• IBEC researcher Zaida Álvarez and UB researcher Alberto Ortega have produced the first highly mature neurons grown in the lab from pluripotent stem cells using a synthetic matrix. (ibecbarcelona.eu)
  • Researchers working with induced pluripotent stem cells (iPSCs) gain an unprecedented understanding of human biology and disease. (the-scientist.com)
  • In this virtual symposium brought to you by The Scientist , a panel of experts will present how they model a variety of neurological disorders with induced pluripotent stem cells (iPSCs) in 2D and 3D cell culture. (the-scientist.com)
  • The main areas of study include pluripotent and neural stem cells, as well as epidermal stem cells. (wikipedia.org)
  • Drs. John B. Gurdon, Irving L. Weissman, and Shinya Yamanaka have been pioneers in studying stem cells and the reprogramming of highly differentiated adult cells into pluripotent cells capable of directing differentiation from a single cell to an adult animal. (brandeis.edu)
  • The awards will be given March 26 in a private reception, following a free public symposium entitled "Generation of Pluripotent Stem Cells. (brandeis.edu)
  • He called these 'induced pluripotent stem cells' (iPS cells) for their ability to differentiate into any of the body's cell types. (nature.com)
  • The era of induced pluripotent stem (iPS) cell has empowered the stem cell research field on a scale never before seen. (sciencewatch.com)
  • Our paper builds on the findings made in Dr. Yamanaka's laboratory that skin cells can be turned into stem cells (induced Pluripotent Stem or iPS cells). (sciencewatch.com)
  • The team from the RIKEN Research Centre for Allergy and Immunology said they had created cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS) - those which have been artificially extracted from adult cells. (scotsman.com)
  • NEI just received FDA approval to begin the first-ever trial using tissue derived from patient-derived human induced pluripotent stem cells (hIPSCs), reprogrammed adult cells that can be converted into other cell types. (nih.gov)
  • Researchers produced pluripotent stem cells from the fibroblast cells in the brain lining of human corpses. (livescience.com)
  • Mature cells can be made or induced to become immature cells, known as pluripotent stem cells , which have the ability to become any tissue in the body and potentially can replace cells destroyed by disease or injury. (livescience.com)
  • Cadaver-collected fibroblasts can be reprogrammed into induced pluripotent stem cells using chemicals known as growth factors that are linked with stem cell activity. (livescience.com)
  • Now scientists have taken fibroblasts from the scalps and the brain linings of 146 human brain donors and grown induced pluripotent stem cells from them as well. (livescience.com)
  • Successfully reprogramming induced pluripotent stem cells so they behave like the cells they are meant to replace means that samples of the mimicked cells must be present for comparison. (livescience.com)
  • Studying how induced pluripotent stem cells develop into various tissues could also shed light on disorders that are due to malfunctions in development. (livescience.com)
  • Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
  • The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3-D printing to produce a grid-like 3-D structure to grow embryoid body that demonstrated cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy. (phys.org)
  • The researchers say this unexpected discovery could have important implications because the stem cells remain alive inside the tooth for a short time after it falls out of a child's mouth, suggesting the cells could be readily harvested for research. (scienceblog.com)
  • The identification of a common pathway runs counter to widespread belief among some researchers in the taste field who have long held the view that the different tastes require distinct machinery within the cell to transduce their signals to the brain, which is responsible for processing taste perceptions. (scienceblog.com)
  • Researchers funded by the National Institutes of Health have discovered how an embryo initially attaches to the wall of the uterus?what appears to be one of the earliest steps needed to establish a successful pregnancy. (scienceblog.com)
  • The collaboration gives U.S. researchers a way to overcome funding restrictions imposed by the Bush administration and participate in stem cell research. (voanews.com)
  • The project, called the World Stem Cell Hub, is headquartered at Seoul National University, where researchers led by Hwang Woo-Suk have been in the vanguard of stem cell research. (voanews.com)
  • South Korean researchers would travel regularly to the labs to perform the complex task of creating embryos outside the womb and extracting new stem cell lines American, British, and other scientists could use for experiments on cures. (voanews.com)
  • The learning and physical disabilities that affect people with Down syndrome may be due at least in part to defective stem cell regulation throughout the body, according to researchers. (sciencedaily.com)
  • The defects in stem cell growth and self-renewal observed by the researchers can be alleviated by reducing the expression of just one gene on chromosome 21, they found. (sciencedaily.com)
  • The researchers conducted their studies in both mouse and human cells. (sciencedaily.com)
  • And Michael M. Gottesman, the NIH's deputy director for intramural research, said researchers at the agency's headquarters in the Washington suburb of Bethesda could resume work involving embryonic stem cells, though he suggested "prudence" in carrying out such activities given the still-tenuous legal situation, Nature reported. (chronicle.com)
  • By semi-automating tissue differentiation, researchers from the Moscow Institute of Physics and Technology (MIPT) and Harvard have made the process nearly four times faster, without compromising on quality. (labmanager.com)
  • The researchers compared the quality of the robot- and human-grown cells by producing several thousand retinal tissue samples for automatic processing and the same amount for manual handling. (labmanager.com)
  • The approach reduced the time researchers needed for cell processing from two hours to just 34 minutes. (labmanager.com)
  • Starting with stem cells, the researchers turned them into types of cells that make up a human embryo, from placenta to fetus. (yahoo.com)
