MetabolitesSpectrometryCharacterization of bioactiveSpectroscopyBiomarkerCompoundsSpongesBiologicalTissue samplesDrug discovery1977ChemicalSubsequentEtherAnticancerDeterminationOccurrenceMethodInhibitionAnalysisHumansDrugsNatural productsChallengeComplexCollectionPreparationIdentifyStudiesApproximatelyPlantsEnvironmentalTotalActivitiesRecent
Metabolites2
- Marine natural products, especially sponges, are the primary producers of secondary metabolites that of interest for investigation for clinical applications globally. (upm.edu.my)
- The collection window can be widened significantly when measuring organic arsenic levels as opposed to specific metabolites in blood or tissue samples using gas chromatography mass spectroscopy (GC-MS). Arsenic levels in combination with a patient's cytogenetic profile and clinical presentation may help pinpoint exposure to specific organoarsenic agents. (medscape.com)
Spectrometry7
- Passive sampling (Chemcatcher® with a HLB receiving phase) together with high-resolution tandem mass spectrometry-targeted screening was used to provide high sensitivity and selectivity for the identification of a wide range of emerging pollutants in these urban waters. (springer.com)
- image: In an integrated approach for drug discovery, natural product fractions are isolated from marine bacteria, screened through two biological screening platforms, and subjected to high-resolution mass spectrometry-based metabolomics profiling. (eurekalert.org)
- Mass spectrometry methods are widely used for the large-scale study of small molecules ("metabolomics") and can help identify the chemical constituents of each fraction. (eurekalert.org)
- An approach called Compound Activity Mapping developed by Linington and others combines mass spectrometry-based metabolomics with biological screening data to identify which compounds in a mixture are driving a particular biological signature. (eurekalert.org)
- Discover how Dr. Hajšlová was able to capitalize on the performance of Orbitrap-based mass spectrometry for the analysis of mycotoxins. (thermofisher.com)
- The most active fraction were chosen for nuclear magnetic resonance (NMR) and liquid chromatography mass spectrometry (LCMS) profiling before proceeding with various chromatographic methods for isolation. (upm.edu.my)
- Quantitative peptide analysis by mass spectrometry (MS) has become indispensable for interrogation of proteins in complex biological samples. (genengnews.com)
Characterization of bioactive1
- Biological activity and metabolite profiling of marine sponges and characterization of bioactive compounds isolated from Haliclona sp. (upm.edu.my)
Spectroscopy2
- Analysis of immunophenotypically defined cell populations markedly increased specificity of liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Over 375 differentially expressed proteins were analyzed by Ingenuity Pathway Analysis (Ingenuity Systems). (genengnews.com)
- Current methods can quantitate DPAA and DPAA-GS levels within hours, using gas chromatography and mass spectroscopy analysis (GC-MS/MS). (medscape.com)
Biomarker1
- Biomarker discovery requires both reduction of sample complexity and retention of coverage," he explains. (genengnews.com)
Compounds3
- In this application, mycotoxins are used as a model suite of aromatic compounds to demonstrate why and how orthogonal chemistries can help us determine the best column choice when running a sample in a complicated matrix. (thermofisher.com)
- In conclusion, the current study successfully assessed the bioactivity of 16 species from marine sponges collected from Malaysian waters and characterized isolated compounds from the nonpolar active fractions of Haliclona sp. (upm.edu.my)
- Ten out of the previous eleven model compounds could be quantified in the oxidized humic acid sample. (lu.se)
Sponges1
- The extraction, fractionation and HIV-1 inhibition potential of polysaccharides extracted from three species of marine sponges, Erylus discophorus , Cliona celata and Stelletta sp. (mdpi.com)
Biological3
- By integrating the results of two completely different screening platforms and combining this with next-generation metabolomics analysis of their natural products libraries, the researchers created a unique and powerful framework for natural product biological characterization. (eurekalert.org)
