Satellite cell and regenerative. Medical search. Frequent questions

For example, "chief" cells express the stem cell marker Troy. (wikipedia.org)
Cell Stem Cell 2013;13(5):590-601. (scielo.br)
The Genetics Policy Institute, the Canadian Stem Cell Network, and Radiant 3D Animation Studio bring you Stem Cell School , an educational website designed for high school and undergraduate level life-science educators. (ca.gov)
The unique educational content found on this site was developed collaboratively with award-winning high school educators, international stem cell organizations, and professional medical animators-creating dynamic and engaging educational resources that teach pertinent cellular biology topics through the lens of stem cells and cellular reprogramming. (ca.gov)
California's landmark stem cell research program made headlines nationally, but what is the latest story behind the science? (ca.gov)
At UC Davis Veterinary Hospital, competitive performance horses receive stem cell treatments that are still off limits to humans. (ca.gov)
Soon after Barack Obama is sworn in as President next week, he is expected to reverse the ban on federal funding for embryonic stem cell research. (ca.gov)
NWABR (https://www.nwabr.org/stem-cell-curriculum-request) curriculum and resources explore the scientific and ethical issues involved in stem cell research. (ca.gov)
While exploring the ethics of stem cell research, students develop an awareness of the many shades of gray among the viewpoints of stakeholders in the debate. (ca.gov)
They become familiar with current U.S. stem cell research policies and regulations, issues regarding private and public funding, and how stem cells may be used to treat diseases and advance scientific knowledge. (ca.gov)
ConnectEd California created a module exploring the government's role in medical decisions that affect people's lives, focusing on stem cell research ( Subunit 1 ) and other areas in which federal or state governments have influenced biomedical research and healthcare practices. (ca.gov)
Stem Cell Resources (www.stemcellresources.org) is a clearinghouse with a global perspective. (ca.gov)
It contains stem cell biology, ethics, and policy information and teaching resources. (ca.gov)
One of the cell types involved in the regenerative stem cell niche are fibro/adipogenic progenitors (FAPs). (usz.ch)
Consensus has been reached that a specialized self-renewing stem cell termed the satellite cell plays the major role during the process of regeneration in amniotes. (monash.edu)
An intriguing aspect of this debate is the fact that a number of amphibia and many fish species have been shown to exhibit epimorphic regenerative processes in specific tissues, whereby regeneration occurs by the dedifferentiation of the damaged tissue itself, and does not deploy specialized stem cell populations analogous to satellite cells. (monash.edu)
Day two presentations included discussion of testosterone measurement and levels in males and females along with the latest developments in stem cell therapies and new therapeutic agents affecting muscle growth and metabolism. (drugfreesport.org.nz)
Here, we developed a minimal gene regulatory network (GRN) model of human pluripotent stem cell (hPSC) lineage commitment and embedded it into "cellular" agents that respond to a dynamic morphogenetic signaling microenvironment. (bvsalud.org)
Groups from the consortium will work on better understanding stem cell function and dysfunction with age. (helmholtz-muenchen.de)
However, it is not known whether muscle satellite cells in denervated muscle retain their stem cell characteristics. (ucsf.edu)
Determining whether the native muscle stem cell population in denervated muscle possesses regenerative potential, or whether supplementation of regeneration-capable cells from another source is necessary and feasible, will clarify what the most effective treatment strategies will be. (ucsf.edu)
With foundations in muscle and cancer biology, the lab investigates regenerative mechanisms including stem cell development and de-differentiation. (ucsf.edu)
The Harvard lab of Lee Rubin, a professor of stem cell and regenerative biology, has developed a way to culture millions of cells in the lab that behave like skeletal muscle stem cells, also called satellite cells. (buzzy.click)