  • But Takashi Shinohara, a reproductive biologist at Kyoto University in Japan, is among researchers who have doubts about the work: he notes that scientists have struggled to replicate several previous claims that sperm can be made in a dish. (scientificamerican.com)
  • Researchers at the University of Southern California found genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are permanently silenced in cancers. (sciencedaily.com)
  • Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development. (sciencedaily.com)
  • Finding that a Polycomb target in an embryonic stem cell is 12 times more likely to become abnormally methylated in cancer is highly significant," says Peter Laird, Ph.D., one of the lead researchers and associate professor of surgery, biochemistry and molecular biology, and director of basic research for surgery at the Keck School of Medicine of USC. (sciencedaily.com)
  • June 30, 2022 Researchers have created artificial Hox genes -- which plan and direct where cells go to develop tissues or organs -- using new synthetic DNA technology and genomic engineering in stem cells. (sciencedaily.com)
  • Japanese researchers keen to get hold of iPS cells can apply to the BioResource Center at the Institute of Physical and Chemical Research (RIKEN) in Tsukuba, north of Tokyo, which will start distributing mouse iPS cells from previous work by Yamanaka in March. (nature.com)
  • Nishikawa has already been in touch with organizers of a stem-cell consortium in China, and hopes that researchers everywhere, especially in the Asia-Pacific region, will be able to work together. (nature.com)
  • Researchers and scientists at the University College London Great Ormond Street Institute of Child Health (UCL GOS ICH) have developed a pair of human eyes to easily study and understand a rare genetic disorder called Usher syndrome. (com.pk)
  • A multidisciplinary team led by researchers at the Schepens Eye Research Institute of Mass Eye and Ear has identified a promising new strategy for glaucoma cell replacement therapy. (nih.gov)
  • Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers. (stowers.org)
  • THE prospect of a major breakthrough in cancer treatment was announced by researchers yesterday who said they had created stem cells capable of killing diseased cancer cells for the first time. (scotsman.com)
  • The researchers, whose work is reported in the journal Cell Stem Cell , said previous research had shown that producing such cells in a laboratory using conventional methods had been inefficient in killing cancer cells, mainly because of their short lifespan. (scotsman.com)
  • And as the researchers haven't shown that these reprogrammed T cells can actually kill cancer cells in animals or humans, more research is needed to find out whether this approach will be safe and effective for treating -patients. (scotsman.com)
  • A bill approved by the Senate yesterday to spur stem cell research would go a long way toward removing restrictions that have slowed progress, burdened laboratories with red tape, reduced American competitiveness and discouraged young researchers from entering the field, several leading stem cell scientists said. (consumerwatchdog.org)
  • Researchers have created synthetic human embryos using stem cells, according to media reports . (lifeboat.com)
  • Editas Medicine, a biotech company building on work by NEI researchers is conducting the first-in-human CRISPR trial to help patients with vision loss caused by a mutation in CEP290, another crucial gene in the eye, which was also discovered by NEI scientists. (nih.gov)
  • These grants provide substantial support to a pool of very distinguished researchers in human embryonic stem cell research," declared Zach W. Hall, Ph.D., CIRM's President and Chief Scientific Officer. (ca.gov)
  • As such, this work could help lead to novel stem cell therapies and shed light on a variety of mental disorders, such as schizophrenia , autism and bipolar disorder, which may stem from problems with development, researchers say. (livescience.com)
  • Such "guidelines" will ensure that stem cell researchers are not treated poorly as was Hwang when he was eventually found guilty of falsifying his data. (lifeissues.net)
  • He developed the chromosome conformation capture technologies, biochemical techniques for determining how DNA segments interact and are linked to one another, which are the heart of the "3C," "5C," "Hi-C" and "Micro-C" tools used by researchers worldwide to map the structure and organization of chromosomes inside cells. (umassmed.edu)
  • Researchers are conducting the first-in-human trial of a universal influenza vaccine candidate, the National Institutes of Health (NIH) announced April 3. (medscape.com)
  • By focusing on the HA stem, the researchers believe the new vaccine candidate could provide wider and longer-lasting immunity. (medscape.com)
  • To create the vaccine candidate, researchers used the stem of an H1N1 influenza virus. (medscape.com)
  • Dr. Rudnicki is the Scientific Director of Canada's Stem Cell Network and a Senior Scientist at OHRI and Director of OHRI's Sprott Centre for Stem Cell Research, as well as a Professor of Medicine at the University of Ottawa. (medicalxpress.com)
  • This project was funded by the Canadian Institutes of Health Research, the Muscular Dystrophy Association, the National Institutes of Health, the Howard Hughes Medical Institute, Canada's Stem Cell Network and the Canada Research Chairs Program. (disabled-world.com)
  • Scientists at the National Institutes of Health (NIH) report that newly formed brain cells in the mouse olfactory system - the area that processes smells - play a critical role in maintaining proper connections. (nih.gov)
  • Twenty-five percent of this research was funded by federal grants from the National Institutes of Health (R00NS089013, R56AG064077). (eurekalert.org)
  • The new appeals-court action was especially welcome to stem-cell scientists because Judge Lamberth's injunction had prevented the National Institutes of Health from distributing millions of dollars in research money at a time, near the end of the federal fiscal year on September 30, when the NIH often awards many of its grants, said Anthony J. Mazzaschi, senior director for scientific affairs at the Association of American Medical Colleges. (chronicle.com)
  • This work was supported by grants from the European Union and from the FWF Austrian Science Fund awarded to Dr. Martin Widschwendter and by a National Institutes of Health grant awarded to Laird. (sciencedaily.com)
