Schiff base complexes. Medical search. Frequent questions

Here, the systematic characterization by X-ray crystallography and UV-visible spectroscopy of a salphenazine ligand (H 2 L I ), containing the O-N-N-O salen type bonding motif, and corresponding metal complexes revealed the extended π-conjugation of these ligands results in differentiation of a uranyl signal as compared to these transition metal contaminants. (auburn.edu)
On the basis of characterization of the ligands and the complexes which were substituted benzofuran derivatives, by elemental analysis, magnetic moment, measurement of electrical conductance, electronic transition and the infrared spectroscopy. (jetir.org)
Characterization of the complexes has been done on the basis of elemental analysis, molar conductivity, magnetic studies, thermal studies, IR, electronic spectral techniques, ESR spectral studies etc. (derpharmachemica.com)
The characterization and nature of bonding of these complexes were elucidated by elemental analysis, melting point, molecular weight determinations, electronic spectra, redox behavior, magnetic and EPR studies, IR, 1 H and 13 C NMR spectral studies. (ijpsr.com)
Gharamaleki, J. , Akbari, F. , Karbalaei, A. , Ghiassi, K. and Olmstead, M. (2016) Synthesis, Characterization and Crystal Structure of a New Schiff Base Ligand from a Bis(Thiazoline) Template and Hydrolytic Cleavage of the Imine Bond Induced by a Co(II) Cation. (scirp.org)
In this project, our efforts were directed to the synthesis and characterization of nickel(II) and zinc(II) complexes with tetradentate N 2 O 2 -Schiff base ligands based on diaminomaleonitrile and various aldehydes such as 2-hydroxybenzaldehyde, 3-methoxy-2-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde. (springer.com)
Synthesis and characterization of Schiff base ligands derived from substituted amine and salicylaldehyde and their complexes (Cu 2+ , Co 2+ ) are reported. (scirp.org)

abstract = "In (he present communication eight new lanthaiiuni(lll) and praseodymium(III) complexes of the general formula (LnCI(L)(H2O)) (Ln = LaIII and PrIII: LH2= Schiff bases derived from 2,6-diacetylpyridine and 4-amino-3-(phcnyl/2-chlorophenyl/4-chlorophcnyl/4-nitrophenyl)-5-mercaplo-1,2,4-trizoles were synthesized In the presence of base. (edu.sa)

To investigate the effect of different halogen substituents and leaving groups and the flexibility of ligands on the anticancer activity of copper complexes, sixteen copper(ii) complexes with eight different tridentate Schiff-base ligands containing pyridine and 3,5-halogen-substituted phenol moieties were synthesized and characterized by spectroscopic methods. (unl.pt)
A series of ONO-tridentate Schiff base ligands derived from chiral and achiral amino alcohols and amino acids were synthesized and reacted with AlEt 3 to provide dimeric aluminum complexes. (acs.org)

Based on their spectral studies the ligandN,N / Bis(2-hydroxybenzylidene)-1,4-phenylenediimine(M) was observed to be bidentate through the participation of the oxygen from their hydroxyl endand N,N / - Bis(4-dimethylaminobenzylidene)-1,4-phenylenediimine (N) was bidentate through the participation of their imine nitrogen end. (projects.ng)
New complexes of La (III) and Nd (III) with bidentate Schiff base ligands, 1-H indole-(2, 3-dione) hydrazinecarbothioamide (L1H), 1-H indole-(2, 3-dione) hydrazinecarboxamide (L2H) have been synthesized and characterised. (ijpsr.com)
The Schiff base ligands and their complexes have been further characterized by H-1 NMR The results suggest that the Schiff base acts as a bidentate ligand which bonds to the metal ions through the imino nitrogen and carboxylate oxygen. (sdu.edu.tr)