- Preliminary studies focused on several biological activities [α-glucosidase, cytotoxicity, antioxidant potential, nitric oxide (NO) scavenging activity, and antimicrobial] from marine sponge samples collected from Langkawi Island and Port Dickson. (upm.edu.my)
- However, the Port Dickson samples showed the highest inhibition among all the tested biological activities except for the NO scavenging. (upm.edu.my)
Tissue samples1
- Most surgically removed tissue samples contain a low percentage of tumor cells embedded in a dense stroma. (genengnews.com)
Drug discovery3
- A new approach using molecular biology, analytical chemistry, and bioinformatics to integrate information from different screening platforms addresses some of the biggest challenges in natural products drug discovery, according to a study published November 30 in Proceedings of the National Academy of Sciences . (eurekalert.org)
- These findings are also useful and may serve as an important basis for future drug discovery and development from marine organisms. (upm.edu.my)
- As part of the drug discovery program, DTP has contracts with various organizations for the collection of plants, microbes and marine macro-organisms worldwide. (wipo.int)
19771
- 1977. Accumulation and release of petroleum hydrocarbons by edible marine animals. (cdc.gov)
Chemical6
- In addition to MacMillan, the collaboration involves Scott Lokey, professor of chemistry and biochemistry and director of the Chemical Screening Center at UC Santa Cruz, Roger Linington at Simon Fraser University in British Columbia, and Michael White at the University of Texas Southwestern Medical Center. (eurekalert.org)
- Chemical additions to creosote were screened using this method. (irg-wp.com)
- Chemical modification of Aspen wood (Populus tremula L.) in the form of solid wood, veneers and sawdust was undertaken by a two step procedure consisting of esterification with maleic anhydride (MA) and subsequent oligoesterification with MA and glycidyl methacrylate (GMA) or allyl glycidyl ether (AGE). (irg-wp.com)
- If considering chemical warfare agent poisoning in the differential, obtain extra blood and urine samples for subsequent toxicologic testing. (medscape.com)
- Screening level fish community risk assessment of chemical warfare agents in the Baltic Sea. (medscape.com)
- Human health risk screening due to consumption of fish contaminated with chemical warfare agents in the Baltic Sea. (medscape.com)
Subsequent1
- The data generated in this study provides a solid foundation for subsequent work to further characterise (suspect screening) and quantify (target analysis) these substances. (springer.com)
Ether1
- It is built from methylated aromatic alcohols that are linked contributed to the total organic carbon in territorial samples by ether and carbon bonds. (lu.se)
Anticancer3
- DTP/NCI will screen the extracts of all material provided for anticancer and AIDS-antiviral activity, and will provide the test results to Source Country Institution on a quarterly basis. (wipo.int)
- The Developmental Therapeutics Program ('DTP'), Division of Cancer Treatment and Diagnosis ('DCTD'), National Cancer Institute ('NCI') is currently investigating plants, microbes, and marine macro-organisms as potential sources of novel anticancer and AIDS-antiviral drugs. (wipo.int)
- 1) DTP/NCI will screen the extracts of all plants, microbes and marine macro-organisms provided from [Source Country] for anticancer and AIDS-antiviral activity, and will provide the test results to [SCI] on a quarterly basis. (wipo.int)
Determination1
- Mass fragmentographic determination of polymethylbiphenyl in foods contaminated with petroleum products. (cdc.gov)
Occurrence1
- Occurrence and sorption properties of arsenicals in marine sediments. (medscape.com)
Method3
- The researchers used a bioinformatic method called Similarity Network Fusion (SNF), developed for integrating complex datasets, to combine data from two natural product screening platforms their labs had developed. (eurekalert.org)
- Using this method, samples from patients with diagnosed pancreatic cancer were compared to the healthy controls. (genengnews.com)
- Here, we develop a filter-based sampling method compatible with both air quality monitoring and Raman spectral imaging (RSI) for the detection of inhalable-sized microplastics. (acs.org)
Inhibition1
