci (GCGS). (cdc.gov)
The notable contribution of the anginosus group to human infections suggests that this group of obligate pathogens deserves more attention in healthcare and research. (cdc.gov)
Most SDSE strains isolated from human infections possess emm genes ( 9 , 10 ), which code for the potent virulence factor called M protein ( 11 ). (cdc.gov)
Streptococci of the anginosus group can reside commensally in the human oral cavity but have a certain propensity to cause pharyngitis, bacteremia, and serious purulent infections in the deep neck and soft tissue and in internal organs such as the brain, lung, and liver ( 17 - 25 ). (cdc.gov)
Group3
Group C and group G streptococci (together GCGS) were first recognized as human pathogens in 1935 by Lancefield and Hare ( 1 ). (cdc.gov)
Other streptococcal species that are pathogenic in humans and that occasionally expose groups C and G carbohydrates are gathered under the umbrella term anginosus group ( 15 ). (cdc.gov)
In the literature, the designation S. milleri ( 16 ) has often been used for streptococci of this group, although it has never been an officially approved name ( 15 ). (cdc.gov)