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  • Critical Care Med
  • Blockade of the programmed death-1 pathway restores sarcoidosis CD4 + T-cell proliferative capacity," American Journal of Respiratory and Critical Care Medicine , vol. 190, no. 5, pp. 560-571, 2014. (hindawi.com)
  • Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, USA. (biomedsearch.com)
  • manifestations
  • HPS comprises a rare group of autosomal recessive disorders characterized by the triad of OCA, bleeding diathesis, and, in many cases, the accumulation of ceroid lipofuscin, resulting in pulmonary, gastrointestinal, and cardiac manifestations. (jcadonline.com)
  • Chest
  • Optimal scoring of serial change on chest radiography in sarcoidosis. (biomedsearch.com)
  • These patients showed a significant improvement in their pulmonary function and chest radiographs over the follow up period whereas patients with "low intensity alveolitis" did not. (bmj.com)
  • The constitutional symptoms continued until 2007, when she was noted on a follow-up, high-resolution, chest CT to have bilateral hilar lymphadenopathy and diffuse pulmonary nodules. (jcadonline.com)
  • immune
  • Most medications used to treat sarcoidosis suppress the immune system. (nyhq.org)
  • Our results indicate a possible immune cell imbalance in sarcoidosis. (hindawi.com)
  • Paradoxically, decreased DC immune reactivity was reported in blood samples from pulmonary sarcoidosis patients. (pubmedcentralcanada.ca)
  • mDCs purified from BAL of sarcoidosis patients induced T cell proliferation and differentiation and did not show diminished immune reactivity. (pubmedcentralcanada.ca)
  • These data have led to the hypothesis that sarcoidosis emerges from an exaggerated Th1 immune response upon presentation of an unidentified antigen by an antigen presenting cell (APC). (pubmedcentralcanada.ca)
  • Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis," Respiratory Research , vol. 11, p. 161, 2010. (hindawi.com)
  • The antigen responsible for the induction of immune response in sarcoidosis is not yet known. (hindawi.com)
  • Sarcoidosis patients had, as expected, an enhanced Th1 mediated immune response in their lungs, as compared to healthy subjects. (ki.se)
  • It is still unclear if sarcoidosis occurs due to an autoimmune reaction, in which the immune system attacks and injures the body's own tissues, or if it's caused by remnants of infectious agents that persist in immune system cells. (sarcoidosisnews.com)
  • Circumstantial evidence implicates a possible role for remnant mycobacterial proteins in the initiation of sarcoidosis, and SAA proteins may contribute to ongoing immune stimulation," the researchers said. (sarcoidosisnews.com)
  • diagnostic
  • There is a lack of robust data on accurate diagnostic tools and therapeutic options for PH in sarcoidosis. (springer.com)
  • The group provides multidisciplinary comprehensive consultation, diagnostic and management services for a wide array of pulmonary conditions. (massgeneral.org)
  • bilateral
  • Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. (biomedcentral.com)
  • severe
  • Vitamin D deficiency can lead to poor elimination of microorganisms and their persistence inside the cells and decreased levels of vitamin D in patients with severe sarcoidosis were accompanied by reduced cathelicidin mRNA expression [ 6 , 7 ]. (hindawi.com)
  • antigen
  • Increased proportions of oligoclonal CD4 + T cells were found in the BAL from patients with sarcoidosis, consistent with a MHC-restricted antigen-driven process [ 8 , 9 ]. (pubmedcentralcanada.ca)
  • BAL and blood TCR AV2S3pos T cells were more activated and differentiated than TCR AV2S3neg T cells, indicating their encountering with a postulated sarcoidosis antigen in vivo. (ki.se)
  • Association of Sarcoidosis
  • Instead, they say, there is more evidence that an infectious agent may be to blame, pointing to a study that "found an association of sarcoidosis and exposure to insecticides, mold and mildew, home central air conditioning, and birds, possibly representing contact with microbe-rich environments. (sarcoidosisnews.com)
  • prognostic
  • The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value. (beds.ac.uk)
  • cardiac
  • We offer specialists in sarcoidosis, immunology, heart failure, cardiac imaging, and arrhythmias, working together to optimize patient-centered care for Cardiac Sarcoidosis. (bu.edu)
  • pathogenesis
  • Our Mission is to improve the lives of persons with sarcoidosis by providing state-of-the-art patient care coupled with innovative research aimed at understanding the pathogenesis and natural history of sarcoidosis. (bu.edu)