Scientists healthy cells. Medical search. Frequent questions

The shells, which at about 100 nanometers are roughly half the size of the smallest bacterium, degrade harmlessly in non-cancerous cells. (understandingnano.com)
The process does not present the risk of genetic mutation posed by gene therapies for cancer, or the risk to healthy cells caused by chemotherapy, which does not effectively discriminate between healthy and cancerous cells, Tang said. (understandingnano.com)
Just a handful of mutations -- between one and ten -- are required for the cancerous cells to emerge. (zmescience.com)
For example, cancerous cells, happily living on, having slipped the grasp of the Grim Reaper, begin to spread instead of dying off. (livescience.com)
A scientific team led by a Greek researcher believe they may have found a way to "turn off cancer" by reverting cancerous cells to healthy tissue. (ellines.com)
The researchers found that when the usual sequence of cell regulation is disrupted, cancerous cells quickly occur and multiply out of control, but by adding mircoRNAs molecules scientists were able to prevent cancer. (ellines.com)

Tests done on human breast cancer cell lines in laboratory mice showed significant reduction in tumor growth. (understandingnano.com)
Delivering a large protein complex such as apoptin to the innermost compartment of tumor cells was a challenge, but the reversible polymer encapsulation strategy was very effective in protecting and escorting the cargo in its functional form," said Muxun Zhao, lead author of the research and a graduate student in chemical and biomolecular engineering at UCLA. (understandingnano.com)
Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too. (the-scientist.com)
New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture. (the-scientist.com)
Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize. (the-scientist.com)
Our work shows, for the first time, that there is a role for telomerase in adult cells beyond promoting tumor formation. (sciencedaily.com)
The CXCR4 receptor on the surface of MSC reacts with the SDF-1 chemokine and makes the cells move closer to the tumor. (news-medical.net)
How do tumoral cells replace healthy cells to promote tumor progression? (pasteur.fr)
How does the immune system act when faced with tumor cells? (pasteur.fr)
When the CAR-T cells return to the patient's body, they target cell-surface antigens expressed on tumor cells. (corning.com)
3D multicellular tumor spheroids are a type of 3D cell culture models, which have been shown to more accurately mimic in vivo solid tumor biology. (corning.com)
3D spheroids develop hypoxic cores and exhibit a diffusion profile for drugs similar to tumors, according to a study of CAR-T cell screening in tumor spheroids. (corning.com)
The study used Corning ® Spheroid Microplates - which enable faster, more reliable creation of 3D multicellular tumor spheroids - to quantify the cytotoxic effects of CAR-T cells on tumor cells grown as spheroids. (corning.com)
Results showed that the CAR-T cells specifically targeted the tumor cells and induced cytotoxicity. (corning.com)
In combination with CAR-T cells and cytotoxicity assays, the microplate provides a high-throughput platform for creating and screening tumor spheroids using CAR-T cell assays. (corning.com)
One challenge in using CAR-T immunotherapy to treat solid tumors is delivering the CAR-T cells directly to the tumor. (corning.com)
But though T cells can cross the blood-brain barrier and reach brain tumors, for example, they don't usually arrive in sufficient numbers to kill the tumor. (corning.com)

Telomerase's only known role in normal tissue was to protect certain cells that divide regularly, such as embryonic cells, sperm cells, adult stem cells and immune cells. (sciencedaily.com)
With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors. (snopes.com)
Previously, scientists thought the layer was simply dense connective tissue. (nationalgeographic.com)
The organ has seemingly been hidden in plain sight, and scientists say they missed it because of the way tissue is studied. (nationalgeographic.com)
Treatment generally involves working with a person's remaining healthy brain tissue to help rehabilitate mobility, motor and other skills," they wrote. (newsweek.com)
First, however, the team had to collect individual cells from the adult mouse brain in a way that reflects the cellular diversity of native, intact tissue. (broadinstitute.org)
In salivary gland tissue from one of the people who had died, as well as from a living person with acute COVID-19, the scientists detected specific sequences of viral RNA that indicated cells were actively making new copies of the virus - further bolstering the evidence for infection. (nih.gov)
Embryonic stem cells are intriguing because they can differentiate into any of the specialized tissue cells of the body. (latimes.com)
This may allow scientists to culture healthy tissue cells in the lab to replace damaged ones in the human body. (latimes.com)
Identify different types of tissue found in a teratoma and see just how many different types of cell an embryonic stem cell can become. (eurostemcell.org)
Type-1 diabetes is an autoimmune disease caused by an inappropriate immune-system attack on healthy tissue. (medindia.net)
Our observations constitute an initial proof of principle for in vivo regeneration of an entire three-dimensional tissue like the skin, not just individual cell types as previously shown," says Salk Professor Juan Carlos Izpisua Belmonte, holder of the Roger Guillemin Chair and senior author of the new paper, published in the journal Nature on September 5, 2018 . (workerscompensation.com)
Another treatment, sprifermin, is a type of human fibroblast growth factor, which plays a role in cell growth and tissue repair. (medscape.com)
With every new study, scientists learn more about these autoantibodies that target the body's own tissue. (lu.se)

In 2005, he wrote an essay in Nature challenging the importance of "cell theory"-a concept that holds cells as the basic structure of all organisms, and in 2001, he published a paper finding that adult stem cells could be made to act similarly to embryonic cells. (nationalgeographic.com)
Both the embryonic and extra-embryonic cells start to talk to each other and become organised into a structure that looks like and behaves like an embryo," explains Professor Magdalena Zernicka-Goetz from the Department of Physiology, Development and Neuroscience, who led the research. (cam.ac.uk)

