• The best-described PRRs include Toll-like receptors (TLRs), nucleotide-binding oligomerization domain-containing proteins, scavenger receptors, integrins such as complement receptors, DC-specific intercellular adhesion molecule-3-grabbing nonintegrin, dectin-1 and C-type lectin receptors, such as the macrophage mannose receptor. (medscape.com)
  • Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied. (silverchair.com)
  • The repertoire of receptors expressed on the alveolar macrophage (AM) surface is critical for binding, uptake, and response to microbes and inhaled unopsonized environmental particles. (silverchair.com)
  • One family of receptors likely to be important for normal host defense of the lung are the class A macrophage scavenger receptors (SRAs). (silverchair.com)
  • Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation. (ox.ac.uk)
  • In human carotid endarterectomy specimens TLR7 levels were consistently associated with an M2 anti-inflammatory macrophage signature (interleukin [IL]-10, IL-1RA, CD163, scavenger and C-type lectin receptors) and collagen genes, whereas they were inversely related or unrelated to proinflammatory mediators (IL-12/IL-23, interferon beta, interferon gamma, CD40L) and platelet markers. (ox.ac.uk)
  • It binds to a specific high affinity receptor ( RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR ). (lookformedical.com)
  • Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. (nih.gov)
  • The transmembrane C-type lectins human dendritic cell-speci﫿c intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and its mouse homolog SIGN-R1 are distributed in LRs and expressed on splenic marginal zone (MZ) macrophages. (sagepub.com)
  • Fibrates are a unique hypolipidemic drugs that lower plasma triglyceride and cholesterol levels through their action as peroxisome proliferator-activated receptor alpha (PPARα) agonists. (biomedcentral.com)
  • They function as agonists for peroxisome proliferator-activated receptor alpha (PPARα). (biomedcentral.com)
  • This protein is a scavenger receptor that displays several functions associated with host defense. (wikipedia.org)
  • It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. (nih.gov)
  • The protein is also a member of the scavenger receptor family. (nih.gov)
  • This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. (utsouthwestern.edu)
  • The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. (utsouthwestern.edu)
  • Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. (utsouthwestern.edu)
  • This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. (nih.gov)
  • Description: A sandwich ELISA kit for detection of Formyl Peptide Receptor 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
  • Description: A sandwich ELISA kit for detection of Sialic Acid Binding Ig Like Lectin 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • CD36 is a scavenger receptor present on various types of cells, including pancreatic β-cell, α-cells and contributes to lipid accumulation and in the progression of metabolic dysfunction. (e-dmj.org)
  • For the purpose of this BAA, adjuvants are defined as molecules that act via innate immune receptors to activate beneficial innate and/or adaptive (T and B cell-mediated) immune responses. (nih.gov)
  • Furthermore, in addition to their use for specific vaccine applications, adjuvants targeting innate immune receptors might be useful as stand-alone immunotherapeutic agents for the short term prevention or treatment of infectious disease. (nih.gov)
  • Recently, Lox-1 (lectin-type oxidized LDL receptor 1), an innate immune scavenger receptor, has emerged as a promising target for early diagnosis and cardiovascular risk prediction and is also being considered as a treatment target. (nih.gov)
  • In this study, we discovered a novel l-rhamnose binding lectin (DrRBL) and studied its innate i. (researchgate.net)
  • The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. (utsouthwestern.edu)
  • Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. (nih.gov)
  • system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human IL-31RA / IL-31 receptor alpha ELISA Kit製品コード:HUFI00631サイズ:96Tエイリアス:IL31RA, CRL3, GLM-R, class I cytokine receptor, Cytokine receptor (assaygenie.jp)
  • cytokine receptor like factor 1 [Source. (gsea-msigdb.org)
  • LRs play crucial roles in complex Accordingly, in this study, the role of LRs was examined physiological processes, such as phagocytosis, in C-type lectin-mediated phagocytosis in order to eluci- receptor-receptor associations, receptor-pathogen asso- date the role of DC-SIGN in the human spleen. (sagepub.com)
  • BACKGROUND: Toll-like receptors (TLRs) have long been considered to be major culprits in the development of atherosclerosis, contributing both to its progression and clinical complications. (ox.ac.uk)
  • One of the major immune cell types present in the PDA microenvironment is a subset of macrophages commonly termed tumor-associated macrophages (TAM). (nih.gov)
  • The progress in understanding T cell function in cancer has and will continue to improve harnessing of the immune system across broader tumor types to benefit more patients. (salk.edu)
  • C-type lectins (CTLs) are important immune-related molecules in crustaceans. (researchgate.net)
  • TAMs express scavenger receptors such as CD206 which facilitate tumor angiogenesis and migration. (nih.gov)
  • The effects of the N-methyl-D-aspartate receptor activators D-serine, D-alanine, and sarcosine against schizophrenia and depression are promising. (researchgate.net)
  • Make note that certain genes are listed as markers for multiple cell types. (nih.gov)
  • A class of oxidized LDL receptors that contain C-type lectin-like extracellular domains. (nih.gov)
