• Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. (duke.edu)
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT) results from mutations affecting proteins related to intracellular calcium regulation (particularly upregulation of the sarcoplasmic reticulum ryanodine receptor) in the heart. (msdmanuals.com)
  • The overall objective of this thesis was to examine mechanisms involved in the acute regulation of sarcoplasmic reticulum (SR) Ca2+-handling properties by second messenger signaling pathways in skeletal and cardiac muscle. (uwaterloo.ca)
  • The aim of the first study (Chapter Two) was to characterize changes in the kinetic properties of sarco(endo)-plasmic reticulum Ca2+-ATPase (SERCA) proteins in cardiac and skeletal muscles in response to b-adrenergic, Ca2+-dependent calmodulin kinase II (CaMKII) and protein kinase C (PKC) signaling. (uwaterloo.ca)
  • Calsequestrin (CS) is segregated to the junctional sarcoplasmic reticulum (jSR) of skeletal muscle fibers and is responsible for intraluminal Ca(2+) binding. (unipd.it)
  • CD97 is expressed at the sarcoplasmic reticulum and the peripheral sarcolemma in skeletal muscle. (abcam.com)
  • However, lack of CD97 only affects the structure of the sarcoplasmic reticulum, but not the function of skeletal muscle. (abcam.com)
  • Here we have shown that the dystrophic phenotype observed in δ-sarcoglycan-null (Sgcd-/-) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca2+ ATPase 1 (SERCA1). (jci.org)
  • Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermia. (cdc.gov)
  • Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. (duke.edu)
  • Alteration in calcium metabolism in the sarcoplasmic reticulum causes accelerated junctional rhythm. (medscape.com)
  • Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release channels on sarcoplasmic reticulum within junctional membrane complexes. (duke.edu)
  • The cytosolic side of the pump then closes and the sarcoplasmic reticulum side opens, releasing the Ca2+ into the SR. A protein found in cardiac muscle, called phospholamban (PLB) has been shown to prevent SERCA from working. (wikipedia.org)
  • Dual effects of cyclic ADP-ribose on sarcoplasmic reticulum Ca2+ release and storage in cardiac myocytes isolated from guinea-pig and rat ventricle. (ox.ac.uk)
  • The actions of cyclic ADP-ribose (cADPR), a regulator of Ca2+-induced Ca2+ release (CICR), were investigated on Ca2+ release and sarcoplasmic reticulum (SR) Ca2+ loading in cardiac myocytes at physiological temperature. (ox.ac.uk)
  • Membrane formation by the adenosine triphosphatase of sarcoplasmic reticulum. (wikidata.org)
  • Mechanical stretch decreased the expression of sarcoplasmic reticulum adenosine triphosphatase 2, and thus slower calcium reuptake kinetics, which was responsible for the susceptibility to alternans. (tmu.edu.tw)
  • Overexpression of sarcoplasmic reticulum adenosine triphosphatase 2 reversed all the effects of stretch on susceptibility to alternans. (tmu.edu.tw)
  • The sarcoplasmic reticulum (SR) is a membrane-bound structure found within muscle cells that is similar to the smooth endoplasmic reticulum in other cells. (wikipedia.org)
  • Ryanodine-sensitive Ca2+ release ('Ca2+ sparks') through the sarcoplasmic reticulum (SR) can activate plasmalemmal Ca2+-turned on K+ channels (KCa) to cause membrane hyperpolarization and soft muscle relaxation. (biongenex.com)
  • Background - Increasing sarcoplasmic/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) uptake activity is a promising therapeutic approach for heart failure. (gla.ac.uk)
  • SERCA1 overexpression reversed a defect in sarcoplasmic reticulum Ca2+ reuptake that characterizes dystrophic myofibers and reduced total cytosolic Ca2+. (jci.org)
  • New and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca²⁺ release? (ox.ac.uk)
  • ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
  • The sarcoplasmic reticulum is a network of tubules that extend throughout muscle cells, wrapping around (but not in direct contact with) the myofibrils (contractile units of the cell). (wikipedia.org)
  • The ATP2A2 gene provides instructions for making an enzyme called sarco(endo)plasmic reticulum calcium-ATPase 2 (SERCA2). (medlineplus.gov)
  • Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. (expasy.org)
  • InsP(3)R-RyR channel crosstalk augments sarcoplasmic reticulum Ca(2+) release and arrhythmogenic activity in post-MI pig cardiomyocytes. (amedeo.com)
  • The HC appeared to affect the release and accumulation of Ca+2 by the sarcoplasmic reticulum. (cdc.gov)
  • Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. (osu.edu)
  • It prevents calcium release from sarcoplasmic reticulum. (medscape.com)
  • The abnormalities increase release of calcium from the sarcoplasmic reticulum in response to adrenergic stimulation. (msdmanuals.com)
  • At the time of surgery, cellular Ca2+ transients (CaTs) and the sarcoplasmic reticulum (SR) Ca2+ content were smaller in the poAF group. (nih.gov)
  • In this review, we focus, not on RyR/IP3 R, but on other ion-channels that are known to be present in the sarcoplasmic/endoplasmic reticulum (ER/SR) membranes. (ox.ac.uk)
  • This is equal to the measured increase of sarcoplasmic reticulum (SR) calcium content obtained by applying caffeine (20 mm) and integrating the resulting Na+-Ca2+ exchange current. (manchester.ac.uk)
  • Waves are initiated when sarcoplasmic reticulum (SR) Ca2+ content reaches a threshold level. (manchester.ac.uk)
  • from the sarcoplasmic reticulum (SR) potentially contributing to decreased function. (gla.ac.uk)
  • Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum. (umassmed.edu)
  • Although the L-VDCC subunits are most abundant in fast skeletal transverse tubules, Ca 2+ influx is not required for contraction in skeletal muscle, unlike cardiac muscle, which requires Ca 2+ entry with each beat and triggers Ca 2+ release from the sarcoplasmic reticulum (SR) via Ca 2+ -release channels, e.g., ryanodine receptor 2 (RyR2). (jci.org)
  • Such localized Ca(2+) signals may initiate global Ca(2+) waves and contraction of the myocytes through the recruitment of ryanodine receptors on the sarcoplasmic reticulum via Ca(2+)-induced Ca(2+) release. (ox.ac.uk)
  • These lysosomal stores facilitate this process by co-localizing with a portion of the sarcoplasmic reticulum expressing ryanodine receptors to comprise a highly specialized trigger zone for NAADP-dependent Ca(2+) signaling by the vasoconstrictor hormone, endothelin-1. (ox.ac.uk)
  • Contraction of skeletal muscle is triggered by the rapid release of Ca 2+ from the sarcoplasmic reticulum via the ryanodine receptor/calcium-release channel. (aspetjournals.org)
  • Here, we used high-affinity [ 3 H]ryanodine binding to sarcoplasmic reticulum from rabbit skeletal muscle to screen for more potent analogs of suramin. (aspetjournals.org)
  • Here, we report that nanomolar concentrations of EGCG significantly enhance contractility of intact murine myocytes by increasing electrically evoked Ca(2+) transients, sarcoplasmic reticulum (SR) Ca(2+) content, and ryanodine receptor type 2 (RyR2) channel open probability. (nih.gov)
  • Ryanodine: antithetical calcium channel effects in skeletal muscle sarcoplasmic reticulum. (aspetjournals.org)
  • The potential for luminal Ca2+ to modulate the activity of both SERCA1 pumps and RyR1 channels was examined in isolated skeletal muscle heavy sarcoplasmic reticulum vesicles. (umanitoba.ca)
  • Organization of junctional sarcoplasmic reticulum proteins in skeletal muscle fibers. (nih.gov)
