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  • RYR1
  • Ion channels directly involved in the skeletal muscle E-C coupling (RyR1 and Cav1.1 voltage-gated Ca 2+ channels) were labeled using indirect immunofluorescence. (biomedcentral.com)
  • Mutations in the RYR1 gene cause several rare inherited skeletal muscle disorders, including malignant hyperthermia and central core disease (CCD). (rupress.org)
  • Collectively, these findings indicate that in vivo muscle weakness observed in IT/+ knock-in mice arises from a reduction in the magnitude and rate of RYR1 Ca 2+ release during EC coupling that results from the mutation producing a dominant-negative suppression of RYR1 channel Ca 2+ ion permeation. (rupress.org)
  • The RYR1 functions as the Ca 2+ release channel in the skeletal muscle SR. The functional RYR1 SR Ca 2+ release channel is a 2.3-megadalton homomeric assembly of four ∼565-kD RYR1 subunits. (rupress.org)
  • Chemically
  • A series of studies by Smith and colleagues ( 24 , 37 , 38 , 43 ) using a decerebrate rat preparation has suggested that in spontaneous hypertensive rats (SHRs), both mechanically and chemically sensitive muscle afferents engaged during skeletal muscle contraction are stimulated excessively compared with those in normotensive rats, thereby evoking exaggerated sympathoexcitatory and pressor responses to contraction. (physiology.org)
  • In humans with hypertension, the elevation in muscle sympathetic nerve activity seen during postexercise ischemia, a maneuver that selectively excites chemically sensitive muscle afferents, was higher than that in normotensive subjects ( 10 ). (physiology.org)
  • tissue
  • What are the universal characteristics of muscle tissue? (brainscape.com)
  • 10) The muscle tissue that normally exhibits voluntary contractions is __________ muscle. (scribd.com)
  • RT-PCR and immunoblot experiments showed that mRNA and protein for gp91 phox , a NADPH oxidase subunit, in skeletal muscle tissue were upregulated in hypertensive rats. (physiology.org)
  • Skeletal muscle is a unique tissue because of its structure and function, which requires specific protocols for tissue collection to obtain optimal results from functional, cellular, molecular, and pathological evaluations. (jove.com)
  • Overall, this manuscript provides an outline of how fresh tissue can be effectively distributed for a variety of phenotypic studies and thereby provides standard operating procedures (SOPs) for pathological studies related to congenital muscle disease. (jove.com)
  • Be able to describe the top-down structure of skeletal muscle tissue from muscle fiber, to myofibril, to sarcomere. (wikipremed.com)
  • Muscle is contractile tissue of the body and is derived from the mesodermal layer of embryonic germ cells. (wikipremed.com)