• A study conducted to determine the antioxidative activities of the extracts from Psidium guajava Linn leaves showed that it has effects on scavenging hydroxyl radicals and inhibiting lipid peroxidation in the dose-dependent manner, The guava extracts possess the potential antioxidative activities and the flavonoids may be one of their antioxidative components. (medicalhealthguide.com)
  • MECG also inhibited lipid peroxidation (IC50 150.56±3.02 ?g/ml) and promoted metal chelation (IC50 50.29±2.00 ?g/ml) in a dose-dependent manner. (degruyter.com)
  • The free radical scavenging activity of an ethanol extract of the leaves of Stachytarpheta angustifolia was assessed by measuring its capability for scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide anion radical (), hydroxyl radical (OH), nitric oxide radicals (NO), as well as its ability to inhibit lipid peroxidation, using appropriate assay systems. (edu.ng)
  • This extract showed a potent antioxidant activity in the DPPH radical-scavenging assay (EC50 = 9.65 μg/ml), significantly inhibited OH radical (IC50 = 99.43 μg/ml), anion radical (IC50 = 64.68 μg/ml), non-enzymatic lipid peroxidation (IC50 = 282.91 μg/ml) and accumulation of nitrite in vitro. (edu.ng)
  • Furthermore, LA can scavenge lipid peroxidation products such as hydroxynonenal and acrolein. (weeksmd.com)
  • GPx, a selenium-containing antioxidative enzyme scavenging system, act directly as an antioxidant and an inhibitor of lipid peroxidation. (ijbs.com)
  • The catechins inhibit the key enzymes involved in lipid biosynthesis and reduce intestinal lipid absorption, thereby improving the lipid profile. (zenithnutrition.com)
  • One well-known mechanism of action is its role as an antioxidant that scavenges and neutralizes harmful free radicals, while also inhibiting lipid peroxidation-a process linked to liver injury. (purerawz.co)
  • Studies have shown that α-LA can inhibit the oxidation and lipid peroxidation catalyzed by Cu2+, and can also combine with Cu2+ to form lipophilic complexes. (nmn-bio.com)
  • Objective: The present study was undertaken to evaluate the phytochemical constituents and antioxidant and free radical scavenging properties of Clerodendron glandulosum.Coleb.Methods: - Methanolic extract of C.glandulosum.Coleb (MECG) was studied for its qualitative and quantitative phytochemical constituents and free radical scavenging potential using different in vitro assays for hydrogen peroxide, hydroxyl, superoxide, DPPH, nitric oxide, peroxynitrite, singlet oxygen and hypochlorous acid radicals scavenging assays. (degruyter.com)
  • The MECG scavenges hydrogen peroxide (IC50 120.23± 1.53 ?g/ml), hydroxyl (IC50 70.23±1.36 ?g/ml) superoxide (IC50 80.36±1.36 ?g/ml), DPPH (IC50 50.11±1.36 ?g/ml) and nitric oxide (IC50 90.11±1.55 ?g/ml) radicals in a dose dependent manner. (degruyter.com)
  • Antioxidant analysis methods like scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power were carried out. (google.com)
  • It was found that methanolic extracts elicited higher total phenolic content, higher percentage scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power. (google.com)
  • The generations of ROS, such as superoxide anion, hydrogen peroxide, and the hydroxyl radical can result in the damage to cell membranes. (ijbs.com)
  • and non-free radical species such as hydrogen peroxide (H 2 O 2 ) are diverse kinds of activated oxygen and mostly produced by exogenous factors or oxidation product of biological reactions [ 1 - 3 ]. (ijpsonline.com)
  • Antioxidant activity of extract was analyzed using DPPH free radical scavenging assay and the effect of the investigated extracts on the proliferation of keratinocytes (HaCaT) and fibroblasts (BJ) was measured. (biomedcentral.com)
  • In addition, the extracts possess antioxidant properties through radical (DPPH and OH) scavenging and metal (Fe 2+ ) chelating abilities. (degruyter.com)
  • LA chelates redox-active transition metals, thus inhibiting the formation of hydroxyl radicals and also scavenges reactive oxygen species (ROS), thereby increasing the levels of reduced glutathione. (weeksmd.com)
  • Similarly, freeze-dried açaí extract has demonstrated unrivalled scavenging capacity against two of the most damaging reactive oxygen species, the superoxide and peroxyl radicals. (lifeextension.com)