  • In addition, they found that the lymph node cell subsets that are most efficacious in stimulating M. tuberculosis -specific, T-cell receptor-transgenic CD4 + T lymphocytes are not infected with the bacteria, and are scarce or absent from the lungs of infected mice. (medscape.com)
  • We have previously reported the up-regulation of galectin-3, a β-galactoside-binding lectin, in the endothelium and sera of diabetic mice, implicating this molecule in diabetic vasculopathy and suggesting its potential as a biomarker of the disease. (biomedcentral.com)
  • Galectin-3 knockout mice (KO) and wild-type mice (WT) were fed either a high-fat diet (HFD) (60 % fat calories) to produce insulin resistant diabetes, or standard chow (12 % fat calories), and their metabolic and endothelial responses were measured. (biomedcentral.com)
  • Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. (gsea-msigdb.org)
  • PPARα is a transcriptional nuclear receptor and forms a heterodimer with another nuclear receptor, retinoid X receptor (RXR). (biomedcentral.com)
  • This database provides mean TPM values for the cell type selective markers expressed in mouse whole kidney (WK) samples. (nih.gov)
  • Representation and relative abundance of cell-type selective markers in whole-kidney RNA-Seq data. (nih.gov)
  • WK TPM values with a β superscript signify non-proximal tubule cell type selective markers with rat proximal tubule RPKM values >10 in at least one proximal tubule subsegment. (nih.gov)
  • [ 20 ] Cholesterol has been shown to act as a docking site for pathogens and facilitates the interaction between mycobacteria and surface receptors. (medscape.com)
  • Phagocytic cells express a range of cellular receptors known as pattern-recognition receptors (PRRs), which are involved in sensing microorganisms. (medscape.com)
  • CD206 is a member of the large C-type lectin receptor family and not found on other TAM population like undifferentiated M0 or M1-like macrophages. (nih.gov)
  • [ 26 ] M. tuberculosis also escapes the killing by various metabolites of respiratory burst, including reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs), by releasing scavenger enzymes, such as superoxide dismutase and catalase (KatG). (medscape.com)
  • Blue cells = expressed in wild-type. (jax.org)
  • However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor b (TGF-b) or Th17-specific orphan nuclear receptors RORa and RORg in vivo. (gsea-msigdb.org)
  • l-rhamnose-binding lectin (RBL), which is a class of animal lectins independent of Ca2+, can specifically bind l-rhamnose or d-galactose. (researchgate.net)
  • By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits. (bvsalud.org)
  • Here we investigated ATM phenotype in visceral (VAT) and subcutaneous (SAT) adipose tissue from healthy lean and obese individuals using two molecules previously identified as markers of M1-like and M2-like/tissue-resident macrophages, the C-type lectin CLEC5A and the scavenger receptor CD163L1, respectively. (nih.gov)
  • They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. (lookformedical.com)
  • We report the unexpected finding that TLR7, a receptor recognizing self-nucleic acid complexes, is protective in atherosclerosis. (ox.ac.uk)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Formyl Peptide Receptor 1 (FPR1) in Cell lysates, cell culture supernates and other biological fluids. (wildpalm.net)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Formyl Peptide Receptor 1 (FPR1) in samples from Cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
  • Thus, we sought to determine the role of galectin-3 in the vascular pathology and metabolic derangement observed in type II diabetes. (biomedcentral.com)
  • In light of our preliminary findings, we suspected that galectin-3 is involved in the endothelial dysfunction that leads to the vascular complications of type II diabetes. (biomedcentral.com)
  • AIMS/HYPOTHESIS: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. (bvsalud.org)
  • We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. (bvsalud.org)
  • METHODS: Midwife records were traced for 6866 individuals with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. (bvsalud.org)
  • Weighted polygenic scores (PS) for type 2 diabetes and birthweight were calculated to assess the impact of genetic predispositions. (bvsalud.org)
  • Heterogeneity in type 2 diabetes presentation, progression and treatment has the potential for precision medicine interventions that can enhance care and outcomes for affected individuals. (bvsalud.org)
  • We undertook a systematic review to ascertain whether strategies to subclassify type 2 diabetes are associated with improved clinical outcomes, show reproducibility and have high quality evidence. (bvsalud.org)
  • Both approaches require a higher grade of evidence but support the premise that type 2 diabetes can be subclassified into meaningful groups. (bvsalud.org)
  • Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. (e-dmj.org)
  • Type 2 diabetes mellitus (T2DM) is strikingly increasing globally and leads not only to the threatened health of individuals but to the economic burdens of society [ 1 ]. (e-dmj.org)
  • Here we show a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β-adrenergic receptor ADRB1. (salk.edu)
  • ClinicalTrials.gov: Number, "type":"clinical-trial","attrs":"text":"NCT00345930″,"term_id":"NCT00345930″NCT00345930 Antagonists, Hepatotoxicity, Autoimmunity Biological response modifiers are prescribed to modify the bodys response to inflammation, infection, and PQM130 neoplasia. (health-e-nc.org)
  • Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. (lookformedical.com)
  • Gene symbols marked with an α superscript are listed as markers in multiple cell types. (nih.gov)
  • The structure and chemical properties may vary with the species and type of releasing cell. (lookformedical.com)