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  • neuromuscular
  • 5. In skeletal muscle neuromuscular junctions a. (physiologyplus.com)
  • This mechanism of action has demonstrated encouraging pharmacological activity in preclinical models that may relate to the potential treatment of diseases associated with aging, muscle wasting, and neuromuscular dysfunction. (marketwired.com)
  • This novel drug candidate may represent an important approach to treating skeletal muscle weakness that is a consequence of a wide array of diseases associated with muscle wasting or primary neuromuscular dysfunction. (marketwired.com)
  • In non-clinical models, skeletal sarcomere activators have demonstrated pharmacological activity that may lead to new therapeutic options for diseases associated with aging, muscle wasting, and neuromuscular dysfunction. (marketwired.com)
  • SMA is a severe, genetic neuromuscular disease that leads to debilitating muscle function and progressive, often fatal, muscle weakness. (cytokinetics.com)
  • Myocyte
  • On the functional side, depolarization-induced intracellular Ca 2+ transients mediating E-C coupling were recorded using Fura-2 ratiometric Ca 2+ imaging, and myocyte contraction was captured by digital photomicrography. (biomedcentral.com)
  • myofilament
  • The effect of paralysis in early embryos (aged between 17 and 24 hours post-fertilization, hpf) on skeletal muscle structure at both myofibrillar and myofilament level was determined using both immunostaining with confocal microscopy and small angle X-ray diffraction. (nih.gov)
  • Cardiac troponin consists of three subunits (C, I and T) of which only troponin T (cTnT) and troponin I (cTnI) are expressed to be specific isoforms of the cardiac muscle (almost exclusively) in thin Myofilament in the contractile apparatus (4). (ac.ir)
  • mechanisms
  • This study demonstrates that both contraction and contractile-independent mechanisms are important for the regulation of myofibril organization, which in turn is necessary for establishing proper skeletal muscle structure and function during development in vivo in zebrafish. (nih.gov)
  • The detailed molecular mechanisms involved in the decline of skeletal muscle are still unclear. (biomedcentral.com)
  • rectus
  • For others, such as the rectus femoris or deltoid muscle , it becomes more complicated. (wikipedia.org)
  • The midventral hypaxial musculature in all tetrapods consists of the rectus abdominis, a longitudinal muscle on each side of the midline that extends from the pelvic region to the anterior part of the trunk. (encognitive.com)
  • FSTA
  • Under our collaboration with Astellas, we look forward to now exploring the potential of this next-generation FSTA in a fourth patient population in which it may alter the decline of muscle function and performance. (cytokinetics.com)
  • Cytokinetics
  • The initiation of this Phase I clinical trial is further demonstration of Cytokinetics' expertise in building a portfolio of novel drug candidates that leverage our expertise in the cytoskeletal pharmacology and biology of muscle contractility," stated Robert I. Blum, Cytokinetics' President and CEO. (marketwired.com)
  • Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing, and commercializing first-in-class muscle activators. (cytokinetics.com)
  • Cytokinetics' unparalleled expertise has kept it at the forefront of drug discovery and development for diseases impacting muscle performance. (cytokinetics.com)
  • In collaboration with Astellas (TSE:4503) ("Astellas"), Cytokinetics is developing CK-2127107 as a potential treatment for people living with SMA and certain other debilitating diseases and conditions associated with skeletal muscle weakness and/or fatigue. (cytokinetics.com)
  • We are pleased to advance this clinical trial to the next phase of execution and appreciate the enthusiasm of our investigators to explore the potential of this novel mechanism drug candidate that specifically targets skeletal muscle and potentially improves muscle force, function and stamina," said Fady I. Malik, MD, PhD, Cytokinetics' Executive Vice President, Research and Development. (cytokinetics.com)
  • Starting FORTITUDE-ALS reflects our increased commitment to explore the potential of our muscle-biology directed investigational therapies for the potential treatment of people with ALS," said Fady I. Malik, MD, PhD, Cytokinetics' Executive Vice President of Research & Development. (cytokinetics.com)
  • pharmacological
  • In this study the role of movement in skeletal muscle maturation was investigated in intact zebrafish embryos using a combination of genetic and pharmacological approaches. (nih.gov)
  • overlap
