Sarcoma virus genome. Medical search. Frequent questions

The viral genome sequence was annotated by comparison with the KSHV and RFHVMn genome sequences (Geneious v. 11.1.3 ( 5 ). (cdc.gov)
The RSV capsid enclosing the viral genome materials is assembled from 1500 copies of the 237-residue RSV capsid protein CA. In vitro, tubular assembly can be obtained with the CA with similar underlying structural properties as the authentic RSV capsid. (dtic.mil)
The portal is a molecular motor through which the viral genome enters the capsid during virion morphogenesis. (gla.ac.uk)
Our 3D reconstruction of the portal-vertex also shows that one end of the viral genome extends outside the portal in the manner described for some bacteriophages but not previously seen in any eukaryote viruses. (gla.ac.uk)
Finally, we show that the viral genome is consistently packed in a highly ordered left-handed spool to form concentric shells of DNA. (gla.ac.uk)
Virus infection may reprogram host metabolism for viral genome and protein synthesis, as well as lipid envelope generation for virion production. (frontiersin.org)
During lytic infection of alpha- and betaherpesviruses, the viral genome is replicated as a precursor form, which contains tandem genomes linked via terminal repeats (TRs). (bvsalud.org)
Subsequent research, with the advent of genome sequencing, showed that a cellular rat gene had been incorporated into the viral genome in both cases (3). (promegaconnections.com)

In the Muller Lab, student researchers work with Muller studying how Kaposi sarcoma-associated herpesvirus (KSHV) hides for years inside the human body before seeking to gain control over human gene expression to complete the viral infection. (uncommondescent.com)
Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. (frontiersin.org)
Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic gamma-herpesvirus, can establish life-long latent infection in human. (frontiersin.org)
KSHV is tightly associated with Kaposi's sarcoma (KS) and two B-cell lymphomas including primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD) by infecting B-lymphocyte and endothelial cells, respectively. (frontiersin.org)
Kaposi´s sarcoma (KS)-associated herpesvirus (KSHV) is tightly linked with KS, primary effusion lymphoma, and multicentric Castleman's disease. (ucp.pt)
KSHV latently infects cells, and its genome persists as a multicopy, extrachromosomal episome. (ucp.pt)
Whole-genome sequencing of KSHV from Zambian Kaposi's sarcoma biopsies reveals unique viral diversity. (cdc.gov)
Subsequently, during her post-doctoral training, at Tel Aviv University and then at Columbia University (New York), she has specialized on herpesvirus biology, in particular on the Kaposi's sarcoma-associated herpesviruses (KSHV). (biu.ac.il)
KSHV is one few viruses proven to be associated with cancer in humans and she has been engaged on the study of this virus almost from its discovery. (biu.ac.il)
Of note, the study of KSHV is important from clinical and public health standpoints, but also provides a source of basic information on how viruses might induce cellular proliferation and transformation. (biu.ac.il)
In 2006, Blossom was named a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease in support of her research into the role of signaling proteins in the pathogenesis of viral-associated cancers such as Kaposi's sarcoma-associated herpesvirus, or KSHV. (bwfund.org)
2 Kaposi's sarcoma is an example of cancer caused by a virus: the Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpes virus-8) that belongs to the family of human herpesviruses, which are responsible for a range of debilitating acute and recurrent diseases, including a number of cancers. (mappingignorance.org)
It was relatively recently (1994) that KSHV was identified in biopsies from tumours of a patient with Kaposi sarcoma, 6 a relatively rare disease prior to the AIDS epidemic. (mappingignorance.org)
Recently, Sophie Schumann and her colleagues have published a study 7 on KSHV that might have many implications in the future, not only for the treatment of Kaposi's sarcoma but for the inhibition of a number of viruses. (mappingignorance.org)
Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA (dsDNA) gammaherpesvirus with a poorly characterized lytic replication cycle. (bvsalud.org)
ORF67.5-deficient KSHV failed to produce infectious virus and cleave the TRs, and numerous soccer ball-like capsids were observed in ORF67.5-deficient KSHV-harboring cells. (bvsalud.org)
Thus, our data indicated that ORF67.5 functions as a component of the KSHV terminase complex by contributing to TR cleavage, terminase complex formation, capsid formation, and virus production. (bvsalud.org)
IMPORTANCE Although the formation and function of the alpha- and betaherpesvirus terminase complexes are well understood, the Kaposi's sarcoma-associated herpesvirus (KSHV) terminase complex is still largely uncharacterized. (bvsalud.org)