  • CS is synthesized in the ER (endoplasmic reticulum) and is targeted to the TC (terminal cisternae) of SR via mechanisms still largely unknown, but probably involving vesicle transport through the Golgi complex. (unipd.it)
  • CS (calsequestrin) is an acidic glycoprotein of the SR (sarcoplasmic reticulum) lumen and plays a crucial role in the storage of Ca2+ and in excitation-contraction coupling of skeletal muscles. (unipd.it)
  • The topology of Ca 2+ -ATPase in sarcoplasmic reticulum (SR) vesicles was investigated with the aid of sequence-specific antibodies, produced against oligopeptides corresponding to sequences close to the membranous portions of the protein. (psu.edu)
  • ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. (nih.gov)
  • In sarcoplasmic reticulum (SR) of skeletal muscles, we investigated the development of AA. (aston.ac.uk)
  • Inhibition of calcium release from the sarcoplasmic reticulum by Dantrium reestablishes the myoplasmic calcium equilibrium, increasing the percentage of bound calcium. (nih.gov)
  • signaling by tethering the sarcoplasmic reticulum and mitochondria in rat aortic smooth muscle cells. (bvsalud.org)
  • Therefore, close contact of mitochondria with the sarcoplasmic reticulum (SR) is required for maintaining Ca2+ homeostasis . (bvsalud.org)
  • Ultrastructural analysis of heart tissue from chemical-related myofiber vacuolation has elucidated the primary site of damage in various organelles, including mitochondria and smooth endoplasmic reticulum. (nih.gov)
  • Experiments were performed to characterize the properties of the intrinsic Ca2+ buffers in the sarcoplasmic reticulum (SR) of cut fibers from frog twitch muscle. (edu.au)
  • To investigate whether the energy derived from glycolysis is functionally coupled to Ca 2+ active transport in sarcoplasmic reticulum (SR), we determined whether glycolytic enzymes were associated with SR membranes and whether metabolism through these enzymes was capable of supporting 45 Ca transport. (johnshopkins.edu)
  • The sarcoplasmic reticulum is a network of tubules that extend throughout muscle cells, wrapping around (but not in direct contact with) the myofibrils (contractile units of the cell). (wikipedia.org)
  • Sarcoplasmic Reticulum" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • The sarcoplasmic reticulum (SR) plays an essential role in muscle excitation-contraction coupling by regulating the cytosolic free Ca2+ concentration. (wyatt.com)
  • Silva worked on the Ca2+-ATPase of the sarcoplasmic reticulum, responsible for calcium pumping and crucial to the function of the muscle fiber. (biophysics.org)
  • Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. (planteome.org)
  • The aim of this work was to investigate whether beat-to-beat alternation in the amplitude of the systolic Ca2+ transient (Ca2+ alternans) is due to changes of sarcoplasmic reticulum (SR) Ca2+ content, and if so, whether the alternans arises due to a change in the gain of the feedback controlling SR Ca2+ content. (manchester.ac.uk)
  • This graph shows the total number of publications written about "Sarcoplasmic Reticulum" by people in this website by year, and whether "Sarcoplasmic Reticulum" was a major or minor topic of these publications. (umassmed.edu)
  • The glycosidic bond torsion angles and the conformations of the ribose of Mg2+ATP, Mg2+ADP and Mg2+AdoPP[NH]P (magnesium adenosine 5'-[beta, gamma-imido]triphosphate) bound to Ca2+ATPase, both native and modified with fluorescein isothiocyanate (FITC), in intact sarcoplasmic reticulum have been determined by the measurement of proton-proton transferred nuclear Overhauser enhancements by 1H-NMR spectroscopy. (nih.gov)
  • In other cases, vacuolation forms from distension of the sarcoplasmic reticulum within cardiomyocytes. (nih.gov)
  • Below are the most recent publications written about "Sarcoplasmic Reticulum" by people in Profiles. (umassmed.edu)