Scleroderma limited. Medical search. Frequent questions

There are two main types, limited disease (CREST syndrome) and diffuse disease. (medlineplus.gov)
Limited scleroderma, sometimes referred to as CREST syndrome, affects the face, hands and feet. (uwhealth.org)
Healthcare providers usually refer to limited scleroderma with the acronym CREST syndrome. (clevelandclinic.org)
Limited scleroderma is sometimes called CREST syndrome. (scleroderma.org)
CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias-although not all are needed for the disorder to be called CREST) is an older term used to describe this subset of limited cutaneous systemic sclerosis. (medscape.com)
People with this type of scleroderma often have CREST syndrome. (adam.com)
CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias) refers to a subset of patients with limited scleroderma. (logicalimages.com)
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibrous skin. (medindia.net)
Scleroderma/CREST syndrome is classified as rheumatic and connective tissue disease. (medindia.net)
CREST syndrome , also known as limited cutaneous systemic sclerosis , is an autoimmune condition, and its name is an acronym that stands for calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias. (osmosis.org)
CREST syndrome , also known as the limited cutaneous form of systemic sclerosis is a multisystem connective tissue disorder. (osmosis.org)
1 Systemic sclerosis is commonly divided into the limited form (formerly termed CREST) or the diffuse form. (skintherapyletter.com)
Scleroderma / CREST syndrome (calcinosis cutis, Raynaud phenomena, esophageal dysfunction, sclerodactyly, and telangiectasia) is the most common overlap syndrome resulting in sclerodermatomyositis. (medpagetoday.com)
I have CREST too, which is now known as Limited Scleroderma. (bcna.org.au)

Scleroderma is more likely to cause serious complications if it affects your ability to breathe or process nutrition. (clevelandclinic.org)
This form of scleroderma can also cause complications like pulmonary arterial hypertension. (home-remedies-for-you.com)
This form of scleroderma develops very slowly, causes few complications, and rarely spreads to other parts of the body. (healthstatus.com)
Other complications caused by systemic scleroderma are cancer, heart and kidney failure, pulmonary hypertension (high blood pressure in the lungs), and malabsorption (difficulty absorbing nutrients from food). (healthstatus.com)
Limited cutaneous systemic sclerosis - distal skin sclerosis, Raynaud phenomenon, frequent severe late-stage complications such as pulmonary hypertension and gastrointestinal involvement. (logicalimages.com)
Scleroderma can attack any part of the body and damage internal organs, eventually leading to severe complications or even death. (dailyadvocate.com)
Treatment for scleroderma is aimed at managing the symptoms and preventing complications. (welovelmc.com)
While there is no cure for scleroderma, early diagnosis and treatment can help manage the symptoms and prevent complications. (welovelmc.com)
and scleroderma renal crisis are the major complications. (msdmanuals.com)
Renal and cardiovascular complications were the leading causes of death.Conclusion: Diffuse systemic sclerosis is a more serious disease than the limited form. (bvsalud.org)

Lungs Some impairment in lung function is almost universally seen in patients with diffuse scleroderma on pulmonary function testing, but it does not necessarily cause symptoms, such as shortness of breath. (wikipedia.org)
Digestive tract Diffuse scleroderma can affect any part of the gastrointestinal tract. (wikipedia.org)
Diffuse scleroderma develops faster and causes more skin thickening. (uwhealth.org)
If you have diffuse scleroderma, you are at higher risk for developing sclerosis. (uwhealth.org)
In diffuse scleroderma , skin thickening occurs more rapidly and involves more skin areas than in limited disease. (scleroderma.org)
In addition, people with diffuse scleroderma have a higher risk of developing "sclerosis" or fibrous hardening of the internal organs. (scleroderma.org)
Although internal problems occur, they are less frequent and tend to be less severe than in diffuse scleroderma and are usually delayed in onset for several years. (scleroderma.org)
However, persons with limited scleroderma, and occasionally those with diffuse scleroderma, can develop pulmonary hypertension, a condition in which the lung's blood vessels become narrow, leading to impaired blood flow through the lungs resulting in shortness of breath. (scleroderma.org)
The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA. (bvsalud.org)

Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. (wikipedia.org)
Localized scleroderma rarely spreads and rarely affects your internal organs. (uwhealth.org)
Systemic scleroderma can lead to the hardening of internal organs (sclerosis). (uwhealth.org)
The internal organs are usually not affected, and persons with localized scleroderma rarely develop systemic scleroderma. (scleroderma.org)
Scleroderma is an aspect of systemic sclerosis , a systemic connective tissue disease that also involves subcutaneous tissue, muscles, and internal organs. (medscape.com)
There are two more versions - morpha and linear scleroderma - which affect the skin and may afflict the internal organs. (home-remedies-for-you.com)
The word scleroderma literally means "hard skin," but the disease is much more than that, often affecting the internal organs with life-threatening consequences. (looktothestars.org)
Scleroderma is a connective tissue disease that is a type of autoimmune disorder causing changes in skin, muscle, blood vessels and internal organs. (healthstatus.com)
Persons only affected with localized scleroderma have a better outlook than persons suffering from systemic scleroderma as the condition is localized to only a small area of the skin on the face and hands and rarely if ever spreads to internal organs. (healthstatus.com)
Scleroderma is a group of diseases that cause skin, and sometimes internal organs, to become hard and tight. (adam.com)
Systemic scleroderma is more serious and affects connective tissue in many parts of your body, including internal organs. (adam.com)
Scleroderma, or progressive systemic sclerosis, is an autoimmune connective tissue disease that involves sclerotic changes of the skin and may involve internal organs. (logicalimages.com)
Scleroderma is a multi-system disease characterized by functional and structural abnormalities of small blood vessels, thickening of the skin and internal organs, and immune system activation. (cohencenters.com)
An autoimmune disease that affects the skin, muscles, blood vessels, and internal organs is known as scleroderma. (growthmarketreports.com)
Limited cutaneous scleroderma: This type of scleroderma affects only the skin on the face, neck, and limbs, and does not usually affect the internal organs. (welovelmc.com)
Diffuse cutaneous scleroderma: This type of scleroderma affects the skin on the face, neck, and limbs, as well as the internal organs, and can progress more rapidly than limited cutaneous scleroderma. (welovelmc.com)
Typically only affecting the skin, localized scleroderma can spread to muscles, bones, and joints, but not to the internal organs. (mountain-ice.com)
The systemic form scleroderma involves the sclerosis (hardening) of internal organs. (drwilderman.com)

Pulmonary arterial hypertension related to scleroderma (PAH-Scl) is associated with high morbidity and mortality as well as poorer response to therapy and worse outcomes compared with the idiopathic form of PAH (IPAH). (nih.gov)
Scleroderma is an autoimmune disease that can affect left and right heart function directly through inflammation and fibrosis and indirectly through systemic and pulmonary hypertension. (nih.gov)
Natural history of mild-moderate pulmonary hypertension and the risk factors for severe pulmonary hypertension in scleroderma. (jrheum.org)
OBJECTIVE: To determine risk factors for developing pulmonary hypertension (PH) in patients with scleroderma (SSc, systemic sclerosis). (jrheum.org)
Risk factors for progression of PH include older age, limited skin disease, and elevated pulmonary artery pressures at the time of initial evaluation. (jrheum.org)
In limited SSc, a significant proportion of patients develop life-threatening pulmonary hypertension. (skintherapyletter.com)
Mortality was similar between the two groups, and similar rates were also seen between the two for severe SSc-related end-organ damage, including pulmonary fibrosis, pulmonary hypertension , and scleroderma renal crisis. (medscape.com)

Because scleroderma can affect your joints, bones, muscles and connective tissue, it is also considered a rheumatic condition. (uwhealth.org)
Joint pain is associated with scleroderma and many other rheumatic diseases. (facty.com)
In the case of scleroderma, this rheumatic autoimmune disease tends to involve the thickening or tightening of the skin and the connective tissue under it, but many other symptoms may be present. (mountain-ice.com)
As we've said, diagnosing scleroderma can be difficult because some of the symptoms are shared with other autoimmune and rheumatic disorders. (mountain-ice.com)
Scleroderma is one of our most challenging rheumatic diseases to treat. (medscape.com)
Scleroderma, or progressive systemic sclerosis (PSS), an autoimmune rheumatic condition affecting the connective tissues , has a profound impact on oral health . (bvsalud.org)

Patients with limited systemic sclerosis have a better prognosis than those with the diffuse form. (wikipedia.org)
Systemic scleroderma is a serious condition, while localized scleroderma carries a good prognosis and normal lifespan. (mountsinai.org)
The aim is to coordinate and focus research activities, in order to improve treatment, quality of life and prognosis of patients with scleroderma. (eustar.org)
Systemic sclerosis (SSc) differs from localized scleroderma in prognosis as well as clinical expression. (skintherapyletter.com)