  • Green tea extract has a strong potential to boost the immune system, reduce the formation of reactive oxygen species, increases the activity of pro-oxidant enzyme such as glutathione peroxidase, and superoxide dismutase through its antioxidant properties. (zenithnutrition.com)
  • The health benefits of green tea extract are mainly attributed to its antioxidant properties, including the ability of catechins to scavenge reactive oxygen species or chelate with metal ions. (zenithnutrition.com)
  • respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
  • Metabolism of glutathione peroxidase, can further inflammation, and - along with oth- many exogenous agents through cy- convert these reactive species to er radical species - play key roles tochrome P450-mediated reactions wate r (Benzie, 2000) . (who.int)
  • 17-19 Developed by scientists at the USDA Human Nutrition Research Center on Aging at Tufts, the ORAC test is considered one of the most sensitive and reliable methods for measuring the ability of antioxidants to absorb free radicals. (lifeextension.com)
  • 20 It measures both the degree and speed with which a certain food inhibits the action of an oxidizing agent, then integrates these two measurements into a single value, producing an accurate assessment of different types of antioxidants of different strengths. (lifeextension.com)
  • The extract is a potential source of antioxidants/free radical scavengers having important metabolites which maybe linked to its ethno-medicinal use. (biomedcentral.com)
  • These results shown that crude ethanol and water extracts of Iris taochia had effective reducing effect, radical scavenging activity and metal chelating effects when compared to standard antioxidants. (ijpsonline.com)
  • The results indicated that the ethanol and water extracts of Iris taochia could be used as a potential source of natural antioxidants by the pharmaceutical industry or as a conceivable food supplement. (ijpsonline.com)
  • Possible correctable measures include foremost lifestyle changes, but also supplementation with antioxidants to scavenge excessive ROS. (hindawi.com)
  • DHLA has a low redox potential (-0.24V), it can reduce the oxidized glutathione GSSH to GSH, and can also regenerate other endogenous antioxidants such as VE, ascorbic acid and other endogenous antioxidants through redox coupling. (nmn-bio.com)
  • An extremely important role in the fight against damage caused by free radicals play antioxidants derived from diet. (biomedcentral.com)
  • Andrikopoulos et al (2003) studied various resins for their potential protective in vitro activity against copper-induced LDL oxidation . (masticlife.com)
  • The aim of the present study was to evaluate the in vitro antioxidant and free radical scavenging capacity of bioactive metabolites present in Newbouldia laevis leaf extract. (biomedcentral.com)
  • Excessive heavy metal ions such as Cu2+, Fe2+, Pb2+, Hg2+, Zn+ will catalyze the decomposition of H2O2 in vivo to produce highly toxic OH, resulting in oxidative damage to tissues, while α-LA and DHLA can chelate in vivo and in vitro These metal ions inhibit the formation of ROS and reduce oxidative damage. (nmn-bio.com)
  • Promising results obtained in vitro as well as on animal studies suggest that GSE may have a great relevance as source of potential new pharmacological molecules,and could represent an important opportunity for clinical research. (oatext.com)
  • This study was undertaken to evaluate the glycaemic potential of Psidium guajava unripe fruit peel extract on blood glucose level of normal and streptozotocin induced diabetic rats. (medicalhealthguide.com)
  • 10 organisms grown separately on nutrient agar plateswere subjected to guava water extract and results have shown that the growth of all these organisms was inhibited suggesting the antidiarrhoeal activity. (medicalhealthguide.com)
  • Assay of reducing capacity of MECG showed a dose-dependent response.Conclusion: The results suggest that a methanolic extract of Clerodendron glandulosum.Coleb possesses a strong antioxidant activity against all known radicals and can be considered as a natural antioxidant. (degruyter.com)
  • Phytochemical Constituents and Free Radical Scavenging Activity of Clerodendron glandulosum.Coleb Methanolic Extract" Journal of Complementary and Integrative Medicine , vol. 6, no. 1, 2009. (degruyter.com)
