Satellite genome. Medical search. Frequent questions

To address this challenge, I will present a whole-genome de novo assembly that surpasses the continuity of GRCh38, along with the first complete, telomere-to-telomere assembly of a human X chromosome. (labroots.com)
Key events in vertebrate evolution, leading to humans, include two rounds of whole-genome duplication," Ragsdale said. (scitechdaily.com)
With this new work, we now know that the evolution of soft-bodied cephalopods involved similarly massive genome changes, but the changes are not whole-genome duplications but rather immense genome rearrangements, as if the ancestral genomes were put in a blender. (scitechdaily.com)
While whole exome sequencing (WES) remains popular and effective as a method of genetically profiling different cancers, advances in sequencing technology has enabled an increasing number of whole-genome based studies. (frontiersin.org)
Compared to whole genome sequencing (WGS), exome sequencing covers only the 1% of the genome that is translated into protein, greatly reducing the technical burden of data collection and analysis. (frontiersin.org)
performed the first whole-genome sequencing study on AML cells collected from a single patient. (frontiersin.org)
To evaluate species designation, population connectivity, and the corresponding conservation implications, we assembled a de novo genome and used whole-genome resequencing of historical specimens. (scilifelab.se)
Complex population structure of the Atlantic puffin revealed by whole genome analyses. (scilifelab.se)
Our results highlight the power of whole genome data to reveal unexpected population structure in vagile marine seabirds and its value for seabird taxonomy, evolution and conservation. (scilifelab.se)
We talk about 'whole-genome sequencing,' but it's a misnomer because there are parts of the genome that have been unseen, and there have been parts that have, what I'd call, weak assembly," Topol told Medscape Medical News . (medscape.com)
Researchers will learn techniques like Mendelian Randomization and Colocalization to analyze whole-genome sequencing and transcriptome data in human health studies. (columbia.edu)
African swine fever whole-genome sequencing-Quantity wanted but quality needed. (cdc.gov)
Compartmentalized Replication of SARS-Cov-2 in Upper vs. Lower Respiratory Tract Assessed by Whole Genome Quasispecies Analysis. (cdc.gov)

Release of the first human genome assembly was a landmark achievement, and after nearly two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. (labroots.com)
Here, we elucidate the population structure of the Atlantic puffin (Fratercula arctica) by assembling its reference genome and analyzing genome-wide resequencing data of 72 individuals from 12 colonies. (scilifelab.se)
Here, we analyse sequence gaps in the current reference genome sequence of barley cv. (cas.cz)
Improved reference genome of the arboviral vector Aedes albopictus. (cdc.gov)

