• In reality a salvage radical prostatectomy can be considered for men with locally recurrent prostate cancer after external beam radiotherapy has failed. (malecare.org)
  • 2 The argument for postoperative radiotherapy (RT) is predicated on the assumption that some patients may have residual local disease of a potentially lethal phenotype after surgery and that the delivery of secondary local therapy may interrupt the natural history of disease and prevent progression to systemic disease. (jnccn.org)
  • Salvage therapy options include further chemo-radiotherapy and autologous or allogeneic haematopoietic SCT (HSCT). (nih.gov)
  • Salvage radical prostatectomy after primary radiotherapy (sRP) is considered a challenging procedure. (unito.it)
  • Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
  • González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)
  • The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
  • Magnetic Resonance Imaging and targeted biopsies compared to transperineal mapping biopsies prior to salvage focal therapy/ablation in localised and metastatic recurrent prostate cancer after radiotherapy. (ucl.ac.uk)
  • OBJECTIVE: To evaluate the role of prostate MRI in detection of prostate cancer recurring after radiotherapy and the role of salvage focal ablation in treating recurrent disease. (ucl.ac.uk)
  • Background: Disease progression following salvage radiotherapy (SRT) for prostate cancer (PC) is common, and the time to biochemical recurrence (BCR) is heterogeneous. (elsevierpure.com)
  • Patient summary: Many men will develop biochemical recurrence of prostate cancer after salvage radiotherapy. (elsevierpure.com)
  • Men with biochemical recurrence within 18 mo of salvage radiotherapy constitute a cohort at higher risk of distant metastasis and prostate cancer-specific mortality. (elsevierpure.com)
  • Salvage surgery is considered an option for isolated recurrences of retroperitoneal and pelvic tumors , in patients who have undergone previous radiotherapy . (bvsalud.org)
  • Salvage chemotherapy is a treatment that is given after the cancer has not responded to other chemotherapy regimens. (wikipedia.org)
  • Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. (biomedcentral.com)
  • Although applying multi-modal therapies (radiation, chemotherapy, and surgery) has increased 5-year survival amongst standard-risk MB patients, overall survival (OS) rates seem to have plateaued. (biomedcentral.com)
  • Bendamustine/rituximab is the preferred initial therapy for most patients, while ibrutinib/rituximab is an acceptable alternative for elderly patients who cannot tolerate chemotherapy. (medscape.com)
  • A small number of patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) may benefit from chemotherapy intensification after not responding to venetoclax-based salvage therapy, according to a study published in the European Journal of Haematology . (hematologyadvisor.com)
  • Autologous HSCT following high-dose chemotherapy, the standard treatment for adult patients with relapsed HL, is also effective in paediatric patients, but randomized trials showing its superiority to conventional therapy are lacking. (nih.gov)
  • Epidermal growth factor receptor-tyrosine kinase inhibitors ( EGFR -TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung non-squamous cell carcinoma harboring susceptible EGFR mutations when used as first-line therapy. (biomedcentral.com)
  • Cytotoxic chemotherapy is regarded as being the standard therapy to overcome acquired resistance to an initial EGFR TKI. (biomedcentral.com)
  • Two hundred and nine patients with mutated EGFR and who took gefitinib as the first-line therapy were identified in the study period, of whom 86 received second-line cytotoxic chemotherapy, and 60 who received third-line therapy were eligible for this study. (biomedcentral.com)
  • Retreatment with an EGFR TKI is not inferior to cytotoxic chemotherapy when used as salvage therapy for patients with adenocarcinoma with an EGFR mutation, especially if a third-generation EGFR TKI is not available, or if the reason for resistance is unknown or is not related to the T790M mutation. (biomedcentral.com)
  • According to study protocol, treatment was switched to salvage chemotherapy with the standard etoposide/cisplatin regimen etoposide/carboplatin (Par-aplatin) in some cases if tumor regression of less than 25% was seen following the first course. (cancernetwork.com)
  • Likewise, patients with tumor regression of less than 50% after the second course were switched to salvage chemotherapy. (cancernetwork.com)
  • Radical prostatectomy and nonsurgical salvage treatments for radiorecurrent prostate cancer offer similar 5-year recurrence-free survival rates, but toxicities appear less severe with high-dose-rate brachytherapy and stereotactic body radiation therapy, a meta-analysis found. (oncologynurseadvisor.com)