- However, the other samples from Port Dickson showed inhibition ranges approximately 20 to 30% for DPPH and 30 to 40% for NO scavenging testing. (upm.edu.my)
Analysis3
- The other platform, a cytological profiling (CP) technology developed by Lokey's lab, involves high-content image analysis of cells exposed to the samples being screened and then stained with a panel of fluorescent probes to highlight key cytological features. (eurekalert.org)
- Sample Design and Analysis Guidelines. (cdc.gov)
- The high separation power and short analysis time obtained demonstrate for the first time that supercritical fluid chromatography is a fast and reliable technique for the analysis of lignin-derived phenols in complex environmental samples. (lu.se)
Humans1
- The algae have the ability to produce marine biotoxins (MBTXs), which are dangerous to humans and other aquatic life. (thermofisher.com)
Drugs1
- Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking. (eurekalert.org)
Natural products1
- The researchers used the CP and FUSION technologies to screen complex natural products libraries developed by MacMillan's and Linington's labs. (eurekalert.org)
Challenge1
- This download handbook of provides you how to thank a superior crown set yoghurt to get you build your PurchaseJust from challenge sampling to a safer interval. (viotechsolutions.com)
Complex1
- Survey (NHANES III), conducted from 1988 through 1994, was the seventh in a series of these surveys based on a complex, multi-stage sample design. (cdc.gov)
Collection3
- Should the appropriate agency in [SCG or SCO] have any knowledge of the medicinal use of any plants, microbes and marine macro-organisms by the local population or traditional healers, this information will be used to guide the collection of plants, microbes or marine macro-organisms on a priority basis where possible. (wipo.int)
- The collection of plants, microbes, and marine macro-organisms will be within the framework of the collection contract between the NCI and the NCI Contractor ('Contractor') which will collaborate with the appropriate agency in the [SCG or SCO]. (wipo.int)
- Inadequate data are available regarding the metabolic products of diphenylaminearsine (Dm, adamsite), thereby limiting GC-MS/MS methods to the parental Dm molecule and creating a shorter collection window, predominantly from blood samples. (medscape.com)
Preparation1
- At the same time, such sample preparation for the pipeline must be cost-efficient and robust. (genengnews.com)
Identify1
- Screening 2000 individuals from consecutive mass-spectrometric studies, we herein identify five healthy German adults without exhaled isoprene. (nature.com)
Studies1
- More than 229,000 Armed Forces personnel have been diagnosed as having TBI since 2000 (5), and recent studies found that 10% to 23% of OEF/OIF service members screened positive for TBI (6,7). (cdc.gov)
Approximately2
- After a mass loss of approximately 5.5%, wafers were dried and analyzed for acid-insoluble lignin. (irg-wp.com)
- In Europe, the widespread consumption of plastic waste led to the accumulation of 25.8 million tons of waste in the terrestrial and marine environment, with polyesters accounting for approximately 15% thereof ( Plastics Europe and EPRO, 2019 ). (frontiersin.org)
Plants3
- Plants, microbes and marine macro-organisms. (wipo.int)
- DTP/NCI has an interest in investigating plants, microbes and marine macro-organisms from [Source Country], and wishes to collaborate with the SCG or SGO, as appropriate, in this investigation. (wipo.int)
- The [SCG or SCO], in turn, desires to collaborate closely with the DTP/NCI in pursuit of the investigation of its plants, microbes and marine macro-organisms, subject to the conditions and stipulations of this agreement. (wipo.int)
Environmental1
- Engineering, Lund University in environmental samples are generally time consuming. (lu.se)
Total1
- Automated fluorescence microscopy images yield a total of 251 unique cytological features for each sample. (eurekalert.org)
Activities1
- A screening with model substrates demonstrated hydrolytic activities of rumen fluid on p -NP-esters with four to eight carbon atoms. (frontiersin.org)
Recent1
- In recent years, many countries have had to deal with the negative effects of toxic microalgal blooms in both marine and fresh water, such as the death of wild animals and domestic livestock. (thermofisher.com)