The genetic defect responsible for limb girdle muscular dystrophy causes shortages of an enzyme in muscle cells called CaMK. (uclahealth.org)
Researchers unmask unique genetic signatures of more than 560 cell populations across nine brain regions, and lay the groundwork for deeper insights into the biology of brain disorders. (broadinstitute.org)
The new atlas, reported in Cell , provides a window into the brain's remarkable diversity of cells, a starting point for studying how genes and genetic variants contribute to neurological and psychiatric disorders, and insights into how different kinds of neurons achieve their highly specialized functions. (broadinstitute.org)
Genetic studies of psychiatric and neurological disorders are now implicating many specific genes, but we need to be able to make the scientific connections from genes to cell populations and circuits," said study senior author and Broad institute member Steven McCarroll , the director of genetics at the Stanley Center for Psychiatric Research and the Dorothy and Milton Flier Professor of Biomedical Science and Genetics at Harvard Medical School. (broadinstitute.org)
PTC124, an oral medication that changes the way muscle cells interpret genetic information, holds promise as a treatment for some patients with Duchenne muscular dystrophy (DMD), the Muscular Dystrophy Association ( http://www.mda.org/ ) announced today. (news-medical.net)
A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. (news-medical.net)
A team led by Johns Hopkins scientists has unraveled the first step in translating genetic information in order to build a protein, only to find that it's not one step but two. (news-medical.net)
Andrews is known for her studies on cell cycle-regulated transcription and protein kinase function in yeast and for pioneering work with Charles Boone on genetic networks. (wikipedia.org)
Now, a team of scientists has reported a discovery that might explain how multiple genetic flaws can lead to the same disease. (jax.org)
They've identified something that some of those diabetes-linked genetic defects have in common: they seem to change the way certain cells in the pancreas "read" their genes. (jax.org)
The research could eventually make a difference for people with sickle cell disease, those who develop antibodies against most donor blood types, or those with genetic disorders in which their body can't make red blood cells or the blood cells they make don't work well. (cnn.com)
At three and six months later, the generated cells behaved like healthy skin cells in a number of molecular, genetic and cellular tests. (workerscompensation.com)
Reassortment occurs when two or more flu viruses infect a single host cell, which allows the viruses to swap genetic information. (cdc.gov)

Mice engineered to overproduce the organelles involved in cell division spontaneously develop malignancies. (the-scientist.com)
The researchers discovered that as normal, healthy adult cells approach cell-death, they produce a burst of telomerase that prevents malignancies and softens the final steps in the aging process. (sciencedaily.com)
At critical telomere length, cells stop dividing and either die or experience DNA damage that could cause malignancies. (sciencedaily.com)
For patients with B-cell malignancies, CAR-T therapy has shown the possibility of achieving complete remission. (corning.com)

This gene forms a protein 'doorway', allowing HIV to enter cells and infect patients. (mirror.co.uk)
While it's well known that the upper airways and lungs are primary sites of SARS-CoV-2 infection, there are clues the virus can infect cells in other parts of the body, such as the digestive system, blood vessels, kidneys and, as this new study shows, the mouth. (nih.gov)
When bacteria like salmonella infect and sicken people, they hijack a person's cell proteins to develop a defense against an immune response. (purdue.edu)
This model will allow the researchers to directly infect human airway cells ex vivo with a SARS-CoV-2 pseudovirus, as well as examining the potential efficacy of drugs in cells derived from patients with underlying co-morbidities known to increase Covid-19-associated disease severity and mortality. (lu.se)

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that occurs when a person's immune system attacks healthy cells in the body. (medicaldaily.com)
The disease begins when a person's own antibodies attack the insulin-producing cells in the pancreas. (medindia.net)

The caspases that are first activated, activate other molecules of caspases, which activate yet others, until the entire cell is destroyed. (livescience.com)
It doesn't get any lower in amplitude because every step of the way it's generating its own impetus by converting more inactive molecules to active molecules, until apoptosis has spread to every nook and cranny of the cell. (livescience.com)
After pumping the brains with the liquid for six hours, the scientists noticed the activity of some molecules, cells and synapses were restored. (newsweek.com)
Thanks to new research from scientists at BYU and the University of Utah Health, researchers now have a more complete understanding of how chaperone molecules direct the protein folding process. (byu.edu)
These cellular functions include DNA repair, maintenance of the ends of chromosomes (regions called telomeres), and protection of cells from damage caused by unstable oxygen-containing molecules (free radicals). (medlineplus.gov)

image: In the fly, the sensory hearing cells are neurons located in a segment of their antennae known as the Johnston's Organ, or JO. (eurekalert.org)
The scientists were able to label, trace and view newborn JO neurons in live flies under microscopes. (eurekalert.org)
In healthy flies, JO neurons were naturally turning over. (eurekalert.org)
Instead, they observed JO neurons proliferate and produce more of themselves--although this doesn't rule out the potential for other types of cells to also produce JO neurons. (eurekalert.org)
In flies given the chemotherapy drug cisplatin, which is known to kill sensory hearing cells, JO neurons compensated for the damage by proliferating even more. (eurekalert.org)
The scientists also observed the JO neurons developing hair-like extensions known as cilia, and extending long nerve fibers called axons into hearing- and balance-related circuits in the brain. (eurekalert.org)
Trigger waves also help cells reproduce, neurons propagate signals through the brain and viruses spread from cell to cell. (livescience.com)
Microscope images of brain cells collected for Drop-Seq analysis: neurons (pink), astrocytes (green), oligo- and polydendrocytes (blue). (broadinstitute.org)
Starting from choline and acetylcoenzyme A (AcCoA), the enzyme choline O acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in neurons, T cells and B cells. (lu.se)