  • Scientists believed that stem cell differentiation was controlled by multiple, highly specific and complex chemical systems, each capable of producing only a limited variety of cells. (rejuvalife.md)
  • Prior to this discovery, controlling stem cell differentiation often involved direct genetic modification of the cell, which came with a significant risk of the cell becoming cancerous. (rejuvalife.md)
  • Key advances in stem cell science at the centre include the elucidation of the role of the nanog protein in pluripotency and work on inhibiting cellular differentiation. (wikipedia.org)
  • This involves placing stem cell clusters into a special medium that induces the spontaneous formation of undeveloped neurons, followed by their differentiation into retinal cells. (labmanager.com)
  • We implemented automated liquid change during retinal differentiation and showed it had no negative effect on cell specialization," commented Evgenii Kegeles of the Genome Engineering Lab at MIPT. (labmanager.com)
  • One of our goals in this research has been to scale up cell differentiation to enable a high-throughput tissue production for drug tests and cell transplantation experiments. (labmanager.com)
  • The ICOC has approved a very well-balanced portfolio of research proposals, including those aimed at understanding stem cell differentiation and identifying new ways of obtaining hESCs, and many that target specific diseases," Hall said. (ca.gov)
  • The 2024 edition of the Stem Cell Stars seminar series will explore diverse topics from the dynamic processes of cell differentiation to the latest advances in stem cell engineering. (lu.se)
  • Dr. Irving L. Weissman is professor of pathology and developmental biology at the Stanford University School of Medicine , where he is director of the Institute of Stem Cell Biology and Regenerative Medicine. (brandeis.edu)
  • Flies have the potential to provide many insights into how to promote the regeneration of sensory hearing cells," said Bonaguidi, who is an assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine of USC. (eurekalert.org)
  • It is a natural evolution," says S Ramaswamy, former CEO of C-Camp and professor at the Institute for Stem Cell Biology and Regenerative Medicine ( InStem ). (indiatimes.com)
  • Findings from the USC study also can be applied to stem cell research funded by the California Institute for Regenerative Medicine (CIRM), which was created through passage of California Proposition 71 in 2004. (sciencedaily.com)
  • The health ministry will add close to ¥100 million in the 2008 fiscal year directly to Yamanaka, in addition to ¥410 million for regenerative medicine infrastructure, such as a cell-processing centre. (nature.com)
  • Chris Mason, professor of Regenerative Medicine Bioprocessing at University College London, said: "For the next decade, the role of iPS cells in therapy is more likely to be in the fight against cancer than for permanent implantation to regenerate tissues and organs. (scotsman.com)
  • The 29-member Independent Citizens Oversight Committee (ICOC), governing board of the California Institute for Regenerative Medicine (CIRM), today approved 29 Comprehensive Research Grants for approximately $74.6 million over four years, to accomplished stem cell investigators at academic and non-profit research centers throughout the state. (ca.gov)
  • Like Gulliver, the California Institute for Regenerative Medicine, has been pinned down by countless pygmies equipped with lawsuits. (bioedge.org)
  • A new seminar series featuring some of the brightest minds in stem cell science and regenerative medicine from around the world. (lu.se)
  • The results are super-exciting and important," says Jacob Hanna, a stem-cell scientist at the Weizmann Institute of Science in Rehovot, Israel. (scientificamerican.com)
  • The function of these neuroprogenitor cells remains an intense area of research. (nih.gov)
  • Although still in its early phases, stem cell research is producing some of the most promising advances in modern medicine, and the potential it may have for disease treatment in the future is simply astonishing. (rejuvalife.md)
  • A research team from the Genome Institute of Singapore, in collaboration with the Cancer Science Institute of Singapore, discovered that the type of cell that a stem cell will eventually turn into is actually controlled by a single communication system. (rejuvalife.md)
  • The Wellcome - MRC Cambridge Stem Cell Institute at the University of Cambridge is a research centre for the nature and potential medical uses of stem cells. (wikipedia.org)
  • The work, supported by the National Institute of Dental and Craniofacial Research, has been made freely available online. (scienceblog.com)
  • New research from Sydney's Garvan Institute might be able to stop it. (thenakedscientists.com)
  • The South Korean government has established an international stem cell research program with scientists in the United States and Britain. (voanews.com)
  • According to the English-language newspaper South Korea Herald , the Ministry of Health and Welfare says the new World Stem Cell Hub combines South Korean expertise in stem cell research with broader U.S. and European knowledge of diseases. (voanews.com)
  • U.S. stem cell research has lagged because of Bush administration funding restrictions. (voanews.com)
  • The government, the country's largest source of research grants, provides money only for study on stem cells obtained before August, 2001, when President Bush announced this restriction. (voanews.com)
  • I applaud what they are doing, but I regret that the United States is falling farther behind in world leadership in scientific research generally and specifically on stem cell research,' said Mr. Specter. (voanews.com)
  • News reports quote South Korean President Roh Moo-hyun as saying that his government will try to resolve the ethical issues surrounding stem cell research so that the scientists can continue their work. (voanews.com)
  • The 2009 Rosenstiel Award for Distinguished Work in Basic Medical Science will be awarded to three pioneers in stem cell research. (brandeis.edu)
  • Medals are presented annually at Brandeis University on the basis of recommendations of a panel of outstanding scientists selected by the Rosenstiel Basic Medical Sciences Research Center. (brandeis.edu)
  • Awards are given to scientists for recent discoveries of particular originality and importance to basic medical research. (brandeis.edu)
  • Clarke's past research has focused on how normal stem cells and cancer stem cells regenerate themselves, and Adorno was searching for genes that could inhibit a specific molecular pathway involved in the self-renewal of these cells. (sciencedaily.com)
  • Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
  • Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
  • Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa have discovered a powerful new way to stimulate muscle regeneration, paving the way for new treatments for debilitating conditions such as muscular dystrophy. (medicalxpress.com)
  • The research, to be published in the June 5 issue of Cell Stem Cell , shows for the first time that a protein called Wnt7a increases the number of stem cells in muscle tissue , leading to accelerated growth and repair of skeletal muscle. (medicalxpress.com)
  • The federal government can continue to finance embryonic-stem-cell research, temporarily, because a federal appeals court on Thursday lifted an injunction that had blocked such work. (chronicle.com)
  • The move added to optimism about eventual victory for university scientists who use this research in a search for cures for a range of devastating diseases. (chronicle.com)
  • During that trial, Judge Lamberth will hear a full set of arguments over the legality of the Obama administration's policy of expanded federal support for embryonic-stem-cell research. (chronicle.com)
  • An NIH spokeswoman, Marin P. Allen, declined to say whether the agency would restart research involving embryonic stem cells at its own laboratory facilities or resume awarding grants for such research by outside scientists. (chronicle.com)
  • Ms. Allen, however, cited a report by the journal Nature quoting Sally J. Rockey, the NIH's deputy director for extramural research, as saying that 24 existing grants due for annual renewal this month "should be fast-tracked, as should new human-embryonic-stem-cell grants competing to get funded a first time. (chronicle.com)
  • While these approaches target different diseases and employ different mechanisms and methodologies, one thing is universally true: Their development requires massive amounts of retinal cells for research purposes. (labmanager.com)
  • Numbers matter: The automation empowered us to produce trillions of retinal neurons for transplantation and we are excited to see the translation of our approach into routine cell manufacture," commented Petr Baranov from the Schepens Eye Research Institute of Massachusetts Eye and Ear. (labmanager.com)
  • Since our research shows that cancer is rooted in stem cells, it would be very important to screen for the epigenetic abnormalities that we uncovered, so as to prevent people from receiving potentially cancer-prone cells. (sciencedaily.com)
  • Research funded by the National Eye Institute suggests that low density of pigment in the macula, the region of the retina required for sharp central vision, is associated with thinning of the retina and may serve as an early warning sign of glaucoma. (nih.gov)
  • Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. (stowers.org)
  • My laboratory has a long history in the field of developmental biology, genetics, and stem cell research. (sciencewatch.com)
  • The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the University's Faculties of Medicine and Health Sciences. (disabled-world.com)
  • Cancer charities and experts gave the research a cautious welcome, but said a similar treatment method - adoptive T cell therapy - was further advanced. (scotsman.com)
  • Dr Emma Smith , Cancer Research UK's senior science information officer, said: "Boosting the body's own immune system to attack cancers is an exciting field and this new research shows how scientists are making progress. (scotsman.com)
  • Professor Sir John Burn, of the Institute of Genetic Medicine at Newcastle University, said: "This is a very appealing concept and the research team are to be congratulated on demonstrating the feasibility of expanding these killer cells using iPS techniques. (scotsman.com)
  • The legislation would end a policy put in place by Mr. Bush that restricts federal financing for human embryonic stem cell research only to cell lines, or colonies, that were derived on or before Aug. 9, 2001, the day the policy was announced. (consumerwatchdog.org)
  • And over time some of the cells have accumulated genetic abnormalities that make them more difficult to use even for basic research. (consumerwatchdog.org)
  • Scientists are tenacious and resourceful, so we figure out ways to get our work done regardless," said Dr. Evan Snyder, professor and director of the stem cell program at the Burnham Institute for Medical Research in San Diego. (consumerwatchdog.org)
  • This development , widely described as a breakthrough that could help scientists learn more about human development and genetic disorders, was revealed this week in Boston at the annual meeting of the International Society for Stem Cell Research. (lifeboat.com)
  • The research, announced by Professor Magdalena Żernicka-Goetz of the University of Cambridge and the California Institute of Technology, has not yet been published in a peer-reviewed journal. (lifeboat.com)
  • One avenue of research the scientists are currently exploring is to study how the immune system interacts with bowel cancer. (qub.ac.uk)
  • The purpose of this initiative, led by the National Institute of Nursing Research, is to support intervention research that addresses structural inequities and reduces disparities in severe maternal morbidity and maternal mortality. (nih.gov)
  • AGI has launched three key research consortia, to image individual cells in the eye as they respond to light, to identify factors that control cell regeneration in the visual system, and to develop animal models to test regenerative therapies. (nih.gov)
  • LOS ANGELES, March 16, 2007 - Just a month after approving nearly $45 million for embryonic stem cell research, California's stem cell agency authorized another $75.7 million in additional funds for established scientists at 12 non-profit and academic institutions. (ca.gov)
  • With these new grants, California is continuing on the path of turning the hope and promise of stem cell research into the reality of therapies and cures for millions of Californians and people across the globe. (ca.gov)
  • The California spirit - the perseverance, creativity and resourcefulness that has made us a leader on everything from gold mining in the 19th Century to fighting global warming in this one - is fully present in our stem cell research teams. (ca.gov)