A minimum of three different cobalt(III) complexes could be isolated when CoCl2 is dissolved in aqueous ammonia after which oxidized by air towards the +3 oxidation condition. (ihelptostudy.com)
In each one of the cobalt(III) complexes formerly described, three Cl - ions are necessary to fulfill the primary valence from the Co 3+ ion. (ihelptostudy.com)
Werner assumed the secondary valence from the transition metal during these cobalt(III) complexes is six. (ihelptostudy.com)
Based on his theory, the ligands in six-coordinate cobalt(III) complexes are oriented toward the corners of the octahedron, as proven within the figure below. (ihelptostudy.com)
This paper presents the schiff base ligands and their complexes of divalent transition metals such as cobalt, nickel and copper. (jetir.org)

The mono-negative ligands L-1 and L-2 are chelated in all four complexes through the four donor atoms to form square planar nickel(II) and copper(II) complexes Structures of 3 and 4 reveal that enantiomeric pairs are crystallized together with opposite chirality in the nitrogen and carbon atoms. (reading.ac.uk)
The nickel(II), copper(II), and zinc(II) complexes with Schiff bases derived from 1-naphthylarnine and 2-hydroxy naphthaline-1-carbaldehyde (HL) or 1,4-diaminobutane and 4-methoxy benzaldehyde (L') have been prepared. (bozok.edu.tr)
The title complex, [Ni 2 (C 11 H 11 Br 2 N 2 O) 2 (NCS) 2 ], is a thio-cyanate-bridged dinuclear nickel(II) complex. (iucr.org)
The two Ni centers in the title dinuclear nickel(II) complex are doubly-bridged by thiocyanato ligands. (iucr.org)

Despite the high stability of Schiff bases, these newly obtained compounds hydrolyze in aqueous media, the process being accelerated by metal cations. (nih.gov)
The term Schiff base is normally applied to these compounds when they are being used as ligands to form coordination complexes with metal ions. (wikipedia.org)
Analytical data and conductance spectral and magnetic studies provide evidence of the existence of mononuclear compounds corresponding to a stoichiometry of the M-II : L (1 : 2) type, Furthermore, the conductometric determination of the complexation constant, Ke, of AgNO3, ZnCl2, and Cu(NO3)(2) in 80% dioxane-water in the presence of HL and L' Schiff bases has been investigated. (bozok.edu.tr)
Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. (journalcra.com)
The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
Mitochondrial membrane potential was found at low levels in cells treated with Schiff base compounds and doxorubicin. (ijpsonline.com)
This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)

Treatment of K 2 PtCl 4 with the MeO-salen Schiff base H 2 L [H 2 L = N,N′-bis(3-methoxysalicylidene)ethylene- 1,2-diamine] gave the precursor complex PtL, which, upon recrystallization from two different solvent mixtures, afforded different solvate forms of PtL·H 2 O (1) and PtL·DMF (2) with different solid-state colors. (edu.hk)

They're also referred to as complex ions or coordination complexes since they're Lewis acidity-base complexes. (ihelptostudy.com)
The ions or molecules that bind to transition-metal ions to create these complexes are known as ligands (from Latin, to tie or bind). (ihelptostudy.com)
However, only two Cl - ions within the CoCl3 5 NH3 complex and just among the Cl - ions in CoCl3 4 NH3 could be precipitated with Ag + ions. (ihelptostudy.com)
Measurements from the conductivity of aqueous solutions of those complexes claim that the CoCl3 6 NH3 and CoCl3 5 NH3 H2 O complexes dissociate in water to provide as many as four ions. (ihelptostudy.com)
G. N. Lewis was the first one to notice that the response from a transition-metal ion and ligands to create a coordination complex was similar towards the reaction between your H + and OH - ions to create water. (ihelptostudy.com)
A novel schiffbase ligand is synthesized by aldehyde with Aromatic Amine to form Schiffbase ligand (L). It is mixed with 1stRow transition metal ions to form metal complexes. (journalcra.com)
An ethanolic solution of (2 × 10 −2 M) Schiff base was added to (10 −2 M) of metal ions (as dehydrated acetate salts). (scirp.org)