  • Surgical and nonsurgical local salvage treatments for prostate cancer (PCa) that recurs following radiation therapy offer similar 5-year recurrence-free survival (RFS) rates, but re-irradiation appears to result in less toxicity, according to a new meta-analysis. (oncologynurseadvisor.com)
  • We find that many men will experience early biochemical recurrence following postprostatectomy salvage radiation therapy. (elsevierpure.com)
  • The addition of IOERT to salvage resection for isolated recurrence of gynecologic cancers suggest favorable local control in cases with concern for residual microscopic disease . (bvsalud.org)
  • In explaining the rationale for the study, Parekh and colleagues noted that while the use of BCMA-directed CAR T-cell therapies in relapsed and refractory multiple myeloma have demonstrated high response rates, optimal treatment regimens have yet to be defined for patients who relapse. (medpagetoday.com)
  • however, risks associated with extravasation of Act-D and adverse effects such as alopecia and neutropenia make MTX regimens more commonly used as front-line therapy (see Table 1, below). (medscape.com)
  • Such information will lead providers to recommend off-label targeted therapy, which now routinely costs in excess of 100 000 dollars per year of treatment, [ 3 ] but the response rate to this strategy and whether it improves overall survival (OS) or progression-free survival (PFS) for these patients over alternative (typically cytotoxic) salvage regimens are currently unknown. (medscape.com)
  • Salvage Radical Prostatectomy for Recurrent Prostate Cancer after Radiation Therapy. (malecare.org)
  • Subsequently they were treated with salvage surgery for clinically localized prostate cancer once their PSA scores again began to rise. (malecare.org)
  • Reflecting this, the most recent update of the NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer states "new evidence supports offering adjuvant/salvage RT in all men with adverse pathologic features or detectable PSA" 3 (to view the most recent version of these guidelines, visit the NCCN Web site at www.NCCN.org ). (jnccn.org)
  • Salvage Local Treatments After Focal Therapy for Prostate Cancer. (endourology.ph)
  • Whether focal therapy (FT) for prostate cancer (PC) jeopardizes outcomes from salvage treatments is a matter of debate still to be resolved. (endourology.ph)
  • We performed a literature search to determine the treatment options available for prostate cancer after failure of focal therapy and their outcomes. (endourology.ph)
  • Learn about how to talk to your doctor Androgen Deprivation Therapy (ADT) for prostate cancer. (urologyhealth.org)
  • Learn about Androgen Deprivation Therapy (ADT) for prostate cancer, who should receive ADT, how is ADT given and the benefits, risks and side effects of ADT. (urologyhealth.org)
  • Learn about salvage radiation therapy (SRT) as a type of cancer treatment given to men who had their prostate removed yet their prostate-specific antigen (PSA) levels begin to rise. (urologyhealth.org)
  • Since measurable differences in RFS are unlikely to translate to overall survival in the salvage setting, one might advocate selecting the local salvage treatment with the lowest toxicity until randomized data are available," the authors wrote. (oncologynurseadvisor.com)
  • Studies examining the survival and toxicity of therapies administered to treatment-refractory pediatric MB patients will be included. (biomedcentral.com)
  • Among 79 patients who were given a total of 237 salvage treatments, median overall survival (OS) from the date of relapse post-CAR T-cell therapy was 17.9 months (95% CI 14.0 to not estimable [NE]), reported Samir Parekh, MD, of the Icahn School of Medicine at Mount Sinai in New York City, and colleagues. (medpagetoday.com)
  • The median progression-free survival (PFS) with the first attempted salvage therapy was 3.5 months. (medpagetoday.com)
  • This suggests that for eligible patients that progress after BCMA-directed CAR T, additional T-cell-engaging therapies contribute meaningfully to survival and that T-cell activation is feasible down the line," Parekh and team wrote. (medpagetoday.com)
  • Four-year survival and event-free survival estimates of 91% and 60%, respectively, together with a median postsalvage therapy survival of more than 5 years justify the conduct of a prospective randomized clinical trial to determine the clinical value of preemptive therapy in SMM. (elsevierpure.com)
  • Median intracranial progression-free survival of patients in the WBRT arm (10.4 months) was longer than that of patients in the salvage SRS arm (4.0 months). (elsevierpure.com)