  • As of today, California is the largest and most stable source of funding for human embryonic stem cell research in the world," Klein said. (ca.gov)
  • Combined with our training and SEED grants, the CIRM is now funding embryonic stem cell research in more than 100 California laboratories. (ca.gov)
  • We focused our initial grants on human embryonic stem cells specifically," Klein said, "because human embryonic stem cell research receives minimal funding from the federal government, and even those funds are restricted to lines of questionable value. (ca.gov)
  • Going forward, we will support a diverse range of stem cell research projects. (ca.gov)
  • The lengthy delay in launching its ambitious US$3 billion research program, with a focus on embryonic stem cells, appears to be taking its toll. (bioedge.org)
  • Such is the fate of two entire fields of academia intertwined in the current issue of human embryonic stem cell research. (lifeissues.net)
  • See Irving, "Human Embryonic Stem Cell Research: Are official positions based on scientific fraud? (lifeissues.net)
  • AREAS COVERED: Major aims of the VCSCC are to support research on cancer stem cells (CSC) in hematopoietic malignancies and to translate CSC-related markers and targets into clinical application. (bvsalud.org)
  • A primary focus of research in the VCSCC is the leukemic stem cell (LSC). (bvsalud.org)
  • Between 2013 and 2021, members of the VCSCC established a special research program on myeloproliferative neoplasms and since 2008, members of the VCSCC run the Ludwig Boltzmann Institute for Hematology and Oncology. (bvsalud.org)
  • Senior Scientist and Canada Research Chair, Princess Margaret Cancer Centre, University Health Network. (lu.se)
  • Co-Director, Translational Research Initiative in Leukemia, Ontario Institute for Cancer Research. (lu.se)
  • The Gene Therapy Resource Program: A Decade of Dedication to Translational Research by the National Heart, Lung, and Blood Institute. (cdc.gov)
  • This phase 1 clinical trial is the culmination of years of research and development made possible by the unique collaborative setting that the VRC offers by bringing together top scientists, manufacturing expertise, and an outstanding clinical team," VRC Director John Mascola, MD, said in the news release. (medscape.com)
  • Dr. Hodes (pronounced "HODE-es") has been the Director of the NIH National Institute on Aging (NIA) since 1993, where he oversees research on all aspects of the aging process. (medlineplus.gov)
  • To pursue these research questions we have established long-term close collaborations both nationally (Swedish Winter Sports Research Centre, Östersund, Sweden) and internationally (Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany and the Broad Institute of Harvard and MIT, Boston, US). (lu.se)
  • There are a number of California institutions that have strong programs in adult and other stem cells, for example, that are just beginning to build embryonic stem cell capabilities. (ca.gov)
  • For decades, scientists thought that neurons in the brain were born only during the early development period and could not be replenished. (nih.gov)
  • More recently, however, they discovered cells with the ability to divide and turn into new neurons in specific brain regions. (nih.gov)
  • Dr. Belluscio, who studies the olfactory system, teamed up with Heather Cameron, Ph.D., a neurogenesis researcher at the NIH's National Institute of Mental Health, to better understand how the continuous addition of new neurons influences the circuit organization of the olfactory bulb. (nih.gov)
  • Using two types of specially engineered mice, they were able to specifically target and eliminate the stem cells that give rise to these new neurons in adults, while leaving other olfactory bulb cells intact. (nih.gov)
  • Until now, neurons obtained from stem cells were insufficiently mature. (ibecbarcelona.eu)
  • image: In the fly, the sensory hearing cells are neurons located in a segment of their antennae known as the Johnston's Organ, or JO. (eurekalert.org)
  • The scientists were able to label, trace and view newborn JO neurons in live flies under microscopes. (eurekalert.org)
  • Instead, they observed JO neurons proliferate and produce more of themselves--although this doesn't rule out the potential for other types of cells to also produce JO neurons. (eurekalert.org)
  • In flies given the chemotherapy drug cisplatin, which is known to kill sensory hearing cells, JO neurons compensated for the damage by proliferating even more. (eurekalert.org)
  • The scientists also observed the JO neurons developing hair-like extensions known as cilia, and extending long nerve fibers called axons into hearing- and balance-related circuits in the brain. (eurekalert.org)
  • In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
  • This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. (dkfz.de)
  • When the scientists switched off Tlx, there were no more detectable stem cells in the brain and the formation of new neurons ceased. (dkfz.de)
  • Here, the stem cells are shown expressing various markers and differentiating into neurons. (livescience.com)
  • Reprogrammed cells could then develop into a multitude of cell types, including the neurons found in the brain and spinal cord. (livescience.com)
  • There appear to be defects in the stem cells in all the tissues that we tested, including the brain," said Michael Clarke, MD, Stanford's Karel H. and Avice N. Beekhuis Professor in Cancer Biology. (sciencedaily.com)
  • We've entered what can be considered the third phase of the human genome project," said Job Dekker, PhD, Howard Hughes Medical Institute Investigator , professor of biochemistry & molecular pharmacology and co-director of the Program in Systems Biology. (umassmed.edu)
  • Experiments with iPSCs are especially illuminating in studies of the brain, where they provide scientists access to this intractable region so that they can model and develop therapies for psychiatric disorders, neurodegeneration, brain development, and infectious diseases. (the-scientist.com)
  • His demonstration that the expression of four master regulatory genes was sufficient to cause the reprogramming of adult cells has opened up many possibilities for human stem cell therapies. (brandeis.edu)
  • However, his method was not suitable for actual human therapies, as it used viruses to deliver the reprogramming factors needed to make iPS cells. (sciencewatch.com)
  • These insights will be crucial for developing efficient and safe cell-based therapies in the future. (sciencewatch.com)
