Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene. (wikipedia.org)
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikipedia.org)
Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (expasy.org)
Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
SCPx3
The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (wikipedia.org)
Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (wikipedia.org)
HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)
Encodes2
HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)
Encodes a hydrophilic protein similar to Late Embryogenesis Activated (LEA) proteins expressed during embryogenesis, which are thought to be involved in the acquisition of dessication tolerance. (or.jp)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Peroxisomal1
SCP2 has been shown to interact with Caveolin 1 and peroxisomal receptor PEX5. (wikipedia.org)
Fatty acids1
Fatty acids provide the acyl skeleton for lipid synthesis. (biomedcentral.com)
Synthesis2
This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. (wikipedia.org)
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
Membrane1
Transcriptional analysis of ACBP-deficient parasites revealed differentially expressed genes involved in a wide range of biological processes such as lipid metabolism, posttranslational modification, and membrane biogenesis. (biomedcentral.com)
Metabolism3
Lipid metabolism is pivotal for the growth of apicomplexan parasites. (biomedcentral.com)
Lipids are crucial to the biology of all cells and organisms, acting not only as primary sources of energy but also as regulators of metabolism and growth, participating in various signaling networks [ 4 ]. (biomedcentral.com)
Vitro2
The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
Encode1
Predicted to encode a PR (pathogenesis-related) protein. (or.jp)
Interproscan5
Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
OstA-like protein, LPS transport system D [Interproscan]. (ntu.edu.sg)
Cell division protein FtsL [Interproscan]. (ntu.edu.sg)
Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
We developed three signature patterns for this family of proteins, two of which are based on the regions around the biologically important cysteines. (expasy.org)
Amino1
We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
Host1
Lipids can also act as pivotal pathogenetic factors that allow pathogens to escape immune responses, manipulate host processes, and develop disease [ 7 ]. (biomedcentral.com)
Storage1
Carnitine palmitoyl transferase 2 (CPT 2) deficiency represents the most common lipid storage disease at 1:300,000. (medicover-genetics.com)
Highly1
The third is based on a highly conserved region in the C-terminal part of these proteins. (expasy.org)
Type1
Lipid extraction from ΔNcACBP or the wild-type of N. caninum was analyzed by GC-MS or TLC. (biomedcentral.com)
Sterol carrier9
Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene. (wikipedia.org)
3. Aberrant oxidation of the cholesterol side chain in bile acid synthesis of sterol carrier protein-2/sterol carrier protein-x knockout mice. (nih.gov)
4. Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells. (nih.gov)
6. Altered ovarian sterol carrier protein expression in the pregnant streptozotocin-treated diabetic rat. (nih.gov)
8. New aspects of sterol carrier protein 2 (nonspecific lipid-transfer protein) in fusion proteins and in peroxisomes. (nih.gov)
12. Chicken sterol carrier protein 2/sterol carrier protein x: cDNA cloning reveals evolutionary conservation of structure and regulated expression. (nih.gov)
16. Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice. (nih.gov)
17. Phytanic acid accumulation is associated with conduction delay and sudden cardiac death in sterol carrier protein-2/sterol carrier protein-x deficient mice. (nih.gov)
19. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. (nih.gov)
Degradation2
9. Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals. (nih.gov)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Gene2
The molecular genetic cause of the disease are pathogenic variants in the gene encoding Microsomal Triglyceride Transfer Protein (MTTP). (medicover-genetics.com)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Hepatic1
11. Differential expression of hepatic sterol carrier proteins in the streptozotocin-treated diabetic rat. (nih.gov)
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
Expression1
PN inhibited IL-1ß induced destruction of genes and proteins by downregulating the expression of MMP3, MMP13, iNOS, and COX-2 while increasing the expression of aggrecan (ACAN) and collagen II (COL2A1). (bvsalud.org)
Activity1
Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Liver1
MTTP is a multifunctional heterodimeric protein involved in the assembly and secretion of Apo B-containing lipoproteins (mainly LDL and VLDL) in the liver. (medicover-genetics.com)
Role1
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Human1
In-depth understanding of the changing functions of human milk (HM) proteins and the corresponding physiological adaptions of the lactating mammary gland has been inhibited by incomplete knowledge of the HM proteome. (mdpi.com)