At that point, people with a weakened immune system may develop Kaposi sarcoma cancer lesions in the mouth, skin or other organs. (uncommondescent.com)
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. (gla.ac.uk)
In the specific case of the association between the HIV virus and Kaposi sarcoma, as well as some other cancers. (bwfund.org)
In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). (medscape.com)
[ 2 ] For some time, Kaposi sarcoma was seen in 30-40% of patients with AIDS, often as the presenting sign. (medscape.com)
The incidence of Kaposi sarcoma has fallen markedly in recent times, although its prevalence has not. (medscape.com)
The challenge remained to explain the reason male patients who have sex with males and have AIDS exhibited Kaposi sarcoma much more commonly than did patients with AIDS unassociated with homosexuality, with the exception of small foci of this group in isolated midwestern communities. (medscape.com)
The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
HHV-8 has been linked closely with all 4 types of Kaposi sarcoma, ie, classic (traditional), endemic (African), epidemic (AIDS related), and iatrogenic (related to immunosuppression). (medscape.com)
[ 3 ] Since then, much research has shown that HHV-8 appears to be necessary to, but not sufficient for, the development of Kaposi sarcoma. (medscape.com)
Is Kaposi sarcoma a hyperplasia or a neoplasm? (medscape.com)
Kaposi sarcoma and its causative agent, Karposi sarcoma-associated herpesvirus, have distinctive largely unexplained geographic distributions. (medscape.com)
Quinine and its derivatives might better explain the epidemiology of Kaposi sarcoma in Africa than oncoweeds. (medscape.com)
Thus, an "oncodrug" hypothesis has been proposed, specifically with regard to quinine and its derivatives for African Kaposi sarcoma. (medscape.com)
Elderly American man of Armenian origin with characteristic violaceous plaques of the legs, a good example of classic Kaposi sarcoma. (medscape.com)
Evaluation for Kaposi sarcoma should include a complete physical examination and a biopsy of suspected lesions including lymph nodes. (medscape.com)
Solitary Kaposi sarcoma lesions may be excised surgically or removed using laser surgery. (medscape.com)
Because the natural history of Kaposi sarcoma (KS) is variable, assessment of therapy may be difficult. (medscape.com)
Management modalities for Kaposi sarcoma include nonintervention, surgical removal of skin nodules or severely affected areas (eg, areas of the extremities, intussuscepted bowel), laser surgery, conventional and megavoltage radiotherapy, chemotherapy, immunotherapy, antiviral drugs, and cessation of immunosuppressive therapy in iatrogenically immunosuppressed patients. (medscape.com)
Although the authors prefer intralesional vinblastine, intralesional vincristine as first-line therapy for nodules in classic Kaposi sarcoma has also been recommended. (medscape.com)
HHV-8 is associated with Kaposi sarcoma (KS), and evidence links it with body-cavity lymphomas and Castleman disease. (medscape.com)

These include the retroviruses avian leucosis/sarcoma viruses (ALSV) and reticuloendothesiosis viruses (REV), and the herpesvirus Marek's disease virus (MDV). (cdc.gov)
Herpesvirus family members are icosahedral DNA viruses. (medscape.com)