  • Ex vivo the extract inhibited phorbol myristate acetate (PMA)-induced production of superoxide anion (), and also exhibited a dose-dependent reduction in the levels of the immune activation marker CD38 and CD69 on phytohemagglutinin A (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). (edu.ng)
  • The observed antioxidant activity and immunomodulatory potentials of the extract suggest that it could impart health benefits when consumed. (edu.ng)
  • Compounds isolated in freeze-dried açaí extract have been shown to enter human cells and neutralize free radicals at very low doses. (lifeextension.com)
  • By activating AMPK, green tea extract inhibits synthesis of fatty acids, decrease gluconeogenesis, and fatty acid synthesis. (zenithnutrition.com)
  • The extract of Chios Mastic inhibited both apoptosis and necrosis, restored glutathione levels and downregulated CD36 expression, even at the mRNA level. (masticlife.com)
  • The study therefore, evaluated the principal metabolites present in the ethanolic leaf extract of the plant as well as the antioxidant potential and free radical scavenging activity of the leaf extract. (biomedcentral.com)
  • The ability of samples' extract to inhibit some of key enzymes relevant to erectile dysfunction and type-2 diabetes could render them cheap, natural and alternative therapy with erectogenic and antidiabetic potentials. (degruyter.com)
  • Superoxide dismutase (SOD) is responsible for the conversion of superoxide radicals to H 2 O 2 . (biomedcentral.com)
  • Oxygen free radicals generated by spermatozoa may be involved in the production of spermicidal cytotoxic end products [ 4 ]. (ijbs.com)
  • One of the most relevant central dogmas of the aging theories was the free radical theory of aging (FRTA), claiming that oxygen free radicals are harmful by-products of the aerobic life and as such, are responsible for aging and numerous diseases. (antiaging-systems.com)
  • I have analyzed the contradictory items of the FRTA, outlining a new, comprehensive interpretation of the possible biological role of oxygen free radicals in the living state, cell differentiation and aging, called the membrane hypothesis of aging (MHA). (antiaging-systems.com)
  • The MHA attributes a role to the constant flux of oxygen free radicals in the living state, i.e., offers a much wider basis for the interpretation of the free radical function. (antiaging-systems.com)
  • This theory postulates that aging and its related diseases are the consequence of free-radical induced damage to cellular macromolecules and the inability to counterbalance these changes by endogenous antioxidant defenses [1]. (symbiosisonlinepublishing.com)
  • Fortunately, well-functioning cells have the ability to defend against the destructive effects of free radicals by the endogenous systems which consist of various enzymes such as superoxidase dismutase (SOD), catalase (CAT) and glutathione peroxide (GPX). (biomedcentral.com)
  • Current emphasis on healthy living based on antioxidant intake and the implication of oxidative stress molecules/free radicals on certain diseased condition [ 2 ] has generated renewed interest in screening for plants with high antioxidative properties. (biomedcentral.com)
  • Phenolic compounds are also widely distributed in plants and have been found to possess antioxidative potential as well [ 34 ]. (ijpsonline.com)
  • Antioxidant compounds are molecules that can inhibit or delay the oxidation of lipids or other biomolecules by inhibiting the initiation and propagation of oxidative chain reactions [ 29 ]. (ijpsonline.com)
  • NaHS alleviated Cd stress mainly through inhibiting Cd absorbtion, promoting CdS nanoparticles formation, increasing oxidation resistance, and regulation of transport in free-living unicellular T. thermophila . (biomedcentral.com)
  • This leads to production of free radicals contributed by cyclo-oxygenases (COX), acid sensing ion channels (ASIC) and matrix metalloproteinases (MMPs) causing adverse conditions of inflammation, oxidative stress, and acidosis leading to neuronal death thereby proving these enzymes as potent targets. (brjnmims.org)
  • When ROS production is greater than a plant's ability to scavenge excess ROS, there is rapid leakage of excess ROS (a state known as oxidative stress) into other parts of the plant. (biomedcentral.com)
