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  • myelination
  • In studies of contusion SCI in the rat using mitogen-expanded cells, we have shown that SC transplantation at seven days after injury significantly fosters axon regeneration and myelination, improves host tissue preservation, 4 and reduces cavitation 4,14 in a thoracic SCI paradigm and increases numbers of preserved NeuN positive neurons rostral and caudal to the injury/graft site 17 after cervical SCI. (genengnews.com)
  • membrane
  • In the lesion milieu, transplanted SCs may be effective through their production of growth promoting trophic molecules, 7 their deposition of matrix molecules collagen and laminin into the extracellular space, 8 as well as their expression of surface membrane cell adhesion molecules such as NCAM and L1. (genengnews.com)
  • Signaling
  • Loss of function of merlin encoded by the NF2 tumor suppressor gene leads to activation of multiple mitogenic signaling cascades, including platelet-derived growth factor receptor (PDGFR) and SRC in Schwann cells. (harvard.edu)
  • 1990
  • Since 1990, scientists at the Miami Project to Cure Paralysis have generated extensive preclinical data suggesting Schwann cell transplantations are successful in rodents with SCI. (clinicaltrials.gov)
  • Autologous
  • Large numbers of autologous human SCs (ahSCs) can be obtained for implantation after a peripheral nerve biopsy followed by dissociation and expansion of their cell numbers in culture with mitogens. (genengnews.com)
  • 23 Autologous cells in general offer important safety advantages over allogeneic sources that include minimal risk of disease transfer, low risk of tumorigenicity, and the absence of immunosuppressive medication requirements. (genengnews.com)
  • Autologous cells offer important safety advantages that include no need for immune suppression, minimal risk of disease transfer, and a low risk of tumorigenicity. (clinicaltrials.gov)