The Rous Sarcoma Virus RSV is the ideal platform to study retrovirus. (dtic.mil)
Transcription of DNA from the 70S RNA of Rous sarcoma virus. (wikidata.org)
A number of studies have examined the structure of the Rous sarcoma virus (RSV), which affects birds and provides a good model for other retroviruses, but none have been able to provide a high-resolution look at the immature stage of the virus. (sciencedaily.com)
Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). (edu.au)
Many labs were beginning to work with tumor viruses as the only tractable way to understand cancerous transformation, and Rubin chose to focus on a virus known since 1911 to cause cancer in chickens: the Rous sarcoma virus (RSV). (berkeley.edu)
This allowed Harold Varmus and Michael Bishop of UC San Francisco to identify an analogous gene in the cellular genome - a gene evidently stolen by the Rous sarcoma virus. (berkeley.edu)

The viral DNA then invades the host cell's genome. (sciencedaily.com)
Retroviruses are enveloped RNA viruses defined by their mechanism of replication via reverse transcription to produce DNA copies that integrate into the host cell's genome. (msdmanuals.com)

It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
For each type of virus, what is known about the roles of DNA methylation, histone modifications, nucleosome positioning, and regulatory RNA in epigenetic regulation of the virus infection will be discussed. (mdpi.com)
The genome also exits the capsid through the portal-vertex when it is injected through the nuclear pore into the nucleus of a new host cell to initiate infection. (gla.ac.uk)
Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma. (umassmed.edu)
Increasing evidence has shown that virus infection, similar to cancer development, depends on the reprogramming of cellular metabolism to produce biomass for viral replication and virion production. (frontiersin.org)
Viruses modulate biochemical cellular pathways to permit infection. (ucp.pt)
This deficiency was confirmed under physiological conditions, on infection of mice with a murine gammaherpesvirus 68 chimera expressing LANA, where the virus was highly deficient in establishing latent infection in germinal center B cells. (ucp.pt)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
It is not difficult to imagine that, at least in theory, by disrupting the interactions between ORF-57 and hTREX, the lytic cycle of the virus could be halted and therefore the infection stopped. (mappingignorance.org)
Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection in Infants and Children Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
[ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)

A new group of oncogenic viruses: reticuloendotheliosis, chick syncytial, duck infectious anemia, and spleen necrosis viruses. (wikidata.org)
Identification of the RAS gene family can be traced back to the 1970s, with the definition of the oncogenic sequences of the Kirsten and Harvey strains of murine sarcoma virus [ 1 ] . (oaepublish.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
But under conditions of immunosuppression, such as people infected with HIV or people taking immunosuppressive therapies in order to get a transplant, for example, it's under those types of circumstances that these viruses can manifest themselves and have oncogenic potential. (bwfund.org)
Yes, I think that many of these viruses, although they're very different from each other, they use very similar mechanisms or pathways to actually induce the transformation process of the oncogenic process. (bwfund.org)
So I think that understanding how one virus can induce transformation opens a window into how other oncogenic viruses in the human population also cause cancer. (bwfund.org)
The virus has viral proteins that it comes with that can modulate these host signal transduction pathways and the same signal transduction pathways that are modulated by one virus may also be modulated by other oncogenic viruses. (bwfund.org)
Cancer risk in workers exposed to oncogenic viruses. (cdc.gov)

McElwee, M. , Vijayakrishnan, S. , Rixon, F. and Bhella, D. (2018) Structure of the herpes-simplex virus portal-vertex. (gla.ac.uk)
Here, we show the structure of the herpes simplex virus portal-vertex at subnanometer resolution, solved by electron cryomicroscopy (cryoEM) and single-particle 3D reconstruction. (gla.ac.uk)
HHV-1, also known as herpes simplex virus (HSV)-1, causes primary herpetic gingivostomatitis, or oral herpes. (medscape.com)

KIT has also gone by several other names including c-kit , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor, mast cell growth factor receptor, and CD117 . (creation.com)

Sarcoma Viruses, Feline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. (childrensmercy.org)
This graph shows the total number of publications written about "Sarcoma Viruses, Feline" by people in this website by year, and whether "Sarcoma Viruses, Feline" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Sarcoma Viruses, Feline" by people in Profiles. (childrensmercy.org)

