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  • progenitors
  • Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. (semanticscholar.org)
  • Conclusions: Together these studies provide a simple, yet detailed method for the isolation and culture of myogenic progenitors from adult zebrafish, while further promoting their therapeutic potential for the study of muscle disease and drug screening. (pubmedcentralcanada.ca)
  • 9 Consequently, the development of an efficient and simple method for the isolation and in vitro study of myogenic progenitors from adult zebrafish muscle mutants, combined with the amenability of zebrafish for high-throughput chemical screens, can significantly accelerate identification of compounds and optimization of parameters for new therapeutic approaches prior to further evaluation in mammalian disease models. (pubmedcentralcanada.ca)
  • This finding reveals an added level of complexity in the mechanism of the fate choice of mesoderm progenitors and suggests that using endogenous cardiac stem cells therapeutically will require specially tailored procedures for certain genetic diseases. (rupress.org)
  • subpopulation
  • Taking into account the advances in the isolation of new subpopulation of stem cells and in the creation of artificial stem cell niches, we discuss how these emerging technologies offer great promises for therapeutic approaches to muscle diseases and muscle wasting associated with aging. (frontiersin.org)
  • lineage
  • Transgenic animals also had elevated levels of cells coexpressing markers of SC lineage and myogenic commitment at sites of muscle damage. (pnas.org)
  • 2005), indicating that early activation occurs independently of compound mutants do not form the myogenic lineage (Rudnicki et al. (a-443654.com)
  • regulation
  • These results indicate the effects of resistance exercise on the regulation of satellite cells and provide insight into the molecular mechanism of satellite cell activation following physical exercise. (hindawi.com)
  • Exercise positively affects muscle fiber composition via regulation of satellite cells to improve muscle performance. (hindawi.com)
  • Later on Mitf and Chx10 continue to be expressed in adjacent regions of the eye, suggesting a reciprocal regulation between these two factors ( Nguyen and Arnheiter, 2000 ). (biologists.org)
  • mice
  • Although in lethally irradiated mice, bone marrow-derived SCs replenish the depleted satellite cell pool and subsequently incorporate effectively into exercised skeletal muscle ( 9 ), less is known about the ability of bone-marrow-derived SCs to ameliorate muscle damage under more clinically relevant conditions. (pnas.org)
  • We have previously reported that postmitotic expression of a local isoform of insulin-like growth factor 1 (mIGF-1) induces myocyte hypertrophy ( 16 ), increases mass and strength of postnatal muscle, and preserves regenerative capacity in senescent and dystrophic mice ( 17 - 19 ). (pnas.org)
  • The SP from bone marrow cells was isolated from femur and tibia of 8-week-old c -kit / GFP transgenic mice by fluorescence-activated cell sorter (FACS) analysis. (pnas.org)
  • WT and MLC / mIgf-1 transgenic recipient mice were lethally irradiated with 9.8 Gy, and each recipient received 1 × 10 3 SP-derived-c -kit / GFP cells by tail-vein injection. (pnas.org)
  • Recipient mice also received 1.5 × 10 5 non-SP cells isolated from WT mice. (pnas.org)
  • These mice survived after birth but surprisingly also did not develop alveolar rhabdomyosarcomas despite having every muscle satellite cell, prebirth and postbirth, express Pax3:Fkhr . (aacrjournals.org)
  • Deletion of in mice leads to normal numbers of stem cells 1211441-98-3 at birth followed by excessive wasting of stem cells during the first weeks of postnatal development (Oustanina et al. (a-443654.com)
  • Concomitant with the loss of Pax7-positive SCs, we also noted a rapid decline of Pax7 mRNA concentrations in TAM-treated Pax7CE/loxP-Gu mice (Figures S3A and S3F) and a rapid decline of SCs as assessed by the expression of calcitonin receptor (Calcr), a marker. (a-443654.com)
  • Here we show that myostatin/activin A inhibition can cause muscle hypertrophy in mice lacking either syndecan4 or Pax7, both of which are important for satellite cell function and development. (pnas.org)
  • Here, we show that muscle-restricted expression of a localized insulin-like growth factor (Igf) -1 isoform maintained muscle integrity and enhanced satellite cell activity in SOD1 G93A transgenic mice, inducing calcineurin-mediated regenerative pathways. (rupress.org)
  • In the present study, we establish skeletal muscle as a primary target in inherited forms of ALS by showing that localized expression of the coinherited MLC/mIgf-1 transgene exclusively in the skeletal muscle of SOD1 G93A mice counteracted the symptoms of ALS, induced satellite cell activity, stabilized neuromuscular junctions, and led to a reduction in astrocytosis in the SOD1 G93A spinal cord. (rupress.org)
  • fetal
  • These cells are maintained as a proliferating population in embryonic and fetal muscles of the trunk and limbs throughout development. (nih.gov)
  • The GFP transgene was highly expressed in the majority of c- kit + cells in embryonic sites of haematopoiesis, such as the aorta gonad mesonephros region, fetal liver, and bone marrow. (pnas.org)
  • Transdifferentiation of rat fetal brain stem cells into penile smooth muscle cells. (biomedsearch.com)