A de novo assembly of the genome of Phytophthora parasitica, an important oomycete plant pathogen, led to the identification of several families of tandemly repeated sequences varying in size, copy number, and sequence conservation. (figshare.com)
The genome sequence sheds new light on the genes and biochemical pathways in the bacterium, and the research offers a starting point for defining the mechanisms by which the organism causes disease and helping devise new strategies to detect infected animals and ultimately help control the spread of the organism. (innovations-report.com)
The analysis of the M. paratuberculosis genome found that its sequence contains nearly 5 million base pairs that are represented on a large circular chromosome with more than 4,500 predicted genes. (innovations-report.com)
The sequencing project represents part of an ambitious "microbial pathogenomics" research program at the University of Minnesota to sequence the genomes of a wide range of human and animal pathogens and use this information as a basis to understand the mechanisms by which they cause disease. (innovations-report.com)
Second, we highlight the importance and potential of complete or 100% genome sequencing, i.e., the ability to sequence highly repetitive non-coding sequences beyond the reach of current NGS technologies. (frontiersin.org)
Evolutionary consequences associated with hybridization events have been studied at various levels such as chromosomal rearrangements, repetitive DNA sequence evolution, genome size change, and diploidization ( Hegarty and Hiscock, 2008 HEGARTY, M.J. and HISCOCK, S.J., 2008. (scielo.br)
Each characterized sequence comprised 1-3% of the genome. (usda.gov)
However, sequence assemblies of most plant genomes remain fragmented. (cas.cz)
Optical map and sequence raw data, complemented by ChIP-seq data for centromeric histone variant CENH3, were used to estimate the abundance of centromeric, ribosomal DNA, and subtelomeric repeats in the barley genome. (cas.cz)
We found that almost all centromeric sequences and 45S ribosomal DNA repeat arrays were absent from the MorexV3 pseudomolecules and that the majority of sequence gaps can be attributed to assembly breakdown in long stretches of satellite repeats. (cas.cz)
Researchers completed the first draft of the human genome sequence almost 20 years ago. (medscape.com)
This year, an international research team reported that they completed the human genome sequence using handheld nanopore devices in about 2 months at a cost of around $30,000. (medscape.com)
Eric Topol, MD, founder and director of the Scripps Translational Science Institute in La Jolla, California, seconds that statement, noting that many people thought it would take years before the human genome sequence could be assembled inexpensively from small machines. (medscape.com)
The goal of the project is to sequence the genome of 10,000 species of vertebrates (~1 species from every genus). (scienceblogs.com)
After decades of attempts, genetic scientists led by the Telomere-to-Telomere Consortium -a team of researchers funded by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH)-have finally "generated the first truly complete sequence of a human Y chromosome," which is "the final human chromosome to be fully sequenced," of the 24 human chromosomes, SciTechDaily reported. (darkdaily.com)
Twenty years ago the first human genome sequence was completed. (darkdaily.com)
His innovative biotechnologies and computational tools to study the sequence and function of genomes are advancing the understanding of the structure, evolution, and function of genomes for medicine - particularly autism spectrum disorders, cancer, and other human diseases - and agriculture. (agbt.org)

Probably the greatest advance in this new work is providing chromosomal-level assemblies of no less than three cephalopod genomes, all of which are available for study at the MBL," said co-author Clifton Ragsdale, professor of Neurobiology and of Biology and Anatomy at the University of Chicago. (scitechdaily.com)
Chromosomal-level assemblies allowed us to better refine what genes are there and what their order is, because the genome is less fragmented," Albertin said. (scitechdaily.com)
Complete and accurate genome assemblies form the basis of most downstream genomic analyses and are of critical importance. (bvsalud.org)
Genome assemblies are currently being produced at an impressive rate by consortia and individual laboratories. (scilifelab.se)
Telomere-to-telomere assemblies are not a reality yet for most organisms, but by leveraging technology choice it is now possible to minimize genome assembly gaps for downstream analysis. (scilifelab.se)
Consequently, it has been difficult to achieve genome assemblies at centromeres using traditional next generation sequencing approaches, so that centromeres represent gaps in the current human genome assembly. (duke.edu)

Despite their potential impact on the architecture and evolution of the genome, satellite DNAs have not been investigated in oomycetes due to the paucity of genomic data and the difficulty of assembling highly conserved satellite arrays. (figshare.com)
The accessibility of almost complete genome sequences of uncultivable microbial species from metagenomes necessitates computational methods predicting microbial phenotypes solely based on genomic data. (biomedcentral.com)
We study statistical estimators of the number of genomic events separating two genomes under a Double Cut-and Join (DCJ) rearrangement model, by a method of moment estimation. (biomedcentral.com)
Although genomic changes associated with these events has been studied at various levels but the genome size and GC content variation is less understood because of absence of sufficient genomic data. (scielo.br)
In this study the flow cytometry technique was used to uncover the genome size and GC contents of 46 Nicotiana species and we compared the genomic changes associated with the hybridization events along evolutionary time scale. (scielo.br)
However, the difficulty in assembling repeat-rich and GC-rich regions (genomic "dark matter") limits insights into the evolution of genome structure and regulatory networks. (scilifelab.se)
When you find variation that you haven't seen before, the hope is always that those genomic variants will be important for understanding human health," said Adam Phillippy, PhD, a senior investigator and head of the Genome Informatics Section at the National Human Genome Research Institute, in a press release. (darkdaily.com)
Human centromeres typically form at large megabase-sized arrays of alpha satellite DNA for which there is little genomic understanding due to its repetitive nature. (duke.edu)

