• Computer scientists at DePaul University applied a bioinformatics workflow to reconstruct one of the most complete genomes of a top cotton species, African domesticated Gossypium herbaceum cultivar Wagad. (phys.org)
  • While the cost of sequencing genomes has come down, this study still took nearly two years of work across disciplines. (phys.org)
  • The sequencing project represents part of an ambitious "microbial pathogenomics" research program at the University of Minnesota to sequence the genomes of a wide range of human and animal pathogens and use this information as a basis to understand the mechanisms by which they cause disease. (innovations-report.com)
  • Through start-up support from the Advanced Molecular Detection (AMD) program, StrepLab now sequences whole genomes of group A strep and other bacteria. (cdc.gov)
  • Scientists have done this before for viruses, but viruses typically have much smaller genomes than bacteria. (cdc.gov)
  • Finding the genomic equivalent of gold nuggets in the rough ore of a much larger set of data, TIGR scientists and collaborators have discovered the genomes of three new types of the microbe Wolbachia in fruitfly sequence data. (jcvi.org)
  • To learn more about the origins of the sledge dog, researchers further sequenced genomes of a 33,000-year-old Siberian wolf and ten modern Greenlandic sledge dogs. (tcd.ie)
  • The consortium is a UK-wide partnership working to sequence SARS-CoV-2 virus genomes to understand the spread of the virus and advise local and national control strategies. (cardiff.ac.uk)
  • CLIMB has proved pivotal to this, providing the computing infrastructure and bioinformatics analysis capability that has so far helped sequence more than 100,000 virus genomes. (cardiff.ac.uk)
  • The Shenzhen company says the low cost will be possible with an "extreme" DNA sequencing system it plans to offer that is capable of decoding the genomes of 100,000 people a year. (technologyreview.com)
  • A new era of personalized medicine beckons if sequencing technologies keep advancing, allowing whole genomes - not just select sections - to be sequenced cheaply. (extension13.com)
  • MONDAY, Jan. 25, 2010 (HealthDay News) -- The sequencing of nearly 100 full genomes from three successive epidemics of flesh-eating bacteria have given scientists the first clear picture of the biological events that contribute to deadly epidemics of severe infection. (healthday.com)
  • Our collaborative team has rapidly expanded its capacity and formulated new processes to be able to sequence genomes on a scale we have not done before. (vighneshworld.com)
  • The laboratory staff are now sequencing genomes from samples taken from patients with confirmed cases of COVID-19 at a rate of over 100 a week. (vighneshworld.com)
  • Humans have been mapping the world for several millennia, but genomes have been mapped and explored for just a single century with the greatest advancements in making a sequence reference map of the human genome possible in the past 30 years. (scienceblogs.com)
  • A reference genome sequence is a map that provides the essential coordinate system for annotating the functional regions of the genome and comparing differences between individuals' genomes. (scienceblogs.com)
  • Scientists have sequenced Neanderthal and Denisovan genomes from fossils discovered in Europe and Asia. (medlineplus.gov)
  • Repetitive DNA sequences make up more than 50% of our genomes. (lu.se)
  • This has been announced by the researchers this morning, during a special press conference at 'Bessensap', a yearly meeting of scientists and the press in the Netherlands. (eurekalert.org)
  • The researchers announced their news at the yearly 'Bessensap' meeting, bringing together the Dutch scientists and the press. (eurekalert.org)
  • The same group of researchers initially published both sequences, but there is a qualitative difference between the papers. (news-medical.net)
  • The researchers found that using the available data, they were unable to detect any contiguous sequences larger than 17 kb, using several different settings. (news-medical.net)
  • Now, the same group of researchers has filled in the missing information, publishing a complete Y chromosome sequence Wednesday in the journal Nature . (cnn.com)
  • Brush Up: What Is Bisulfite Sequencing and How Do Researchers Use It to Study DNA Methylation? (the-scientist.com)
  • Prior to DNA methylation sequencing, researchers treat their samples with sodium bisulfite to distinguish methylated cytosine from unmethylated cytosine. (the-scientist.com)
  • This opens up the possibility for more researchers to sequence many crops that are important to the global economy and to feeding the population. (phys.org)
  • University of Minnesota researchers, with collaborators at the U. S. Department of Agriculture s National Animal Disease Center in Ames, Iowa, have completed sequencing the genome of the bacteria that causes Johne s disease, a major chronic wasting disease found in dairy cattle. (innovations-report.com)
  • The gene sequencing will allow researchers to develop new ways of early diagnosis, prevention and treatment of a disease that costs the dairy industry more than $200 million a year. (innovations-report.com)
