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  • lengths
  • However, iPSC-CM generated in 2D protocols constantly displayed larger sarcomere lengths as compared to the 3D protocol. (mdpi.com)
  • See, for example, Figure 2, which shows that different muscles not only have different resting lay sarcomere lengths, but also different operating ranges. (movementsci.com)
  • The heterogeneity of resting lay lengths is further evidenced by a cadaver study by Ward and colleagues 9 , who reported sarcomere lengths of every major lower extremity muscle (Table 1). (movementsci.com)
  • myofilaments
  • Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments. (nih.gov)
  • Length
  • the peak-to-peak amplitude of oscillation reached as much as 30% of the average sarcomere length. (springer.com)
  • Moreover, our system enables accurate measurement of sarcomere length in the isolated heart. (hindawi.com)
  • To manipulate muscle sarcomere length, the psoas major muscles were used because of their appropriate anatomical locations. (spiedigitallibrary.org)
  • Subsequently, all sarcomeres mature, reaching 1.5 µm diameter and 3.2 µm length and acquiring stretch-sensitivity. (nih.gov)
  • In multiple classes, I was taught that muscles, and thus their sarcomeres, produce the most amount of force while at resting length. (movementsci.com)
  • From the definitions presented above, one can clearly see that optimal length is the appropriate term to describe the length at which sarcomeres produce the most force, especially when compared to resting proper , as the passive length-tension curve may shift horizontally in a muscle-specific manner (Figure 1). (movementsci.com)
  • The operating range and resting lay length of sarcomeres within a muscle appear to be heterogeneous and muscle-dependent. (movementsci.com)
  • The increase in Ca2+ sensitivity that occurs when sarcomere length (SL) is increased (LDA), is considered the cellular basis of the Frank-Starling law of the heart. (grantome.com)
  • fibers
  • Iwazumi, T. & Pollack, G. H. (1981) The effect of sarcomere non-uniformity on the sarcomere lengthtension relationship of skinned fibers. (springer.com)
  • Sarcomeres are aligned precisely in muscle fibers and are readily observed using light microscopy as alternating light and dark bands called the I-band and A-band. (spiedigitallibrary.org)
  • examine
  • However, few studies, if any, have been conducted to investigate the possibility of using optical detection to examine sarcomere structure changes in whole muscles. (spiedigitallibrary.org)
  • propagation
  • Because the periodic sarcomere structures can significantly alter light propagation directions in muscle, we hypothesize that changes in sarcomere structure can be monitored in whole muscle by measuring the scattering coefficient. (spiedigitallibrary.org)
  • muscles
  • Normal biomechanical and physiological functions of striated muscles are facilitated by the repeating sarcomere units. (spiedigitallibrary.org)
  • In this paper, we study the reduced scattering coefficients derived from spatially resolved reflectance measurements 5 on pre- and postrigor whole muscles and investigate their relationships with sarcomere structure. (spiedigitallibrary.org)
  • A consistent result was observed in the shortened soleus: a significant decrease in sarcomere number was observed in the muscles from both wild-type (approximately 26 %) and knockout (approximately 12 %) mice. (biologists.org)
  • Structure
  • CICR), resulting in an increase in [Ca 2+ ] i and subsequently the binding of Ca 2+ to troponin (Tn), resulting in the subsequent formation of cross-bridges (see Figure 1 for sarcomere structure). (hindawi.com)
  • We conducted a series of experiments to demonstrate that optical scattering properties measured in whole muscle are related to changes in sarcomere structure. (spiedigitallibrary.org)
  • Although whole muscle scattering coefficients have been measured before, 4 the effects of sarcomere structure changes have not been studied. (spiedigitallibrary.org)
  • demonstrate
  • Invaluable not only for physiology classes, but also for athletic trainers, sports medicine specialists, physical and massage therapists, the working sarcomere model can also plainly demonstrate muscle tone, muscle cramps, knots and tears. (shopanatomical.com)
  • arrangement
  • We speculate that desmin may play a role in regulating the optimal arrangement of sarcomeres within the muscle or in sensing the magnitude of the immobilization effect itself. (biologists.org)
  • model
  • Included with the sarcomere model is translucent sheath (shown at right) representing the sarcoplasmic reticulum which can be wrapped around the sarcomere to elicit discussion and elucidate understanding of the role calcium ion transport plays in muscle contraction. (shopanatomical.com)
  • Measuring 22"L 6"W 8"H inches overall, the working sarcomere model comes complete with sarcoplasmic reticulum and user manual. (shopanatomical.com)