• The authors sought to evaluate glibenclamide's impact on mortality and functional outcomes of patients with aneurysmal SAH (aSAH). (thejns.org)
  • Nine studies demonstrated prognostic value of the FOUR score in predicting mortality and functional outcomes. (springer.com)
  • Thirty-two studies demonstrated equivalency or superiority of the FOUR score compared to Glasgow Coma Score in prediction of mortality and functional outcomes. (springer.com)
  • 1, 2 External ventricular drain (EVD) placement in these patients has been associated with improved mortality and functional outcomes. (westjem.com)
  • TBIs may be closed or open injuries and are categorized on the basis of severity as measured by the Glasgow Coma Scale score (GCS). (medscape.com)
  • The Clinical Institute Withdrawal Assessment for Alcohol, revised scale for alcohol withdrawal score objectifies alcohol withdrawal severity to help guide therapy. (ebmedicine.net)
  • Imaging studies were visually scored for severity of brain injury. (ajnr.org)
  • Our PSM-based approach outperformed well-known ICU severity of illness scores. (plos.org)
  • For example, severity of illness (SOI) scores used in intensive care, such as the Acute Physiology and Chronic Health Evaluation (APACHE) [ 2 ] or Simplified Acute Physiology Score (SAPS) [ 3 ] systems, were developed based on large-scale data collected from numerous countries. (plos.org)
  • A study to assess the utility of peradeniya organophosphorous poisoning (POP) scale, poisoning severity score (PSS) and glasgow coma scale (GCS) in predicting severity and treatment outcome in acute organophosphorous poisoning. (aaem.pl)
  • Here, our aim was to determine if glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) measured 1-year postinjury in EVs could distinguish patients from controls, and whether these biomarkers relate to TBI severity or recovery outcomes. (quanterix.com)
  • These findings suggest that blood-derived EV concentrations of GFAP and NfL drawn even 1 year after injury are higher in TBI patients compared to controls, and are related to injury severity and poor recovery outcomes, suggesting that TBIs alter the activity of these biomarkers, likely contributing to individual variability in recovery. (quanterix.com)
  • Outcomes depend on resuscitation efforts and on the severity of global brain injury, which is comprised of primary insult (accrued during circulation standstill) and ongoing injury due to gaps between the energetic supply and demand from the brain (secondary brain injury). (biomedcentral.com)
  • The 30-day and 6-month mortality rate is 39% and 49%, respectively, and only 23% of patients have a favorable outcome, as evaluated using a modified Rankin scale (mRS) score of 0-2 2 . (nature.com)
  • inhibition of brain edema provides favorable outcome of ICH. (karger.com)
  • The primary endpoint is favorable outcome according to the Extended Glasgow Outcome Score (5-8) at 12 months. (biomedcentral.com)
  • Prior trials examining vasopressin in cardiac arrest, however, have not demonstrated improved overall rates of sustained ROSC, long-term survival, or favorable neurological outcome. (emra.org)
  • A systematic review of controlled studies in animal brain injury models showed that BB2 antagonists reduce brain oedema and improve neurological outcome [ 6 ]. (biomedcentral.com)
  • Similar results were found for analyses considering the dichotomized 6-month mRS score (favorable score 0-2), as well as for the secondary outcomes of discharge mRS score (either ordinal or dichotomized), mortality, and delayed cerebral ischemia. (thejns.org)
  • Secondary outcomes included time interval from emergency department transfer request to arrival, and in-hospital mortality. (westjem.com)
  • The bottom line of this neuroprotective study was that there was no difference either in primary or secondary outcomes. (medscape.com)
  • The Glasgow Outcome Score applies to patients with brain damage allowing the objective assessment of their recovery in five categories. (wikipedia.org)
  • The Full Outline of UnResponsivness (FOUR) score is a neurological assessment score. (springer.com)
  • Its theoretical benefit over preexisting scores is its evaluation of brainstem reflexes and respiratory pattern which may allow better assessment of patients with severe neurologic impairment. (springer.com)
  • Clinical assessment of neurological status is a vital element in decision making, outcome prediction, and information sharing among medical professionals. (springer.com)
