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  • synovial
  • April 27-May 1 - 2016 Extreme Sailing Series in Qingdao May 2 - The Cyberspace Administration of China announces an investigation into the death of Wei Zexi, a student who died following experimental treatment for synovial sarcoma he discovered on the search engine Baidu. (wikipedia.org)
  • 1994 - April 12, 2016) was a 21-year old Chinese college student from Shaanxi who died after receiving experimental treatment for synovial sarcoma at the Second Hospital of the Beijing Armed Police Corps, which he learned of from a promoted result on the Chinese search engine Baidu. (wikipedia.org)
  • In 2014, Wei was diagnosed with synovial sarcoma, a rare form of cancer that affects tissue around major joints. (wikipedia.org)
  • Antibodies to CD99 are used in diagnostic immunohistochemistry to distinguish Ewing's sarcoma from other tumours of similar histological appearance, as well as for the identification of thymic tumours, and of spindle cell tumours, such as synovial sarcoma, haemangiopericytoma, and meningioma. (wikipedia.org)
  • Differential expression profiles suggest that DEPDC1B is higher expressed in many cancerous disease states, including: papillary thyroid cancer, breast cancer, synovial sarcoma, and prostatic cancer progression. (wikipedia.org)
  • SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma. (wikipedia.org)
  • Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. (wikipedia.org)
  • metastases
  • Among the five patients treated with quadrantectomy four are alive and free of disease after 3 to 5 years follow-up, while the patient with sarcoma arising in pregnancy, although is still alive, developed lung metastases four years after surgery. (biomedcentral.com)
  • The first and most important therapeutic approach to primary sarcomas of the breast is surgical which has the purpose to achieve radical tumor excision to prevent local recurrence and skip metastases. (biomedcentral.com)
  • To address this deficit, we developed an orthotopic implantation/amputation model in which patient-derived sarcoma xenografts are surgically implanted into mouse hindlimbs, allowed to grow, then subsequently amputated and the animals observed for development of metastases. (springer.com)
  • Krishnan K, Khanna C, Helman LJ (2005) The biology of metastases in pediatric sarcomas. (springer.com)
  • radiotherapy
  • Patients with primary, high-grade soft tissue sarcoma of the extremities will undergo treatment of their primary tumor with either amputation or limb-sparing surgery and radiotherapy, and then be randomized to either observation or adjuvant treatment with doxorubicin and ifosfamide with mesna (with G-CSF) for five cycles beginning post-operatively. (bioportfolio.com)
  • efficacy
  • We evaluated efficacy and toxicity of high-dose ifosfamide in the patients with recurrent or advanced sarcoma in this study. (exp-oncology.com.ua)
  • Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity. (bioportfolio.com)
  • gene
  • The most common genetic mutation (found in 80-90% of epithelioid sarcomas) is the inactivation of the SMARCB1 gene, or the loss of INI-1 function, which is thought to be a major contributor to disease progression. (wikipedia.org)
  • Metastasis
  • Overall survival rates for pediatric high-grade sarcoma have improved greatly in the past few decades, but prevention and treatment of distant metastasis remain the most compelling problems facing these patients. (springer.com)
  • Traditional preclinical mouse models have not proven adequate to study the biology and treatment of spontaneous distant sarcoma metastasis. (springer.com)
  • Epithelioid sarcoma also demonstrates lymphatic spread (in 22-48% of cases), and metastasis (in 21-63% of cases). (wikipedia.org)
  • More recently it has been demonstrated to potentiate certain schedules of chemoradiotherapy and suppress metastasis in soft tissue sarcomas,in part by improvement of oxygen and drug delivery. (wikipedia.org)
  • malignancies
  • The incidence of sarcomas constitutes approximately 1% in adults and up to 12% in children of all malignancies. (biomedcentral.com)
  • He coordinates translational research projects associated with new drug development and in diseases such as sarcoma, urogenital and endocrine malignancies, and others. (wikipedia.org)
  • Outcome
  • All articles were read in full by both authors and data relating to design, diagnosis, number of subjects, treatments for experimental and control groups, outcome measures and results were extracted independently by both authors. (biomedcentral.com)
  • diseases
  • Historically, the challenge of treating sarcoma has been that it's a very complex group of different diseases," says Memorial Sloan Kettering medical oncologist and sarcoma expert Mark A. Dickson . (mskcc.org)
  • Analogy with several infectious diseases of man and the lower animals, caused by ultramicroscopic organisms, gives support to this view of the findings, and at present work is being directed to its experimental verification. (theperthgroup.com)
  • diagnosis
  • In general, epithelioid sarcoma is a slow-growing and relatively painless tumor, often resulting in a lengthy period of time between presentation and diagnosis. (wikipedia.org)
  • genetic
  • Several research teams are currently developing techniques to reverse this loss of genetic function characteristic of epithelioid sarcoma. (wikipedia.org)