• Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (expasy.org)
  • Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (fn-test.com)
  • Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx. (expasy.org)
  • HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)
  • This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikiversity.org)
  • The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (wikiversity.org)
  • Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and probably also phospholipids and gangliosides between cellular membranes. (wikipedia.org)
  • These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus. (wikipedia.org)
  • Encodes a hydrophilic protein similar to Late Embryogenesis Activated (LEA) proteins expressed during embryogenesis, which are thought to be involved in the acquisition of dessication tolerance. (or.jp)
  • HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)
  • Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73139","fkpB","Escherichia coli","FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73161","apaG","Escherichia coli","protein associated with Co2+ and Mg2+ efflux [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73196","murE","Escherichia coli","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73197","murF","Escherichia coli","UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73288","bamA","Escherichia coli","BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73290","lpxD","Escherichia coli","UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73627","ppiB","Escherichia coli","peptidyl-prolyl cis-trans isomerase B (rotamase B) [Ensembl]. (ntu.edu.sg)
  • We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin fibroblasts from two patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (rhea-db.org)
  • The diminution of trifunctional protein was associated with a decreased activity of enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase, when measured using medium-chain to long-chain substrates. (rhea-db.org)
  • Taken together, the results obtained show that in both patients, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is caused by an abnormality in the trifunctional protein, even though there is a heterogeneity in both patients. (rhea-db.org)
  • This domain occurred 5 times on human genes ( 6 proteins). (umbc.edu)
  • In the case of genes that are used to produce proteins, the RNA polymerase II holoenzyme that actually performs the transcription from the template strand needs to find chemical cues for attachment to the DNA and where to begin transcription. (wikiversity.org)
  • Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
  • The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
  • Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene. (wikiversity.org)
  • The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids. (wikipedia.org)
  • Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)
  • The Atg12 protein in yeast is an indispensable polypeptide in the highly conserved ubiquitin-like conjugation system operating in the macroautophagy/autophagy pathway. (bvsalud.org)
  • alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene. (wikiversity.org)
  • The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein. (umbc.edu)
  • Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
  • Predicted to encode a PR (pathogenesis-related) protein. (or.jp)
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. (genome.jp)
  • Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. (genome.jp)
  • Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)
  • Distal protein-protein interactions in vitro may be favored on supercoiled DNA because of topological constraints. (wikiversity.org)
  • A multifunctional role of Atg8-family proteins (Atg8 from yeast and human LC3 and GABARAP subfamilies, all referred to here as ATG8s) in macroautophagy/autophagy is carried out by two protein domains, the N-terminal helical domain (NHD) and ubiquitin-like (UBL) domain. (bvsalud.org)
  • The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
  • The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
  • This domain is involved in binding sterols. (wikipedia.org)
  • We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
  • Atg12 is comprised of a ubiquitin-like (UBL) domain preceded at the N terminus by an intrinsically disordered protein region (IDPR), a domain that comprises a major portion of the protein but remains elusive in its conformation and function. (bvsalud.org)
  • Here, we show that the IDPR in unconjugated Atg12 is positioned in proximity to the UBL domain, a configuration that is important for the functional structure of the protein. (bvsalud.org)
  • A major deletion in the IDPR disrupts intactness of the UBL domain at the unconjugated C terminus, and a mutation in the predicted α0 helix in the IDPR prevents Atg12 from binding to Atg7 and Atg10, which ultimately affects the protein function in the ubiquitin-like conjugation cascade. (bvsalud.org)
  • If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)
  • Search proteins in UniProtKB for this molecule. (rhea-db.org)
  • These findings provide evidence that the IDPR is an indispensable part of the Atg12 protein from yeast. (bvsalud.org)
  • Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
  • The third is based on a highly conserved region in the C-terminal part of these proteins. (expasy.org)