When these patients lose muscle, they struggle to gain it back," said Melissa Spencer, the paper's senior author and a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA . (uclahealth.org)
Flies have the potential to provide many insights into how to promote the regeneration of sensory hearing cells," said Bonaguidi, who is an assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine of USC. (eurekalert.org)
Regenerative medicine is the heart of what we do at ICR, with many parts centered on induced pluripotent stem (iPS) cells, iPS cell-derived stem ce. (biospace.com)

And sometimes our cells don't die when we really do want them to - say, in cancer," senior author Dr. James Ferrell, a professor of chemical and systems biology and biochemistry at Stanford University, said in a statement . (livescience.com)
This study reshapes the current understanding of telomerase's function in normal cells,"said Kan Cao, senior author of the study and an associate professor of cell biology and molecular genetics at UMD. (sciencedaily.com)
The study brings together two so-far unrelated research fields - cell-to-cell adhesion and miRNA biology - to resolve a long-standing problem about the role of adhesion proteins in cell behavior that was baffling scientists," says the study's lead author Antonis Kourtidis, Ph.D., a research associate in Dr. Anastasiadis' lab. (ellines.com)
As an example, in 2015, Andrews co-led a team of biology scientists at the University of Toronto's Donnelly Centre to create the first ever fully detailed protein map of a cell, the map showed the location of all protein in a cell, the project aimed to benefit and help increase research for cancer cells. (wikipedia.org)

In a new study, published online Feb. 1 in the peer-reviewed journal Nano Today, a group led by Yi Tang, a professor of chemical and biomolecular engineering and a member of the California NanoSystems Institute at UCLA, reports developing tiny shells composed of a water-soluble polymer that safely deliver a protein complex to the nucleus of cancer cells to induce their death. (understandingnano.com)
The cell-destroying material, apoptin, is a protein complex derived from an anemia virus in birds. (understandingnano.com)
This protein cargo accumulates in the nucleus of cancer cells and signals to the cell to undergo programmed self-destruction. (understandingnano.com)
The study, which although in its early stages has been hailed by cancer charities as "crucial", works by focusing on the PLEKHA7 protein that clumps healthy cells together. (ellines.com)
Ferritin is a natural protein that can be found in cells from all living species. (medscape.com)

Scientists at the University of Cambridge have managed to create a structure resembling a mouse embryo in culture, using two types of stem cells - the body's 'master cells' - and a 3D scaffold on which they can grow. (cam.ac.uk)
These are the body's raw materials - the cells from which all specialized cells, like a red blood cell, can generate. (cnn.com)
Red blood cells are the helper cells that carry oxygen from the lungs to the body's tissues, which use this oxygen to produce energy. (cnn.com)
Some of the gene variants that contribute to a long life are involved with the basic maintenance and function of the body's cells. (medlineplus.gov)
A blood sample that shows the presence of one of these autoantibodies indicates that the insulin-producing cells in the pancreas are being attacked by the body's immune system. (lu.se)

Devising a method for more precise and less invasive treatment of cancer tumors, a team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has developed a degradable nanoscale shell to carry proteins to cancer cells and stunt the growth of tumors without damaging healthy cells. (understandingnano.com)
The polymer shells are developed under mild physiological conditions so as not to alter the chemical structure of the proteins or cause them to clump, preserving their effectiveness on the cancer cells. (understandingnano.com)
Tang's group continues to research ways of more precisely targeting tumors, prolonging the circulation time of the capsules and delivering other highly sought-after proteins to cancer cells. (understandingnano.com)
For the 'chaperonin' subgroup, the scientists have already been able to show in detail how they work: They encapsulate proteins during their folding so that aggregates cannot form. (mpg.de)
Vulnerable cells contain RNA instructions for making "entry proteins" that the virus needs to get into cells. (nih.gov)
RNA for two key entry proteins - known as the ACE2 receptor and the TMPRSS2 enzyme-was found in certain cells of the salivary glands and tissues lining the oral cavity. (nih.gov)
This indicated increased vulnerability because the virus is thought to need both entry proteins to gain access to cells. (nih.gov)
Understanding how that works and developing methods for defending against these bacteria is difficult because scientists haven't been able to track the hundreds of proteins involved in real time. (purdue.edu)
The HAPTIP method involves labeling the salmonella bacteria with a diazirine group, a chemical group that creates covalent bonds between Salmonella proteins and host cell proteins when an ultraviolet light is shined on the cell. (purdue.edu)
A chemical probe enriches all the crosslinked proteins and isolates them from the other cell extracts. (purdue.edu)
Scientists can then use mass spectrometry to identify the proteins. (purdue.edu)
In their findings, the scientists tested the method at 15 minutes, one hour and six hours after salmonella infected a cell and identified more than 400 proteins interacting with the salmonella bacteria. (purdue.edu)
By looking at which proteins are interacting with the bacteria at those different times, we can determine the method the bacteria are using to hijack the cell, which will differ as time passes. (purdue.edu)
A novel multifunctional chemical proteomics probe was introduced to label living bacteria followed by in vivo crosslinking of bacteria proteins to their interacting host cell proteins at different time points initiated by UV for label-free quantitative proteomics analysis. (purdue.edu)
The researchers first compared the levels of different proteins of the two cell types (inflammation and keratinocytes) to get a sense of what they'd need to change to reprogram the cells' identities. (workerscompensation.com)