From an elemental analysis, the complexes are in 1:3 (metal: ligand). (ijpsr.com)
The complex was characterized by elemental analysis, spectroscopy (IR and UV) as well as by a single-crystal X-ray structure determination. (sunway.edu.my)
Complexes are characterized by Elemental analysis, UV- spectroscopy, Infrared spectroscopy and NMR. (journalcra.com)
Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:2 (metal-ligand). (journalcra.com)
The obtained solids were further investigated by elemental analysis and UV-Vis titration that confirmed the formation of [CoL] and [ClCuHL] complexes. (scirp.org)
Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 3-chloro-4-fluoroaniline (HL 1 ) and 4-fluoroaniline (HL 2 ) with 2-thiophenecarboxaldehyde have been synthesized and characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR and magnetic susceptibility. (hindawi.com)
The ligands and ligand-complexes were characterized by melting point, FTIR, CHN-elemental analysis and UV-Visible analysis. (scirp.org)
The UV-Visible and elemental analysis of complexes established (1:2) mole ratio (M:L). The stability constant and thermodynamic parameters (K, ΔG, ΔH, ΔS) were determined at different temperature (30 - 40)°C which established that the metal-complexes were very stable. (scirp.org)
The structure of all Schiff bases was characterized by using FTIR spectra, CHN elemental analysis and UV-Visible. (scirp.org)

Spin Interaction in Octahedral Zinc Complexes of Mono- and Diradical Schiff and Mannich Bases. (univ-grenoble-alpes.fr)

In organic chemistry, a Schiff base (named after Hugo Schiff) is a compound with the general structure R1R2C=NR3 (R3 = alkyl or aryl, but not hydrogen). (wikipedia.org)

However, hydrolytic cleavage of Schiff base ligands readily occurs due to the reversible nature of the synthetic procedure. (scirp.org)

Biological activities of these complexes were also inspected, and antibacterial and antifungal activities were tested against four different bacterial strains (E. coli, P. aureginosa, S. aureus and E. feacalis) and a fungus species (C. albicans). (tu-darmstadt.de)
Complexes were demonstrated to induce a higher loss of cell viability in the ovarian carcinoma cell line (A2780) with respect to the other two tumor cell lines, and therefore the biological mechanisms underlying this loss of viability were further investigated. (unl.pt)
Despite the ability of theCu(BrCl-L 1 )Clcomplex to induce programmed cell death in A2780 cells, its therapeutic window turned out to be low making theCu(Cl 2 -L 1 )NO 3 complex the most promising candidate for additional biological applications. (unl.pt)
These metal complexes can be used in catalytic reactions and as models for biological systems. (scirp.org)
The review describes the promising biological activities of Schiff base and their metal complexes. (scirp.org)

Although coordination complexes are particularly significant within the chemistry from the transition metals, some primary group elements also form complexes. (ihelptostudy.com)
Studies on metal chelates with Schiff bases of dehydroacetic acid have received attention due to their excellent chelating capacity in modern coordination chemistry. (derpharmachemica.com)

The recent developments and prospects of near-infrared molecular probes based on luminescent lanthanide coordination complexes in bioimaging are described, which is important to emphasise the importance of lanthanide chemical biology. (rsc.org)

Molecular structure of the complexes has been optimized by MM2 calculations and suggests a tetrahedral geometry. (cognizure.com)
The 3D molecular modeling structures of the ligand and its metal complexes are obtained by using Argus lab software. (derpharmachemica.com)
Synthesis of Ultrahigh Molecular Weight PLAs Using a Phenoxy-Imine Al(III) Complex. (acs.org)
Molecular diagnostic assays, such as nested polymerase chain reaction and a species-specific DNA probe from the ribosomal DNA complex, have been useful to identify P. insidiosum in the absence of culture ( 8 , 9 ). (cdc.gov)
Molecular and Growth-Based Drug Susceptibility Testing of Mycobacterium tuberculosis Complex for Ethambutol Resistance in the United States. (cdc.gov)