  • Cells from corpses might play a key role in developing future stem cell therapies . (livescience.com)
  • This is a surprising new role for brain stem cells and changes the way we view them," said Leonardo Belluscio, Ph.D., a scientist at NIH's National Institute of Neurological Disorders and Stroke (NINDS) and lead author of the study. (nih.gov)
  • The NIH's National Institute of Allergy and Infectious Diseases (NIAID) hopes to develop a vaccine that will overcome the challenges associated with seasonal changes among influenza strains. (medscape.com)
  • His team was the first to clone human embryos for their stem cells last year. (voanews.com)
  • Stem cells are the basic, undifferentiated cells in embryos that can develop into any kind of tissue. (voanews.com)
  • Embryos are destroyed when embryonic stem cells are taken from them. (chronicle.com)
  • Scientists aren't aiming to put any of these pseudo-embryos into humans, the BBC reported . (yahoo.com)
  • Federal financing would still be restricted to stem cell lines derived from embryos that were slated to be discarded by in vitro fertilization clinics. (consumerwatchdog.org)
  • But creating the stem cells now involves the destruction of human embryos, which some people, including Mr. Bush, say is immoral. (consumerwatchdog.org)
  • Even under the new legislation, scientists said, they could still not use federal money to create new cell lines if it involved the destruction of embryos. (consumerwatchdog.org)
  • Scientists have created synthetic human embryos. (lifeboat.com)
  • Remarkably, these embryos have reportedly been created from embryonic stem cells, meaning they do not require sperm and ova. (lifeboat.com)
  • But Żernicka-Goetz told the meeting these human-like embryos had been made by reprogramming human embryonic stem cells . (lifeboat.com)
  • Chinese scientists have successfully created chimeric embryos containing a combination of human and pig cells. (bioedge.org)
  • A virtual consortium whose members will be able to share iPS cell information and materials without going through time-consuming material-transfer agreements is planned for the Kyoto University centre. (nature.com)
  • Dr. Kian Leong Lee, who led the study, says this finding "paves the way for advanced studies in cell regeneration and tissue repair, which could ultimately lead to its use in personalized medicine, where stem cells from the same patient could be manipulated to make other types of cells that are genetically matched to the donor. (rejuvalife.md)
  • The fact that people with Down syndrome have three copies of chromosome 21 and the Usp16 gene "accelerates the rate at which stem cells are used during early development, which likely exhausts stem cell pools and impairs tissue regeneration in adults with Down syndrome. (sciencedaily.com)
  • Dr. Rudnicki's team found that the Wnt7a protein, when introduced into mouse muscle tissue, significantly increased the population of these satellite stem cells and fueled the regeneration process, creating bigger and stronger muscles. (medicalxpress.com)
  • It would make a major impact, but there wouldn't likely be a windfall of funding in this area," said Dr. Arnold Kriegstein, director of the Institute for Regeneration Medicine at the University of California, San Francisco. (consumerwatchdog.org)
  • About 650 publications in the fields of neuroanatomy, neuronal regeneration, cell transplantation and repair in the central nervous system. (lu.se)
  • His laboratory has also identified human stem cells including human leukemia stem cells that have helped to form the concept of cancer stem cells. (brandeis.edu)
  • Adorno and colleagues in the laboratory of co-author Samuel Cheshier, MD, assistant professor of neurosurgery, found that the presence of excess Usp16 caused skin cells from unaffected people to grow more slowly. (sciencedaily.com)
  • Furthermore, neural progenitor cells (those self-renewing cellular factories responsible for the development and maintenance of many of the cell types in the brain) were less able to form balls of cells called neurospheres -- a laboratory test that reflects the number and robustness of nerve stem cells in a culture. (sciencedaily.com)
  • They report that they have been able to grow miniature eyes in the laboratory from stem cells. (com.pk)
  • The technique to produce iPS cells was first discovered in Shinya Yamanaka's laboratory in Japan. (sciencewatch.com)
  • We were the first and, until now, the only laboratory to establish new lines of human embryonic stem cells in Canada. (sciencewatch.com)
  • They are behaving bizarrely," Dr. George Q. Daley, associate professor at Harvard and Children's Hospital Boston, said of one of the cell lines his laboratory had been nurturing for five years. (consumerwatchdog.org)
  • A new breakthrough in understanding how stem cells differentiate may be one of the most significant contributions toward advancing this field in years. (rejuvalife.md)
  • Satellite stem cells are specialized muscle stem cells that live in adult skeletal muscle tissue and have the ability to both replicate and differentiate into various types of muscle cells. (medicalxpress.com)
  • One of CIRM's aims," says Laird, "is to culture and differentiate embryonic stems cells -- cells that would then be placed into patients. (sciencedaily.com)
  • IPS cells can then, in turn, be directed to differentiate into any cell type found in the human body. (sciencewatch.com)
  • In 1988 he first identified and isolated the blood-forming stem cells from mice and went on to define the stages of development between the stem cells and differentiated cells of the immune system. (brandeis.edu)
  • This gene is clearly regulating processes that are central to aging in mice and humans," said Clarke, "and stem cells are severely compromised. (sciencedaily.com)
  • Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
  • Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
  • The team first made mouse PGCs, and then added cells taken from the testicular tissue of newborn mice, as well as other biological molecules. (scientificamerican.com)
  • In a Stanford Medicine study, scientists transplanted stem cells into mice and found reduction of brain abnormalities typical of Alzheimer's disease. (stanford.edu)
  • Vav1-driven overexpression of the ILEIind transgene in all hematopoietic cells (Vav-ILEIind) did not render mice anemic or lower overall fitness, demonstrating that no intrinsic mechanisms of erythroid development were dysregulated by ILEI and that hematopoietic ILEI hyperfunction did not contribute to death. (bvsalud.org)