Host sequences were removed by mapping the reads to the UCSC hg19 human reference genome. (cdc.gov)
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. (edu.au)
Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. (edu.au)
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. (edu.au)
A variety of simple repeat sequences that are distributed throughout the GENOME. (lookformedical.com)
These genomic sequences contained a mutation later shown to be responsible for the development of sarcomas, and the word "oncogene" became a common part of the vocabulary in cancer publications during the early 1980s (4). (promegaconnections.com)

Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1. (wikidata.org)
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. (wikidata.org)
Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction in vivo . (hindawi.com)
Transgenic mice bearing PB promoter fused to simian virus 40 large tumor antigen gene all consistently develop prostate adenocarcinoma [ 13 ]. (hindawi.com)
2004. Virus-induced gene silencing in Solanum species . (berkeley.edu)
The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. (edu.au)
Finally, effects of FUS on HIV gene transcription are also exhibited genome wide, where FUS mainly occupies gene promoters at transcription starting sites, while its knockdown leads to an increase in AFF4 and Cdk9 occupancy on gene promoters of FUS affected genes. (biomedcentral.com)
Early studies on the regulation of gene transcription of the proviral human immunodeficiency virus (HIV) have laid the foundations to our current understanding of how metazoan transcription elongation is regulated [ 1 ]. (biomedcentral.com)

Differences in the exact size classes of virus-specific RNAs and, in their relative proportions were found to exist in the four different tissue types examined and no correlation between a specific RNA size-profile and the proliferating activity of a tissue could be detected. (microbiologyresearch.org)

Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
Harry Rubin, a leader in the search to understand how viruses cause cancer - research that ultimately led to the discovery of cancer-causing genes called oncogenes - died on Sunday, Feb. 2, at the age of 93. (berkeley.edu)
Since tumor viruses have such small genomes and carry only a few genes, it was clear that studying tumor viruses would provide an entry point into the basic mechanisms of cancer. (berkeley.edu)
During the twentieth century in the United States, Alfred Day Hershey studied phages, or viruses that infect bacteria, and experimentally verified that genes were made of deoxyribonucleic acid, or DNA. (asu.edu)

Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)
The researchers use genome-wide sequencing, post-transcriptional sequencing and molecular biology to examine how the human cell or the virus knows how to prevent degradation. (uncommondescent.com)
That means the human system can no longer express the proteins that it needs to express, and that means also that a lot of resources are suddenly available for the virus. (uncommondescent.com)
This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. (mdpi.com)
A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)
AIDS (Acquired Immunodeficiency Syndrome) is a condition caused by the Human Immunodeficiency Virus (HIV). (clinmedjournals.org)
Approximately 37.6 million people (about twice the population of New York) worldwide are infected with the human immunodeficiency virus (HIV) according to data from the Joint United Nations Program on HIV-AIDS [ 1 ]. (clinmedjournals.org)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
These in vitro, and their expression in these human tumour virus. (who.int)
Usually, viruses are associated with things like flu or Ebola, and they actually have been a number of human viruses that are associated with human malignancy. (bwfund.org)
And these viruses usually establish lifelong latency in the human population and normally don't cause much of a problem. (bwfund.org)
The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. (edu.au)
15% of human cancers worldwide may be attributed to viruses, 1 with both DNA and RNA viruses being capable of causing the disease. (mappingignorance.org)
Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses capable of causing the development of human cancer, whereas human T lymphotrophic virus type 1 and hepatitis C virus are the two RNA viruses that contribute to it. (mappingignorance.org)
11 12 Through a series of complex biochemical processes, the interaction between ORF57 and the human protein complex hTREX 13 produces viral ribonucleoprotein particles (vRNPs, formed by viral proteins and genetic material) that are essential for the lytic replication of the virus. (mappingignorance.org)
These viruses have been shown to be capable of infecting human cells in vitro, and causing them to become cancerous. (cdc.gov)
Human exposure to these viruses occur occupationally (workers in poultry slaughtering/processing plants and poultry farms, egg candlers, veterinarians, cooks, laboratory workers, etc. (cdc.gov)
Two critical pieces of evidence are needed to incriminate these viruses as causing cancer in humans: 1) laboratory demonstration of ALSV integrated within the human genome, and 2) epidemiologic evidence of excess cancer occurrence in human exposed to these viruses. (cdc.gov)
p53 operates as a tumor suppressor protein, often lauded as the "guardian of the human genome" , due to its dedication to governing controlled cell division and assessing damaged DNA. (promegaconnections.com)
The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. (biomedcentral.com)
In 1983, Nobel Prize in Physiology or Medicine recipients Françoise Barré-Sinoussi and Luc Montagnier discovered a new retrovirus, the human immunodeficiency virus, or HIV, at the Pasteur Institute in Paris, France. (asu.edu)
Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and mother-to-child transmission (MTCT), which can occur during the birth process or during breastfeeding. (medscape.com)
Electron microscopy of human immunodeficiency virus (HIV)-1 virions. (medscape.com)
Human immunodeficiency virus (HIV) is a retrovirus. (msdmanuals.com)

