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  • eukaryotes
  • In all eukaryotes, the receptor-mediated transport of nuclear proteins across the NE from their site of synthesis in the cytoplasm is essential for all nuclear processes. (genetics.org)
  • Eukaryotes have at least six SMC proteins in individual organisms, and they form three distinct heterodimers with specialized functions: A pair of SMC1 and SMC3 constitutes the core subunits of the cohesin complexes involved in sister chromatid cohesion. (wikipedia.org)
  • In the third protein group, the coiled-coil domain is essential for dimerization in simple eukaryotes. (wikipedia.org)
  • 1999
  • The precise tissue-specific and temporal regulation of nuclear protein import is also critical in the regulation of cell cycle progression and in developmental and signal transduction pathways (reviewed in K affman and O'S hea 1999 ). (genetics.org)
  • localization
  • The nuclear import of classical nuclear localization signal-containing proteins depends on importin-α transport receptors. (genetics.org)
  • Msps is not only responsible for transporting bicoid mRNA throughout the cell, but it also localizes mRNA to the anterior (head) end of the oocyte Additionally, this gene is critical for the organization of tubular endoplasmic reticulum and in Exuperantia protein localization. (wikipedia.org)
  • In 2006, sub-cellular localization of almost all the proteins in S. pombe was published using green fluorescent protein as a molecular tag. (wikipedia.org)
  • Multiple conserved nuclear localization signals were also predicted within the QSER1 protein by pSORT. (wikipedia.org)
  • Genome
  • Its genome, which is approximately 14.1 million base pairs, is estimated to contain 4,970 protein-coding genes and at least 450 non-coding RNAs. (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or rasGAP domain. (wikipedia.org)
  • Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that do not share sequence similarity with ras GAPs. (wikipedia.org)
  • These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. (wikipedia.org)
  • spindle
  • Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. (string-db.org)
  • In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. (wikipedia.org)
  • Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity. (wikipedia.org)
  • chromatin
  • Deletion of Msc1 did not disrupt the S. pombe Swr1C or its ability to bind and load H2A.Z into euchromatin, however H2A.Z was ectopically found in the inner centromere and in subtelomeric chromatin. (uib.no)
  • These data describe H2A.Z action in S. pombe and identify a new mode of chromatin surveillance and maintenance based on negative regulation of histone variant misincorporation. (uib.no)
  • May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis (PubMed-8343962, PubMed-7957098). (string-db.org)
  • taxonomy
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • binds
  • p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • The N-terminal domain binds to protein kinases. (wikipedia.org)
  • phosphorylation
  • impairs gcn1- mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down- regulation of protein synthesis. (string-db.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • wee1
  • The Cdr2, Cdr1, Wee1, Mid1, and Blt1 proteins are also located at the medial node during interphase and are believed to be part of the signaling pathway for mitotic entry. (wikipedia.org)
  • bind
  • It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. (wikipedia.org)
  • Human
  • The following human genes encode SMC proteins: SMC1A SMC1B SMC2 SMC3 SMC4 SMC5 SMC6 cohesin condensin Cornelia de Lange Syndrome Losada A, Hirano T (2005). (wikipedia.org)
  • nucleotide
  • For example, the ste11 transcript in Schizosaccharomyces pombe has a 2273 nucleotide 5′ UTR while the lac operon in Escherichia coli only has 7 nucleotides in its 5′ UTR. (wikipedia.org)
  • The protein encoded by this gene removes 5' overhanging "flaps" (or short sections of single stranded DNA that "hang off" because their nucleotide bases are prevented from binding to their complementary base pair-despite any base pairing downstream) in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. (wikipedia.org)
  • During nucleotide excision repair, several protein complexes cooperate to recognize damaged DNA and locally separate the DNA helix for a short distance on either side of the site of a site of DNA damage. (wikipedia.org)
  • Transcription
  • The encoded protein acts as a transcription factor and may be autoregulatory. (genecards.org)
  • These results reveal that flocculation in S. pombe is regulated by a complex network of multiple transcription factors and target genes encoding flocculins and cell wall-remodeling enzymes. (prolekare.cz)
  • The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. (genecards.org)
  • interaction
  • The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. (genecards.org)
  • The biophysicists participating in QBM (Braun, Jungmann, Rädler, Schwille) bring a wealth of advanced expertise and novel methodologies, permitting the high-resolution quantitative and dynamic analysis of regulatory processes, including protein folding/conformation and the interaction of proteins with small molecules, nucleic acids, or other proteins in different settings (single molecule, purified/crude extracts). (lmu.de)
  • The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions, genetic interactions, chemical interactions, and post-translational modifications created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital. (wikipedia.org)
  • The BioGRID's original focus was on curation of binary protein-protein and genetic interactions, but has expanded over several updates to incorporate curated post-translational modification data, chemical interaction data, and complex multi-gene/protein interactions. (wikipedia.org)
  • The Biological General Repository for Interaction Datasets (BioGRID) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species and humans. (wikipedia.org)
  • The BioGRID architecture has been improved in order to support a broader range of interaction and post-translational modification types, to allow the representation of more complex multi-gene/protein interactions, to account for cellular phenotypes through structured ontologies, to expedite curation through semi-automated text-mining approaches, and to enhance curation quality control. (wikipedia.org)
  • Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. (wikipedia.org)
  • This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. (wikipedia.org)
  • intracellular
  • Moshkov, I. 2007-11-07 00:00:00 The control of plant growth, differentiation, and development is considered in relation to the involvement of monomeric GTP-binding proteins (mG-proteins) in the extra-and intracellular signal transduction. (deepdyve.com)
  • checkpoint
  • This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. (wikipedia.org)
  • The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. (wikipedia.org)
  • subunits
  • By primary sequence and protein structural similarity, the ERCC1-XPF nuclease is a member of a broader family of structure specific DNA nucleases comprising two subunits. (wikipedia.org)
  • This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. (wikipedia.org)
  • ATPase
  • Other names in common use include multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, and ATP phosphohydrolase (steroid-exporting). (wikipedia.org)
  • Initiation
  • RNA-binding proteins sometimes serve to prevent the pre-initiation complex from forming. (wikipedia.org)
  • Rad3 is required for activation of chk1 and initiation of G2 arrest, but different proteins are believed to maintain G2 arrest so that DNA repair can occur. (wikipedia.org)
  • triggers
  • Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. (genecards.org)
  • recruitment
  • This supports a model where phosphorylation by rad3 causes recruitment of these proteins to sites of DNA damage where they mediate the activity of DNA polymerases involved in DNA repair. (wikipedia.org)