  • The researchers also found that the chromosome has a large number of sequences repeated throughout the genome. (innovations-report.com)
  • Researchers at the Cold Spring Harbor Laboratory (CSHL) have developed the world's first mobile genome sequence analyzer app for smartphones, bringing humanity one step closer to the realm of science fiction. (rt.com)
  • After determining the sequence of chemical "letters" that made up the genetic code of each species, researchers then "aligned" those sequences so that they could be comprehensively compared. (wuky.org)
  • Scientists at the HudsonAlpha Institute for Biotechnology with the help of Mars Wrigley Confectionery have created the newest weapon in that battle-an improved reference genome to help researchers and farmers develop healthier, more productive cacao crops. (hudsonalpha.org)
  • Then, researchers can sequence each generation of selectively bred plants to quickly find which ones carry the desirable traits. (hudsonalpha.org)
  • Irvine, Calif., March 11, 2022 - In a paper published today in Sciences Advances , researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible. (uci.edu)
  • By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders. (news-medical.net)
  • Experts have also said that this knowledge will help researchers around the world "better identify when testing samples whether they are looking at sequences from the Covid-19 virus or vaccines to treat the virus because they can give false positives. (independent.co.uk)
  • In a second study led by University of Washington geneticist Pille Hallast, researchers went one step further, using the reference sequence to assemble human Y chromosomes from 43 male individuals, half of whom represented African lineages. (extension13.com)
  • The researchers decided to sequence the genome of D. pachys to test how the single chromosome was structured, whether by loss or by fusion of multiple ancestral chromosomes. (sciencebulletin.org)
  • It will be published in full on a public database used by researchers and scientists working on solutions to the coronavirus outbreak worldwide. (vighneshworld.com)
  • The CCG has established technology platforms to assist researchers in both genome-wide and gene-focused efforts using next-generation sequencing to characterize tumors at the genomic (genotyping, somatic mutation detection, copy number analysis), transcriptomic (single-cell and single nucleus RNA-seq), and epigenomic (single-nucleus ATAC-seq) levels. (rna-seqblog.com)
  • We seek a Single-cell/-nucleus Sequencing Group Leader, Scientist II to coordinate scientific projects across multiple groups or collaborators, interact with researchers and clinicians within the Dana-Farber Cancer Institute (DFCI), and manage a team of laboratory specialists. (rna-seqblog.com)
  • For instance, the largest contig contains genetic material with 98% similarity to the full-length mitochondrial sequence of the Chinese rufous horseshoe bat ( Rhinolophus sinicus ), an unlikely event since a complete assembly of such a sequence is typically interrupted by stop codons. (news-medical.net)
  • The first attempt to determine the building blocks of our genetic code took place 20 years ago, but there were still significant gaps left in the sequences of all 23 pairs of human chromosomes. (cnn.com)
  • Having a complete Y chromosome genetic reference may help scientists and doctors further explore this potential link. (cnn.com)
  • A whole-genome sequencing is required for identification of genetic mutations and recombinations of the virus, while epidemiological studies can help assess its distribution. (dst.gov.in)
  • In interpreting evolutionary histories using ancient DNA, for example, scientists rely on assumptions about how DNA changes over time, and those assumptions rely on accurate genetic sequencing. (uci.edu)
  • The amount of information gathered via next-generation sequencing has made the diagnosis of genetic disorders quicker and more accessible to clinicians than ever before, but with expanded testing options come questions about ordering the correct type of testing. (news-medical.net)
  • A study of nearly 6,000 families, combining three genetic sequencing technologies, finds that mutations that occur after conception play an important role in autism. (news-medical.net)
  • Or it can be built from molecular information, like genetic sequences. (thetech.org)
  • On the biologists' site ( http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html ), you can listen to the compositions and even submit your own genetic sequence and have it translated to music. (sciencedaily.com)
  • Now that we have this 100 percent complete sequence of the Y chromosome, we can identify and explore numerous genetic variations that could be impacting human traits and disease in a way that we weren't able to do before," says Dylan Taylor, a geneticist at Johns Hopkins University and one of the study authors. (extension13.com)
  • After the deoxyribonucleic acid (DNA) sequence of the human genome was completed in 2003, the reference sequence underwent several improvements and today provides the underlying comparative resource for a multitude genetic assays and biochemical measurements. (scienceblogs.com)