  • It is therefore necessary to investigate the feasibility and efficacy of image guided permanent implantation of 125 I seeds as a salvage therapy for locally recurrent STS in children and to determine local control, survival, and complications. (biomedcentral.com)
  • Two phase 3 trials have compared SRT with and without androgen deprivation therapy (ADT), finding that combined treatment (SRT+ADT) improves both PFS and overall survival. (wjgnet.com)
  • For one of those patients, a survival of more than 836 days post-amrubicin therapy has been recorded. (cancernetwork.com)
  • We investigated the feasibility, efficacy, and morbidity of permanent interstitial 125 I seed implantation under image guidance as a salvage treatment for pediatric patients with recurrent or metastatic soft tissue sarcoma. (biomedcentral.com)
  • Four retrospective series assessed salvage treatments after FT failure evaluating cases of radical prostatectomy (RP) and repeat ablation (sample size from 12 to 22 patients). (endourology.ph)
  • Other options are radiation therapy (RT) and whole-gland or focal repeat ablations, although these have only been described after whole-gland ablation. (endourology.ph)
  • LP-irinotecan TACE was conducted in 42% of patients as salvage therapy, 20% as an intensification treatment, 16% as a first-line treatment, 14% a consolidation treatment and 8% combination treatment with ablation with curative intent. (springer.com)
  • Patients with multiple myeloma who relapse after treatment with B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy can be salvaged with multiple lines of therapy, a retrospective study suggested. (medpagetoday.com)
  • Patients with multiple myeloma who relapse after BCMA-directed CAR T have a limited prognosis but can be potentially treated with multiple lines of salvage therapy," they wrote. (medpagetoday.com)
  • The 13 patients who received a T-cell-engaging therapy immediately after relapse on CAR T had an ORR of 75.0% and a median PFS of 9.1 months. (medpagetoday.com)
  • In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
  • 12 months after completion of therapy) may be cured with conventional therapy, those with progressive disease or early relapse (3-12 months) are considered candidates for autologous HSCT. (nih.gov)
  • Regorafenib and TFTD+B are both standard salvage options for metastatic CRC. (mybestmedicine.com)
  • Comparison of First-Line Anti-PD-1-Based Combination Therapies in Metastatic Renal-Cell Carcinoma: Real-World Experiences from a Retrospective, Multi-Institutional Cohort. (endourology.ph)
  • Image guided permanent interstitial 125 I seed implantation as a salvage treatment appears to have a satisfactory outcome in children with recurrent or metastatic soft tissue sarcoma. (biomedcentral.com)
  • Salvage therapy, in this context, is the attempt to contain the replicating HIV once the usual line of treatments have been exhausted. (wikipedia.org)
  • Patients received a median of two salvage treatments. (medpagetoday.com)
  • Furthermore, high-quality data on new minimally invasive salvage focal ablative treatments are needed. (ucl.ac.uk)
  • Novel predictive biomarkers are needed to identify men harboring micrometastatic disease to avoid potentially futile local therapies or allow for intensification of systemic therapies. (elsevierpure.com)
  • However, they suggested that prospective clinical trials are needed to evaluate the role of salvage transplant-based approaches. (medpagetoday.com)
  • Background Endovascular therapy has been shown to be effective in patients with acute cerebral large vessel occlusion, but real-world efficacies are unknown. (bmj.com)
  • We enrolled both consecutive patients who were treated with or without endovascular therapy. (bmj.com)
  • We constructed the matched cohort based on a propensity score for endovascular therapy and estimated the adjusted odds ratio [OR]. (bmj.com)
  • Results A total of 2420 patients were recruited, 2399 (1,278 in endovascular therapy vs 1121 in no endovascular therapy) provided the primary outcome at 90 days, and 2242 (1,121 each) propensity score matched cohort was analyzed. (bmj.com)
  • Favorable outcomes were observed in 35.3% and 30.7% of patients in the endovascular therapy and no endovascular therapy groups, respectively (p = 0.02). (bmj.com)
  • The efficacy of endovascular therapy in achieving favorable outcomes did not differ between our subgroups. (bmj.com)
  • Conclusions Endovascular therapy decreased disabilities at 90 days in real-world patients with acute cerebral large vessel occlusion. (bmj.com)