Alpha satellites are tandemly repeated sequences found in all human centromeres. (srce.hr)
All human alpha satellite sequences originate from one pra-ancestral alpha satellite monomer. (srce.hr)
Satellite DNA is a class of repetitive sequences that are organized in long arrays of tandemly repeated units in most eukaryotes. (figshare.com)
Long considered as selfish DNA, satellite sequences are now proposed to contribute to genome integrity. (figshare.com)
The researchers also found that the chromosome has a large number of sequences repeated throughout the genome. (innovations-report.com)
Most models of genome evolution concern either genetic sequences, gene content or gene order. (biomedcentral.com)
Repetitive sequences from the apple genome. (girinst.org)
Satellite sequences from megabat. (girinst.org)
Satellite sequences in the apple genome. (girinst.org)
We characterized satellite DNA sequences from 2 foreign species, E. mundus (Spain) & E. hyati (Pakistan), & one native U.S. species, E. eremicus. (usda.gov)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
However, missing sequences cannot fully account for the difference between assembly size and flow cytometric genome size estimates. (cas.cz)
It could have been very chaotic, but instead, nearly half of the chromosome is made of alternating blocks of two specific repeating sequences known as satellite DNA . (darkdaily.com)
Repetitive elements can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. (irb.hr)
Performing genome-wide target profiling on data sets obtained by retrieving chromosomal targeting sequences from individual clones, we have identified several piggyBac and Tol2 hotspots and observed that (4) piggyBac and Tol2 display a clear difference in targeting preferences in the human genome. (biomedcentral.com)
DNA transposons are natural genetic elements residing in the genome as repetitive sequences. (biomedcentral.com)

By understanding the cephalopod genome, we can gain insight into the genes that are important in setting up the nervous system, as well as into neuronal function. (scitechdaily.com)
This presents an interesting situation: genes are put into new locations in the genome, with new regulatory elements driving the genes' expression. (scitechdaily.com)
Using a genome scan, we identified genes that may form the basis for color divergence and act as reproductive barriers. (scilifelab.se)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)
He is head of the collection of EMBL-EBI resources focused on Genes, Genomes and Variation and in this role provides strategic leadership of the six faculty groups that together provide all of EBI's genome annotation resources. (agbt.org)
To date, most gene therapy trials have utilized viral vectors for permanent gene transfer due to their high transduction rate and their ability to integrate therapeutic genes into host genomes for stable expression. (biomedcentral.com)

The genome represents a record of the different impacts a species has faced. (wildlabs.net)
The 2000s witnessed an explosion of genome sequencing and mapping in evolutionarily diverse species. (wikipedia.org)
While full genome sequencing of mammals is rapidly progressing, the ability to assemble and align orthologous whole chromosomal regions from more than a few species is not yet possible. (wikipedia.org)
published this week, the team analyzed and compared the genomes of three cephalopod species - two squids ( Doryteuthis pealeii and Euprymna scolopes ) and an octopus ( Octopus bimaculoides ). (scitechdaily.com)
The tetraploid species in genus Nicotiana including section Polydiclae , Repandae , Nicotiana , Rustica and Sauveolentes revealed both up and downsizing in their genome sizes when compared to the sum of genomes of their ancestral species. (scielo.br)
The genome sizes of three homoploid hybrids were found near their ancestral species. (scielo.br)
Hybridization and genome size evolution: timing and magnitude of nuclear DNA content increases in Helianthus homoploid hybrid species. (scielo.br)
The ups and downs of genome size evolution in polyploid species of Nicotiana (Solanaceae). (scielo.br)
These avian species highlighted the presence of a GC-rich Corvoidea satellitome composed of 61 satellite families and provided a set of candidate satDNA monomers for being centromeric on the basis of length, abundance, homogeneity and transcription. (scilifelab.se)
Here we report a comparative analysis of genome-wide DNA polymorphism data for population pairs from eighteen Indo-Pacific bird species from the Moluccan islands of Buru and Seram and from across the island of New Guinea. (scilifelab.se)
It is a broadly observed pattern that the non-recombining regions of sex-limited chromosomes (Y and W) accumulate more repeats than the rest of the genome, even in species like birds with a low genome-wide repeat content. (scilifelab.se)
We propose that the excess of W-linked active ERVs over the rest of the genome may be an additional explanatory variable for Haldane's rule, with consequences for genetic incompatibilities between species through TE/repressor mismatches in hybrids. (scilifelab.se)
We characterized genomes of 11 songbird species, with 5 genomes of bird-of-paradise species. (scilifelab.se)
I was very excited to see the website recently updated in July to include numerous additional species for which the genome has been or is in the process of being sequenced. (scienceblogs.com)

Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes. (crossref.org)

Satellite DNA (satDNA) is a fast-evolving portion of eukaryotic genomes. (scilifelab.se)
Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)

The small sequencing devices have been used previously to track the Ebola and Zika epidemics, but the human genome is many orders of magnitude larger than those bacterial and viral genomes, making this "a huge technical achievement," Benedict Paten, PhD, one of the collaborators in the latest sequencing effort, told Medscape Medical News . (medscape.com)

The non-overlapping targeting preference of piggyBac and Tol2 makes them complementary research tools for manipulating mammalian genomes. (biomedcentral.com)

Phased diploid genome assembly with single-molecule real-time sequencing. (crossref.org)
The first step of the Human Genome Project took place when Tjio and Levan, in 1956, reported the accurate diploid number of human chromosomes as 2n = 46. (wikipedia.org)
For diploid human genomes sequenced to 30× HiFi coverage, HiCanu achieved superior accuracy and allele recovery compared to the current state of the art . (bvsalud.org)

DNA transposons have emerged as indispensible tools for manipulating vertebrate genomes with applications ranging from insertional mutagenesis and transgenesis to gene therapy. (biomedcentral.com)
The Medaka fish ( Orizyas latipes ) Tol2 , belonging to the hAT family of transposons, is the first known naturally occurring active DNA transposon discovered in vertebrate genomes [ 10 ]. (biomedcentral.com)

Genome research 30, 9 ( 2020 ), 1291–1305. (crossref.org)
In this study, we investigated the emergence of HPAI H5N8 viruses in wild ducks in Ningxia, in western China, during October 2020 and performed satellite tracking to determine the flyways of wild ducks. (cdc.gov)
Migratory routes of 6 of 9 successfully satellite-tracked mallards infected with highly pathogenic avian influenza A(H5N8) clade 2.3.4.4b viruses, Ningxia, China, 2020. (cdc.gov)
Genome Res, Sep 2, 2020. (cdc.gov)

HiCanu: accurate assembly of segmental duplications, satellites, and allelic variants from high-fidelity long reads. (crossref.org)
We benchmark HiCanu with a focus on the recovery of haplotype diversity, major histocompatibility complex (MHC) variants, satellite DNAs , and segmental duplications . (bvsalud.org)

In 1977, the first complete genome of an organism was sequenced. (darkdaily.com)
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. (bvsalud.org)