There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse. (wikipedia.org)
Systemic scleroderma, or sclerosis -- May affect large areas of skin and organs such as the heart, lungs, or kidneys. (medlineplus.gov)
Systemic sclerosis has three subtypes - diffuse, limited and sine sclerosis. (clevelandclinic.org)
Sine sclerosis causes limited sclerosis symptoms, but doesn't affect your skin. (clevelandclinic.org)
Systemic scleroderma is also called systemic sclerosis . (mountsinai.org)
localized scleroderma and systemic sclerosis (SSc). (scleroderma.org)
Systemic scleroderma (systemic sclerosis) may affect the connective tissue in many parts of the body. (scleroderma.org)
Systemic sclerosis is a complex and heterogeneous disease with clinical forms ranging from limited skin involvement (limited cutaneous systemic sclerosis) to forms with diffuse skin sclerosis and severe and often progressive internal organ involvement (diffuse cutaneous systemic sclerosis), and occasionally a fulminant course (fulminant systemic sclerosis). (medscape.com)
Limited cutaneous systemic sclerosis involves areas distal to the elbows and knees but may involve the face and neck. (medscape.com)
In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
There is the limited systemic sclerosis or scleroderma which affects the hands, arms and face. (home-remedies-for-you.com)
The next type is diffuse systemic sclerosis or scleroderma. (home-remedies-for-you.com)
The term includes a variety of diseases, from localized scleroderma (LS) to systemic sclerosis. (hindawi.com)
Another, more serious variant of the disease, is called Systemic scleroderma, or sclerosis, and can affect large areas of the skin as well as other organs such as the heart, lungs, and kidneys. (healthstatus.com)
The European Scleroderma Trials and Research group (EUSTAR) aims to foster the awareness, understanding and research on systemic sclerosis and its management throughout Europe and the rest of the world. (eustar.org)
Systemic sclerosis sine scleroderma - Raynaud phenomenon and systemic involvement without skin sclerosis. (logicalimages.com)
The systemic sclerosis overlap syndrome is characterized by features of one of the scleroderma subsets with those of another autoimmune disease (eg, lupus erythematosus , dermatomyositis , Sjögren syndrome , and/or rheumatoid arthritis ). (logicalimages.com)
Patients with systemic sclerosis, also known as systemic scleroderma, experience a sudden hardening, or fibrosis, of the skin. (medindia.net)
A rare connective tissue autoimmune disorder, systemic sclerosis, also known as scleroderma, is difficult to treat. (medindia.net)
Effective treatment of IPF, systemic sclerosis and localized scleroderma, represents an unmet medical need. (globenewswire.com)
Early diagnosis and individualized therapy can be helpful, but treatment of systemic sclerosis is limited to symptom management. (globenewswire.com)
Scleroderma, also called systemic sclerosis, is an autoimmune disease that produces scars and patches of thick, rough, or scaly skin. (facty.com)
Dobrota et al 1 have analysed the EUSTAR (EULAR Scleroderma Trials and Research) systemic sclerosis (SSc, scleroderma) database using a subset of diffuse cutaneous SSc (dcSSc) to determine predictors of skin improvement over 1 year in randomised trials. (bmj.com)
However, the ASTIS (Autologous hematopoietic stem cell transplantation vs. intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis) trial for stem cell transplantation versus cyclophosphamide had no upper limit of mRSS (inclusion criteria of mRSS of at least 15) and the mean baseline mRSS was 25-26. (bmj.com)
Scleroderma, also known as systemic sclerosis, is a rare autoimmune disorder that causes the skin and connective tissues to harden and thicken. (welovelmc.com)
Scleroderma, also known as systemic sclerosis, is a chronic connective tissue disease characterized by the hardening of skin and connective tissue. (drwilderman.com)
In systemic sclerosis sine scleroderma, patients have systemic sclerosis-related antibodies and visceral manifestations of the disease but no skin tightening. (msdmanuals.com)
Patients with both systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are more likely to be female, Black, and diagnosed with limited cutaneous SSc. (medscape.com)