Generic diiminopyridine complex Chiral Schiff bases were one of the first ligands used for asymmetric catalysis. (wikipedia.org)
The chiroptical properties of enantiopure complexes and their catalytic applications in asymmetric oxidative coupling of 2‐naphthol to chiral 1,1'‐Bi‐2‐naphthol (BINOL) achieved in good yield and ee were discussed. (jyu.fi)

However, recrystallizaion of the Co(II) complex in dimethylsulfoxide caused the complete hydrolysis of the imine bond and afforded a Co(II) complex in which two 5-nitro-salicylaldehyde and two DMSO molecules were coordinated to the central metal in an octahedral fashion. (scirp.org)

A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B. (maynoothuniversity.ie)
The presence of coordinated water molecule in the complex was inferred from TO which indicates the loss of one water molecule at 150-165 °C. All these Schiff bases and their complexes have also been screened for their antifungal activities by MIC method. (edu.sa)

In the light of the above we have synthesized some new noble Schiff's Bases and their G-6 metal carbonyl derivatives. (org.in)
The aim of the study is the preparation of Schiff base derived from salicylaldehyde with a series of aniline derivatives. (scirp.org)
Accumulation of fatty aldehydes, which are highly reactive molecules, can form covalent Schiff-base derivatives with phosphatidylethanolamine, which may influence myelin membrane properties and alter the function of membrane-bound proteins. (medscape.com)

Werner assumed that transition-metal complexes had definite shapes. (ihelptostudy.com)
Transition-metal complexes happen to be characterised with coordination figures that vary from 1 to 12, but the most typical coordination figures are 2, 4, and 6. (ihelptostudy.com)
Salens, as chelating, double Schiff base ligands, are an important group utilized in transition metal catalysis. (nih.gov)
All of the free ligands and their metal complexes were tested for their anti-Candida activity. (maynoothuniversity.ie)
In 1968 Ryōji Noyori developed a copper-Schiff base complex for the metal-carbenoid cyclopropanation of styrene. (wikipedia.org)
Schiff bases have also been incorporated into metal-organic frameworks (MOF). (wikipedia.org)
It was prepared by the condensation reaction of 1,4-phenylenediamine with 4-dimethylaminobenzadehyde and 2-hydroxybenzaldehde .Their Co(II), Mn(VII), Mo(VII) metal complexes were synthesized by coupling them respectively with the individual formed ligands. (projects.ng)
Spectrophotometric analysis gave the stoichiometry to be 1:1 metals to ligand mole ratio for the Co(II) and Mn(VII) complexes of the N,N / - Bis(2-hydroxybenzylidene)-1,4-phenylenediimine(M) ligand and a 1:2 metal to ligand mole ratio for its Mo(VII) complex. (projects.ng)
Secondly its N,N / - Bis(4-dimethylaminobenzylidene)-1,4-phenylenediimine (N) ligand gave a 2:3 metal to ligand mole ratio for its Co(II) complex, a 1:4 ratio for its Mn(VII), and a 1:1 ratio for Mo(VII) complexes. (projects.ng)
These screening were performed at different concentrations by the agar-well diffusion method and the gram negative organism showed activity that the metal complexes are more potent than the parent Schiff base ligand. (projects.ng)
The ligands and the metal complexes were synthesized carefully the ligands were L1 and L2, which coordinated to metal ion through the 'O' of carbonyl group and the 'N' of hydrazine group. (jetir.org)
The complexes of transition metal (II) usually Co(II), Ni(II) and Cu(II) were highly active against all microbes. (jetir.org)
Co(II), Ni(II) and Zn(II) complexes of Schiff bases derived from condensation of 4-anisaldehyde with anisidine, (AAN) or 2,4 dinitrophenylhydrazine ,(ADN) have been prepared in 1:2 molar ratio (metal:ligand). (ijpsr.com)
La (III) and Nd (III) metal complexes and their parent ligands tested antimicrobial potency in-vitro, and the result indicates that metal complexes are more active than parent ligands. (ijpsr.com)
Homoleptic tris(bipy) rare earth metal complexes were synthesized and structurally characterized. (rsc.org)
Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. (journalcra.com)
The UVspectrum gives clear idea about the metal complexes. (journalcra.com)
Anti-oxidant properties of metal complexes also have been studied. (journalcra.com)
The reaction of (1) with Co(NO 3 ) 2 ·6H 2 O and CuCl 2 ·2H 2 O in methanol afforded the corresponding metal complexes. (scirp.org)
Schiff base ligands with a variety of donor atoms including nitrogen, oxygen and sulfur can be coordinated with transition metal atoms. (springer.com)
Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. (hindawi.com)
The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases. (hindawi.com)
Physical measurements of the synthesized ligand and their metal complexes and their expected formula are shown in Table 1 . (scirp.org)
Physical properties of synthesized ligand and their metal complexes. (scirp.org)