  • The controlling nutritional status (CONUT) score, which is calculated based on patients' serum albumin, total lymphocytes and total cholesterol, is associated with Full Nutritional Assessment (FNA) and was recently introduced as a nutritional screening tool 12 . (nature.com)
  • The Clinical Institute Withdrawal Assessment for Alcohol, revised (CIWA-Ar) scale provides an efficient and objective means of assessing alcohol withdrawal that can then be utilized in treatment protocols. (ebmedicine.net)
  • Assessment protocols utilizing the CIWA-Ar scale vary and include medication dosing triggered by symptoms only and combined symptom-triggered and fixed-dose medication dosing. (ebmedicine.net)
  • The use of a validated and well-known instrument to evaluate neurological functioning, such as the Glasgow Coma Scale, provides a reliable assessment of CNS impairment and its progression over time. (mhaus.org)
  • This is a phase IIa, single-center, open-label, pilot clinical trial with blinded outcome assessment, of a single dose of vigabatrin in 12 consecutive PASE subjects. (biomedcentral.com)
  • This audit aimed to report the assessment and management of these fistulae to benchmark the outcomes from these approaches at a South African tertiary colorectal unit METHODS: Retrospective analysis of prospectively collected data of patients with anorectal fistulae over a 13-year period at a tertiary referral centre. (scielo.org.za)
  • The assessment of patients in coma is a Neurological outcomes [6] were determined medical emergency. (who.int)
  • The score of frailty is assigned by an investigator at the time of upper GI bleed from an overall clinical assessment after their informed consent. (who.int)
  • The primary outcome of interest was patient global outcome, as assessed by any of: mortality, modified Rankin Score, Glasgow Outcome Score, or any other functional or neuropsychiatric outcome. (springer.com)
  • The primary outcome was time interval from arrival at any intensive care units (ICU) to time of EVD placement (ARR-EVD). (westjem.com)
  • Controlling for age, admission Glasgow Coma Scale score, penetrating as compared to blunt injury, and presence of multiple trauma, females were 1.75 times more likely to die of their brain injury than males. (hindawi.com)
  • Sixty-seven patients, aged 16-65 yrs, Glasgow Coma Scale score of 4-8, injured within 6 hrs of treatment. (erowid.org)
  • Statistical analysis of these differences by a logistic model using dose, entry Glasgow coma scale score, and computed tomograph as covariates yielded p values for the effect of treatment of .03 and .14 at 3 and 6 months, respectively. (erowid.org)
  • Adults with traumatic brain injury and a Glasgow Coma Scale score of 12 or less, who had a CT scan showing an intracranial abnormality consistent with trauma, and were within eight hours of their injury were randomly allocated to low, medium or high dose Anatibant or to placebo. (biomedcentral.com)
  • Glibenclamide has been shown to improve outcomes in cerebral ischemia, traumatic brain injury, and subarachnoid hemorrhage (SAH). (thejns.org)
  • The International Consensus Statements on Concussion in Sport, among others, highlighted the need for continued research and evidence-based strategies to improve diagnosis, prognostication, and treatment of mTBI to help improve outcomes for children with mTBI. (cdc.gov)
  • Moreover, based on previous studies, the importance of specialized trauma teams and trauma centers in charge of treating patients with severe trauma is understood, and the positive effects of trauma centers and trauma teams on overall trauma patient treatment outcomes have been demonstrated [ 4 - 6 ]. (jtraumainj.org)
  • Pain levels in sterilisation surgery patients were assessed at four time points after surgery using the Colorado State University Canine Acute Pain Scale, a Visual Analogue Scale and a modified version of the Glasgow Composite Measure Pain Scale - Short Form. (iasp-pain.org)
  • Creation and validation of the Italian version of the Glasgow Composite Measure Pain Scale-Short Form (ICMPS-SF). (newmetrica.com)
  • Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. (newmetrica.com)
  • In this study the authors analyzed the relationship of intraventricular hemorrhage (IVH) to in-hospital complications and clinical outcome in a large population of patients with aneurysmal subarachnoid hemorrhage (SAH). (nih.gov)
  • The FOUR score has been shown to be a useful outcome predictor in many patients with depressed level of consciousness. (springer.com)