The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)

Certain viruses naturally infect and cause cancer in chickens and turkeys. (cdc.gov)

RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus. (wikidata.org)
When Rubin moved to UC Berkeley in 1958 to join the Department of Virology, he continued work on RSV and developed other assays, including one to detect avian leukosis virus in vaccines, such as the measles vaccine, that are produced in chicken cell cultures. (berkeley.edu)

The CbGHV1 genome sequence was deposited in NCBI GenBank (accession number MH932584). (cdc.gov)
Tumor virus ribonucleic acid directed deoxyribonucleic acid synthesis: nucleotide sequence at the 5' terminus of nascent deoxyribonucleic acid. (wikidata.org)
ISMapper: identifying transposase insertion sites in bacterial genomes from short read sequence data. (cdc.gov)
Complete Genome Sequence of Strain H5989 of a Novel Devosia Species. (cdc.gov)

RNA metabolism of murine leukemia virus II. (microbiologyresearch.org)
In 1963, Jennifer Harvey was studying Moloney murine leukemia virus (MMLV) at the cancer research department of the London Hospital Research Laboratories. (promegaconnections.com)

To overcome this obstacle, conditional oncolytic viruses (such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) systemic toxicity due to viral self-replication. (hindawi.com)
Replication-competent viruses, also known as oncolytic viruses, replicate within transduced cells and force these cells into a lytic cycle. (hindawi.com)
Therefore, strategies to use conditional oncolytic virus, or the so-called attenuated replication-competent viruses, to specifically target prostate tissue have been developed [ 2 - 4 ]. (hindawi.com)
He also showed that one strain of RSV was a replication-defective virus that could transform normal cells into cancer cells, but required a leukosis virus - a "helper virus" - to replicate and spread. (berkeley.edu)
This was one of the very first observations to suggest that the virus might carry information about cell transformation and tumorigenesis that was separate from the information needed for the replication cycle of the virus," Martin said. (berkeley.edu)

Prevalence of the group-specific (gs) antigen and infectious virus expression of the murine C-type RNA viruses during the life span of BALB/cr mice. (microbiologyresearch.org)
Then, working with Caltech graduate student Howard Temin, Rubin developed a way to measure the amount of infectious virus using cultured fibroblast cells from chicken embryos. (berkeley.edu)
Cells carry the Ki-MSV genome but do not produce infectious virus particles or viral antigens. (cls.shop)
Moreover, ORF67.5 was required for terminal repeat (TR) cleavage, infectious virus production, and enhancement of the interaction between ORF7 and ORF29. (bvsalud.org)