  • Genetic analysis is error prone and the data require validation because the methods for collecting DNA sequences create artifacts and the reference sequence used for comparative analyses is incomplete. (scienceblogs.com)
  • Dyes are used to determine, which of the nucleotides (basis of genetic material) are present in a sequence. (cdc.gov)
  • We do not yet have evidence to standardize donor genetic sequencing prior to allo-HSCT. (bvsalud.org)
  • After allo-HSCT, HM relapse monitoring with genetic testing effectively results in genetic sequencing of the donor as the transplanted hematopoietic system is donor derived, which presents ethical challenges for disclosure to patients and donors. (bvsalud.org)
  • Despite their abundance, scientists have yet to fully understand their role in human biology - in large part due to technological limitations in studying these genetic repeats. (lu.se)
  • To bridge this gap, Christopher and his team will use new CRISPR-based tools and long-read sequencing techniques to analyze the genetic basis of neurological diseases. (lu.se)
  • The DNA sequencing was done with the Illumina 1G equipment. (eurekalert.org)
  • The claim, made today at a DNA technology conference in Marco Island, Florida, could intensify competition between BGI and Illumina, the California firm whose speedy instruments have dominated the gene-sequencing scene for more than a decade. (technologyreview.com)
  • San Diego-based Illumina is the world's leading maker of DNA sequencing equipment. (sandiegouniontribune.com)
  • San Diego gene sequencing giant Illumina announced an $8 billion deal Monday to acquire Grail Therapeutics, a Bay Area biotech once part of Illumina that is developing a blood test to catch cancer sooner. (sandiegouniontribune.com)
  • This deal is quite transformative for Illumina," said Dr. Phil Febbo, chief medical officer, as it shows that the gene sequencing giant is "a company that also cares about testing for providers and patients. (sandiegouniontribune.com)
  • Illumina estimates all forms of sequencing-based cancer testing, from screening the healthy to monitoring those who've been diagnosed, could be worth $75 billion by 2035. (sandiegouniontribune.com)
  • Our correspondent Amelia Smith went back to meet Illumina scientists Julian Gehring and Ursula Arndt. (thenakedscientists.com)
  • The participants had hands-on training on Illumina sequencing with Miseq and Oxford Nanopore Technology (ONT) MinION. (acegid.org)
  • 122 SARS-CoV-2 genome sequences ( 50 on ONT MinION and 72 on Illumina Miseq) were assembled during the training. (acegid.org)
  • It has been a pleasurable and unforgettable experience: learning NGS by performing sequencing using ONT and Illumina as well as analysing and curating the generated data using bioinformatics tools. (acegid.org)
  • According to the scientists, the development of molecular tools and genomic resources will accelerate molecular breeding and ultimately the utility of basil in medical community. (livemint.com)
  • Full experimental details backed up the published genomic sequence of SARS-CoV-2, but not so that of the RaTG13. (news-medical.net)
  • School of Young Scientists 'Genomic Sequencing and Data Analysis', organised by Institute of Chemical Biology and Fundamental Medicine SB RAS , is devoted to the problems of analysis of data produced by the high-throughput DNA sequencing. (nsc.ru)
  • Indian Scientists, in partnership with Scientists from China, Russia and Brazil, will carry out genomic sequencing of SARS-CoV-2 and studies on the epidemiology and mathematical modelling of the COVID-19 pandemic. (dst.gov.in)
  • Chinese and Russian scientists will carry out the Real-Time PCR detection of SARS-CoV-2 in biological material (nasopharyngeal swabs) from patients with symptoms of respiratory diseases and investigate the genomic variability, comparative genomics and phylogenetic analysis. (dst.gov.in)
  • If anyone could properly consider the ramifications of knowing his or her sequence, it is a clinical geneticist," says professor Gert-Jan B van Ommen, leader of the LUMC team and director of the 'Center for Medical Systems Biology' (CMSB), a center of the Netherlands Genomics Initiative. (eurekalert.org)
  • This information is highly beneficial for mining biosynthetic pathways for important metabolites in related species, said a 2014 study published by the CSIR scientists behind the exercise in BMC Genomics. (livemint.com)
  • Lastly Hi-C sequence data from Phase genomics were used to construct chromosome level genome. (phys.org)
  • In February a Boston startup, Nebula Genomics, began inviting consumers to get sequenced for just $299 . (technologyreview.com)
  • The mission of the Center for Cancer Genomics (CCG) is to facilitate the development and implementation of innovative methods and emerging sequencing technologies that directly aid precision cancer medicine efforts. (rna-seqblog.com)
  • IARC scientists established the Rare Cancers Genomics Team to focus on the study of rare cancers. (who.int)
  • Lead author Yao Yang and colleagues note in the paper [" Quantitative and multiplexed DNA methylation analysis using long-read single-molecule real-time bisulfite sequencing (SMRT-BS) "] that existing methods for methylation analysis are limited by cost and throughput in the case of Sanger sequencing, or short read lengths with NGS technologies. (pacb.com)