Nor are they sure how well a patient's body will accept stem cell treatments derived from cells donated by a stranger, or whether the growth of implanted cells can be managed. (latimes.com)

Dr. Basiliana Emidi is a Principal Research Scientist in Field Medical Entomology working with the National Institute for Medical Research (NIMR) in Tanzania with vast experience of over 19 years. (who.int)

It's often said that the bacteria and other microbes in our body outnumber our own cells by about ten to one. (nature.com)
A 'reference man' (one who is 70 kilograms, 20-30 years old and 1.7 metres tall) contains on average about 30 trillion human cells and 39 trillion bacteria, say Ron Milo and Ron Sender at the Weizmann Institute of Science in Rehovot, Israel, and Shai Fuchs at the Hospital for Sick Children in Toronto, Canada. (nature.com)
The numbers are similar enough that each defecation event may flip the ratio to favour human cells over bacteria," they delicately conclude in a manuscript posted to the preprint server bioRxiv 1 . (nature.com)
Though American waists are getting bigger, research is showing that the gut microbiome-the bacteria living in our digestive tracts-and the energy-producing compartments of cells, the mitochondria, remain hungry for nutrients missing in the American diet. (medicalxpress.com)
PhysOrg.com) -- Bacteria are able to build camouflaged homes for themselves inside healthy cells - and cause disease - by manipulating a natural cellular process. (phys.org)
Now, W. Andy Tao , a Purdue University professor of biochemistry , and colleagues at Purdue and Fudan University in China, have developed a chemical method - host and pathogen temporal interaction profiling, or HAPTIP - for labeling a living bacteria and tracking it as it invades a host cell. (purdue.edu)
Salmonella bacteria fend off a cell's immune defenses by creating a pocket within the cell, called a Salmonella-containing vacuole, in which to hide. (purdue.edu)
The PulseNet specimens have no connection other than symbiotic flora, colonization, contamination, or infection by bacteria that at some point years ago were progeny of the same cell. (cdc.gov)

Targeted drug delivery can help reduce the toxic effects of chemotherapy by minimizing the negative impact on healthy cells. (news-medical.net)
Studies have shown that spheroids can show more resistance to chemotherapy than 2D monolayer cell cultures. (corning.com)

it killed lung, breast and brain cancer cells and left the healthy cells alone. (snopes.com)
Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
they're also working on ways to administer the cells locally, such as into the intrapleural space for lung cancer. (corning.com)
Many people don't realize the severity of this disease,' says John Tisdale, M.D., senior investigator at NIH's National Heart, Lung, and Blood Institute, who leads NIH sickle cell disease research along with Griffin Rodgers, M.D., director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (medlineplus.gov)
We will use lung cells taken from healthy patients and patients with underlying diseases known to have increased risk for developing Covid-19 from SARS-CoV-2 infection to hopefully identify approved compounds which could be repurposed for preventive SARS-CoV-2 therapy in vulnerable populations. (lu.se)

UCLA researchers have identified a compound that can reproduce the effect of exercise in muscle cells in mice. (uclahealth.org)
Cao and her colleagues suspected telomerase may have a function in adult cells when they observed dramatic differences in the laboratory among sibling mice with shortened telomeres. (sciencedaily.com)
To understand what was going on, Cao and her colleagues compared the skin cells of the sibling mice and found that while both cell lines had comparably short telomeres, cells from telomerase-deficient mice stopped dividing sooner and had more malignant transformations than cells from siblings that produced telomerase. (sciencedaily.com)
What's more, the researchers found that as skin cells from non-telomerase-deficient mice approached critical telomere length, they naturally produced a burst of telomerase, which slowed the process of telomere shortening and reduced the amount of DNA damage that could lead to cancer. (sciencedaily.com)
To see if what they observed in mice held true for humans, the team conducted laboratory studies on human skin cells. (sciencedaily.com)
A chemical compound discovered by scientists treats both blindness and diabetes in rats and mice. (medindia.net)
When the team topically treated skin ulcers on mice with the four factors, the ulcers grew healthy skin (known as epithelia) within 18 days. (workerscompensation.com)

The death of insulin-producing beta cells in the pancreas is a core defect in diabetes. (medicaldaily.com)
They report that many diabetes-linked DNA changes affect the ability of RFX to bind to specific locations in the genomes of pancreas cell clusters called islets. (jax.org)

The researchers also found that reactivating the gene for expressing telomerase in the telomerase-deficient cells rescued them, prolonging their ability to divide and reducing DNA damage. (sciencedaily.com)
Researchers have generated a cellular atlas of the mouse brain, based on the gene expression profiles of nearly 700,000 individual cells covering nine major brain regions. (broadinstitute.org)
The research team generated the atlas by analyzing gene expression in 690,000 individual cells isolated from nine brain regions, including the frontal and posterior cortex, hippocampus, cerebellum, thalamus, striatum, and substantia nigra. (broadinstitute.org)
With their latest discovery, researchers have significantly advanced the understanding of how human cells protect themselves from constant and potentially destructive changes in gene expression. (news-medical.net)
Gene therapy and monoclonal antibodies didn't arrive with even a fraction of the hype surrounding embryonic stem cell research. (latimes.com)