Characterization of a 105,000 molecular weight gag-related phosphoprotein from cells transformed by the defective avian sarcoma virus PRCII. (wikidata.org)
Released virus is then able to infect neighboring cells until all susceptible cells are eliminated. (hindawi.com)
Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. (microbiologyresearch.org)
Virus-specific messenger RNA on free and membrane-bound polyribosomes from cells infected with Rauscher leukemia virus. (microbiologyresearch.org)
The viruses that are released from infected cells are initially in an immature state and are composed of an RNA genome surrounded by a coat of protein. (sciencedaily.com)
These newly released viruses must in turn mature before they can infect other cells. (sciencedaily.com)
The virus tricks cells into reverse transcribing its RNA into DNA and integrating it into its own genome. (berkeley.edu)
At that time, there was really no way of studying the molecular or genetic basis of cancer by studying cancer cells, because the genome of the cell is so enormous," said G. Steven Martin, one of Rubin's former postdoctoral fellows and a UC Berkeley professor emeritus of molecular and cell biology. (berkeley.edu)
The cells are useful producing MSV pseudotypes with various ecotropic and xenotropic murine leukemia viruses. (cls.shop)
once a number of them have accumulated, the cell bursts due to high internal osmotic pressure and this releases the new viruses ready to go on to infect the surrounding cells). (mappingignorance.org)
In this study we identify fused in sarcoma (FUS) as a partner of AFF4 in cells. (biomedcentral.com)

This cell line was derived from the HOS cell line (TE-85) by transformation using Kirsten murine sarcoma virus (Ki-MSV). (cls.shop)
A few years later, Werner Kirsten at the University of Chicago observed similar results working with mouse erythroblastosis virus (MEV) (2). (promegaconnections.com)

Intracellular and virion 35S RNA species of murine sarcoma and leukemia viruses. (microbiologyresearch.org)

For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)

1. Chmielewicz B, Goltz M, Lahrmann KH, Ehlers B. Approaching virus safety in xenotransplantation: a search for unrecognized herpesviruses in pigs. (cdc.gov)

Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. (medscape.com)
The most common histological type was squamous cell adenocarcinoma (patients with good adherence to treatment), followed by non-Hodgkin lymphoma and Kaposi's sarcoma (patients with poor adherence or no treatment) [ 3 ]. (clinmedjournals.org)
The most frequent neoplasms are gastrointestinal, which are divided into two groups: AIDS-defining neoplasms: Kaposi's Sarcoma and Non-Hodgkin's Lymphoma (which are considered opportunistic tumors) and in second place are non-defining neoplasms: bronchopulmonary, anal, and hepatocellular [ 4 ]. (clinmedjournals.org)
Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus. (umassmed.edu)

Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)
However, except non-primate species often do not mour viruses is often problematic, for Epstein-Barr virus (EBV), which accurately reflect the mechanism of Part 1 · Chapter 9. (who.int)

Harvey's discovery led to the naming of the corresponding rat sarcoma oncogene as HRAS, while Kirsten's related oncogene was named KRAS. (promegaconnections.com)

Now an atomic model of the immature retrovirus RSV has been constructed by researchers in order to understand and block the virus. (sciencedaily.com)

Endogenous virus-specific RNA in uninfected BALB/c cell line JLS-V9. (microbiologyresearch.org)
Transcription of endogenous C-type virus in resting and proliferating tissues of BALB/Mo mice. (microbiologyresearch.org)
Variations in hybridization of RNA from different mouse tissues and embryos to endogenous C-type virus DNA transcripts. (microbiologyresearch.org)
Changes in transcription of endogenous type-C virus genome during mouse liver regeneration. (microbiologyresearch.org)

Los virus son realmente virus de la leucemia felina recombinantes (FeLV), en los que parte del genoma ha sido reemplazada por oncogenes celulares. (bvsalud.org)

Systemic delivery is a major goal in the field of oncolytic viruses. (karger.com)

HIV is a virus that attacks the immune system and weakens the body's ability to fight off infections and diseases. (clinmedjournals.org)
And what the virus does is that it modulates or changes or manipulates those pathways so that the virus is able to either stick latent and hidden from the host immune system or replicate itself and disseminate throughout the host's body, or, in fact, a new individual. (bwfund.org)

Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens. (umassmed.edu)