  • We offer a broad range of services for sequencing including NGS, targeted genotyping by sequencing, sanger sequencing, and more. (biosearchtech.com)
  • This machine is a sequencing instrument, a Sanger sequencer. (cdc.gov)
  • Sanger sequencing implements a traditional type of sequencing. (cdc.gov)
  • Scientists have fully sequenced the Y chromosome for the first time, uncovering information that could have implications for the study of male infertility and other health problems. (cnn.com)
  • Now, the smallest member of the human chromosome family has been fully sequenced, completing a puzzle that's taken three decades to solve. (extension13.com)
  • Those blanks were largely filled in last year by an international group of 100 scientists called the Telomere-to-Telomere (T2T) Consortium. (cnn.com)
  • Led by genomicist Arang Rhie from the US National Human Genome Research Institute, the aptly named Telomere-to-Telomere consortium used advanced sequencing techniques and newly developed bioinformatic algorithms to stitch long stretches of DNA together, finally mapping the Y chromosome in full. (extension13.com)
  • In an effort to improve outcomes for patients with some of the deadliest childhood cancers, St. Jude Children's Research Hospital scientists have created the world's largest collection of pediatric solid tumor samples, drug-sensitivity data and related information and have made the resource available at no charge to the global scientific community. (news-medical.net)
  • In another recent publication, entitled " CGGBP1 mitigates cytosine methylation at repetitive DNA sequences ," scientists at the Science for Life Laboratory at Uppsala University used bisulfite conversion paired with PacBio® sequencing to examine the effect of depleting the transcription factor CGGBP1 on the level of methylation in Alu and LINE repeats. (pacb.com)
  • In fact, repetitive DNA sequences have been linked to various diseases, including neurological conditions. (lu.se)
  • Today, the cost (mostly for chemicals) is around $600 for the largest sequencing centers. (technologyreview.com)
  • This infrastructure is easily adaptable for various research settings ranging from small research labs to large sequencing centers. (selectbiosciences.com)
  • This Centers for Disease Control and Prevention (CDC) scientist was performing one of the last steps in a poliovirus testing process. (cdc.gov)
  • The availability of the genome sequence now opens the possibility of identifying genes involved in producing therapeutic molecules and to produce them in vitro (in the lab) according to CSIR. (livemint.com)
  • The genome sequence and annotation of Basil provides new insights into the function of genes and the medicinal nature of the metabolites synthesized in this plant. (livemint.com)
  • In particular, groups of genes on the man's Y chromosome and in his mitochondrial DNA were unlike those seen in earlier studies of ancient Romans but similar to sequences carried by some people living today on the Italian island of Sardinia. (newscientist.com)
  • The genome sequence sheds new light on the genes and biochemical pathways in the bacterium, and the research offers a starting point for defining the mechanisms by which the organism causes disease and helping devise new strategies to detect infected animals and ultimately help control the spread of the organism. (innovations-report.com)
  • During the sequencing project, scientists discovered several genes that may help differentiate M. paratuberculosis from other closely related bacterial species. (innovations-report.com)
  • The analysis of the M. paratuberculosis genome found that its sequence contains nearly 5 million base pairs that are represented on a large circular chromosome with more than 4,500 predicted genes. (innovations-report.com)
  • Machines have been whirring and computers have been computing to sequence the genes of Bruce the black lab puppy. (thenakedscientists.com)
  • They also corrected multiple errors in previously sequenced sections and discovered 41 new protein-coding genes. (extension13.com)
  • There were also striking structural differences: the precise sequences of genes were conserved (so they still encoded the right proteins) but sometimes larger sections of DNA were flipped, oriented in the opposite direction along the Y chromosome. (extension13.com)
  • As a cost-effective alternative to other targeted bisulfite sequencing techniques, SMRT-BS is an efficient and highly quantitative method for DNA methylation analysis. (pacb.com)
  • Any DNA, RNA, or protein sequences can be used to draw a phylogenetic tree. (thetech.org)
  • UCLA molecular biologists have turned protein sequences into original compositions of classical music. (sciencedaily.com)
  • Takahashi and Miller are not the first scientists to attempt to convert protein sequences into music, but they believe their music is more melodic and less "jumpy" than previous attempts. (sciencedaily.com)
  • Now they are piloting a computer program, written by colleague Frank Pettit, that uses their translation rules to convert the protein sequences to music. (sciencedaily.com)