In 2014, molecular biologist Judah Rosner at the US National Institutes of Health at Bethesda, expressed his doubts about the 10:1 claim, noting that there were very few good estimates for the numbers of human and microbial cells in the body. (nature.com)
To find a drug that could help restore the signals related to CaMK, Spencer and her colleagues worked with Robert Damoiseaux, director of UCLA's Molecular Shared Screening Resource, to screen more than 2,000 compounds to see which ones worked in lab-grown muscle cells. (uclahealth.org)
And while scientists have a general idea of the different types of cells that make up some brain regions, the detailed identities, molecular repertoires, and functional roles of cells at a brain-wide level have yet to be fully cataloged, further complicating efforts to link variant to cell to function. (broadinstitute.org)
We haven't had a global framework for understanding, at the molecular, single-cell level, the cells that make up the core components of the brain," said Arpiar Saunders, a postdoctoral researcher in the McCarroll laboratory and co-first author of the study with Stanley Center associate member and Massachusetts General Hospital psychiatrist Evan Macosko. (broadinstitute.org)
A team of University of Maryland scientists have made a discovery that will help better direct drug therapies to their molecular targets. (news-medical.net)

Composed of antibodies, B-cells and T-cells, the adaptive immune system can remember a threat and better target threats it's seen before. (msdmanuals.com)

Solid cancerous masses are often hypoxic, acidic, and immunosuppressive, The Scientist writes, and T cells have a hard time surviving in that environment - if they can infiltrate it at all. (corning.com)

In human bodies there is a natural cancer fighting human cell, the mitochondria, but they need to be triggered to be effective. (snopes.com)
Scientists used to think that these mitochondria cells were damaged and thus ineffective against cancer. (snopes.com)
it triggers the mitochondria which in turn fights the cancer cells. (snopes.com)
You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. (snopes.com)
The microbiome's biochemical signals also regulate the growth and function of energy-producing mitochondria across many cell types, including those in fat, muscles, heart and the brain. (medicalxpress.com)
Mitochondria are organelles that provide most of the energy necessary for the cell. (pasteur.fr)
The phrase lives of a cell refers to the independent yet interrelated parts of a human cell including mitochondria, centrioles, and basal bodies that once led independent lives. (cdc.gov)

The findings are published in the journal Cell Reports Medicine. (uclahealth.org)
Moreover, the findings point to the possibility that the mouth plays a role in transmitting SARS-CoV-2 to the lungs or digestive system via saliva laden with virus from infected oral cells. (nih.gov)
None has yet shown it can prevent or cure osteoarthritis , and all are in early phases, caution the scientists who presented their findings at the recent annual meeting of the American College of Rheumatology in San Diego, CA. (medscape.com)

We are pleased that the process we've identified using immune cells to help predict Alzheimer's risk will be further developed by MP Biomedicals. (uclahealth.org)

Most of them had the scans to see if they had cancer and the scans also assessed the activity of blood cells in bone marrow. (scitechdaily.com)
Red blood cells typically last about 120 days, but a transfusion from a standard donation contains cells that are a variety of ages because the bone marrow continuously makes these cells. (cnn.com)
Then, he or she receives a bone marrow transplant from a healthy donor. (medlineplus.gov)
Now we can take the patient's own bone marrow, use an engineered virus that carries genes to the bone marrow, and give repaired bone marrow stem cells back to the patient so that healthy bone marrow cells can grow,' Dr. Tisdale says. (medlineplus.gov)

Researchers at VIB and KU Leuven have underlined the need for more research into the role that the metabolism of stromal support cells and immune cells play in the development of diseases. (medindia.net)

While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals. (the-scientist.com)

In a new study published in the journal Development , USC Stem Cell scientists describe how adult flies can regenerate sensory hearing cells in their antennae, and how studying flies can provide a new way to understand and develop treatments for the hundreds of millions of patients worldwide who live with hearing and balance disorders. (eurekalert.org)
New research reveals a new role for the enzyme telomerase, which scientists thought was turned off in most normal adult cells, except in cancerous tumors where it promotes unlimited cell division. (sciencedaily.com)
The new study found that telomerase reactivates in normal adult cells at a critical point in the aging process. (sciencedaily.com)
In normal adult cells, telomerase is turned off and telomeres shorten with every cell division until they reach a critical length. (sciencedaily.com)
Before this new work, scientists thought that telomerase expression in most adult cells could only lead to unlimited cell division like that seen in cancerous tumors. (sciencedaily.com)
This is no small feat, given that adult brain cells weave together in a dense, complicated fashion as they age, making them difficult to tease apart. (broadinstitute.org)
It's very hard to keep cells healthy as you dissociate them, especially in adult models," Saunders explained. (broadinstitute.org)
A factory produces a contaminated product, and the lives of a cell connect a retired person on a limited income to a young adult consuming the same product in a different county. (cdc.gov)

