This domain occurred 5 times on human genes ( 6 proteins). (umbc.edu)
The genes encoding non-specific lipid transfer proteins (nsLTPs), members of a small multigene family, show a complex pattern of expressional regulation, suggesting that some diversification may have resulted from changes in their expression after duplication. (korea.ac.kr)
SCPx2
Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx. (expasy.org)
HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)
Thiolase1
The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein. (umbc.edu)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Dehydrogenase3
HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)
Nematodes, amoebas, ciliates, apicomplexans, and oomycetes express an alternative DBP with the SCP-2 domain directly connected to the D-3-hydroxyacyl-CoA dehydrogenase. (slu.se)
Our results indicate that the fusion between D-3-hydroxyacyl-CoA dehydrogenase and SCP-2 was formed early during eukaryotic evolution. (slu.se)
Intracellular2
SCP-2 has multiple roles in intracellular lipid circulation and metabolism. (umbc.edu)
Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)
SCOP1
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
Peroxisomal2
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
Lipid1
Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (expasy.org)
DEFICIENCY1
Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
Amino2
The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
In this report, a metal-chelating amino acid, 2,2′-bipyridylalanine (BPA), was genetically introduced into defined sites of a monomeric protein and used to form protein oligomers. (ward-lab.ch)
Interproscan5
Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
OstA-like protein, LPS transport system D [Interproscan]. (ntu.edu.sg)
Cell division protein FtsL [Interproscan]. (ntu.edu.sg)
Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. (guidetoimmunopharmacology.org)
It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)
Family1
We developed three signature patterns for this family of proteins, two of which are based on the regions around the biologically important cysteines. (expasy.org)
Depending on the number of BPAs introduced into the protein and the species of metal ions (Ni2+ and Cu2+), dimers or oligomers with different oligomerization patterns were formed by complexation with a metal ion. (ward-lab.ch)
Enzyme1
The construction of protein assemblies has great potential for biosensors, enzyme catalysis, and biomedical applications. (ward-lab.ch)
Functional1
Therefore, this method would be useful for the design and construction of functional protein assemblies. (ward-lab.ch)
Domain1
If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)
Activity1
The toxic effects of C. colocynthis on development periods, protein contents and esterase activity of the life stages of E. vittella were also evaluated. (bvsalud.org)
Dependent1
Although a few methods are available for this purpose, most of them are dependent on existing PPIs of natural proteins to some extent. (ward-lab.ch)
Evolution1
We have extracted SCP-2 domains from databases and analyzed the evolution of the eukaryotic SCP-2. (slu.se)
Reaction1
Crystal structure of activated Rubisco from G. partita complexed with the reaction intermediate analogue, 2-carboxyarabinitol 1,5-bisphosphate (2-CABP) has been determined at 2.4-A resolution. (lookformedical.com)
Many natural proteins function in oligomeric forms, which are critical for their sophisticated functions. (ward-lab.ch)
The method proposed in this report is technically simple and generally applicable to various proteins with interesting functions. (ward-lab.ch)
Early2
2. Advantage of early selection through shortening the breeding cycle. (upsc.se)
2. {Advantage} of early selection through shortening the breeding cycle}, volume = {48}, issn = {0037-5349}, abstract = {Three main advantages from early selection in tree breeding have been recognized: 1. (upsc.se)
Plasma1
Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)
Addition1
In addition, when Cu2+ was used for complex formation with the protein containing two BPAs, a linear complex was formed. (ward-lab.ch)
Complex1
When three BPAs were introduced, the monomeric protein formed a large complex with Ni2+. (ward-lab.ch)
Cells1
Molecules and cells , 24 (2), 215-223. (korea.ac.kr)