One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
In 2009 beginning of 2010 we have focused on investigating what factors human embryonic stem cells (hESCs) may produce that enhance regeneration and if those factors have any effects by themselves on regeneration. (ca.gov)
We have submitted the several manuscripts on topics of enhanced tissue regeneration and we are preparing the manuscript that identifies hESC-based novel strategies for restoring high regenerative capacity to old muscle. (ca.gov)
Finally, our data suggest that muscle stem cells either do not accumulate DNA damage with age or can efficiently repair such damage, when activated for tissue regeneration. (ca.gov)
Muscle regeneration is characterised by a well-timed network of different cell types providing an environment that allows the activation of muscle stem cells, called satellite cells (SCs) to regenerate the damaged tissue. (usz.ch)
Master thesis projects are available to better understand the role of microRNAs in this process using mouse models for muscle regeneration and work with primary muscle cells from mice and humans. (usz.ch)
Regeneration of muscle after injury normally occurs rapidly with satellite stem cells that reside in the space between the basal lamina and the sarcolemma, playing a major role [ 11 ]. (hindawi.com)
Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
Surprisingly, hypertrophic fibres from Mtn-/-/ErrγTg/+ mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. (reading.ac.uk)
We conclude that in the vertebrates so far examined, epimorphosis does not appear to be deployed during muscle regeneration, and that analogous cells expressing similar marker genes to satellite cells appear to be deployed during the regenerative process. (monash.edu)
The symposium focused on exploring the theme Recovery, Repair, and Regeneration: From Steroids to Stem Cells. (drugfreesport.org.nz)
To understand why regeneration occurs in the peripheral but not the central nervous system, our lab studies a unique cell type that spans both systems: sensory neurons of the dorsal root ganglia. (parisdescartes.fr)
1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
Epimorphic regeneration can be thought of as occurring in two phases: wound healing and cell proliferation. (biomedcentral.com)
Morphological indications of Schwann cell hyperplasia, hypertrophy, and axonal sprouting supported the contention that a continuous cycle of axonal degeneration and regeneration was occurring. (duke.edu)
Adult tissue repair and regeneration require stem-progenitor cells that can self-renew and generate differentiated progeny. (bvsalud.org)
If healthy muscle progenitor cells were introduced and could fuse to existing deficient fibers, as well as form new muscle fibers, regeneration of muscle might occur 11 , 12 . (plos.org)
With age the number of neural stem cells decays bringing along memory and regeneration impairments and increased risk of tumor initiation. (helmholtz-muenchen.de)
Our laboratory recently isolated human skeletal muscle stem cells (hMuSCs) that regenerate skeletal muscle after transplant into a mouse, making them a potential source of regeneration-capable cells. (ucsf.edu)

Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
On the first day of the Symposium talks on the structure and molecular biology of skeletal muscle, role of IGF-1, anabolic steroids and satellite cells were presented. (drugfreesport.org.nz)
Findings The present research exposed that EZH2 affects many elements of South carolina biology, including self-renewal, expansion, and cell identification. (cancer-ecosystem.com)
The most prominent example is the changes in cell biology and morphology when it evolves from a healthy to a cancerous state [1, 3]. (globaltechbiz.com)
Heart, bone and even placenta are built on these networks of cells," says Lawrence Schwartz, Professor of Biology at the University of Massachusetts. (robert-gorter.info)

They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent - iMSC, also called an induced multipotent progenitor cell - iMPC) or unipotent - (iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
Skeletal muscle contains a number of different progenitor cells, including satellite and mesenchymal progenitor cells. (hindawi.com)

To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF‐β, where old differentiated tissues and blood circulation inhibit the regenerative performance of organ stem cells. (ca.gov)
Exercise can produce Irisin and Semaphorin-3A by stimulating muscle and nerve cell, which have positive effects on other tissues, including the lungs. (jeoct.com)
Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)
Discover Satellite Bio's groundbreaking SAT platform, designed to transform various cell types into bioengineered tissues, offering potential solutions for currently untreatable conditions. (labcentral.org)
The age-associated progressive degeneration of many tissues is thought to be driven by the functional decline and gradual attrition of adult stem cells. (helmholtz-muenchen.de)
In older tissues with greater levels of molecular damage, ever more stem cells slip from quiescence into an irreversible senescent state. (drwiggy.com)
Using model organisms such as zebrafish and mice, and extending discoveries to human cells and tissues, the lab hopes to gain fundamental insight that can be translated into clinical advances, notably solving the structural and reconstructive problems of the limbs, face, and head, whether congenital or acquired. (ucsf.edu)

This Satellite Symposium gave an overview of the many aspects of Alzheimer's Disease (AD) from understanding the manifestation of clinical disease to current therapies, translational models, and gene-environment interactions. (iatpfellow.org)
Satellite cells, a population of resident stem cells in skeletal muscle, can proliferate and repair damaged muscle, making them promising targets for muscle regenerative therapies. (ucsf.edu)
The research will include biologic drugs, vaccines, nucleic acids, and cell and gene therapies. (buzzy.click)
The partners said that these cells retain their regenerative potential, which means that it's possible they can be used in cell therapies. (buzzy.click)

Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. (scielo.br)
non-committed originate cells and Pax7+/Myf5+ muscle mass progenitors. (cancer-ecosystem.com)
Unlike additional research in which removal was conditionally acquired in dedicated progenitors or differentiated cells (Chen et al. (cancer-ecosystem.com)
Skeletal muscle progenitors (satellite cells), murine cell line and immortalized human myoblasts are studied in vitro to identify, in a controlled environment, the pathways regulating the regenerative potential of the skeletal muscle. (units.it)

After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
A number of different local transcription factors called myogenic regulatory factors (MRFs), including MyoD, myf-5, myogenin, and myf-6, stimulate proliferation and differentiation of satellite cells [ 9 ]. (hindawi.com)
In addition, insulin, such as growth factor (IGF) 1Ea and/or IGF-1Ec (MGF), also stimulates proliferation and differentiation of satellite cells. (hindawi.com)

This capacity to regenerate does not decline with age and may be linked to their ability to make new stem cells from muscle cells on demand. (wikipedia.org)
Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)
Thus, the use of hESC-produced pro-regenerative factors for boosting the regenerative capacity of organ stem cells is likely to yield healthy, young tissue. (ca.gov)
From a sport viewpoint, it predicts that any benefits of clenbuterol treatment are likely to impose any extra stress on the satellite cells and this method could risk the regenerative capacity in the long term. (wada-ama.org)
to evaluate key markers of regenerative capacity and reinnervation (N-CAM expression endplates and satellite cells). (agrifutures.com.au)
These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced. (reading.ac.uk)
Importantly, the peripheral axon has a much greater regenerative capacity than the central axon. (parisdescartes.fr)
Skeletal muscle regenerative capacity relies on muscle satellite cells (MuSCs) and their interplay with different cell types within the niche. (bvsalud.org)
Within the blood system, anemia of ageing is characterized by peripheral blood cytopenias, bone marrow aplasia and decreased engraftment capacity upon transplantation, indicating impaired hematopoietic stem cells function. (helmholtz-muenchen.de)
Skeletal muscle mass and function decline with age (sarcopenia), linked to progressive reduction in regenerative capacity of skeletal muscle stem cells (satellite cells). (helmholtz-muenchen.de)

[ 13 ] is that of a reactive or regenerative hyperplasia associated with an inflammatory process. (medscape.com)

They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)
For six decades since the discovery of the satellite cell, it has not been possible to expand therapeutic numbers of satellite cells in vitro, until we made real headway on it at Harvard," Rubin said in a prepared statement. (buzzy.click)

Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)
These novel immune-deficient mouse models of DMD, LGMD2B, and LGMD2D will be useful for long-term gene and cell therapy studies involving transfer of foreign genes and cells. (plos.org)
Because of their monoallelic genetic basis, the addition of genes or cells that could provide the DMD, SGCA, or DYSF protein that is deficient in these disorders has the potential to be an effective treatment. (plos.org)

Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
The in dedicated skeletal myogenic cells (MyoD+ cells), we carefully bred rodents (Supplemental Fig. H5A). (cancer-ecosystem.com)
Body and muscle mass mass had been significantly decreased in mutilation in skeletal myogenic cells. (cancer-ecosystem.com)

Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)
Rodents with conditional mutilation of Ezh2 in Pax7-produced muscle mass precursor cells possess decreased muscle mass mass with smaller sized myofibers was selectively ablated in Pax7-produced cells by traversing knock-in rodents articulating Cre recombinase from the Pax7 locus (alleles (Su et al. (cancer-ecosystem.com)

This meant that the cells can change their differentiation pathway. (wikipedia.org)
In Drosophila imaginal discs, cells have to choose from a limited number of standard discrete differentiation states. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
Upon injury, FAPs enter the cell cycle and expand to produce cytokines and deposit extracellular matrix (ECM) to enhance differentiation of SCs into muscle fibers. (usz.ch)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)

