Suspected Ewing sarcomaEwing'sAnti-tumourTumorsCarcinomaPulmonaryDiagnosisOsteosarcomaTranslocationChromosomalNeoplasmsCytotoxicityTumorigenesis in micePNETExperimentalCharacterizationBoneSkeletalSoft tissueRatsCellsSurvivalImagingDeficientProliferationHumanSignificantlySpontaneousClinicalSufficientCell deathFamilyModelExpressionProteinSpecificGrowthRareEvidenceStudyActivation
Suspected Ewing sarcoma1
- Hence, MRI is the test of choice for staging in cases of suspected Ewing sarcoma. (medscape.com)
Ewing's11
- In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also known as EWS) with the 3' Ets domain of Fli-1. (wikipedia.org)
- The family and friends of Michael Lio have raised more than $100,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
- The family and friends of Nicholas Theodore Strub have raised more than $17,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
- Ewing's sarcoma is one of more than 50 kinds of sarcoma. (sarcomahelp.org)
- What is Ewing's Sarcoma Family of Tumors? (sarcomahelp.org)
- Ewing's sarcoma (ES) was first described by James Ewing in 1921 as a 'diffuse endothelioma of bone' (Ewing 1921). (sarcomahelp.org)
- The tumor which bears his name is generally referred to as Ewing's sarcoma when spoken and either Ewing's sarcoma or Ewing sarcoma when written. (sarcomahelp.org)
- Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
- Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
- Ewing's sarcoma family of tumors consists of small round cell neoplasms, inclusive of primitive neuroectodermal tumor (PNET), Askin's tumor, and PNET of the bone. (biomedcentral.com)
- Extraosseous Ewing's sarcoma occurs commonly a. (biomedcentral.com)
Anti-tumour2
- Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma. (go.jp)
- This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. (tripod.com)
Tumors7
- The 2 most common malignant bone tumors in children are osteosarcoma and Ewing sarcoma. (medscape.com)
- Ewing sarcoma accounts for approximately 5% of biopsy-analyzed bone tumors and approximately 33% of primary bone tumors. (medscape.com)
- Because the clinical symptoms of Ewing sarcoma are nonspecific and because they frequently mimic osteomyelitis or other malignant tumors, such as leukemia, an initial conventional radiographic and/or magnetic resonance imaging (MRI) examination is performed. (medscape.com)
- The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. (tripod.com)
- [ 2 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors (see image below). (medscape.com)
- Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)
- Although tumor immunosurveillance was first hypothesized more than four decades ago, the observed absence of spontaneous tumors in several immune-compromised mouse strains initially dampened enthusiasm for this idea. (silverchair.com)
Carcinoma2
- The action of antithymocyte serum on tumor growth and metatasis was investigated by using an experimental model of lymphatic metastasis after injection of murine uterine cervix carcinoma No.27 (U27) cells into the footpad of mice. (eurekamag.com)
- Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
Pulmonary1
- Although most guidelines suggest performing a positron emission tomography/computed tomography (PET/CT) with somatostatin receptor (SSTR) ligands for staging of pulmonary carcinoid tumours (PC), only a limited. (springeropen.com)
Diagnosis1
- No single morphologic or functional imaging method provides findings for a specific diagnosis of Ewing sarcoma, but the results do contribute to tumor staging. (medscape.com)
Osteosarcoma2
- METHODS: Cell lines from five main sarcoma types of the musculoskeletal system (chondrosarcoma, osteosarcoma, Ewing sarcoma, fibrosarcoma and rhabdomyosarcoma) as well as their healthy cell counterparts (chondrocytes, osteoblasts, mesenchymal stem cells, fibroblasts, skeletal muscle cells) were subjected to cell stiffness measurements via atomic force microscopy (AFM). (bvsalud.org)
- RESULTS: While AFM stiffness measurements showed that the majority of cancer cells (osteosarcoma, Ewing sarcoma, fibrosarcoma and rhabdomyosarcoma) were significantly less stiff than their corresponding non-malignant counterparts (p (bvsalud.org)
Translocation1
- The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
Chromosomal1
- Drs. Gabriela Mercado and Frederic Barr of the University of Pennsylvania present an excellent discussion of chromosomal translocations in sarcomas elsewhere on this site. (sarcomahelp.org)
Neoplasms1
- Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. (curehunter.com)
Cytotoxicity1
- Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. (tripod.com)
Tumorigenesis in mice1
- p53 has a unique and unequivocal tumor suppression role, which has been confirmed by the cancer susceptibility of individuals affected by Li-Fraumeni syndrome, the p53 inactivation in most sporadic human cancers, and the spontaneous tumorigenesis in mice with the p53 gene knocked out [ 11 ] . (encyclopedia.pub)
PNET2
- [ 4 ] An association exists between Ewing sarcoma and primitive peripheral neuroectodermal tumor (PNET). (medscape.com)
- Pathologists have long known that Ewing sarcoma looks very similar to an even rarer soft tissue tumor called primitive neuroectodermal tumor ( PNET ). (sarcomahelp.org)
Experimental1