The ratio between resident microbes and human cells is more likely to be one-to-one, they calculate. (nature.com)
Putting together these kinds of calculations, the researchers produce a ratio for microbial to human cells for the average man of 1.3:1, with a wide uncertainty. (nature.com)
The researchers found that human cells also expressed telomerase as they approached critical telomere length. (sciencedaily.com)
In addition, human skin cells that were unable to express telomerase reached critical telomere length more quickly and displayed significantly more DNA damage than those that did express telomerase. (sciencedaily.com)
About 70 percent of the human body is made of water, and about two thirds of that is found in cells. (nationalgeographic.com)
Cells within the human organism may be alive for some period of time after the human person has died. (newsweek.com)
Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus. (news-medical.net)
We think that it will be possible to mimic a lot of the developmental events occurring before 14 days using human embryonic and extra-embryonic stem cells using a similar approach to our technique using mouse stem cells," she says. (cam.ac.uk)
It also reinforces learning about the locations of organs in the human body and the way in which organs are built up from cells and tissues. (eurostemcell.org)
We have found that many of the subtle DNA spelling differences that increase risk of Type 2 diabetes appear to disrupt a common regulatory grammar in islet cells," says Stephen C.J. Parker, Ph.D., an assistant professor of computational medicine and bioinformatics, and of human genetics, at the University of Michigan Medical School. (jax.org)
Scientists have transfused lab-made red blood cells into a human volunteer in a world-first trial that experts say has major potential for people with hard-to-match blood types or conditions such as sickle cell disease. (cnn.com)
Preliminary laboratory research at CDC suggests that human cells do not support growth of the bat flu viruses in the test tube (1). (cdc.gov)
However, testing of the bat flu virus's genome suggests that its internal genes are compatible with human flu viruses, so CDC scientists cannot rule out the possibility of these viruses eventually becoming capable of infecting humans. (cdc.gov)
Our human lives do not depend just on the lives in our individual cells. (cdc.gov)
A contamination in dog food can sicken a dog's human owners, while the dogs remain healthy. (cdc.gov)
This model that has been developed with our collaborators will fill an important gap for current and future drug screening efforts for the upper or lower airways using human airway cells", says Sinem Tas, associate researcher. (lu.se)
Together with an industrial partner Cellevate, an innovative biotech company based in Lund, the researchers developed a new method for medium-high throughput drug screening of human airway cells which allows several hundred compounds to be evaluated on cells from individual patients. (lu.se)

Muscle use stimulates chemical messengers inside the muscle cells that increase muscle mass and strength. (uclahealth.org)
It stimulates the cells in the cartilage to make more cartilage," says Marc Hochberg, MD, primary investigator of the study and head of rheumatology and clinical immunology at the University of Maryland School of Medicine. (medscape.com)

Many different mutations linked to Type 2 diabetes all occur in key stretches of active DNA within pancreatic islet cells, interfering with the activity of a master regulator. (jax.org)
Because of their healthy habits, these older adults are less likely to develop age-related chronic diseases, such as high blood pressure, heart disease, cancer, and diabetes, than their same-age peers. (medlineplus.gov)

2019) Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers. (news-medical.net)

scientists finally were able to confirm the presence of immunoglobulin G (IgG) antibodies to SNV in the victim's serum in September of 1994. (medscape.com)

This research shows that across cancer types a relatively consistent small number of such mutated genes is required to convert a single normal cell into a cancer cell, but that the specific genes chosen differ according to cancer type. (zmescience.com)
Historically, months of experiments were often required to figure out which cell populations express even one of these genes. (broadinstitute.org)

Cao said that the next step for researchers is to find out how telomerase expression is turned on as cells approach critical telomere length and to explore the underlying mechanisms by which telomerase acts as a buffer against the stresses of shortening telomeres. (sciencedaily.com)

A diagram of the synthesis of degradable nanocapsules into cell nuclei to induce apoptosis, or programmed cell death, in cancer cells. (understandingnano.com)
This is a unique way to treat cancer cells and leave healthy cells untouched. (understandingnano.com)
And it seems that of the thousands of mutations in a cancer genome, only a small handful are responsible for dictating the way the cell behaves, what makes it cancerous. (zmescience.com)
Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment's toxicity without sacrificing efficacy. (the-scientist.com)
Just before cell death, a burst of telomerase buffers cells from the stresses of aging, slowing the process and reducing DNA damage that could lead to cancer. (sciencedaily.com)
By administering the affected microRNAs in cancer cells to restore their normal levels, we should be able to re-establish the brakes and restore normal cell function. (ellines.com)
Did Scientists Cure Cancer, But No One Took Notice? (snopes.com)
A team of scientists from Peter the Great St.Petersburg Polytechnic University (SPbPU) together with their colleagues developed a method of targeted drug delivery to cancer cells. (news-medical.net)
Americans are likely also deficient in phytonutrients , potassium and certain healthy fats linked to lower rates of cardiovascular disease and cancer. (medicalxpress.com)
You can simulate illness, including cancer, to see how your cells are affected and how your body regulates itself to try and maintain a healthy number of cells. (eurostemcell.org)
Scientists have now come up with a new technology that involves cancer diagnosis through a simple urine test using a strip of paper, making diagnosis simple and affordable for people. (medicaldaily.com)
I suppose you know already, but the links inside http://www.freedomsphoenix.com/News/091724-2011-06-14-scientists-cure-cancer-but-no-one-takes-notice.htm are down already. (freedomsphoenix.com)
Chimeric antigen receptor T cells - CAR-T cells, for short - are an innovative development in the field of oncology, contributing to the emergence of immunotherapy as the fourth pillar of cancer treatment , particularly for patients with late-stage or rare forms of cancer. (corning.com)
If researchers don't build a CAR-T treatment that hits only cancer cells and spares the healthy cells around them, there can be serious and dangerous side effects. (corning.com)
The approach relies on reprogramming the cells to a stem-cell-like state and could be useful for healing skin damage, countering the effects of aging and helping us to better understand skin cancer. (workerscompensation.com)

Made in collaboration with the Centre of the Cell , London. (eurostemcell.org)
Scientists from the Institut Pasteur (Paris, France) and from the Champalimaud Centre. (pasteur.fr)
In order to meet this challenge, the WHO launched a new program from its Kobe Centre ("WKC") to identify and encourage new innovations to support healthy ageing around the world. (who.int)