Linear scleroderma begins as a streak or line of hardened, waxy skin. (uwhealth.org)
There are two main forms of localized scleroderma: morphea and linear scleroderma. (mountsinai.org)
Linear scleroderma causes bands of hard skin across the face or on a single arm or leg. (mountsinai.org)
Linear scleroderma may also involve muscle or bone. (mountsinai.org)
Linear scleroderma is a form of localized scleroderma which frequently starts as a streak or line of hardened, waxy skin on an arm or leg or on the forehead. (scleroderma.org)
Linear scleroderma tends to involve deeper layers of the skin as well as the surface layers, and sometimes affects the motion of the joints, which lie underneath. (scleroderma.org)
Linear scleroderma usually develops in childhood. (scleroderma.org)
Linear scleroderma en coup de sabre (LCsc) is a rare subset of LS. (hindawi.com)
Linear scleroderma is typically diagnosed in childhood and has the potential to affect limb development, so responsive treatment is important. (facty.com)
In 1936, Dillehunt & Chuinard (6) described a case in which a lesion defined as "linear scleroderma" was associated with melorheostosis. (medicaljournals.se)
1) described the clinical and histological features that distinguish the cutaneous changes of LMS from those of linear scleroderma. (medicaljournals.se)
The increased collagen bundles show a normal appearance in LMS, which is distinct from the abnormal appearance noted in linear scleroderma. (medicaljournals.se)
Furthermore, the skin appendages are normal in LMS while they are atrophic in linear scleroderma. (medicaljournals.se)
In addition, hypertrichosis does not usually occur in linear scleroderma. (medicaljournals.se)
linear scleroderma on the face or forehead. (mountain-ice.com)

Widespread scleroderma can occur with other autoimmune diseases, including systemic lupus erythematosus and polymyositis . (medlineplus.gov)
Scleroderma may occur in tangent with other autoimmune diseases such as systemic lupus erythematosus and polymyositis. (healthstatus.com)
This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
There were 24 people with rheumatoid arthritis, one with scleroderma, and one with systemic lupus erythematosus. (cdc.gov)
The prevalence of scleroderma was 0.2% (RR 15.65, 95% CL 0.21-87.03) and the prevalence of systemic lupus erythematosus was 0.2% (RR 11.37, 95% CL 0.15-63.23). (cdc.gov)
Conclusion: Although the association between scleroderma and silicosis has been more widely reported in the literature, the prevalence of rheumatoid arthritis was greater than the prevalence of scleroderma or systemic lupus erythematosus among a cohort of individuals with silicosis. (cdc.gov)
Autoimmune disease overlap - Dermatomyositis can occur in conjunction with systemic lupus erythematosus (SLE), mixed-connective tissue disease, Sjögren syndrome, scleroderma, and rheumatoid arthritis. (medpagetoday.com)

Systemic scleroderma and Raynaud's can cause painful ulcers on the fingers or toes, which are known as digital ulcers. (wikipedia.org)
Local injection with botulinum toxin A (BTX-A) safely and effectively reduces Raynaud's phenomenon (RP) and nailfold small blood vessel, or capillary, abnormalities in women with scleroderma, according to data from a small study in China. (scleroderma.org.au)
Raynaud's phenomenon is one of the most common symptoms of patients with scleroderma. (cohencenters.com)
The report by Scleroderma & Raynaud's UK stated that in 2018 about 19,000 individuals were diagnosed with scleroderma in the UK. (growthmarketreports.com)
This CIB is limited to a discussion of Secondary Raynaud's phenomenon resulting from the use of vibrating hand tools, referred to as vibration syndrome. (cdc.gov)

The limited form affects areas below, but not above, the elbows and knees with or without involvement of the face. (wikipedia.org)
Localized scleroderma (also called morphea) -- Often affects only the skin on the chest, abdomen, or limb but not usually on the hands and face. (medlineplus.gov)
Systemic scleroderma affects your connective tissue and more parts of your body. (uwhealth.org)
Scleroderma usually affects your skin, but can cause symptoms in any tissue throughout your body. (clevelandclinic.org)
Localized scleroderma only affects one part of your body (usually your skin). (clevelandclinic.org)
Localized scleroderma usually affects only the skin on the hands and face. (mountsinai.org)
Rarely, if this type of scleroderma affects children or young adults, it may interfere with growth and cause severe deformities in the arms and legs. (mountsinai.org)
This type of scleroderma affects large portions of the skin and can spread to other organs too. (home-remedies-for-you.com)
This type of scleroderma usually affects both sides of the body, meaning if you have problems with your left arm, you'll have problems with your right arm, too. (adam.com)
Scleroderma is a long-term and rare disease that affects women more than men. (growthmarketreports.com)

