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  • research
  • Dr. Travis Ye, Beike Biotech's CEO, commented, 'This groundbreaking research is consistent with the safety record we have compiled after providing stem cells for the treatment of more than 8,000 patients. (news-medical.net)
  • It is our hope that studies and peer-reviewed articles such as this one will help strengthen our ties to the western medical and scientific research community by demonstrating that Beike's stem cell protocols are both effective and safe. (news-medical.net)
  • findings
  • These new findings could open up the use of cord blood for non-hematological diseases, something that to date has not been performed on a wide-spread basis. (news-medical.net)
  • study
  • Dr. Wanzhang Yang, who led the study at Nanshan Affiliated Hospital of Guangdong Medical College commented, 'This important study, which is the largest of its kind, demonstrates the safety and efficacy of using cord-blood-derived stem cells to treat a variety of neurological conditions. (news-medical.net)
  • This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets. (news-medical.net)
  • embryo
  • The results, published last week in the journal Cell, describe how a newly discovered protein plays a key role in generating HSC's in the developing embryo-giving scientists a more complete recipe to reproduce these cells in the lab. (ca.gov)
  • The 'synthetic' blood could eventually mean that clinical services would no long need to rely on obtaining a fresh supply of blood from donors since, in theory, a single embryo could supply the nation's needs. (bionews.org.uk)
  • Those who donate blood but who defend the right to life of the human embryo may be reluctant to continue giving their blood,' she told the BBC. (bionews.org.uk)
  • genes
  • They then genetically engineered the human blood stem-cells by importing genes for the T-cell receptor into the stem cell nucleus using a viral vehicle. (scienceblog.com)
  • The genes integrate with the cell DNA and are permanently incorporated into the blood stem cells, theoretically enabling them to produce melanoma-fighting cells indefinitely and when needed, said Dimitrios N. Vatakis, the study's first author and an assistant researcher in Zack's lab. (scienceblog.com)
  • It's not impossible for us to turn red blood cells into stem cells already: Viruses can be harnessed to set the clock back on the cells by delivering genes to them, but that can come with complications, like mutated genes or cancer. (planettechnews.com)
  • The research, in collaboration with scientists at the Institut de Recherches Cliniques de Montreal (IRCM) identifies 153 genes that respond to estrogen and one in particular that can be used to halt the growth of breast cancer cells. (news-medical.net)
  • Los Angeles, California - Even though the transplantation of blood stem cells, also known as bone marrow, has saved many lives over many decades, the genes that control the number or function of blood stem cells. (scicasts.com)
  • Of these, 16 areas contained completely new genes, which had not been previously associated with the risk of developing high blood pressure. (bionews.org.uk)
  • Together, they affect a common biological mechanism that causes the disease," said Siddharth Prakash, assistant professor of molecular and human genetics at BCM and first author of "Rare Copy Variants Disrupt Genes Regulating Vascular Smooth Muscle Cell Adhesion and Contractibility in Sporadic Thoracic Aortic Aneurysms and Dissections. (bio-medicine.org)
  • regenerative medicine
  • The method was 100 times more efficient than previous efforts, said Eric Bouhassira, a professor of stem cell biology and regenerative medicine at Albert Einstein College of Medicine in New York. (spokesman.com)
  • Located in Dallas, Texas, CRI is creating interdisciplinary groups of exceptional scientists and physicians to pursue research at the interface of regenerative medicine, cancer biology and metabolism, fields that hold uncommon potential for advancing science and medicine. (healthcanal.com)
  • regulates
  • The pathway is called the Wnt signaling pathway, a very important part of basic cell biology that regulates communications and interactions between cells in animals and people. (medindia.net)
  • This discovery, published today in the scientific journal Nature , illustrates how a protein called Musashi-2 regulates the function and development of important blood stem cells. (georgetown.edu)
  • chemotherapy
  • The research, published in Nature , raises several intriguing possibilities for further investigation that might lead to improved treatments for blood cancers and increased safety and effectiveness of chemotherapy. (healthcanal.com)
  • Can we reduce the toxicity of chemotherapy to the blood-forming system by taking into account estrogen levels in female patients? (healthcanal.com)
  • Blood stem cells can also be wiped out by chemotherapy for leukaemia and other cancers. (newscientist.com)
  • Similarly, ), a growth factor for white blood cells called granulocyte colony stimulating factor is used to remedy low white blood cell counts that often result from chemotherapy or radiation treatments. (stemcellsportal.com)
  • Treatment with pleiotrophin may prove useful in helping patients more quickly regenerate their own blood-forming cells after chemotherapy or bone marrow transplant. (stemcellsportal.com)
  • microenvironment
  • With this improved understanding of the microenvironment and mechanisms that maintain blood-forming stem cells, we are closer to being able to replicate the environment for blood-forming stem cells in culture," said Dr. Morrison, who is also a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research and a Howard Hughes Medical Institute Investigator. (healthcanal.com)