To figure this out, Ferrell and his team observed the process in one of the larger cells present in nature: egg cells of Xenopus laevis , or African clawed frogs . (livescience.com)
Lurking just under your skin might be a new organ only now identified for the first time, say a team of scientists. (nationalgeographic.com)
To analyze so many cells, the team used Drop-Seq , a high-throughput, microfluidics-based, single-cell RNA-sequencing method developed by Macosko and collaborators in 2015 when he was a postdoctoral fellow in McCarroll's laboratory. (broadinstitute.org)
An international team of scientists has found evidence that SARS-CoV-2, the virus that causes COVID-19, infects cells in the mouth. (nih.gov)
We're hiring an exceptional scientist to join our Regenerative Vascular Medicine (RVM) Team. (biospace.com)
This phase 1 clinical trial is the culmination of years of research and development made possible by the unique collaborative setting that the VRC offers by bringing together top scientists, manufacturing expertise, and an outstanding clinical team," VRC Director John Mascola, MD, said in the news release. (medscape.com)
A team of VRC scientists developed the universal influenza vaccine prototype. (medscape.com)

Scientists in Italy and Texas now have discovered a new way that these cells die - by toxic imbalance of a molecule secreted by other pancreatic cells. (medicaldaily.com)
But the common factor for many of these changes was its effect on the area where RFX is predicted to bind, in the cells of pancreatic islets. (jax.org)

Scientists found that death travels in unremitting waves through a cell, moving at a rate of 30 micrometers (one-thousandth of an inch) every minute, they report in a new study published Aug. 10 in the journal Science . (livescience.com)
The interstitium, scientists found, is under our skin and between our organs. (nationalgeographic.com)
When the scientists compared younger patients (25 to 59 years) to older ones (60 to 74 years), they found, as expected, that the younger ones were a healthier group, with lower rates of coronary heart disease. (scitechdaily.com)
RNA for SARS-CoV-2 (pink) and the ACE2 receptor (white) was found in salivary gland cells, which are outlined in green. (nih.gov)
Professor Zernicka-Goetz and colleagues found a remarkable degree of communication between the two types of stem cell: in a sense, the cells are telling each other where in the embryo to place themselves. (cam.ac.uk)
Stick the organs and pictures onto your own body outline to learn about where stem cells are found. (eurostemcell.org)
This activity aims to counter the common misconception that stem cells can only be found in the embryo. (eurostemcell.org)
The study found the greater the activity in nerve cells in the amygdala region of the brain, the sooner the condition known as Takotsubo syndrome (TTS) can develop. (scitechdaily.com)
For decades, scientists have tried to solve this mystery - and have found more than 80 tiny DNA differences that seem to raise the risk of the disease in some people, or protect others from the damagingly high levels of blood sugar that are its hallmark. (jax.org)

Normally, muscles get stronger as they are used, thanks to a series of chemical signals inside muscle cells. (uclahealth.org)
An active, fun game for 1-6 players, introducing the idea that cells differentiate to produce mature cells, and the type of cell produced depends on the signals the cell receives. (eurostemcell.org)

Using a common laboratory method known as flow cytometry, researchers then measured the amount of amyloid beta ingested by the immune cells by assessing how much fluorescence was being emitted from each monocyte cell. (uclahealth.org)
Based on my experience as a laboratory scientist," he told me before taking the podium, "I know that to make an experiment work, we need to have someone in the lab who really believes in it -- and someone who is a skeptic all the way. (latimes.com)
CAR-T cells are made using a patient's T-cells , which are harvested through apheresis and built up in a laboratory through the addition of a chimeric antigen receptor. (corning.com)

Before recommending COVID-19 vaccination for children, scientists conducted clinical trials. (cdc.gov)

According to Cao, these results suggest that telomerase expressed near the end of a cell's lifespan softened the blow of aging and led to a more gradual cell death. (sciencedaily.com)

Because the energy required to achieve this is very high, usually scientists make the capsule small. (thenakedscientists.com)

Fortunately, for people with healthy muscles, that deterioration is reversible. (uclahealth.org)
Meet some of the people featured in the April 2017 issue of The Scientist . (the-scientist.com)
The U.S. government paid scientists to figure out how the deadly bird flu virus might mutate to become a bigger threat to people - and two labs succeeded in creating new strains that are easier to spread. (phys.org)
To explore this possibility, the researchers surveyed oral tissues from healthy people to identify mouth regions susceptible to SARS-CoV-2 infection. (nih.gov)
Islets contain the cells that make hormones, including insulin and glucagon, which keep blood sugar balanced in healthy people. (jax.org)
People with sickle cell often need multiple transfusions over the course of their lives. (cnn.com)
Scientists do not yet know whether the mutation occurs in otherwise healthy people. (cdc.gov)
Many people with sickle cell disease (SCD) are healthier and living longer thanks in part to research led and supported by the National Institutes of Health (NIH). (medlineplus.gov)
Scientists are studying people in their nineties (called nonagenarians) and hundreds (called centenarians, including semi-supercentenarians of ages 105-109 years and supercentenarians, ages 110+) to determine what contributes to their long lives. (medlineplus.gov)
In addition to studying the very old in the United States, scientists are also studying a handful of communities in other parts of the world where people often live into their nineties and older-Okinawa (Japan), Ikaria (Greece), and Sardinia (Italy). (medlineplus.gov)
To arrive at that conclusion, the French scientists looked at blood samples gathered over time from a group of 1,000 healthy people ages 20 to 69. (msdmanuals.com)
Scientists hope to save them- As industry steps aside, scientists seek innovative ways to make sure expensive treatments can reach people who need them. (cdc.gov)

If you'd carry out a comparison between healthy and cancerous tissues, you'd see thousands of differences (mutations). (zmescience.com)
In the future the discovery may secure more precise treatment of tumors without causing damage to healthy tissues. (news-medical.net)
By means of phagocytosis the capsules got into the MSC, and after that the cells were treated with infrared light that penetrates the tissues deeply without damaging them. (news-medical.net)