  • Salzberg had been approached to do the project by Michael Eisen, a University of California-Berkeley assistant professor of molecular and cell biology and a faculty scientist at Lawrence Berkeley National Laboratory. (jcvi.org)
  • However, over half of the sequences within the Y chromosome, the smallest and most complicated of the 46 human chromosomes, remained unknown. (cnn.com)
  • Close relatives, such as C. elegans, have 5-7 chromosomes, but a single-chromosome pair, the scientists say, is so rare in higher organisms that only two other animal species are known with this condition: an ant and a parasitic roundworm. (sciencebulletin.org)
  • The current reference genome sequence is a collection of sequences, an assembly, that include sequences assembled into chromosomes, sequences that are part of structurally complex regions that cannot be assembled, patches (fixes) that cannot be included in the primary sequence, and high variability sequences that are organised into alternate loci. (scienceblogs.com)
  • While CDC's scientists were developing the cluster detection tool in 2017, epidemiologists in Minnesota noticed an increase in invasive group A strep infections. (cdc.gov)
  • The MDH Public Health Laboratory obtained potentially outbreak-related isolates, performed additional testing, and shared these isolates with StrepLab for sequencing and analysis. (cdc.gov)
  • Repeating each initially reactive EIA test increases the specificity of the test sequence by reducing the possibility that technical laboratory error caused the reactive result. (cdc.gov)
  • For the last five years, the cost of genome sequencing has been kept at $1,000. (technologyreview.com)
  • Over 1,000 sequences of the coronavirus genome have now been produced as part of work done by scientists and clinicians from the University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust. (vighneshworld.com)
  • Recent technological advancements like long-read sequencing, which can resolve repetitive sequences with unprecedented accuracy, mean that we can now begin to better understand this. (lu.se)
  • The scientists assembled the viral genome from scratch, performed a metagenomic analysis, and looked at data quality. (news-medical.net)
  • The iGenomics algorithm can reportedly map DNA sequences of viral pathogens, from strains of bird flu to the Zika virus, while also identifying mutations which could save crucial time in both diagnosis and treatment of disease. (rt.com)
  • Additional steps needed to confirm this hypothesis include further culturing of the virus from appropriate specimens, sequencing the viral genome, and examining specimens from patients at different stages of their illness. (cdc.gov)
  • That's because if scientists understand how Taq functions, then they can better understand just how accurate a person's sequenced genome truly is. (uci.edu)
  • The regulator said that after scientists Kevin McKernan and Dr. Phillip J. Buckhaults publicly raised the presence of SV40 enhancers in the vaccines earlier this year, "it was possible for Health Canada to confirm the presence of the enhancer based on the plasmid DNA sequence submitted by Pfizer against the published SV40 enhancer sequence. (theepochtimes.com)
  • Kevin McKernan announced Thursday his team has sequenced the entire genome of the cannabis plant. (abc7news.com)
  • Scientists from the Icahn School of Medicine at Mount Sinai and the University of Saskatchewan teamed up to develop an innovative approach to methylation analysis using Single Molecule, Real-Time (SMRT®) Sequencing. (pacb.com)
  • Amplicon templates are re-amplified and barcoded for multiplexing, and then purified and sequenced prior to CpG methylation analysis. (pacb.com)
  • The scientists found that results from the procedure were "reproducible and highly concordant" with other methylation analysis methods, particularly as sequencing depth increased. (pacb.com)
  • Using long-read sequencing technology "allows for more thorough regional CpG methylation assessment and increases the capacity for studying the relationship between phased single nucleotide variants and allele-specific CpG methylation," they report. (pacb.com)
  • Lead author Prasoon Agarwaal and colleagues used genome-wide amplification of Alu and LINE-1 repeats using consensus primers and PacBio sequencing to examine the extent to which an observed genome-wide increase in CpG methylation after CGGBP1 knock down was focused in these regions. (pacb.com)
  • Interestingly, although there was an increase in Alu methylations overall, "an inspection of the distribution of methylation frequencies indicated two different directions of methlylation change," the scientists report. (pacb.com)
  • More generally, they note that while this experiment reflects an overall characterization of methylation changes, "these data give a sound platform to build upon to uncover the sequence contexts in which CGGBP1 exerts methylation regulation at specific sites. (pacb.com)
  • You can't always sequence your way out of a tight spot: Next-generation sequencing holds great promise for pathogen detection, but the devil is in the details. (cdc.gov)
  • Scientists know of around 6,500 living mammal species, inhabiting practically every environment on Earth - from frigid oceans to high deserts. (wuky.org)
