Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (expasy.org)
Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (fn-test.com)
SCPx4
Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx. (expasy.org)
HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikiversity.org)
The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (wikiversity.org)
Nonspecific lipid transfer2
Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and probably also phospholipids and gangliosides between cellular membranes. (wikipedia.org)
These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus. (wikipedia.org)
HSD17B42
HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)
Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
Encodes1
Encodes a hydrophilic protein similar to Late Embryogenesis Activated (LEA) proteins expressed during embryogenesis, which are thought to be involved in the acquisition of dessication tolerance. (or.jp)
Genes3
This domain occurred 5 times on human genes ( 6 proteins). (umbc.edu)
In the case of genes that are used to produce proteins, the RNA polymerase II holoenzyme that actually performs the transcription from the template strand needs to find chemical cues for attachment to the DNA and where to begin transcription. (wikiversity.org)
Using cloned chicken β A -globin genes, either individually or within the natural chromosomal locus, enhancer-dependent transcription is achieved in vitro at a distance of 2 kb with developmentally staged erythroid extracts. (wikiversity.org)
Fatty acids3
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Thiolase1
The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein. (umbc.edu)
Subunit1
Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene. (wikiversity.org)
Dehydrogenase2
Nematodes, amoebas, ciliates, apicomplexans, and oomycetes express an alternative DBP with the SCP-2 domain directly connected to the D-3-hydroxyacyl-CoA dehydrogenase. (slu.se)
Our results indicate that the fusion between D-3-hydroxyacyl-CoA dehydrogenase and SCP-2 was formed early during eukaryotic evolution. (slu.se)
Intracellular lipid1
SCP-2 has multiple roles in intracellular lipid circulation and metabolism. (umbc.edu)
Lipids2
The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids. (wikipedia.org)
Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)
DEFICIENCY1
Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
Polypeptide1
alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene. (wikiversity.org)
Encode1
Predicted to encode a PR (pathogenesis-related) protein. (or.jp)
SCOP1
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. (genome.jp)
Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)
Interproscan5
Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
OstA-like protein, LPS transport system D [Interproscan]. (ntu.edu.sg)
Cell division protein FtsL [Interproscan]. (ntu.edu.sg)
Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
Distal protein-protein interactions in vitro may be favored on supercoiled DNA because of topological constraints. (wikiversity.org)
Vitro2
The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)
Transport1
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
Plant1
This fusion has not been retained in plant genomes, which solely express unfused SCP-2 domains. (slu.se)
Domains1
We have extracted SCP-2 domains from databases and analyzed the evolution of the eukaryotic SCP-2. (slu.se)