In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. (ca.gov)
However, since there are many different non-muscle cell populations that reside within the tissue, these experiments cannot easily distinguish true myonuclei from those of neighboring mononuclear cells. (frontiersin.org)
Autofluorescence imaging permits label-free cell type identification in live airway tissue and reveals the dynamic formation of airway secretory cell associated antigen passages. (elifesciences.org)
Simone Spuler, Helena Escobar and Andreas Marg demonstrate that satellite cells can be successfully expanded from human adult muscle biopsies in culture and transplantation of satellite cell-containing human muscle fiber fragments into irradiated mice restores damaged muscle tissue. (mdc-berlin.de)
Join us for an enlightening lunch and learn hosted by Promga, featuring Satellite Bio, the pioneers of revolutionary Tissue Therapeutics. (labcentral.org)
Our so-called GARMEN strategy provides a multiscale computational platform to understand how single-cell-based regulatory interactions scale to tissue domains. (bvsalud.org)
Within 15 minutes of injury the damaged tissue consists of disrupted extracellular tissue and dead cells, platelets and plasma, which themselves release powerful enzymes such as thrombin thereby setting off an inflammatory cascade (Schiaffino and Partridge 2008). (musculoskeletalkey.com)
Critical among these is the SASP that includes many cytokines, chemokines, proteases, growth factors, and extra cellular matrix (ECM), as it affects not only senescent cells themselves in an autocrine manner but also nearby cells and the tissue microenvironment in a non-cell-autonomous manner. (molcells.org)
For example, SASP factors can reinforce cell cycle arrest of senescent cells and mobilize the immune system to suppress tumorigenesis and promote an optimal tissue repair. (molcells.org)
It's actually a special type of tissue in your body, where cells are fused together extra close - so close, that they behave a like a giant single cell. (robert-gorter.info)
We have specialized stem cells (called satellite cells) in our muscle tissue. (sunchlorellausa.com)
She has been reviewer for international Journals ( FASEB J , Cell & Tissue Res , Toxicon, Exp Cell Res ), for national grant agencies (MIUR) and international Foundations (AFM, Association Francaise contre les Myopathies). (units.it)

We focused on the glial cells that envelop the sensory neuron soma, known as satellite glial cells (SGC). (parisdescartes.fr)

When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. (frontiersin.org)
There is a general agreement that hypertrophy is accompanied by the addition of new nuclei from stem cells to help the muscles meet the enhanced synthetic demands of a larger cell. (frontiersin.org)
Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
Irradiation treatment, which eliminates satellite cells from these muscles, prevents the compensatory hypertrophy in these types of experiments. (arvojournals.org)
But by far our biggest cells - and biggest syncytia - are our muscles. (robert-gorter.info)
It turns out, as we age these regenerative stem cells in our muscles can't stay dormant. (sunchlorellausa.com)
Methods Cell lifestyle and transfection The mouse skeletal muscles cell series C2C12 was cultured as defined previously (Zhang et al. (ampkpathway.com)

The second expresses markers of smooth muscle and mesenchymal cells (SMMCs) and, while distinct from MuSCs, exhibited myogenic potential and promoted MuSC engraftment following transplantation. (bvsalud.org)
Mouse satellite cells (MuSCs) have been transplanted and shown to correct histopathology and improve muscle function in disease models. (ucsf.edu)

To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. (molcells.org)
In addition to cell cycle arrest, senescent cells have additional effector programs such as an enlarged flattened morphology, an altered chromatin structure called senescence-associated heterochromatin formation (SAHF), and a massive secretion of several factors called senescence-associated secretory phenotype (SASP). (molcells.org)

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
Discussions centered around evolving treatment modalities and anti-doping, and included presentations from researchers in areas such as regenerative medicine, reproductive medicine, skeletal muscle adaptation to over-training and gene therapy. (drugfreesport.org.nz)

The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)
We confirmed that typical growth factor signaling was in fact occurring in muscle cells exposed to hESC produced factors, and that hESCs produce a TGF-beta antagonist. (ca.gov)
In more detail, the team is studying the role of electrical activity and local trophic factors in the microenvironment of satellite cell niche and in the post-mitotic myogenesis. (units.it)

Students begin by studying planaria as a model organism using a lab protocol incorporated in the CIRM-developed Unit 2: Adult Stem Cells, Homeostasis, and Regenerative Medicine. (ca.gov)

We identified two previously understudied cell populations in the interstitial compartment. (bvsalud.org)

Moreover, they can make this transition even in the absence of noticeable injuries and are capable of replenishing entire gastric units, in essence serving as quiescent "reserve" stem cells. (wikipedia.org)

Some types of mature, specialized adult cells can naturally revert to stem cells. (wikipedia.org)

To facilitate gene and cell therapy experiments, we created severely immune-deficient mouse models of Duchenne muscular dystrophy (DMD), limb girdle muscular dystrophy 2B (LGMD2B), and limb girdle muscular dystrophy 2D (LGMD2D) by crossing mdx 4Cv , Bl/AJ, and Sgca-null mice with NRG immune-deficient mice. (plos.org)