  • To construct a tree, we'll compare the DNA sequences of different species. (thetech.org)
  • But as species evolve and diverge, they will accumulate changes in the DNA sequences. (thetech.org)
  • A team of scientists has sequenced, for the first time, a tiny worm that belongs to a group of exclusively asexual species that originated approximately 18 million years ago - making it one of the oldest living lineages of asexual animals known. (sciencebulletin.org)
  • In making this determination, the scientists used DNA to derive a genealogy that revealed D. pachys belongs to a group of exclusively asexual species that originated approximately 18 million years ago. (sciencebulletin.org)
  • But in this study, published in the American Journal of Infection Control , of the 12 isolates that underwent whole-genome sequencing, 42% of the CA-CRE isolates carried the carbapenemase gene. (medscape.com)
  • A team led by TIGR's senior director of bioinformatics, Steven Salzberg, used TIGR's data from the first Wolbachia to be sequenced ( W. pipientis wMel ) as a probe to analyze fruitfly Trace Archive data for other strains of the endosymbiont. (jcvi.org)
  • ACEGID facilitated a three-week training on SARS-CoV-2 sequencing and bioinformatics for Rwandan scientists at the Rwanda Biomedical Centre (RBC). (acegid.org)
  • Lead author Sandra Bulens, MPH, a health scientist in CDC's Division of Healthcare Quality Promotion, told Medscape Medical News , "The findings highlight the potential for CP-CRE to move from healthcare settings into the community. (medscape.com)
  • We considered that sequencing only males, for 'completeness', slows insight into X-chromosome varialibity. (eurekalert.org)
  • Scientists have finally decoded mysteries of the Y chromosome. (cnn.com)
  • The more detailed information provided by the new Y reference sequence will make it easier to study conditions and disorders linked to the chromosome, such as lack of sperm production that leads to infertility. (cnn.com)
  • Last year, scientists unveiled the most complete gapless sequence of the human genome ever produced - but it was missing one small piece: the Y chromosome. (extension13.com)
  • The Y chromosome contains lots of repetitive sequences - including a few long palindromes - that have made it largely 'unreadable' until now. (extension13.com)
  • The team filled in more than 30 million 'letters' in the DNA sequence to assemble the Y chromosome in its entirety: all 62,460,029 base pairs. (extension13.com)
  • Nearly half of the chromosome is made of alternating blocks of two specific repeating sequences known as satellite DNA. (extension13.com)
  • Pictured is Diploscapter pachys (D. pachys), a newly sequenced roundworm that is approximately one-third of a millimeter long and one of a very few known animals that have only a single chromosome. (sciencebulletin.org)
  • HudsonAlpha scientists have completed and released an updated reference genome for Theobroma cacao , the tree that produces cacao beans. (hudsonalpha.org)
  • A key point of the reference genome is that it is not a single sequence. (scienceblogs.com)
  • The reference genome sequence is always product of understanding at a set point in time and continues to evolve. (scienceblogs.com)
  • The health regulator says Pfizer did not disclose the presence of the Simian Virus 40 (SV40) DNA sequence in its mRNA COVID-19 vaccine at the time of filing. (theepochtimes.com)
  • Both scientists made waves after discovering plasmid DNA in the mRNA COVID-19 injections, warning it could potentially alter the human genome. (theepochtimes.com)
  • Dr. Patrick Provost, a professor in the Department of Microbiology, Infectious Diseases and Immunology at the Faculty of Medicine at Laval University, said the SV40 enhancer sequence was used in the vaccines because it's a component of the plasmid used for amplification of the vaccine mRNA. (theepochtimes.com)
  • He said that since the average length of the degraded DNA fragments found by Dr. Buckhaults was 100 base pairs, and the SV40 enhancer sequence is only 72 base pairs long, the chances of finding an intact, fully functional SV40 enhancer sequence in the mRNA vaccines is "relatively high, certainly not negligible. (theepochtimes.com)
  • Stanford scientists have published the mRNA sequence of the Moderna Covid-19 vaccine after reverse-engineering the droplets left in used vials. (independent.co.uk)
  • Praising the work of their peers working at Moderna and Pfizer , the scientists said they had done the world "a great service," however, making the mRNA sequence of vaccines available will "continue to benefit humanity," they told Motherboard . (independent.co.uk)
  • On 25 December last year, Bert Hubert, PowerDNS founder, had used the publicly available information about the BioNTech/Pfizer vaccine to figure out its mRNA sequence. (independent.co.uk)
  • How do you guarantee to a patient that you've accurately sequenced their DNA when it's different from the accepted human genome? (uci.edu)
  • Using technology originally acquired in the US, the Chinese gene giant BGI Group says it will make genome sequencing cheaper than ever, breaking the $100 barrier for the first time. (technologyreview.com)