R−CH=NR' where R' ≠ H). Schiff bases can be synthesized from an aliphatic or aromatic amine and a carbonyl compound by nucleophilic addition forming a hemiaminal, followed by a dehydration to generate an imine. (wikipedia.org)
Schiff bases are common enzymatic intermediates where an amine, such as the terminal group of a lysine residue, reversibly reacts with an aldehyde or ketone of a cofactor or substrate. (wikipedia.org)
The amine or aldehyde fragment regenerated by the cleavage of the C=N functional group of the Schiff base, can coordinate to the central atom. (scirp.org)
Schiff base synthesis is usually acid catalyzed and it usually requires refluxing the mixture of aldehydes and amine in ethanolic solution. (scirp.org)

Adapting one‐pot self‐assembly technique from simple three components systems: 1,1′‐binaphthyl‐2,2′‐diamine, 4‐methyl‐2,6‐diformyl phenol and cupric salts, the helicate‐like [2+2]‐ macrocyclic complexes 1-1″, 2-2″ and 2+4‐μ4‐oxo tetranuclear complexes 3-3″, 4-4″ were obtained by appropriately altering the reaction condition such as temperature and subcomponent ratio. (jyu.fi)

Many Schiff base ligands are derived from alkyl diamines and aromatic aldehydes. (wikipedia.org)
The condensation of DAMN with different aromatic aldehydes can form 1:1 and/or 1:2 Schiff base ligands [ 14 ]. (springer.com)

Sn(II) and Pb(II) complexes of two symmetrical Schiff bases have been synthesized and characterized by various physico-chemical studies. (cognizure.com)

and [Cu(L-2)]ClO4 (4) with these two reduced Schiff base ligands have been synthesized and structurally characterized by X-ray crystallography. (reading.ac.uk)

According to TG, two thermal reactions between 120 and 180 °C endothermic separation of coordinative dimethylformamide molecules and then around 300 °C exothermic decomposition of molecule were observed for Schiff base-prepared complexes. (tu-darmstadt.de)
Both Ni atoms in each molecule have a square-pyramidal coordination geometry, and each center is bound by one O and two N atoms of one Schiff base ligand and by one N atom of a bridging thio-cyanate ligand, which define the basal planes. (iucr.org)

The synthesized Schiff base complexes exhibit higher antibacterial activity against the tested pathogens compared to the free Schiff base because of chelation. (ijpsr.com)

On the other hand, the complexes resulted from reduced Schiff base reactions were shown decomposed around 250-270 °C by exothermic thermal reaction. (tu-darmstadt.de)
In this review, we summarize the nanostructural engineering and applications of rare earth oxide-based nanomaterials with well-defined compositions, crystal phases and shapes for efficiently catalyzing C1 chemical reactions. (rsc.org)