  • It is commonly known that oxidative stress caused by free radicals and their derivatives is responsible for disturbing redox homeostasis [ 1 ]. (biomedcentral.com)
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • You will also gain insight into the specific health benefits of açaí and similarly potent fruits and vegetables-and their unrivalled power to combat free radical damage and the killer diseases of aging. (lifeextension.com)
  • Chios Mastic was found to exhibit potent hydroxyl radical scavenging effects. (masticlife.com)
  • Terrestrial plants are considered potent sources of bioactive compounds and pharmacologically active compounds, however, little is known about the therapeutical potential of mangrove plants. (intechopen.com)
  • It has the extraordinary capacity to control a variety of cellular pathways, and its potential for selective anticancer activity can be explored. (bvsalud.org)
  • Free radical scavenging activity and immunomodulatory effect of. (edu.ng)
  • Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity. (weeksmd.com)
  • Different concentrations of crude methanolic extracts of seaweeds showed potential antimicrobial activity by well diffusion method. (google.com)
  • The methanolic extracts of seaweeds Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata possess high total phenolic content and shows a good free radical scavenging activity and hence are proven to have better antioxidant activity and they might be good candidates for further investigations in order to develop potential anticancer drugs. (google.com)
  • The antioxidant potential of SPs showed increased antioxidant activity with an increase in concentration of NaNO 3 stress. (brjnmims.org)
  • the 2,2-diphenyl-1-picrylhydrazyl scavenging activity showed the highest activity of 63.61%, while the superoxide scavenging activity was 92% at 0.1-1 μg/ml. (brjnmims.org)
  • Also, Chios Mastic presents a notable antiatherogenic activity, and thus comprising a potential novel treatment approach for atherosclerosis. (masticlife.com)
  • Conclusively, Chios Mastic inhibits the production of both NO and PGe2 by activated macrophages mostly via its cytotoxic activity 29. (masticlife.com)
  • The identification and quantification of bioactive components that contribute to free radical scavenging activity and its consequent ethnopharmcological effect may provide link to specific drug discovery. (biomedcentral.com)
  • No extensive report on the presence, and free radical scavenging activity of basic metabolites from the leaves of N. laevis has been provided. (biomedcentral.com)
  • Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and resveratrol, which are both radical scavengers and cyclooxygenase inhibitors exhibiting anticancer activity. (nature.com)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • As for depigmenting activity, both extracts were able to inhibit tyrosinase. (bvsalud.org)
  • Human spermatozoa possess these defense enzymes, which might be useful in the prediction of sperm fertilizing potentials [ 5 ]. (ijbs.com)
  • to superoxide or that "autoxidize", and when coupled with catalase Oxygen radicals clearly contribute to probably through reactions catalysed within peroxisomes or with cytosolic genomic instability, are produced by by transition metals. (who.int)
  • In recent years, molecular hydrogen treatment has the potential to preventive and therapeutic applications against many diseases due to its extensive effects, such as antioxidant, anti-inflammatory, antiapoptotic [16, 17]. (researchgate.net)
  • Free radicals have beneficial or detrimental effects upon sperm functions, which depend on their nature and concentration. (ijbs.com)
  • Although the MHA implicitly contradicts the central dogma of the FRTA, it does not deny the possibility of damaging side effects of these radicals. (antiaging-systems.com)
  • This theory suggested that free radicals produced during aerobic respiration have deleterious effects on cell components and connective tissues, causing cumulative damage over time that ultimately results in aging and death. (symbiosisonlinepublishing.com)
  • Side effects of DMSO can be temporary local irritation of the skin and a potential taste and/or sometimes smell of garlic upon use. (365healthybychoiceshop.com)
