AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
AspirinAsthmaAnti-Asthmatic AgentsPlatelet Aggregation InhibitorsAnti-Inflammatory Agents, Non-SteroidalAsthma, Exercise-InducedFemale Athlete Triad SyndromeAdministration, InhalationPeak Expiratory Flow RateAsthma, OccupationalForced Expiratory VolumeBronchial HyperreactivityBronchodilator AgentsRespiratory SoundsAllergensAdrenal Cortex HormonesTiclopidineAcid Anhydride HydrolasesThromboxane B2HypersensitivityAsthma, Aspirin-InducedCyclooxygenase InhibitorsPlatelet AggregationHypersensitivity, ImmediateRhinitisDrug Therapy, CombinationSalicylatesRespiratory Function TestsRisk FactorsAlbuterolMethacholine ChloridePlatelet Function TestsRhinitis, Allergic, PerennialDouble-Blind MethodSpirometryEosinophilsSeverity of Illness IndexBronchiBudesonideTreatment OutcomePrevalenceBeclomethasoneLeukotriene AntagonistsSkin TestsQuestionnairesNebulizers and VaporizersLungBlood PlateletsProspective StudiesSodium SalicylateDose-Response Relationship, DrugTime FactorsStatus AsthmaticusBronchoconstrictor AgentsAirway RemodelingBronchoconstrictionBronchitisFibrinolytic AgentsAdrenergic beta-AgonistsHemorrhageCase-Control StudiesRespiratory HypersensitivityAnti-Inflammatory AgentsOvalbuminPyroglyphidaeCohort StudiesFollow-Up StudiesAnticoagulantsWarfarinTablets, Enteric-CoatedCyclooxygenase 1Pulmonary MedicineVital CapacityMolecular Sequence DataCross-Sectional StudiesGlucocorticoidsProstaglandin-Endoperoxide SynthasesCatalytic DomainPlatelet ActivationThromboxanesBleeding TimeGastrointestinal HemorrhageSputumBronchoalveolar Lavage FluidCoughAmino Acid SequenceExhalationIbuprofenAcetaminophenThromboxane A2Airway ObstructionDrug ResistanceAir Pollution, IndoorOccupational DiseasesModels, MolecularEosinophiliaDrug HypersensitivityMitesOdds RatioEnvironmental Exposure
Nasal polypsAERDNSAIDsRhinosinusitisRespiratoryNSAIDHypersensitivity reactionsSensitivityDaily aspirin therapyChronicAdultsExacerbationsRhinitisSymptomsInflammationIngestionTriggerSeverityClinicalLeukotrieneSevereExerciseDesensitizationMedicationsDiagnosisIbuprofenInfantsElderlyAllergyPatientsMedicationPeopleTherapyRiskManageDevelopmentImportant
Nasal polyps11
AERD11
  • AERD affects an estimated 0.3-0.9% of the general population in the US, including around 7% of all asthmatics, about 14% of adults with severe asthma, and ~5-10% of patients with adult onset asthma. (wikipedia.org)
  • [ 2 , 5 ] Aspirin and other NSAIDs may also produce nasal symptoms in sensitive individuals, sometimes as part of a broader presentation of aspirin-exacerbated respiratory disease (AERD), formerly known as Samter's Triad, that may include chronic rhinosinusitis with nasal polyps, asthma and aspirin/NSAID sensitivity. (medscape.com)
  • To participate in the AERD/Samter's Triad Patient Registry for research, click below to fill out your medical information online and answer questions specific to your symptoms and history of AERD. (partners.org)
  • Recommendations regarding COVID-19 and asthma/AERD as of Friday, April 10, 2020. (partners.org)
  • In severe cases, ibuprofen use has even been linked to the development of a condition known as aspirin-exacerbated respiratory disease (AERD), also referred to as Samter's triad. (fortunefavorsthebravenyc.com)
  • AERD stands for Aspirin Exacerbated Respiratory Disease or also called Samter's Triad. (rballergy.com)
  • The cause of AERD/ Samter's Triad is not well understood, however patients with AERD have seemingly acquired overproduction of and sensitivity to chemicals known as leukotrienes and often have high levels of cells called eosinophils in their blood and in their sinuses, which may lead to chronic inflammation of the airways and sinuses. (rballergy.com)
  • Alternatively, aspirin desensitization and therapy combined with surgery is a well-recognized therapeutic option for patients with AERD, particularly those with severe asthma and polyp disease. (rballergy.com)
  • In people with AERD/Samter's Triad, aspirin desensitization is performed by administering gradually increasing doses of aspirin to minimize risk of a serious reaction in a hospital or clinic that specializes in such treatment. (rballergy.com)
  • The goal of an aspirin desensitization procedure is to have the patient begin long-term daily aspirin therapy, which can treat the underlying cause of AERD/Samter's Triad and decrease the need for oral corticosteroid medications and reduce the frequency of sinus surgeries needed. (rballergy.com)
  • The most effective known treatment for AERD is aspirin therapy. (rballergy.com)
NSAIDs6
  • In addition to aspirin, patients also react to other NSAIDs such as ibuprofen, and to any medication that inhibits the cyclooxygenase-1 (COX-1) enzyme, although paracetamol (acetaminophen) in low doses is generally considered safe. (wikipedia.org)
  • In addition to aspirin and NSAIDs, consumption of even small amounts of alcohol also produces uncomfortable respiratory reactions in many patients. (wikipedia.org)
  • Leukotriene levels are further elevated after ingestion of aspirin or NSAIDS, which is why patients develop reactions to these medications, and why anti-leukotriene agents are used in the treatment of this condition. (rballergy.com)
  • Without aspirin desensitization, the typical treatment is multiple sinus surgeries, avoidance of aspirin and other NSAIDs,oral and intranasal steroids, anti-leukotriene medications, and treatment of asthma. (rballergy.com)