- For applications, including in the devel- but is required more simply to as- ease of reference, these five agents opment of human tumour profiles to sess the overall weight of the ev- are included in an expanded group assist in the identification of addition- idence in experimental animals. (who.int)
Characterization1
- 2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)
Bone1
- Ewing sarcoma is a highly malignant primary bone tumor that is derived from red bone marrow. (medscape.com)
Skeletal1
- Sharma et al concluded that 18 F-FDG PET/CT demonstrated high accuracy in diagnosing the recurrence of primary skeletal Ewing sarcoma. (medscape.com)
Soft tissue1
- Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
Rats1
- Mice with GIST-T1 xenografts or rats with orthotopic xenografts were injected with IR700-12A8 or AF488-conjugated antibody, and observed under IVIS or autofluorescence imaging (AFI) endoscopy. (thno.org)
Cells4
- FET has been shown to have specific uptake in the cells through LAT1 and LAT2 amino acid transporters, and Ewing sarcoma has been shown to have increased LAT1 transporter expression at the cell surface. (medscape.com)
- Poincloux R, Lizarraga F, Chavrier P . Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. (nature.com)
- 田中 伸哉、鈴鹿 淳、王 磊、津田 真寿美、龔 剣萍、高阪 真路、間野 博行、「ハープ現象の発見：DNゲルでがん幹細胞を創り出す（Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogel）」、実験医学、Nature (hokudai.ac.jp)
- Recruitment of CD11b + CD11c + myelomonocytic cells to the metastatic site was also found after whole thorax irradiation at a dose of 15 Gy of mice that significantly enhanced seeding and metastatic growth of intravenously injected cancer cells. (biomedcentral.com)
Survival1
- Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
Imaging1
- Fusion magnetic resonance imaging (MRI) and positron emission tomography scan studies obtained with fluorodeoxyglucose (FDG) in a patient with a Ewing sarcoma of the left tibia. (medscape.com)
Deficient3
- Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. (silverchair.com)
- A significant incidence of late onset adenocarcinoma observed in both IFN-γ- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance. (silverchair.com)
- references 5 , 14 , and 16 ), key molecules of both the innate and adaptive immune systems, contribute to tumor prevention in mice treated with the chemical carcinogen, methylcholanthrene (MCA), or in mice deficient for p53 expression. (silverchair.com)
Proliferation1
- This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour . (explained.today)
Human1
- ; IARC, human tumour sites. (who.int)
Significantly3
- The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
- Treatment of mice bearing the MAC16 tumor with the polyunsaturated fatty acid, eicosapentaenoic acid (EPA), attenuated loss of body weight and significantly suppressed protein catabolism in soleus muscles through an inhibition of an ATP-dependent proteolytic pathway. (aacrjournals.org)
- The ATP-ubiquitin-dependent proteolytic pathway is considered to play a major role in muscle catabolism in cachexia, and functional proteasome activity, as determined by "chymotrypsin-like" enzyme activity, was significantly elevated in gastrocnemius muscle of mice bearing the MAC16 tumor as weight loss progressed. (aacrjournals.org)
Spontaneous2
- Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. (ucsd.edu)
- Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). (silverchair.com)
Clinical1
- abstract： PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
Sufficient1
- Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
Cell death1
- In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
Family2
- We have identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. (nature.com)
- These data define a novel pathway that directs Lyn/Src family tyrosine kinase signals to sarcoma cell invadopodia through specific recruitment of Vav2 and Nck2 to phosphorylated AFAP1L1, to control cell migration and invasion. (nature.com)
Model1
- Using a syngeneic B16F1 melanoma model in wild type and ADAMTS1 knockout mice we found distinct stroma versus tumor functions for this protease. (oncotarget.com)
Expression1
- These results suggest that EPA induces an attenuation of the up-regulation of proteasome expression in cachectic mice, and this was correlated with an increase in myosin expression, confirming retention of contractile proteins. (aacrjournals.org)
Protein1
- Soleus muscles from mice bearing a cachexia-inducing tumor (MAC16) showed an increased protein degradation in vitro , as measured by tyrosine release, when compared with muscles from nontumor-bearing animals. (aacrjournals.org)
Specific2
- Tumor-specific accumulation of IR700-12A8 was observed in GIST-T1 xenografts in mice. (thno.org)
- Production of gene-targeted mice for specific effector molecules has greatly aided this endeavor ( 4 - 14 ). (silverchair.com)
Growth1
- In an in vivo study, NOX4 shRNA transfected SW1353 have shown impaired growth ability compared to the SW1353 when they were injected into the nude mice. (bvsalud.org)
Rare1
- Radiograph of Ewing sarcoma of the os naviculare, a rare location for the tumor. (medscape.com)
Evidence1
- Direct evidence linking the INK4A locus to tumorigenesis was provided by the targeted disruption of exon 2 of INK4A in mice. (medscape.com)
Study1
- Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
Activation1
- Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma. (go.jp)