The results highlight the need for clinicians to recognize the SSc-SLE overlap syndrome and to watch for scleroderma organ involvement in patients with features of SLE, Raynaud syndrome, anti-U1-RNP antibody positivity, or an isolated nucleolar pattern of antinuclear antibodies. (medscape.com)

Many early scleroderma symptoms are like those of other connective-tissue diseases, such as rheumatoid arthritis, lupus, and polymyositis. (adam.com)
The prevalence of rheumatoid arthritis was 5.2% (relative risk (RR) 2.73, 95% confidence limit (CL) 1.75-4.06). (cdc.gov)
The findings of laboratory evaluation including complete blood count, liver function tests, urinalysis, rheumatoid factor, antinuclear antibody, anti-scl-70 antibody, anti-centromere antibody and anti-mitochondrial antibody were all within normal limits or negative. (medicaljournals.se)
Silica exposure and/or silicosis has also been associated with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, scleroderma, and with glomerulonephritis. (cdc.gov)

As scleroderma progresses, esophageal involvement from abnormalities in decreased motility may worsen due to progressive fibrosis (scarring). (wikipedia.org)
Some laboratory abnormalities commonly seen in systemic scleroderma are frequently absent in the localized form. (scleroderma.org)
Scleroderma is a relatively rare connective tissue disorder characterized by skin fibrosis, obliterative vasculopathy and distinct autoimmune abnormalities. (bvsalud.org)

The survey study, " Barriers to care in juvenile localized and systemic scleroderma: an exploratory survey study of caregivers' perspectives ," was published in the journal Pediatric Rheumatology . (scleroderma.org.au)
There are two types of the disease, localized and systemic scleroderma. (mountain-ice.com)

MUSC's Division of Rheumatology & Immunology is one of the top ranked programs in the country by US News and World Report and an international leader in the field of scleroderma clinical care and research. (globenewswire.com)
Scleroderma has a wide spectrum of clinical manifestations and severity, as well as a variable course. (cohencenters.com)
Ongoing research & development programs and expansion of clinical experiments in the field of scleroderma diagnostics & therapeutics are projected to create lucrative opportunities for market growth. (growthmarketreports.com)
Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)

The cause of scleroderma is unknown. (medlineplus.gov)
The exact cause of scleroderma is not known, but it is thought to be related to an overactive immune system. (welovelmc.com)
Though the exact cause of scleroderma is yet to be determined, the disease itself involves the overproduction of collagen, a protein that binds skin and connective tissue. (drwilderman.com)

These drugs only help alleviate pain and discomfort caused by the symptoms, but there is no cure for scleroderma. (healthstatus.com)
Although there is no cure for scleroderma, medications can reduce symptoms and help individuals lead active lives. (facty.com)

Some people with scleroderma have a history of being around silica dust and polyvinyl chloride, but most do not. (medlineplus.gov)
Most people with scleroderma will develop only mild symptoms. (uwhealth.org)
People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)

Scleroderma is a type of autoimmune disorder . (medlineplus.gov)
Scleroderma is an autoimmune disorder . (clevelandclinic.org)

Scleroderma makes your body produce too much collagen, a protein that you need for healthy skin and tissue. (clevelandclinic.org)
If you have scleroderma, your immune system triggers your body's cells to produce too much collagen (a protein). (clevelandclinic.org)
Scleroderma is a rare disease of unknown etiology, characterized by thickening and hardening of skin resulting from increased collagen production. (hindawi.com)
sufferers of scleroderma will experience a buildup of collagen in the skin and other organs and this is what leads to the symptoms of the disease. (healthstatus.com)
Namely, in scleroderma closely aggregated, coarse collagen bundles occupy the reticular dermis, together with hyalinized collagen bundles that replace the subcutaneous fat (9). (medicaljournals.se)

I had a bilateral mastectomy in 2017 and was also told that radiation was off the table due to interstitial lung disease, from the scleroderma). (bcna.org.au)

About one-third of these patients have systemic scleroderma, the most serious form of the disease. (mountain-ice.com)

Our rheumatologists work with doctors across UW Health to treat the effects of severe scleroderma and other autoimmune diseases. (uwhealth.org)
In some cases, the joints and muscles are affected, resulting in severe pain and limited mobility. (looktothestars.org)
In more severe cases, the disease can affect organs throughout the body - this is known as systemic scleroderma - including the heart, kidneys, and blood vessels. (scleroderma.org.au)
Symptoms range from mild to life-threatening, and in severe cases, scleroderma can damage the blood vessels and organs. (facty.com)
Although most patients have mild to moderate scleroderma, severe forms can injure the lungs, kidneys, and heart. (facty.com)
Severe fatigue is associated with scleroderma and many other chronic illnesses. (facty.com)