  • And to be more explicit, some advocate for Do Not Attempt Resuscitation since outcomes are by no means guaranteed for a survival after the initial resuscitation. (pallimed.org)
  • The Glasgow Coma Scale (GCS) and pupillary reactivity are well-known prognostic factors in traumatic brain injury (TBI). (eur.nl)
  • The aim of this study was to compare the GCS motor score and pupillary reactivity assessed in the field and at hospital admission and assess their prognostic value for 6-month mortality in patients with moderate or severe TBI. (eur.nl)
  • Field GCS motor score and pupillary reactivity at hospital admission, compared to other combinations of these parameters, possess the best prognostic value to predict 6-month mortality in patients with moderate-to-severe TBI. (eur.nl)
  • Given that differences in prognostic performance are only small, both the field and admission values of GCS motor score and pupillary reaction may be reasonable to use in multi-variable prediction models to predict 6-month outcome. (eur.nl)
  • Objective To evaluate the clinical outcomes and prognostic factors in surgically treated patients with severe brain injury (Glasgow Coma Scale [GCS] score ≤8) diagnosed with traumatic epidural hematoma (EDH). (koreamed.org)
  • Hospital mortality was 39.6% for females and 32.5% for males and the rates of unfavorable outcome were 58.7% for females and 53.4% for males [ 8 ]. (hindawi.com)
  • 0.01), in-hospital mortality (9% vs. 24%, p = 0.035) and 6‑month mortality (13% vs. 28%, p = 0.031), as well as of unfavorable outcome (34% vs. 57%, p = 0.015) and observed vs. expected ratio for mortality (0.42 vs. 0.84) in the WNH (citicoline receivers) group. (nih.gov)
  • Assessing the role of frailty as measured by the Canadian Study of Health and Ageing (CSHA) clinical frailty scale, age, and other risk scores (Charles comorbidity index, Glasgow Blatchford score, AIMS 65 score) in predicting mortality in consecutive patients with upper gastrointestinal bleed over 21 months. (who.int)
  • Outcome measures included the length of stay (LOS), the Extended Glasgow Outcome Scale (GOSE), the functional independence measure instrument (FIM), discharge destination, and mortality rate. (hindawi.com)
  • In this study, glibenclamide was not associated with better functional outcomes after aSAH. (thejns.org)
  • In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. (nature.com)
  • These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients. (nature.com)
  • 4 at admission independently predicted patients' functional outcome status at 3 months after aSAH 7 . (nature.com)
  • However, it is unclear whether the CONUT score during hospitalization influences the functional outcomes of aSAH patients. (nature.com)
  • Here, we retrospectively analyzed the relationship between clinical outcomes and the CONUT score in aSAH patients during hospitalization. (nature.com)
  • Traditionally, the Glasgow Coma Scale (GCS) has been widely adopted to document and formally assess neurological status. (springer.com)
  • Nonparametric tests were performed to assess the relationship of patient outcome, MR imaging, and electroencephalography patterns. (ajnr.org)
  • The study was primarily designed to assess the change in the level of neurological impairment in subjects suffering from the symptoms of EHS, from baseline to 90 minutes post-randomization, using the Glasgow Coma Scale ("GCS"), a validated and widely used tool among clinicians. (mhaus.org)
  • The Noorbhai Maharaj (NM) score was used to assess and grade the quality of reporting RESULTS: Each of the five hospitals has different endoscopic reporting systems. (scielo.org.za)
  • The F-test was used to assess the an increasing number of studies that have significance of the relation between GCS looked at non-traumatic coma of different and outcome. (who.int)
  • Outcomes were Serious Adverse Events (SAE), mortality 15 days following injury and in-hospital morbidity assessed by the Glasgow Coma Scale (GCS), the Disability Rating Scale (DRS) and a modified version of the Oxford Handicap Scale (HIREOS). (biomedcentral.com)
  • Our goal was to perform a scoping systematic review on the available literature for FOUR score and outcome prediction in critically ill patients. (springer.com)
  • This will lead to the achievement of the best possible outcomes for critically ill and injured children. (frontiersin.org)