  • The dose is slowly increased until the patient is able to take a full dose (325 mg) of aspirin and is then considered desensitized and can continue to take aspirin and other NSAIDs safely. (rballergy.com)
  • Aspirin sensitive patients who need aspirin or NSAIDs for the treatment of other diseases. (rballergy.com)
Rhinosinusitis1
  • Medical conditions such as rhinosinusitis, gastroesophageal reflux, and aspirin or nonsteroidal anti-inflammatory agent (NSAID) sensitivity may also trigger or exacerbate asthma. (medscape.com)
Respiratory3
NSAID1
Hypersensitivity reactions1
Sensitivity1
Daily aspirin therapy2
  • Paradoxically, daily aspirin therapy after an initial desensitization can also help manage symptoms. (wikipedia.org)
  • Who have had aspirin induced hives or anaphylaxis that do not require daily aspirin therapy for treatment of other conditions. (rballergy.com)
Chronic2
  • Asthma is one of the most common chronic diseases of childhood, affecting about 6 million children in the US. (msdmanuals.com)
  • Asthma is a chronic inflammatory disease characterized by hyper-responsiveness of airways to various stimuli. (medscape.com)
Adults3
  • A case-control cohort study showed that older adults with asthma have a higher rate of allergic sensitization, decreased lung function, and significantly worse quality of life when compared with controls. (medscape.com)
  • Some of the independent risk factors for asthma in older adults include house dust mite sensitization and maternal smoking. (medscape.com)
  • The incidence rate of asthma in adults older than 65 years is similar to that found in other age groups (approximately 100 cases per 100,000 population annually). (medscape.com)
Exacerbations3
Rhinitis1
  • Rhinitis medicamentosa is now generally considered a subset of drug-induced rhinitis that may include the development of congestion and other nasal symptoms from medications that are not administered by the intranasal route. (medscape.com)
Symptoms6
Inflammation2
  • Asthma is a disease of diffuse airway inflammation caused by a variety of triggering stimuli resulting in partially or completely reversible bronchoconstriction. (msdmanuals.com)
  • Airway inflammation, smooth muscle contraction, epithelial sloughing, mucous hypersecretion, bronchial hyperresponsiveness, and mucosal edema are some of the common pathophysiological mechanisms seen in asthma. (medscape.com)
Ingestion1
Trigger1
Severity1
  • Your healthcare provider can help determine the most suitable alternatives based on the severity of your asthma, your individual health history, and any other underlying conditions you may have. (fortunefavorsthebravenyc.com)
Clinical1
  • The purpose of this research is to explore the clinical characteristics of contrast media induced KS. (bvsalud.org)
Leukotriene1
  • Misc: The coupon SINGULAIR is a prescription medicine used to prevent asthma attacks and for Singulair is in a class of medications called leukotriene modifiers. (typepad.com)
Severe1
  • The polyps can cause severe nasal obstruction, loss of sense of smell, and uncontrolled asthma. (rballergy.com)
Exercise1
Desensitization4
Medications1
  • Adult patients with asthma often stop their medications when they feel well. (medscape.com)
Diagnosis1
Ibuprofen8
Infants1
  • Wheezing and Asthma in Infants and Young Children Wheezing is a relatively high-pitched whistling noise produced by movement of air through narrowed or compressed small airways. (msdmanuals.com)
Elderly2
  • Although asthma has an equal incidence across all age groups, asthma in the elderly is often underdiagnosed and undertreated. (medscape.com)
  • Elderly patients with asthma face disproportionate morbidity, mortality and cost when compared with younger patient groups. (medscape.com)
Allergy1
  • Dr. Li reviewed an antiasthma simplified herbal medicine intervention In a second study, presented at the 60th annual meeting of the American Academy of Allergy, Asthma, and Immunology Bielory L, Lupoli K. Herbal interventions in asthma and allergy. (typepad.com)
Patients3
  • once hospitalized, the death rate attributable to asthma for patients older than 65 years is 14 times higher than patients aged 18-35 years. (medscape.com)
  • Aspirin sensitive patients requiring repeated sinus surgeries. (rballergy.com)
  • This comprehensive INDICATIONS: AsthmaMentor has been designed to help clinicians teach patients what to do when their asthma Sometimes you need to know how well your asthma is controlled at home, without going to the doctor's If you have asthma, your doctor may recommend that you use a peak flow meter to help track your asthma control. (typepad.com)
Medication1
  • Singulair Asthma Medication BUY SINGULAIR ONLINE -- ENTER SITE singulair (asthma medicine singulair) - Drugs Pedia offering meds since 2004 providing quality. (typepad.com)
People1
  • Charts 30-32 show the percent of people with diagnosed high cholesterol, asthma, and diabetes. (typepad.com)
Therapy1
  • Even with optimal therapy, the disease is often not well controlled with rapidly recurring polyps and frequent asthma flares. (rballergy.com)
Risk1
Manage2
  • Learn how to perform peak flows and use your peak A peak flow diary is one of the most powerful tools a patient can use to manage asthma at home. (typepad.com)
  • The experts at WebMD explain how to manage your asthma using a peak flow meter. (typepad.com)
Development1
  • Development of asthma is multifactorial and depends on the interactions among multiple susceptibility genes and environmental factors. (msdmanuals.com)
Important1