• kinase
  • As introduced in Chapters II, III and IV checkpoint kinase cds1 Δ, mus81 Δ endonuclease, and smc6-x mutant slowing defects were not suppressed by abrogation of recombination, while the sfr1 Δ, rqh1 Δ, rad2 Δ and nbs1 Δ mutant slowing defects were. (umassmed.edu)
  • damage
  • Checkpoints alter cellular processes in the presence of DNA damage preventing cell cycle transitions until replication is completed or DNA damage is repaired. (umassmed.edu)
  • The exact role MRN serves to slow replication is obscure due to its many roles in DNA metabolism and checkpoint response to damage. (umassmed.edu)
  • We show that replication slowing is lesion density-dependent, prevention of origin firing representing a global response to insult contributes little to slowing, and constitutive checkpoint activation is not sufficient to induce DNA damage-independent slowing. (umassmed.edu)