  • Scientists don't know how these enzymes achieve their accuracy," said Collins, whose lab created the nano-scale devices for studying Taq's behavior. (uci.edu)
  • The focus of the current paper is on the accuracy of the data on these sequences. (news-medical.net)
  • The team's work began with crunching DNA sequence data. (phys.org)
  • They began reconstructing the Wagad genome by assembling high quality long DNA sequence data generated using Pacific Biosciences sequencing technology. (phys.org)
  • Users can now simply AirDrop sequence data to each other without the need for internet access to hosted research servers, allowing highly advanced work to take place at the frontiers of medicine, which may soon include Earth orbit and beyond. (rt.com)
  • The results of the research, published in February in the journal Genome Biology , show "how powerful the public release of raw sequencing data can be," the scientists report. (jcvi.org)
  • The resulting data is the best ever produced on people of African ancestry, the scientists report in the journal Nature . (sleepreviewmag.com)
  • While anyone interested could data-mine and filter these sequences out later, there is a substantial economy of scale and educational value in having the sequences available ASAP and in not having to guess where they have come from," they said. (independent.co.uk)
  • Knowing these sequences and having the ability to differentiate them from other RNAs in analyzing future biomedical data sets is of great utility," the Stanford scientists said in an email interview with Motherboard that first reported on this. (independent.co.uk)
  • The scientists said in the post that "Pfizer/BioNTech data verified the reported sequence for that vaccine while the Moderna sequence could not be checked against a published reference. (independent.co.uk)
  • There is an emerging need for data management, integration, analysis, and interpretation of data generated from NGS (next-generation sequencing) technologies. (selectbiosciences.com)
  • They learnt how to assemble sequences, how to submit data to online repositories, how to identify variants and how to interpret data. (acegid.org)
  • Instead it is an assembly of consensus sequences that are designed to deal with variation in the human population and uncertainty in the data. (scienceblogs.com)
  • DNA sequence data are interpreted through biochemical experiments or comparisons to other DNA sequences. (scienceblogs.com)
  • DNA sequences evolve through duplication and mutation and, as a result, contain many repeated sequences of different sizes, which complicates data analysis. (scienceblogs.com)
  • Ancient DNA from Bronze Age Greek human remains has been sequenced for the first time. (ibtimes.co.uk)
  • Psst, the Human Genome Was Never Completely Sequenced. (mercola.com)
  • It's been 14 years since scientists announced they'd finally sequenced the entire human genome. (mercola.com)
  • See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)
  • Mr. McKernan, a former researcher and team leader for the Massachusetts Institute of Technology Human Genome Project, told The Epoch Times he suspects Pfizer didn't disclose the presence of the DNA sequence due to the association of SV40 with polio vaccines. (theepochtimes.com)
  • He said while there is no evidence the sequence is carcinogenic, he has concerns about its integration into the human genome. (theepochtimes.com)
  • Some previously unknown human Y sequences were, for example, mistakenly thought to be traces of bacterial DNA contaminating samples. (extension13.com)
  • The biggest surprise was how organized the repeats are," says Adam Phillippy, a computer scientist at the US National Human Genome Research Institute. (extension13.com)
  • DNA sequences within the human population undergo continual change and vary highly between individuals. (scienceblogs.com)
  • Deep sequencing of 2009 influenza A/H1N1 virus isolated from volunteer human challenge study participants and natural infections. (cdc.gov)
  • Even as the COVID-19 pandemic enters its ninth month, scientists continue to debate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) intensely. (news-medical.net)
  • While the dataset is unique and contains much information beyond the fragmented coronavirus sequence, not much is known about how it was generated. (news-medical.net)
  • RÉSUMÉ Depuis l'émergence de nouveaux coronavirus pendant l'automne 2012, de nombreuses études ont été menées en laboratoire, mais la plupart des paramètres requis pour l'établissement scientifique de mesures de lutte qui soient capables de protéger contre ces virus restent à définir. (who.int)
  • En 2003, l'expérience de la recherche sur un autre nouveau coronavirus, le syndrome respiratoire aigu sévère, et de la lutte contre ce virus a démontré comment des recherches nationales et locales permettent de mettre en place un front commun au sein d'une coalition internationale et d'éviter efficacement les épidémies. (who.int)
  • Sequence #2 vs #3 have 2 differences. (thetech.org)
  • Sequences #3 vs #4 has 5 differences. (thetech.org)
  • You can actually calculate how similar any two sequences are, and make a table to compare all the differences. (thetech.org)