Highly accurate long-read HiFi sequencing data for five complex genomes. (crossref.org)
Sequencing these three cephalopod genomes, never mind comparing them, was a tour de force effort funded by the Grass Foundation that took place over several years in labs around the world. (scitechdaily.com)
University of Minnesota researchers, with collaborators at the U. S. Department of Agriculture s National Animal Disease Center in Ames, Iowa, have completed sequencing the genome of the bacteria that causes Johne s disease, a major chronic wasting disease found in dairy cattle. (innovations-report.com)
Recent genome assembly projects have relied on a combination of noisy long-read sequencing and accurate short-read sequencing, with the former offering greater assembly continuity and the latter providing higher consensus accuracy. (bvsalud.org)
As the integration of NGS in the study and treatment of cancer continues to mature, we believe that the field of cancer genomics will need to move toward more complete 100% genome sequencing. (frontiersin.org)
The low costs and increasing efficiency of sequencing technologies now enable assembling genomes at unprecedented quality and contiguity. (scilifelab.se)
We provide a roadmap to tailor sequencing projects for optimized completeness of both the coding and noncoding parts of nonmodel genomes. (scilifelab.se)
As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
Jain is one of the first authors on the article, published online January 29 in Nature Biotechnology , that describes the genome sequencing project. (medscape.com)
This study reveals a new mechanism for the fluid gain of beneficial mutations in genetic regions undergoing active recombination in viruses and illustrates the value of long read sequencing technologies for investigating complex genome dynamics in diverse biological systems. (elifesciences.org)
The result was thanks to years of work through the preferred " chain termination " (aka, Sanger Sequencing) method developed by Fred Sanger and a $2.7 billion contribution from the Human Genome Project , according to a study published in the African Journal of Laboratory Medicine ( AJLM ). (darkdaily.com)
Massively parallel or next-generation sequencing (NGS) technologies eliminated the need for multiple personnel working on a genome by automating DNA cleavage , amplification , and parallel short-read sequencing on a single instrument, thereby lowering costs and increasing throughput," the AJLM paper noted. (darkdaily.com)
First record of a tandem-repeat region within the mitochondrial genome of Clonorchis sinensis using a long-read sequencing approach. (cdc.gov)

In this news article by Rutherford Discovery Fellow Emma Carroll, we learn about how genomics and satellite data are helping researchers gain a new understanding of southern right whale population recovery, migration and breeding habits, and how climate patterns play a role in this data. (wildlabs.net)
with genomics research, they can obtain data about long-term responses to past climate fluctuations, and with satellite data, they can understand the present responses to our current climate changes. (wildlabs.net)
The problem of reconstructing ancestral genomes in a given phylogenetic tree arises in many different comparative genomics fields. (biomedcentral.com)
The RECOMB-CG satellite conference, founded in 2003, brings together leading researchers in the mathematical, computational and life sciences to discuss cutting edge research in comparative genomics, with an emphasis on computational approaches and novel experimental results. (wikicfp.com)
We were able to generate enough data to put together a human genome assembly that was in many respects superior to that initial draft," continued Paten, who currently oversees the Center for Big Data in Translational Genomics and is an assistant professor in the Department of Biomolecular Engineering at the University of California, Santa Cruz. (medscape.com)
Paul's research is focused on comparative regulatory genomics, the evolution of transcriptional regulation and annotation of the non-coding genome. (agbt.org)

Composed of tightly packaged, rapidly evolving satellite DNA with conserved functions, centromeres pose conundrums on several levels. (genengnews.com)
Centromeres are central to chromosome segregation and genome stability, and thus their molecular foundations are important for understanding their function and the ways in which they go awry. (duke.edu)
The role of alpha satellite DNA has been debated since centromeres can form, albeit rarely, on non-alpha satellite DNA. (duke.edu)

However, no one chromosome has yet been finished end to end, and hundreds of gaps persist across the genome. (labroots.com)
Comparative chromosome painting and related techniques are very powerful approaches in comparative genome studies. (wikipedia.org)
Here, we show that in birds with highly heteromorphic sex chromosomes, the W chromosome has a transposable element (TE) density of greater than 55% compared to the genome-wide density of less than 10%, and contains over half of all full-length (thus potentially active) endogenous retroviruses (ERVs) of the entire genome. (scilifelab.se)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)

This is a fundamental problem because these gaps vary in repeat structure and copy number between individuals, which can affect genome stability and health. (labroots.com)
These results demonstrate that it is now possible to finish entire human chromosomes without gaps, and our future work (Telomere-to-telomere, T2T Consortium) will focus on completing and validating the remainder of the genome. (labroots.com)
Although gaps and errors still remain within the most challenging regions of the genome , these results represent a significant advance toward the complete assembly of human genomes . (bvsalud.org)
Identifying the causes and consequences of assembly gaps using a multiplatform genome assembly of a bird-of-paradise. (scilifelab.se)