  • These researchers also showed in a prospective observational study of 229 SAH patients that a negative nitrogen balance during the first 14 post-bleed days is a risk factor for infectious complications and is associated with poor outcomes (mRS ≥ 4) at 3 months 11 . (nature.com)
  • Clinical characteristics, in-hospital complications, and outcome at 3 months post-SAH (Glasgow Outcome Scale score) were analyzed with regard to the presence or absence of IVH. (nih.gov)
  • Patients with SAH and IVH differ in demographic and admission characteristics from those with SAH but without IVH and are more likely to suffer in-hospital complications and a worse outcome at 3 months post-SAH. (nih.gov)
  • Study outcomes measures were healing time and secondary outcome measures were complications of surgery RESULTS: One hundred and thirty-three patients (median age 44 and M:F ratio 2.8:1) with 206 fistulae were accrued. (scielo.org.za)
  • Les paramètres cliniques et obstétricales, la prise en charge, les complications et l'évolution maternelle ont été les paramètres étudiés. (bvsalud.org)
  • Outcomes measured included discharge destination and survival. (ajnr.org)
  • Definitive Glasgow acute pain scale for cats: validation and intervention level. (newmetrica.com)
  • Furthermore, females were 1.57 times more likely to experience poor outcomes than males [ 5 ]. (hindawi.com)
  • Malignant electroencephalography patterns are considered predictive of poor outcome in comatose survivors of cardiac arrest. (ajnr.org)
  • We hypothesize that malignant EEG patterns are associated with greater extent of brain injury evident on MR imaging, which would explain the typically poor outcomes within this subset of patients. (ajnr.org)
  • The inflammation, thrombin activation, and erythrocyte lysis caused by primary injury could promote the formation of brain edema, which is associated with poor outcome, and could cause more severe and durable injury [ 3 ]. (karger.com)
  • The outcome of one patient was poor due to the abscess in the basal ganglia region. (biomedcentral.com)
  • The notion that high intracranial pressure (ICP) might be associated with a poor acute-phase outcome of severe cases of encephalitis arose from the historical series of Barnett et al. (biomedcentral.com)
  • If untreated, TBM may have a poor outcome and permanent neurological sequelae, thus requiring rapid diagnosis and treatment. (medscape.com)
  • however, the cardiac arrest literature is confounded by bias arising from a decreased likelihood in the provision of aggressive supportive care when poor outcomes are expected. (biomedcentral.com)
  • 29% cause of coma during the preschool and of the survivors were unimpaired at follow school ages and was accompanied by poor up, 9% of had motor deficits but normal outcome (death or impairment) in more than intellect and 9% had severe intellectual and half of the cases. (who.int)
  • An observational, prospective, patient-outcome study was conducted in five different practice settings on 390 CD patients over 18 months using three outcomes-Glasgow Homeopathic Hospital Outcome Scale (GHHOS), Scoring Atopic Dermatitis (SCORAD), and Dermatology Life Quality Index (DLQI), assessed at baseline, after 3 and 6 months. (thieme-connect.de)
  • The aim of this study was to compare acute outcome between men and women after sustaining a traumatic brain injury (TBI). (hindawi.com)
  • Study outcomes will determine what dose of baclofen is safe to prescribe to those receiving methadone, to inform a subsequent proof-of-concept trial of the efficacy baclofen to facilitate opiate detoxification. (biomedcentral.com)
  • Factors associated with outcomes in organophosphate and carbamate poisoning: a retrospective study. (aaem.pl)
  • The purpose of our study was to investigate whether the operation of a trauma center in a single tertiary general hospital has improved emergency care and clinical outcomes for patients with TBI. (jtraumainj.org)
  • Differences in detailed emergency care time, hospital stay, and clinical outcomes were investigated in this study. (jtraumainj.org)
  • Clinical outcome prediction normally employs static, one-size-fits-all models that perform well for the average patient but are sub-optimal for individual patients with unique characteristics. (plos.org)
  • Our objectives were: 1) to prove that analyzing only similar patients leads to better outcome prediction performance than analyzing all available patients, and 2) to characterize the trade-off between training data size and the degree of similarity between the training data and the index patient for whom prediction is to be made. (plos.org)