  • Despite promising results in animal studies, only a limited number of observational studies have reported potential cancer preventive effects of flavonoids in humans. (oregonstate.edu)
  • MARNAC, Dallas, TX, USA) 7 - 9 is a promising agent with therapeutic potential for IPF that has combined anti-inflammatory, antioxidant and antifibrotic effects in experimental models of pulmonary fibrosis 10 - 14 . (ersjournals.com)
  • The standard index for determining the antioxidant value of various organic compounds is known as oxygen radical absorbance capacity, or ORAC. (lifeextension.com)
  • These compounds have a potential application in medicine. (google.com)
  • Solid and liquid types of the product were found to inhibit the production of pro-inflammatory compounds, like nitric oxide (NO) and prostaglandin (PG) e2 by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells. (masticlife.com)
  • The alterations are due in part to free radical induced molecular damage, and also to the 'residual heat' formed during each depolarization of the resting potential. (antiaging-systems.com)
  • Sequestration in many of the processes identified can also result in the release of ox- of transition metals, principally iron above as necessary for conversion ygen radicals ( Hrycay and Bandiera, and copper, in their oxidized forms of normal cel s into cancer cel s. (who.int)
  • Therefore, α- LA and DHLA can scavenge all the above-mentioned free radicals in the process of mutual conversion and metabolic regeneration in vivo. (nmn-bio.com)
  • The purpose of this review is to provide updated and categorized information on the traditional uses, phytochemistry, biological activities, and toxicological research of Moringa species in order to explore their therapeutic potential and evaluate future research opportunities. (frontiersin.org)
  • Excessive generation of ROS in semen may be associated with reduced sperm fertilizing potentials. (ijbs.com)
  • Excessive production of free radicals can cause cellular and tissue injury through nonspecific modification and disruption of phospholipids, proteins and nucleic acid [ 4 ]. (biomedcentral.com)
  • In this article, we have reviewed several recently identified natural products with potential antiaging properties and have highlighted their cellular and molecular mechanisms. (frontiersin.org)
  • However, exogenous NaHS (donor of H 2 S, 70 μM) significantly alleviated the Cd-induced toxicity by inhibiting Cd absorbtion, promoting CdS nanoparticles formation and improving antioxidant system. (biomedcentral.com)
  • In the older cells of aging animals, to take one example, researchers have found that one out of every three proteins is rendered dysfunctional by unchecked free radical damage. (lifeextension.com)
  • Besides affecting fertilization and the outcome of pregnancy, sperm DNA damage has a negative impact on the health of the offspring as uncorrected sperm DNA damage following zygote formation has the potential to create mutations/epimutations in the offspring [ 7 ]. (hindawi.com)
  • has provided strong biological evidence that free radicals are involved in the aging process. (symbiosisonlinepublishing.com)
  • Plants are rich sources of phytochemicals such as saponin, tannin, flavanoids, phenolic and alkaloids, which possess a variety of biological activities including antioxidant potential. (intechopen.com)
  • There is rising interest in endemic species because these can be used for preparing phytopharmaceuticals with considerable antioxidant potential or for the production of raw materials and health confidants [ 26 - 28 ]. (ijpsonline.com)
  • EPR studies showed that radiation has created some radical defects whose concentration was no more than several dozen ppm. (bvsalud.org)
  • The results revealed that both extracts inhibited α-amylase and α-glucosidase in a concentration-dependent manner. (degruyter.com)
  • Additionally, the retinal protective effect of HRS was inhibited by both the Sirt1 inhibitor EX-527 and Sirt1 targeted short interfering RNAs. (arvojournals.org)
  • It has a specific effect on cardiac contractility by inhibiting calcium to reduce the workload of the heart. (365healthybychoiceshop.com)
  • The present study aimed to investigate the potential of marination with extracts prepared from five legume seeds on heterocyclic amine (HA) formation in chemical models and air-fried fish fillets. (bvsalud.org)