By creating a data resource like this - in which scientists can simply look these things up online - we hope to enable a stronger understanding of how brain illness arises in specific cell populations. (broadinstitute.org)
Navajo oral tradition describes an illness now thought to be HCPS that struck down young healthy members of the tribe after temperate winters, and tradition also warns of the dangers of coexisting with rodents. (medscape.com)

Scientists have revived the brain cells of dead pigs in a study that experts say calls into question our understanding of what makes an animal alive. (newsweek.com)
Not all resolutions to exercise and eat healthy fade away, according to a new study by a Brigham Young University health statistician. (byu.edu)
These persons have been invited to take part in a follow-up study to determine if the number of cells with the mutation increases over time. (cdc.gov)
The major discovery of our study is that smoking has short-term but also long-term effects on adaptive immunity associated with B-cells and regulatory T-cells and with epigenetic changes," Saint-André noted. (msdmanuals.com)

That means, for instance, that a nerve cell, whose body can reach a size of 100 micrometers, could take as long as 3 minutes and 20 seconds to die. (livescience.com)
I am a physician scientist and gastroenterologist who has spent over 20 years studying how food can affect the gut microbiome and whole body health. (medicalxpress.com)
The particular stem cells that will eventually make the future body, the embryonic stem cells (ESCs) cluster together inside the embryo towards one end: this stage of development is known as the blastocyst. (cam.ac.uk)
This simulation provides a dynamic look at how our stem cells help maintain a healthy body. (eurostemcell.org)
Find out how many cells you are making and losing in your body in real time by playing with this computer interactive. (eurostemcell.org)
Scientists do know for sure that the right half of the cerebrum controls the left side of your body, and the left half controls the right side. (kidshealth.org)
Izpisua Belmonte and Kurita wanted to directly convert these other cells into basal keratinocytes -- without ever taking them out of the body. (workerscompensation.com)

However, understanding which variants matter in which cell types, and how they relate to healthy and disease states, remain among the greatest challenges in neuroscience and neuropsychiatric research. (broadinstitute.org)
With sickle cell disease - also called sickle cell anemia - red blood cells take on a folded shape that can clog tiny blood vessels and cause organ damage and pain. (cnn.com)
Scientists also do not know how prevalent the mutation is in the general population, or whether everyone who has the mutation will develop PV or a related blood disease. (cdc.gov)
Recent efforts have led to breakthroughs in treating and even curing the red blood cell disease. (medlineplus.gov)
If we could cure sickle cell disease in a safe and effective way, such as a pill that can reverse the disease, that would be a home run. (medlineplus.gov)
This improved understanding makes it possible for scientists to conduct new types of studies with the goal of preventing the disease. (lu.se)

I'm really excited about the find but, as with all scientists, I approach everything with a little skepticism," she adds. (nationalgeographic.com)

Scientists first noticed the compartments when looking at a bile duct. (nationalgeographic.com)

News and insights Learn about breakthroughs from Broad scientists. (broadinstitute.org)

While it's not a cure, hydroxyurea helps red blood cells better carry oxygen in patients with moderate to severe SCD. (medlineplus.gov)
In this double blind clinical trial, 80 patients with chronic moderate periodontitis and a healthy systemic status were chosen, and divided into two 40-subject groups. (bvsalud.org)

Similarly, the cell darkened at the average rate of 30 micrometers per minute. (livescience.com)

Scientists began by determining the relevance and priority of selected contaminants. (europa.eu)

The scientists tested the vaccine pill on monkeys. (medicaldaily.com)
The trial will examine the safety and tolerability of the vaccine (H1ssF_3928) as well as its immunogenicity in healthy volunteers. (medscape.com)

In particular, the lab is investigating adhesion-mediated signaling events that regulate cell growth, suppress cell motility and invasiveness, and promote the reorganization of the actin cytoskeleton. (ellines.com)
What is Cell Motility? (corning.com)

Apoptosis - or programmed cell death - is necessary for clearing our bodies of unnecessary or harmful cells, such as those that are infected by viruses. (livescience.com)
But it had been unclear how apoptosis, after being triggered, actually spread through the cell . (livescience.com)

Anatomy4

Organisms3

Diseases1

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology14

Phenomena and Processes9

Disciplines and Occupations50

Anthropology, Education, Sociology and Social Phenomena42

Technology, Industry, Agriculture13

Humanities39

Information Science57

Named Groups11

Health Care56

Geographicals2

Cancerous cells6

Tumor17

Tissue14

Embryonic cells2

Genetic13

Malignancies4

Infect4

Person's2

Molecules5

Neurons9

Regenerative medicine3

Biology4

Protein5

Body's5

Proteins15

Patient's body1

Research Scientist1

Bacteria8

Chemotherapy2

Lung5

Mice7

Pancreas2

Gene5

Molecular5

Immune system1

Immunosuppressive1

Mitochondria7

Findings3

Alzheimer's1

Bone4

Metabolism1

Progression1

Adult8

Human17

Stimulates2

Diabetes2

20191

Antibodies1

Genes2

Telomeres1

Cancer15

Centre3

Team7

Pancreatic2

Found9

Signals2

Laboratory3

Clinical trials1

Cell's1

Capsule1

People12

Tissues3

Illness2

Study4

Body7

Disease6

Approach1

Compartments1

Breakthroughs1

Patients2

Similarly1

Relevance1

Vaccine2

Motility2

Apoptosis2