  • Patient outcome prediction has been identified as one of the key learning applications of big health care data [ 1 ], and plays important roles in clinical medicine as it is tightly related to intervention selection, care planning, and resource allocation. (plos.org)
  • A logistic regression model was constructed to evaluate the association of the CONUT score with a modified Rankin scale (mRS) ≥ 3 and delayed cerebral ischemia (DCI). (nature.com)
  • The area under the curve (AUC) and Nagelkerke's R2 were used to evaluate the predictive ability of GCS motor score and pupillary reactivity assessed in the field and at admission. (eur.nl)
  • We also found that a patient's GCS score upon admission did not influence outcome. (biomedcentral.com)
  • Few data are available for the most severe cases of HSE, those admitted to intensive care units (ICUs), particularly as concerns their epidemiology, initial management, acute-phase mortality, and long-term outcome. (biomedcentral.com)
  • Outcome predictors of Glasgow Outcome Scale score in patients with severe traumatic brain injury. (bvsalud.org)
  • The differences between the mean levels for GCS, DRS and HIREOS in the Anatibant and placebo groups, when adjusted for baseline GCS, showed a non-significant trend for worse outcomes in all three measures. (biomedcentral.com)
  • A trauma registry was used to identify patients who had a head Abbreviated Injury Scale score of 3 or more, and the records were matched with prehospital databases. (bmj.com)
  • Patient stratification using the prehospital Glasgow Coma Score (GCS) was also used and outcomes included mortality, with good outcome taken as survival to discharge with a GCS of 14/15. (bmj.com)
  • The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury. (bmj.com)
  • A range of respiratory, cardiovascular, and sedative measures including the National Early Warning Score (NEWS2) and Glasgow Coma Scale will determine DLT. (biomedcentral.com)
  • Subjects with malignant electroencephalography patterns, invariably associated with bad outcomes, were observed to have whole-brain apparent diffusion coefficient measures similar to those in subjects with nonmalignant electroencephalography patterns and good outcome and different from those in subjects with nonmalignant electroencephalography patterns and bad outcomes. (ajnr.org)
  • Goal-oriented management of traumatic brain injury (TBI) can save the lives and/or improve the long-term outcome of millions of affected patients worldwide. (nih.gov)
  • The resource-adapted introduction of trauma care protocols, regionalized care and the growth specialized centers for trauma care within each LMIC are key to improved outcomes and the lowering of trauma-related morbidity and mortality globally. (frontiersin.org)
  • Prognostication of survival and functional outcome in comatose survivors of cardiac arrest is challenging. (ajnr.org)
  • TBM is a very critical disease in terms of fatal outcome and permanent sequelae, requiring rapid diagnosis and treatment. (medscape.com)
  • The outcomes and characteristics of acquired thrombotic thrombocytopenic purpura (TTP) in adolescents is poorly understood due to an absence of studies focused on this population. (bvsalud.org)
  • Regression analyses were used to estim- ate associations between derived latent classes, PSAT scores, and Summary respondent characteristics. (cdc.gov)
  • The Glasgow Outcome Score (GOS) is a scale of patients with brain injuries, such as cerebral traumas that groups victims by the objective degree of recovery. (wikipedia.org)
  • Her main interests are in brain hemorrhage, unusual and rare causes of stroke, cerebral venous thrombosis, anticoagulation management after strokes and use of technology for improving outcomes in the neurological ICU. (stanford.edu)
  • Patients intubated with the use of NMBAs were significantly more likely to survive and have a good outcome, when adjusted for confounding variables. (bmj.com)
  • But, all these treatments fail to provide a promising functional outcome or decrease mortality. (karger.com)
  • Additionally, because of the excessive prevalence of TBI in sufferers who noted the emergency departments (ED), this better wide variety of sufferers result in a better paintings load with inside the ED, boom fitness gadget expenditures, and, in spite of a decrease chance of deadly outcomes, can bring about a extensive wide variety of sufferers with long term disability. (alliedacademies.org)