This unprecedented coverage of ultra-long reads enabled the resolution of most repeats in the genome, including large fractions of the centromeric satellite arrays and short arms of the acrocentrics. (labroots.com)
Long terminal repeats from the megabat genome. (girinst.org)
The minor fraction of HP1β that is chromatin-bound in ESCs is enriched within exons, unlike the situation in differentiated cells, where it binds heterochromatic satellite repeats and chromocenters. (biomedcentral.com)

Ancient Bacterial Genomes Reveal a High Diversity of Treponema pallidum Strains in Early Modern Europe. (cdc.gov)
Comprehensive evolution and molecular characteristics of a large number of SARS-CoV-2 genomes reveal its epidemic trends. (cdc.gov)

Yet gaining knowledge on the structure and evolution of genomes of oomycete pathogens is crucial to understanding the mechanisms underlying adaptation to their environment and to proposing efficient disease control strategies. (figshare.com)
However, 3D genome evolution and its relationship with natural selection remains largely unexplored. (nature.com)
Satellite DNA evolution in Corvoidea inferred from short and long reads. (scilifelab.se)

These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)

Now, scientists have dug into the cephalopod genome to understand how these unusual animals came to be. (scitechdaily.com)
Those ultralong reads mean scientists can see parts of the genome in ways they have not before. (medscape.com)
When the human genome was sequenced a decade ago, scientists hailed the feat as a technical tour de force - but they also knew it was just a start. (latimes.com)
Back in 2003, when the human genome was finished, scientists estimated that less than 2% carries instructions for making proteins, which become physical structures in our bodies and do the myriad jobs inside cells. (latimes.com)

Glunčić M, Rosandić M, Jelovina D, Dekanić K, Vlahović I, Paar V. Global Repeat Map Method for Higher Order Repeat Alpha Satellites in Human and Chimpanzee Genomes (Build 37.2 Assembly). (srce.hr)
Using GRM, we identify in Build 37.2 assembly fifteen different alpha satellite HORs, three of them novel, not reported previously. (srce.hr)
The homogeneous and repetitive nature of such satDNA causes problems during the assembly of genomes, and therefore it is still difficult to study it in detail in nonmodel organisms as well as across broad evolutionary timescales. (scilifelab.se)
Conversely, the simple presence of alpha satellite DNA is not sufficient for centromere function since chromosomes with multiple alpha satellite arrays only exhibit a single location of centromere assembly. (duke.edu)

We sequenced full-length genomes and submitted them to the GISAID EpiFlu database ( https://www.gisaid.org ) ( Appendix Table 1). (cdc.gov)

Satellite-like DNA from zebrafish. (girinst.org)
Tol2 is a standard tool for manipulating zebrafish genomes and has been demonstrated to transpose effectively in frog, chicken, mouse and human cells as well [ 11 ]. (biomedcentral.com)

With this new information, we can begin to ask how large-scale genome changes might underlie those key unique features that cephalopods and vertebrates share, specifically their capacity for large bodies with disproportionately large brains," Ragsdale said. (scitechdaily.com)

In many animals, gene order within the genome has been preserved over evolutionary time," Albertin said. (scitechdaily.com)

This observation, as well as the characterization of transcripts of PpSat families, suggested that these satellite DNA families likely play a conserved role within this important group of pathogens. (figshare.com)

Genome research 27, 5 ( 2017 ), 722–736. (crossref.org)
The genome project-supported by the USDA through the Cooperative State, Research, Education & Extension Service s (CSREES) National Research Initiative Competitive Grants Program and the Agricultural Research Service (ARS)-is expected to provide a boost to wide-ranging research efforts for the development of the next generation of antimicrobial agents and vaccines to protect cattle against infection with the bacterium. (innovations-report.com)
The workshops will investigate priorities for human genome research and satellite observation. (newscientist.com)
Human genome research and society : proceedings of the Second International Bioethics Seminar in Fukui, 20-21 March, 1992 / editors, Norio Fujiki & Darryl R. J. Macer. (who.int)