  • These cells - capable of generating all cell types in the body - could be used as the 'lego bricks' to build tissue constructs, larger structures of tissues, and potentially even micro-organs. (phys.org)
  • The method currently used to produce stem cell-derived tissues has a very limited throughput. (labmanager.com)
  • Scientists hope one day to produce tissues to repair the damage caused by Parkinson's disease, diabetes and other diseases. (consumerwatchdog.org)
  • The bodies had been dead up to nearly two days before scientists collected tissues from them. (livescience.com)
  • In 1962 he made the stunning observation that it was possible to take a differentiated adult cell from a frog and to re-set its genetic program so that the reprogrammed nucleus could be implanted in an enucleated egg and direct the development of tadpoles. (brandeis.edu)
  • For example, Zhou and Zhao report that, on the basis of a genetic analysis, their artificial PGCs were similar to mouse cells at 12.5 days of development. (scientificamerican.com)
  • We found that cancer arises in cells that have already undergone epigenetic alterations," he adds, "which points to epigenetic events preceding genetic events in cancer development. (sciencedaily.com)
  • Interestingly, the mini eyes that the scientists developed in the lab were grown using cells donated both by patients who had the genetic fault and those who had healthy eyes. (com.pk)
  • By using a small biopsy of skin, we now have the technology to reprogram the cells into stem cells and then create lab-grown retina with the same DNA, and therefore same genetic conditions, as our patients," said the first study author Dr Yeh Chwan Leong in a media release. (com.pk)
  • 2,732 nasal wash samples collected during the fi rst year gesting that these viruses might not cause respiratory ill- after allogeneic hematopoietic cell transplantation from 222 ness in immunocompetent children. (cdc.gov)
  • Using this system, called the Nodal/Activin pathway, scientists will be able to control the eventual type of tissue the stem cells will develop into, simply by adjusting the cell's chemical environment. (rejuvalife.md)
  • Chris - And when you say you took these fibroblasts, these are not cancerous cells, these are just in the normal tissue that's around the milieu of the cancer? (thenakedscientists.com)
  • Scientists believe that they have the potential to treat many illnesses by taking over the function of damaged tissue after injection. (voanews.com)
  • Understanding how normal stem cells regenerate themselves could help to repair tissue and organ damage from disease, and understanding how cancer stem cells maintain themselves could help explain why they are unusually resistant to chemotherapy or radiation therapy -- often resulting in a patient's relapse after seemingly successful treatment. (sciencedaily.com)
  • As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
  • This discovery shows us that by targeting stem cells to boost their numbers, we can improve the body's ability to repair muscle tissue," said senior author Dr. Michael Rudnicki. (medicalxpress.com)
  • Stem cells give rise to every tissue and organ in the body. (medicalxpress.com)
  • Since this protein is only produced in developing retinal cells, the high fluorescence intensity points to the parts of the sample with the right tissue. (labmanager.com)
  • The automation algorithm was able to optimize cell production by simultaneously testing many systems-without any adverse effect on tissue quality. (labmanager.com)
  • We also developed a tool for automatic retina identification and organoid classification, which we showed in action, optimizing cell specialization conditions and monitoring tissue quality. (labmanager.com)
  • In other words, dead people can yield living cells that can be converted into any cell or tissue in the body. (livescience.com)
  • Fibroblasts are the most common cells of connective tissue in animals, and they synthesize the extracellular matrix, the complex scaffolding between cells. (livescience.com)
  • The Stem Cell Network, established in 2001, brings together more than 80 leading scientists, clinicians, engineers, and ethicists from universities and hospitals across Canada with a mandate to investigate the immense therapeutic potential of stem cells for the treatment of diseases currently incurable by conventional approaches. (disabled-world.com)
  • There have turned out to be only about 20 cell lines that qualify for federal financing, not more than 60 as the government initially said in 2001. (consumerwatchdog.org)
  • Using chromosome conformation capture technologies in conjunction with advanced computational modeling and a range of imaging methods, the center will generate three-dimensional models of the human genome inside fibroblast cells during metaphase and interphase, as well as in embryonic stem cells in undifferentiated and differentiated states. (umassmed.edu)
  • He was the first to appreciate the therapeutic potential of stem cell therapy and has pioneered its development. (brandeis.edu)
  • Nor could federal money be used for therapeutic cloning, in which stem cells are created from a body cell of a person. (consumerwatchdog.org)
  • Such therapeutic cloning might be used to create stem cells from people with specific diseases. (consumerwatchdog.org)
  • Japan rushes to capitalize on 'reprogrammed' adult cells. (nature.com)
  • The hope is that, in the future, these cells can be used to treat diseases where cell damage has occurred by transplantation of the patient's own iPS-derived cells. (sciencewatch.com)
  • Typically, light-detecting rod cells are located in the back of the eye within the retina. (com.pk)
  • The rod cells "organised themselves into layers mimicking how they would be organised in the retina. (com.pk)
  • They are the cells responsible for the structural and metabolic support of the retina. (com.pk)
  • It's difficult to study the inaccessible tiny nerve cells of the patient's retina as they are so intricately connected and delicately positioned at the back of the eye. (com.pk)
  • In dry age-related macular degeneration (AMD), light-sensitive retina cells die leading to vision loss. (nih.gov)
  • But Democratic Party Senator Mary Landrieu opposes the embryo cloning and stem cell work being done in South Korea. (voanews.com)
  • Scientists built the model embryo, imaged here. (yahoo.com)
  • Scientists understand surprisingly little about the early days of embryo growth , when our cells organize and begin to form our bodies. (yahoo.com)
