All plausible pathways including nucleophilic decomposition, unimolecular decomposition, scrambling reactions, and attack on thiosulfoxides, have been considered to provide the first comprehensive mechanistic picture for this class of reactions. (bvsalud.org)
Amino2
The intact mass generated from each peptide along with the fragmentation data for that peptide can confirm the sequence against a theoretical amino acid sequence . (biopharmaspec.com)
The cDNA display proteolysis method is fast, accurate and uniquely scalable, and promises to reveal the quantitative rules for how amino acid sequences encode folding stability. (nature.com)
Protein4
The enzymes used are chosen based on the theoretical sequence of the protein and a knowledge of how the enzymes will theoretically digest the protein. (biopharmaspec.com)
The use of multiple digestion strategies results in the production of overlapping peptides which tie the sequence of the peptides together along the protein chain. (biopharmaspec.com)
Advances in DNA sequencing and machine learning are providing insights into protein sequences and structures on an enormous scale 1 . (nature.com)
Protein sequences vary by more than ten orders of magnitude in thermodynamic folding stability 2 (the ratio of unfolded to folded molecules at equilibrium). (nature.com)
Present1
In the case of nickel complexes, the interaction of NiII ions with the sequence SKH, present in Cys2His2, results in hydrolysis, contrasting to the preferred zinc ejection produced by the NiII complexes with chelating phosphines, producing Ni(bis-phosphine) fingers. (bvsalud.org)