Vascular damage due to scleroderma can result in loss of fingers, toes and entire limbs. (looktothestars.org)
White fingers and toes that become numb and painful in response to cold could be an early symptom of systemic scleroderma. (facty.com)

If you have morphea scleroderma, you may have waxy patches of skin that vary in size and shape. (uwhealth.org)
In morphea scleroderma, patches of hard skin form and can last for years. (mountsinai.org)

Some types of scleroderma affect only the skin, while others affect the whole body. (medlineplus.gov)
Experts estimate that all types of scleroderma affect around 250 out of every 1 million people in the U.S. Around 100,000 people in the U.S. have systemic scleroderma. (clevelandclinic.org)

Caregivers of children with juvenile scleroderma cited a lack of knowledge about the rare disease within the medical community as the primary barrier to a proper diagnosis and treatment, according to a new survey study. (scleroderma.org.au)

Scleroderma can cause small blood vessels in the kidneys to become narrowed. (medlineplus.gov)
Despite the name, limited scleroderma may narrow the blood vessels of the lungs and lead to lung scarring, which can cause shortness of breath. (facty.com)

Scleroderma is a disease that involves the buildup of fibrous tissue in the skin and elsewhere in the body. (medlineplus.gov)

Methods: This was a prospective study of all the cases of scleroderma seen between January 2012 and June 2015 at the Rheumatology Clinic of the Olabisi Onabanjo University Teaching Hospital. (bvsalud.org)

For some patients, this hardening occurs only in limited areas, but for others, it quickly spreads across the body and to organs such as the heart, intestines and kidneys. (medindia.net)

There is no specific treatment for scleroderma. (medlineplus.gov)

Localized scleroderma occurs most commonly in children, while systemic scleroderma is more common in adults. (drwilderman.com)

The most common scleroderma symptom is having patches or streaks of thickened, waxy skin. (clevelandclinic.org)

Localized Scleroderma The changes, which occur in localized scleroderma, are usually found in only a few places on the skin or muscles, and rarely spread elsewhere. (scleroderma.org)

Several studies have demonstrated a reduction of new skin ulcers and accelerated healing of nondigital ulcers for certain scleroderma patients after taking Bosentan. (mountsinai.org)
The drug was approved in Europe in 2007 for the treatment of skin ulcers related to scleroderma. (mountsinai.org)

Scleroderma is classified into several subsets defined by the degree of clinically involved skin. (cohencenters.com)

Morphea is a form of localized scleroderma characterized by waxy patches on the skin of varying sizes, shapes and color. (scleroderma.org)

Musculoskeletal The first joint symptoms that patients with scleroderma have are typically nonspecific joint pains, which can lead to arthritis, or cause discomfort in tendons or muscles. (wikipedia.org)

Living with scleroderma is difficult, as there is no drug that has been shown to stop or reverse the hardening and thickening of skin, the major symptom of the disease. (mountain-ice.com)
Though scleroderma manifests differently among patients, the most prominent symptom is hardening of the skin. (drwilderman.com)

The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. (medscape.com)

EUSTAR is an international scleroderma research network acting under the umbrella of the World Scleroderma Foundation . (eustar.org)

Sometimes it forms a long crease on the head or neck, referred to as en coup de sabre because it resembles a saber or sword wound. (scleroderma.org)
In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. (hindawi.com)

Anatomy9

Diseases31

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care1

Geographicals1

CREST14

Complications10

Diffuse scleroderma9

Internal organs18

Pulmonary7

Rheumatic6

Prognosis4

Sclerosis28

Linear Scleroderma15

Systemic lupus erythem7

Raynaud's5

Affects10

Raynaud1

Rheumatoid4

Abnormalities3

Localized and systemic scleroderma2

Clinical4

Cause of scleroderma3

Cure for scleroderma2

People with scleroderma3

Autoimmune disorder2

Collagen5

Interstitial lung di1

Patients have systemic1

Severe6

Toes2

Morphea scleroderma2

Types of scleroderma affect2

Diagnosis and Treatment1

Blood vessels2

Fibrous1

Rheumatology1

Kidneys1

Treatment for scleroderma1

Occurs1

Streaks1

Rarely1

Skin ulcers2

Subsets1

Waxy patches1

Typically nonspecific1

Symptom2

Term scleroderma1

International Scleroderma1

Coup de sabre2