Tyrosine-specific protein kinase activity associated with p105 of avian sarcoma virus PRCII. (wikidata.org)
Thus, E1 protein expression will be confined strictly to the prostate tissues and render this a conditional oncolytic virus (CRAD) within the prostate. (hindawi.com)
We have had a pretty good understanding of the mature infectious particle at a level where we can make specific predictions about the local chemical interactions between the protein subunits in the virus," said Rebecca Craven, professor of microbiology and immunology and at Penn State University and one of the study's authors. (sciencedaily.com)
According to Boon Chong Goh, a graduate student in physics at Illinois and lead author on the study, a six-helix bundle domain located on the inside surface of the immature protein shell could be a key to understanding and blocking the virus. (sciencedaily.com)

Electron microscopic observations on RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. (wikidata.org)

Towards eliminating the HIV infected reservoir, understanding the mechanisms by which the virus persists in the face of therapy is important. (biomedcentral.com)

Genetic diversity and evolutionary insights of respiratory syncytial virus A ON1 genotype: global and local transmission dynamics. (cdc.gov)
RSV is an RNA virus, which means that it carries its genetic instructions in the form of RNA, not DNA. (berkeley.edu)

Genome-wide analysis reveals the extent of EAV-HP integration in domestic chicken. (peerj.com)

Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of Kenya. (umassmed.edu)

We have studied the structures of the unintegrated forms of avian sarcoma virus (ASV) DNA using agarose gel electrophoresis in conjunction with restriction endonucleases and molecular hybridization techniques. (tmu.edu.tw)
With that knowledge we can try to understand the precise molecular mechanisms of virus maturation and help to elucidate how drugs can be designed to interfere with that. (sciencedaily.com)

Before taking his current positions in 2016, he was a Professor of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, where he also served as Associate Director of Translational Genomics at the Penn Genome Frontiers Institute. (wikipedia.org)

SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. (cdc.gov)
Virus release was evaluated in a murine cell line (L929). (karger.com)
The way they do this is by triggering a massive RNA degradation event where the virus will wipe out the mRNA from the cell. (uncommondescent.com)
Exposure to holoendemic malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan children. (umassmed.edu)
and proviral DNA inserted covalently into the genome of the host cell. (tmu.edu.tw)
Partial transcription of murine type-C viral genomes in BALB/c cell lines. (microbiologyresearch.org)
A distinct class of inducible murine-type-C viruses that replicates in the rabbit SIRC cell line. (microbiologyresearch.org)
cell for the virus is placed in a mu- studies costly and difficult. (who.int)
These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)
The infected cell is programmed to release multiple copies of the immature virus into the host's bloodstream. (sciencedaily.com)
In 1955, Rubin showed that every cell in an RSV-induced tumor was capable of releasing the virus, implying that RSV was permanently associated with the host cell and suggesting that it plays a direct and continuing role in perpetuating the cell in its malignant state. (berkeley.edu)
The following review highlights the topics of actinic keratoses, basal cell carcinoma, squamous cell carcinoma, Kaposi's sarcoma, and Merkel cell carcinoma. (jcadonline.com)

In addition to the expected leukemia, the mice that received the plasma developed solid tumors (soft-tissue sarcomas), primarily in the spleen (1). (promegaconnections.com)

Anatomy13

Organisms87

Diseases28

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes74

Disciplines and Occupations3

Information Science4

Health Care1

Viral genome8

KSHV18

Kaposi21

Herpesvirus2

Rous Sarco6

Host cell's genome2

Infection14

Oncogenic9

Herpes simpl3

Hardy-Zuckerman1

Feline4

Sequences6

Gene8

RNAs1

Genes4

Human25

Cellular1

Cause cancer in chickens1

Avian leuko2

Sequence4

Murine leuke2

Replication5

Infectious virus4

Cells11

Kirsten2

Virion1

Infect1

Herpesviruses1

Lymphoma4

Species2

Oncogene1

Retrovirus1

Endogenous4

FeLV1

Oncolytic viruses1

Immune system2

Lytic1

Protein4

Chickens1

Persists1

Genetic2

Reveals1

Reactivation1

Molecular2

Genomics1

Cell12

Tumors1