  • The length of the sarcomere-the structure within the muscle cell where filaments overlap to produce the movements required for muscle contraction-is shorter in the multifidus than in any other muscle cell," explained study's first author Samuel R. Ward, P.T., Ph.D., Assistant Professor of Radiology at UC San Diego School of Medicine. (ucsd.edu)
  • potentially
  • There are approximately four hundred muscles in the human body and any one of them can develop trigger points, potentially causing referred pain and dysfunction. (pressurepositive.com)
  • Their findings about the potentially important "scaffolding" role of this poorly understood muscle has been published on line in advance of the January issue of the Journal of Bone and Joint Surgery . (ucsd.edu)
  • somatic
  • Two major groups of skeletal muscles are recognized, somatic (parietal) muscles, which develop from the myotomes, and branchiomeric muscles, which develop in the pharyngeal wall from lateral plate mesoderm. (encognitive.com)
  • The somatic musculature is subdivided into axial muscles, which develop directly from the myotomes and lie along the longitudinal axis of the body, and appendicular muscles, which develop within the limb bud from mesoderm derived phylogenetically as buds from the myotomes. (encognitive.com)
  • frog
  • X‐ray diffraction patterns from live frog skeletal muscles taken with an image plate detector (see Wakabayashi and Amemiya, ) at the small‐angle X‐ray scattering/diffraction beamline of the Photon Factory (Japan). (els.net)
  • High‐resolution X‐ray diffraction patterns from live frog skeletal muscles taken with a CCD detector at the BioCAT beamline of the Advanced Photon Sources (USA). (els.net)
  • weakness
  • We're advancing muscle biology-driven treatments for diseases characterized by compromised muscle function, muscle weakness, and fatigue. (cytokinetics.com)
  • Spinal muscular atrophy manifests in various degrees of severity as progressive muscle weakness resulting in respiratory and mobility impairment. (cytokinetics.com)
  • There are four types of SMA, named for age of initial onset of muscle weakness and related symptoms: Type I (Infantile), Type II (Intermediate), Type III (Juvenile) and Type IV (Adult onset). (cytokinetics.com)
  • diseases
  • We're dedicated to the research and development of therapies for people suffering from debilitating diseases that rob them of key muscle functions. (cytokinetics.com)
  • Formation of typical triads requires other factors/conditions, and this should be taken into account when using in-vitro models to explore skeletal muscle diseases, especially those affecting E-C coupling. (biomedcentral.com)
  • Function
  • Following determination of the MTD and the pharmacokinetic profile of CK-2017357, further evaluation of the drug candidate's pharmacodynamic effects on skeletal muscle function in healthy volunteers may be undertaken in a second stage of this clinical trial. (marketwired.com)
  • Whilst it is recognized that contraction plays an important part in maintaining the structure and function of mature skeletal muscle, its role during development remains undefined. (nih.gov)
  • Recovery of muscle function was also assessed by examining swimming patterns in recovered and control fish. (nih.gov)
  • Using laser diffraction methods that they developed to measure muscle internal properties during back surgery, they demonstrated that the multifidus' unique design serves a critical function as a stabilizer of the lumbar spine. (ucsd.edu)
  • Minimally invasive spine surgery techniques strive to minimize surgical trauma to these muscles in order to best preserve their function. (ucsd.edu)
  • When muscle function is poor due to back problems, support is lost. (ucsd.edu)
  • As in Cohort 1, multiple assessments of skeletal muscle function and fatigability will be performed including respiratory assessments, upper limb strength and functionality for non-ambulatory patients, as well as six-minute walk and timed-up-and-go for ambulatory patients. (cytokinetics.com)
  • The Phase 2 clinical trial, now open to enrollment, is designed to assess the change from baseline in the percent predicted slow vital capacity (SVC) and other measures of skeletal muscle function after 12 weeks of treatment with CK-2127107. (cytokinetics.com)
  • Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. (biomedcentral.com)
  • Sarcopenia, a term for the loss of skeletal muscle mass, strength, and function during the aging process [ 12 ], is a severe muscle disorder that impairs the quality of life in human society. (biomedcentral.com)
  • bones
  • Muscles also help to tie the bones of the skeleton together and supplement the skeleton in supporting the body against gravity. (encognitive.com)
  • The limb muscles also serve as flexible ties or braces that can fix the bones at a joint and support the body. (encognitive.com)