Satellite television cells (SCs) sustain muscle development and empower adult skeletal muscle with strenuous regenerative capabilities. (cancer-ecosystem.com)

But modern cell-type-specific dyes and genetic markers have shown that the dying nuclei other researchers had detected were in fact inflammatory and other cells recruited to atrophic muscle. (robert-gorter.info)
fatty acids may regulate inflammatory responses is based on Results: There were no statistically significantly protective associ- their interaction with GPR43 receptors, which are mainly ex- ations observed between a high intake of soluble fiber and islet pressed on cells of the innate immune system (9). (lu.se)

Induced totipotent cells can be obtained by reprogramming somatic cells with somatic-cell nuclear transfer (SCNT). (wikipedia.org)
L1s exert their function as structural elements in the genome, as transcribed RNAs to influence chromatin structure and as retrotransposed elements to shape genomic variation in somatic cells. (sciencegate.app)

We also found that other cell types, including macrophages, endothelial cells, and mesenchymal cells respond differently to peripheral vs central injuries. (parisdescartes.fr)
Increase inflammation promotes apoptosis in the epithelial cells, endothelial cells, and airways, that resulting Emphysema. (jeoct.com)

TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)

We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. (reading.ac.uk)

Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
However, the functional definition of these cells as self-renewing muscle stem cells remains a final hurdle to the definition of the satellite cell as a generic vertebrate cell type. (monash.edu)
Several types of adenosine receptors have been detected in developing and differentiated skeletal muscle cells, but little is known about the functional outcome of AR modulation on muscle AChRs. (units.it)

Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)
In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)
3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)

The cell bodies of sensory neurons are located in the dorsal root ganglion, a structure that sits just outside the spinal cord. (parisdescartes.fr)
While we continue to study the signaling pathways elicited in sensory neurons, we recently turned our attention to the possibility that other cells residing in dorsal root ganglia contribute to the nerve repair process. (parisdescartes.fr)
This response fails after spinal cord injury and may contribute to the poor pro-regenerative response of sensory neurons after central nervous system injury. (parisdescartes.fr)
Sensory ganglion neurons were normal except for occasional chromatolytic cells, so that nerve cell loss was not present in this peripheral neuropathy. (duke.edu)

These senescent cells are no longer capable of generating new cells, and start to secrete all sorts of harmful signal molecules. (drwiggy.com)

hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)
Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
Skeletal muscle is fairly unique in that the mature cells are syncytial and can contain hundreds of nuclei. (frontiersin.org)
An individual muscle fibre is a long cylindrical cell with multiple nuclei bound by its sarcolemma (Lutz and Lieber 1999). (musculoskeletalkey.com)
Until recently, scientists thought this meant that nuclei - the cell control centers that build and maintain muscle fibers - are also lost to sloth. (robert-gorter.info)
But according to a review published in Frontiers in Physiology, modern lab techniques now allow us to see that nuclei gained during training persist even when muscle cells shrink due to disuse or start to break down. (robert-gorter.info)
Muscle growth is accompanied by the addition of new nuclei from stem cells to help meet the enhanced synthetic demands of larger muscle cells," explains Schwartz. (robert-gorter.info)

Our results indicate that clenbuterol-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle. (wada-ama.org)

The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
Cytoskeleton, U-93631 which is a network of interconnected filaments of different types, connects the cell membrane with underlying sub-cellular components. (globaltechbiz.com)
The nucleus is the largest organelle among sub-cellular components, demonstrating solid-elastic behavior [4], and it is typically stiffer than the cell itself [5]. (globaltechbiz.com)
Researchers have yet to figure out exactly how we can encourage these special cells to "sleep" a little more in order to help us fight off aging at the cellular level. (sunchlorellausa.com)

Anatomy23

Organisms15

Diseases7

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes20

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science5

Health Care2

Stem cell23

Regeneration23

Biology5

Progenitor3

Tissues8

Therapies4

Progenitors5

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Capacity11

Hyperplasia1

Vitro5

Genes3

Myogenic cells3

Precursor cells2

Differentiation7

Tissue13

Glial cells1

Muscles8

MuSCs2

Senescence2

Reproductive2

Factors4

Homeostasis1

Populations1

Quiescent1

Adult cells1

Mice1

Capabilities1

Inflammatory2

Somatic cells2

Endothelial cells2

Embryonic stem1

Positively1

Functional3

Myofibers3

Sensory4

Senescent cells1

Nuclei7

Human skeletal muscle1

Cellular4