  • The findings, published in Nature , provide a significant advance toward understanding the microenvironment in which stem cells reside within the bone marrow. (utsw.edu)
  • Genetics
  • Before the finding, blood-forming stem cells were thought to be regulated similarly in both males and females, according to the paper's senior author, Dr. Sean Morrison , Director of CRI, Professor of Pediatrics, and the Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center. (healthcanal.com)
  • immune system
  • Properly functioning HSCs - which form in the bone marrow - are vital to the ongoing production of different types of blood cells that allow the immune system to fight infections. (medindia.net)
  • There's really a reshaping of the immune system when you inject these cells," says Paolo Fiorina, MD, PhD, of Boston Children's, senior investigator on the study. (medicalxpress.com)
  • Autologous bone-marrow transplant-infusing patients with their own blood stem cells to reboot their immune system-has helped some patients, but not all. (medicalxpress.com)
  • Scientists have discovered that a group of important immune system cells has a surprising resemblance to cinematic British superspy James Bond: the cells receive a "license" that allows them to unleash their most potent attacks on enemies. (news-medical.net)
  • A specialized subpopulation of the antibody-producing B cells of the immune system plays a "double-barreled" role in triggering both kinds of immunity - innate and acquired, Duke University Medical Center immunologists have discovered. (news-medical.net)
  • patient's
  • However, whereas nondiabetic patients generally experience long-term benefits from stem cell therapy for CLI, in which a patient's own bone marrow cells are injected directly into the affected limb, the procedure works only transiently in diabetic patients. (temple.edu)
  • possibility
  • to trauma, infection, or other things the possibility of menstrual blood stem cells could be given to fix it. (blogspot.com)
  • Although, this approach can become a possibility in the future, scientists are planning to develop new bioprocesses and engineering solutions to overcome the challenge of the requirement of stem cells on a large scale. (ygoy.com)
  • induce
  • Elevated estrogen levels that are sustained during pregnancy induce stem cell mobilization and red cell production in the spleen, which serves as a reserve site for additional red blood cell production. (healthcanal.com)
  • function
  • T-cells can be engineered to fight disease, but their function is not long-lasting in most cases, and more engineered T-cells ultimately are needed to sustain a response. (scienceblog.com)
  • Although there is a large amount of data showing that blood stem cell function declines during aging, the molecular processes that cause this remain largely unknown. (medindia.net)
  • It turns out that, in response to injury, a type of cell in the eye called Muller glia - which helps maintain the structure and function of the zebrafish retina - transforms into rod photoreceptors, which allow vision in low light. (ca.gov)
  • breakthrough
  • A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy. (nanowerk.com)
  • biology
  • Our hypothesis is that pleitrophin has the potential to promote blood stem cell growth in the manner that erythropoietin stimulates red blood cell precursors," said principal investigator John Chute, M.D., a Duke professor of medicine, pharmacology and cancer biology. (stemcellsportal.com)
  • Laurent Dollé is a scientist in Biomedical Sciences with 16 years of experience in Cell Biology and Molecular Biology with interests on healthcare systems and innovative technologies/devises. (smi-online.co.uk)
  • retinal
  • Injury to the retina and optic nerve leads to irreversible loss of retinal ganglion cells (RGCs) and irreparable damage to their axons which ultimately leads to blindness. (nanowerk.com)
  • The newly discovered retinal cell - which is highly sensitive to light - controls how the eye grows and develops. (crystalinks.com)
  • receptor
  • When an estrogen receptor that is present within blood-forming stem cells was deleted from those cells, they were no longer able to respond to estrogen, nor were they able to increase red blood cell production. (healthcanal.com)
  • It binds to the PD-1 receptor (inhibitory programmed death 1) on the inflammatory T-cells that are activated to cause autoimmune reactions. (medicalxpress.com)
  • cancer
  • These cells can exist in the periphery of the blood, and if they detect the melanoma antigen, they can replicate to fight the cancer. (scienceblog.com)
  • Over about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells. (scienceblog.com)
  • This new approach engineers the cells that give rise to the T-cells so that "fresh" cancer-killing cells could be generated when needed, perhaps protecting against cancer recurrence later. (scienceblog.com)
  • Prior studies have suggested that pleiotrophin can promote cancer cell growth, so human safety studies will be crucial, Chute added. (stemcellsportal.com)
  • Leukemia (Leukaemia) is a cancer of the blood cells. (news-medical.net)
  • It is the most common type of blood cancer and affects 10 times as many adults as children. (news-medical.net)
  • Scientists at the McGill University Health Centre (MUHC) have made an important discovery that will advance our understanding of how the female hormone estrogen causes growth of breast cancer cells. (news-medical.net)