  • Of note, patients who received a T-cell-engaging therapy (a bispecific antibody or subsequent CAR T-cell therapy) had the greatest success in this setting, with OS not reached after a median follow-up of 21.3 months, they noted in Blood . (medpagetoday.com)
  • Achieving a partial response or better with the first line of salvage therapy was associated with a significantly longer median OS of 29.9 months compared with 14.6 months for patients who did not achieve an objective response ( P =0.028). (medpagetoday.com)
  • The 79 patients included in this analysis had a median age of 60 years at the time of progression after CAR T-cell therapy, and 60% were men. (medpagetoday.com)
  • For 33 evaluable patients, the median age was 66 and the median number of courses of therapy was 4. (cancernetwork.com)
  • The aim of this systematic review will be to investigate the efficacy and safety of salvage therapies for the management of children with progressive, treatment-refractory, or recurrent MB. (biomedcentral.com)
  • In 2010, the dilemma is not in the question of whether postprostatectomy adjuvant or salvage RT are effective among high-risk patients as a group, but rather which individual patients ought to receive it and when. (jnccn.org)
  • From March 2017 to January 2022, 140 patients with multiple myeloma were treated with a BCMA-directed CAR T-cell therapy on a clinical trial at either the Mount Sinai Tisch Cancer Institute or Memorial Sloan Kettering Cancer Center in New York City. (medpagetoday.com)
  • Smoldering multiple myeloma (SMM) is usually followed expectantly without therapy. (elsevierpure.com)
  • Therefore, a systematic review of the literature regarding treatment strategies employed in recurrent pediatric MB will evaluate previous salvage therapies in order to guide future clinical trials. (biomedcentral.com)
  • Maggi JC, Nussbaum E, Babbitt C, Maggi FE, Randhawa I. Pediatric fiberoptic bronchoscopy as adjunctive therapy in acute asthma with respiratory failure. (springeropen.com)
  • A nonsystematic literature review in PubMed using the term "salvage radical prostatectomy" was performed on December 1, 2021. (unito.it)
  • The goal of AMPLITUDE is to see if adding the PARP inhibitor niraparib to standard of care hormone therapy (Abiraterone Acetate, prednisone and androgen deprivation therapy (ADT) is safe and more effective than standard of care alone. (facingourrisk.org)
  • Although often mentioned, but seldom used, men who fail radiation as a primary treatment can also benefit from salvage surgery. (malecare.org)
  • We performed a nonsystematic search of PubMed for articles assessing relevant outcomes for salvage local treatment after FT failure using a manual search. (endourology.ph)
  • Important limitations include the low level of the evidence and the absence of standardized criteria for FT, salvage treatment, and FT failure. (endourology.ph)
  • While it seems that FT has a minimal impact on salvage treatment results, prospective controlled studies are needed to confirm these preliminary data. (endourology.ph)
  • The authors performed a retrospective analysis of 28 patients who received multiple treatment lines and relapsed or did not achieve response after venetoclax-based salvage therapy. (hematologyadvisor.com)
  • 6 patients did not receive salvage treatment because of poor condition. (hematologyadvisor.com)
  • As there was no response to the abovementioned line of treatment, other nonstandard therapies such as intramuscular adrenaline and ketamine were also tried but to no avail. (springeropen.com)
  • Posaconazole can be used off-label for salvage treatment in patients intolerant to amphotericin B. It has also been used as step-down therapy after initial control of the disease with amphotericin. (medscape.com)
  • ONCOLOGY spoke with Eric Ko, MD, PhD, who recently published a review article with his colleagues on strategies for combining radiation therapy with immunotherapy for the treatment of non-small-cell lung cancer. (cancernetwork.com)
  • Intraoperative electron radiation therapy after salvage surgery in gynecological cancers and retroperitoneal sarcomas: outcomes and adverse effects. (bvsalud.org)
  • Secondary outcomes will include safety and toxicity of each therapy administered. (biomedcentral.com)
  • By reviewing the efficacy and toxicity of MB salvage therapies, this study will identify effective therapeutic strategies administered to recurrent MB patients and can inform future clinical trials aimed to improve patient survivorship and quality of life. (biomedcentral.com)
  • Investigation of clinically tested therapies for children with recurrent MB has significant implications for clinical practice. (biomedcentral.com)
  • Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER), aiming to evaluate the effect of oxygen therapy on myocardial salvage and infarct size in patients with ST elevation myocardial infarction (STEMI) treated with a primary percutaneous coronary intervention (PCI). (lu.se)
  • In additional analyses, we will investigate the role of re-irradiation and mono- vs. poly-therapy in recurrent disease, and whether molecular subgrouping of MB influences salvage therapy. (biomedcentral.com)
  • I often discuss the use of salvage radiation after surgery has failed and the PSA begins to rise. (malecare.org)
  • Methods: Fifty-nine patients treated in the Breast Surgery Unit at the University Hospital of Parma (Italy) between January 2010 and December 2017 for ipsilateral breast recurrent cancer, previously treated by partial mastectomy plus whole-breast radiation therapy, were analyzed. (unipr.it)
  • Patients were randomly assigned to WBRT or salvage SRS arms within 21 days of surgery. (elsevierpure.com)
  • We evaluated the outcomes and adverse effects in patients with retroperitoneal sarcoma and gynecologic tumors after salvage surgery and IOERT. (bvsalud.org)
  • A strength of the study was the comprehensive inclusion of both surgical and nonsurgical local salvage modalities as well as clear distinctions among the types of salvage brachytherapy and external beam radiation therapy, the authors noted. (oncologynurseadvisor.com)
  • Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. (neuboron.com)
  • Safety and efficacy of thioridazine as salvage therapy in Indian patients with XDR-TB. (drzarirudwadia.com)
  • This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
  • Nevertheless, the question of whether all patients with the aforementioned adverse features should undergo immediate adjuvant RT versus initial observation with more selective-but early-salvage RT in the event of biochemical failure remains the subject of heated controversy. (jnccn.org)
  • The benefit of combination therapy with different classes of antifungals (including echinocandins) is uncertain. (medscape.com)
  • Dr. Baselga, of Vall D'Hebron University Hospital, Barcelona, Spain, reported phase II data from a multicenter, international, randomized, double-blind, parallel-group study of two different dosages of the investigational EGFR tyrosine kinase inhibitor ZD-1839 (Iressa) as salvage monotherapy for patients with advanced NSCLC. (cancernetwork.com)
  • This systematic review will provide an overview of the current literature regarding salvage therapies for relapsed MB patients. (biomedcentral.com)
  • Current evidence shows acceptable outcomes for post-FT salvage options, although this is based on retrospective data. (endourology.ph)
  • Conclusions: The possibility of initiating salvage therapy earlier is discussed, potentially based on improved future biomarker panels. (lu.se)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
  • Second, F1CDx lacks randomized data showing superiority to the current strategy of selecting a salvage therapy based on histopathology and clinical considerations. (medscape.com)
  • When at least one regimen containing protease inhibitors has failed in a patient, the subsequent attempts to treat the HIV infection may be referred to as salvage therapy. (wikipedia.org)
  • However, targeted therapies did not induce object responses in the patient population analyzed. (hematologyadvisor.com)
  • abstinence) prior to study entry, for the duration of study participation, and for 4 months following completion of therapy. (uci.edu)
  • The Effects of Oxygen Therapy on Myocardial Salvage in ST Elevation Myocardial Infarction Treated with Acute Percutaneous Coronary Intervention: The Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER) Study. (lu.se)
  • Salvage therapy, also known as rescue therapy, is a form of therapy given after an ailment does not respond to standard therapy. (wikipedia.org)
  • Bronchoscopy as a rescue therapy in patients with status asthmaticus: two case reports and review of literature. (springeropen.com)
  • Nucleoside analogs such as fludarabine or cladribine pose a risk of stem cell damage and leukemogenesis and should not be used as initial therapy in patients who are candidates for stem cell transplantation (SCT). (medscape.com)
  • In order to increase local control intra operative electron radiation therapy (IOERT) can be used in these patients to administer additional radiation dose . (bvsalud.org)
  • [ 3 ] Corticosteroids are used as adjunctive initial therapy only in patients with HIV infection who have severe PJP. (medscape.com)
  • [3] There are also substantial benefits for the health of HIV-infected persons and reduced transmission of HIV to uninfected persons associated with the early initiation of highly active antiretroviral therapy (HAART) for those aware of their serostatus. (cdc.gov)