  • DNA sequence variation happens on large and small scales with respect to the lengths of the DNA differences to include single base changes, insertions, deletions, duplications and rearrangements. (scienceblogs.com)
  • Using innovative sequencing technologies that provide information on the molecular characteristics of tumours, they uncover differences among tumours that look similar under a microscope. (who.int)
  • The newly sequenced worm, Diploscapter pachys, is a tiny, transparent, free-living roundworm and closely related to Caenorhabditis elegans, an organism commonly used for biomedical research. (sciencebulletin.org)
  • In the GitHub post, the scientists said: "RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. (independent.co.uk)
  • The work of TOPMed should translate not only into better scientific knowledge but increase diversity at all levels-scientists, trainees, participants-in work to extend personalized medicine for everyone. (sleepreviewmag.com)
  • every scientific field that relies on accurate DNA sequencing stands to benefit from a better understanding of how Taq works. (uci.edu)
  • The odds of complex life arising may be better on planets around K-type main-sequence stars than around Sun-like stars, given the suitable temperature and extra time available for it to evolve. (wikipedia.org)
  • A Protocol for Extraction of Infective Viromes Suitable for Metagenomics Sequencing from Low Volume Fecal Samples. (cdc.gov)
  • Running the genome sequences through the cluster detection tool at CDC showed the samples were near identical. (cdc.gov)
  • Genome sequence information allows scientists to track new strains and antibiotic resistance trends. (cdc.gov)
  • Before genome sequencing, scientists only knew the type of group A strep strains, not if they were identical or near identical. (cdc.gov)
  • Recent research in the Streptococcus Lab (StrepLab) at CDC is improving how scientists identify infections that are part of an outbreak. (cdc.gov)
  • Identifying precise timings and the extent of these migrations will be among the scientists' questions as they pursue this line of research, building up a clearer picture of the origins of Greek civilisation . (ibtimes.co.uk)
  • Keeping this in mind, a research plan has been made by including expertise of scientists and engineers from diverse backgrounds. (dst.gov.in)
  • Super-cheap DNA sequencing could boost cancer screening, prenatal tests, and research into population genetics. (technologyreview.com)
  • But genome sequencing could exacerbate healthcare disparities if historical injustices and the lack of diversity in research studies aren't resolved. (extension13.com)
  • Scientists have been trying to understand how some animals can survive for millions of years without sex because such strict, long-term abstinence is very rare in the animal world," explains New York University Biology Professor David Fitch, one of the co-authors of the research. (sciencebulletin.org)
  • Experts say the results give scientists a more complete picture of how wild cotton was domesticated over time and may help to strengthen and protect the crop for farmers in the U.S., Africa and beyond. (phys.org)
  • The truth was - and still is - there are missing sequences that, at the time, were considered too insignificant to matter. (mercola.com)
  • they also remain stable in the main sequence longer than the Sun by burning their hydrogen slower, allowing more time for life to form on a planet around a K-type main-sequence star. (wikipedia.org)
  • Health Canada expects sponsors to identify any biologically functional DNA sequences within a plasmid (such as an SV40 enhancer) at the time of submission," the agency said in an email to The Epoch Times. (theepochtimes.com)
  • Although the full DNA sequence of the Pfizer plasmid was provided at the time of initial filing, the sponsor did not specifically identify the SV40 sequence. (theepochtimes.com)
  • This isn't the first time the sequence of a Covid vaccine has been made public. (independent.co.uk)
  • Using error-corrected targeted sequencing, a high CH prevalence of 56.4% (variant allele frequency [VAF] ≥1%) at the time of CAR T-cell infusion was detected. (bvsalud.org)
  • Dr. Buckhaults said on social media the SV40 enhancer sequence taken from SV40 is a "standard bit of molecular biology engineering to achieve high level expression of the Neo resistance marker" and that it's been "used for decades. (theepochtimes.com)
  • We converted the sequence of proteins into music and can get an auditory signal for every protein," said Jeffrey H. Miller, distinguished professor of microbiology, immunology and molecular genetics, and a member of UCLA's Molecular Biology Institute. (sciencedaily.com)
  • We believe this can be a tremendous teaching tool to get children, non-scientists and the visually impaired interested in proteins and molecular biology," Miller said. (sciencedaily.com)
  • Following in-depth analysis, the sequence will be made public, except incidental privacy-sensitive findings. (eurekalert.org)
  • The results of the sequencing analysis are available online at www.pathogenoics.umn.edu, and more about Johne s disease can be found at www.johnes.org. (innovations-report.com)
  • A computational system set up for COVID-19 sequencing analysis has won a major award. (cardiff.ac.uk)