A 2-day run on the sequencer provides about threefold coverage of the genome, Jain says. (medscape.com)

The team found that the genome rearrangements resulted in new interactions that may be involved in making many of the novel cephalopod tissues, including their large, elaborate nervous systems. (scitechdaily.com)
His laboratory has assessed the functional impact of genome structural changes, such as CNVs and balance rearrangements. (agbt.org)

To do this, we examine the non-redundant viral diversity stored in public databases, predict proteins in genomes lacking such information, and used all annotated and predicted proteins to identify potential protein domains. (mdpi.com)

EMBO Meeting to attend the 2018 4DN-ASCB Satellite Meeting: Bridging the 4D Genome with Cell Biology from 8 am to 7 pm, on Friday, December 7, at the Marriott Marquis San Diego Hotel and Marina. (ascb.org)
The 2018 4DN-ASCB Satellite Meeting aims to highlight rapid progress in the study of genome organization and facilitate the dissemination of new technologies and concepts to the broader cell biology community. (ascb.org)

The first cancer exomes were sequenced soon after the completion of the Human Genome Project in 2001. (frontiersin.org)
The next eureka moment came while visiting his son at Queens University, who "excitedly talked about the Human Genome Project coming to a conclusion in 2001. (betakit.com)

In many crops, genome engineering techniques have enabled researchers and breeders to take advantage of a vast knowledge base of plant physiology, pathology, and genetics. (frontiersin.org)

Endogenous retroviruses from the megabat genome. (girinst.org)

After close to a decade of globe-spanning effort, the genome of the southern right whale has been released this week , giving us deeper insights into the histories and recovery of whale populations across the southern hemisphere. (wildlabs.net)

Once the amount of heterochromatin is subtracted from total genome content, all mammals have very similar genome sizes. (wikipedia.org)

That would not be enough to assemble a genome from scratch, but it is enough to start an analysis, especially as data continue to accumulate while the machine runs. (medscape.com)
He is currently head of the Ensembl project and has held leadership roles in data management activities for the 1000 Genomes Project, the International Human Epigenome Consortium (IHEC) and the International Mouse Phenotyping Consortium (IMPC). (agbt.org)

We collected small skin samples for genetic and chemical analysis and placed satellite tags on six tohorā . (wildlabs.net)
Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus. (bvsalud.org)

Many TEs proliferate through replicative mechanisms that enable exponential amplification and dispersal to new locations throughout their host genome. (nature.com)

Here, we focus on reconstructing the gene order of ancestral genomes, a proble. (biomedcentral.com)

The human genome was a bit like getting 'War and Peace' in Russian: It's a great book containing all of human experience, but [if] I don't know any Russian it's very hard to read," said Ewan Birney, a computational biologist at the European Bioinformatics Institute in England who coordinated the analysis for the project. (latimes.com)

Anatomy22

Organisms40

Diseases7

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology1

Phenomena and Processes119

Disciplines and Occupations5

Technology, Industry, Agriculture4

Information Science17

Health Care4

Whole-genome13

Reference genome4

Sequence17

Assemblies6

Genomic8

Sequences16

Genes6

Species14

Novo1

Eukaryotic genomes2

Viral Genomes1

Mammalian genomes1

Diploid3

Vertebrate2

20204

Duplications2

Complete genome2

Sequencing14

Genomics6

Centromeres3

Chromosome4

Gaps4

Repeats3

Reveal2

Evolution3

Dynamics1

Scientists4

Assembly4

Https1

Zebrafish2

Vertebrates1

Evolutionary time1

Pathogens1

Research4

Jain1

Rearrangements2

Diversity1

Biology2

20012

Researchers1

Endogenous1

Insights1

Mammals1

Data2

Genetic2

Amplification1

Gene order1

Computational1