  • Magically, as if guided by mini magnets, some of the cell types organized themselves within their dishes in the configurations that you would see in a human embryo. (yahoo.com)
  • Japan is scrambling to harness the promise of Shinya Yamanaka's pioneering work that reprogrammed adult human cells into an embryo-like state. (nature.com)
  • From the biopsies, muscle stem cells (satellite cells) are isolated and later used for preclinical measurements. (lu.se)
  • Douglas Melton (left) and David Scadden, directors of the Harvard Stem Cell Institute, are among the university scientists who study the cells for cures to several devastating diseases. (chronicle.com)
  • In a process known as neurogenesis, adult-born neuroprogenitor cells are generated in the subventricular zone deep in the brain and migrate to the olfactory bulb where they assume their final positions. (nih.gov)
  • At Rejuvalife Vitality Institute, Dr. Berger uses a patient's own fat-derived stem cells in fat transfer procedures to promote the viability and longevity of fat grafts. (rejuvalife.md)
  • Click here to learn more about how Rejuvalife uses a patient's own cells to perform these remarkable procedures. (rejuvalife.md)
  • In a new study published in the journal Development , USC Stem Cell scientists describe how adult flies can regenerate sensory hearing cells in their antennae, and how studying flies can provide a new way to understand and develop treatments for the hundreds of millions of patients worldwide who live with hearing and balance disorders. (eurekalert.org)
  • Sir John B. Gurdon is emeritus professor of zoology at the Gurdon Institute, Cambridge University , in the UK. (brandeis.edu)
  • Dr. Shinya Yamanaka is professor at the Institute for Frontier Medical Sciences in Kyoto University , Kyoto, Japan as well as professor of anatomy at the University of California, San Francisco and senior investigator at the Gladstone Institute of Cardiovacular Disease, in San Francisco. (brandeis.edu)
  • Dekker co-leads the center with Leonid A. Mirny, PhD, professor of medical engineering & science and physics, at the Massachusetts Institute of Technology. (umassmed.edu)
  • Not only does the USC study provide empirical evidence for a stem cell origin of cancer, but, according to Laird, "It also supports a very early involvement of epigenetics in cancer. (sciencedaily.com)
  • One of the main reasons why scientists have not been able to find a cure is that it is nearly impossible to study the core of the issue. (com.pk)
  • In the latest study, experts were able to develop these rod cells in the mini eye. (com.pk)
  • For example, the authors of the study published in Stem Cell Reports found that Muller cells might have a role to play in the development of Usher syndromes. (com.pk)
  • Our current findings published in this paper will aid us tremendously as we are trying to understand the biological processes behind somatic cell reprogramming. (sciencewatch.com)
  • This article chronologically reviews Kim's scientific findings on the Bonghan System, which were verified by the PVS scientists (after 2000), and also the new findings reported by the PVS scientists. (who.int)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • The Stiles-Nicholson Brain Institute developed and oversees the Neuroscience Graduate Program that unites scientists, educators and students. (fau.edu)
  • Central Nervous System Development: Stem Cells to. (hhmi.org)
  • skin cells of the mouse into cells strikingly similar to embryonic stem cells, capable of development into a mouse. (brandeis.edu)
  • Now, Xiao-Yang Zhao, a development biologist at the Southern Medical University in Guangzhou, and Qi Zhou, a cloning specialist and stem-cell biologist at the Institute of Zoology in Beijing, along with colleagues from Nanjing Medical University, say that they have trumped Saitou's work by carrying out more of the process in a dish. (scientificamerican.com)
  • And other stages of germ-cell development occurred unexpectedly quickly: in a real mouse, it takes more than 4 weeks for the PGC to become a spermatid, for example, but the Chinese team reports a 14-day interval between artificial PGC and spermatid. (scientificamerican.com)
  • This permanent silencing," Laird explains, "prevents embryonic stem cells from differentiating, and they thus become the seeds of cancer development later in life. (sciencedaily.com)
  • The lines can be turned into any human cell type enabling new avenues for basic discovery and drug development. (nih.gov)
  • Development of new ways of deriving hESCs and investigating the special capabilities of newly-derived human cell lines. (ca.gov)
  • We were able to culture living cells from deceased individuals on a larger scale than ever done before," researcher Thomas Hyde, a neuroscientist, neurologist and chief operating officer at the Lieber Institute for Brain Development in Baltimore, told LiveScience. (livescience.com)
  • In the adult animal, Tlx is expressed exclusively in brain stem cells. (dkfz.de)
  • Participants in FAU Stiles-Nicholson Brain Institutes' ASCEND NeuroExplorers after-school program graduated as 'Junior Neuroscientists. (fau.edu)
  • Now scientists have harvested such cells from the scalps and brain linings of human corpses and reprogrammed them into stem cells. (livescience.com)
  • Conversely, reducing Usp16 expression in skin and nerve-progenitor cells from people with Down syndrome allowed the cells, which usually proliferate slowly, to assume normal growth patterns. (sciencedaily.com)
  • Surprisingly, scalp cells did proliferate more and grew more rapidly than dura mater cells. (livescience.com)
  • Those older cell lines, because they were grown using animal cells or serum, might not be suitable for use as medical therapy. (consumerwatchdog.org)
  • Laird and his colleagues discovered that some genes repressed by Polycomb in embryonic stem cells are essentially pre-marked to become permanently silenced by DNA methylation. (sciencedaily.com)
  • But most scientists will want to get hold of the viral vectors that Yamanaka used to introduce the four genes. (nature.com)
  • The shape it takes has a profound influence on which genes in a cell are turned on or turned off. (umassmed.edu)
  • Drugs are being developed that will block these checkpoints in cancer cells and let the immune system attack them. (indiatimes.com)
  • We are looking at the response of the patients' immune cells to treatment and cancer. (qub.ac.uk)