The two Cu-II complexes (2 and 4) exhibit both irreversible reductive (Cu-II/Cu-II, E-pc. (reading.ac.uk)
The complexes exhibit coordination number 4 or 6. (hindawi.com)

Electronic data of the complexes suggested the octahedral geometry of the complexes. (jetir.org)
Whole studies propose non-electrolytic behaviour and an octahedral geometry of Ln (III) complexes. (ijpsr.com)

Types of complexes using these coordination figures receive within the table below. (ihelptostudy.com)

The potassium salts of the Schiff bases are 1:1 electrolytes, but all the complexes are non-electrolytes. (sdu.edu.tr)
The reaction of the Schiff base ligand with Co(II) and Cu (II) salts in methanol affords the [CoL] and [ClCuHL] complexes. (scirp.org)

In a typical reaction, 4,4'-oxydianiline reacts with o-vanillin: Schiff bases have been investigated in relation to a wide range of contexts, including antimicrobial, antiviral and anticancer activity. (wikipedia.org)
These ligands and their complexes were characterized on the basis of their melting point, stoichiometry, electronic spectra, infrared spectra and antimicrobial their antimicrobial properties. (projects.ng)
The complexes were screened in vitro against a fungal species and eight species of bacteria, revealing their antimicrobial activity. (springer.com)

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. (maynoothuniversity.ie)

The complex Cu(L) shows very good catalytic activities towards oxidation of benzyl alcohol to benzaldeyhde (under solvent-free condition) and organic thioethers to sulfoxide and sulfones using H2O2 as the oxidant. (ua.pt)

From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, con- sistent with a monomeric protein in complex with about 150 detergent molecules. (lu.se)
16] Schiff-base aldehyde adducts with other amino-containing molecules, including key membrane enzymes and proteins, may also be detrimental to their function. (medscape.com)

Complexes with ligandL 1 (containing a 2-pycolylamine-type motif) were more cytotoxic than complexes withL 2 (containing a 2-(2-pyridyl)ethylamine-type motif). (unl.pt)

1 H NMR spectra were measured on a Bruker AVANCE BRX 250 MHz spectrometer using d 6 -DMSO as solvent for the complexes. (springer.com)

The geometries of the Ni(II) and Zn(II) complexes were square planar and square pyramidal, respectively. (springer.com)

Complexes have been characterized with element analysis, IR spectroscopy and NMR spectroscopy methods and also investigated with Thermogravimetry (TG). (tu-darmstadt.de)

By using bis-N,N′(salicylidene)-1,3-diaminopropane and reduced form of this ligand bis-N,N′(2-hydroxybenzylidene)-1,3-diaminopropane, we prepared eight trinuclear complexes in the core form of NiII-NiII-NiII and NiII-CuII-NiII. (tu-darmstadt.de)
It was observed that thermal characteristics of the complexes prepared by the reduced form of Schiff base are different from complexes prepared by the Schiff base. (tu-darmstadt.de)

The molar conductance values showed that the complexes are non-electrolytes. (ijpsr.com)

The complexes were characterized by physicochemical and spectroscopic methods. (springer.com)

Organisms3

Chemicals and Drugs9

Phenomena and Processes1

Disciplines and Occupations1

Characterization7

Abstract1

Tridentate2

Bidentate3

Cobalt5

Nickel4

Compounds7

Salen1

Ions7

Elemental9

Zinc1

Hugo Schiff1

Ligands readily1

Biological5

Chemistry2

Lanthanide1

Molecular5

Chiral2

Hydrolysis1

Antifungal2

Derivatives3

Metal24

Amine4

Macrocyclic1

Aldehydes2

Symmetrical1

Synthesized and structurally characterized1

Molecule2

Antibacterial activity1

Reactions2

Exhibit2

Octahedral geometry2

Coordination1

Salts2

Antimicrobial3

Condensation1

Catalytic activities1

Molecules2

Cytotoxic1

Solvent1

Square planar1

Spectroscopy1

Reduced form2

Molar conductance1

Spectroscopic methods1